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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ZFYVE21-BIN1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ZFYVE21-BIN1
	FusionPDB ID: 101164
	FusionGDB2.0 ID: 101164
		Hgene	Tgene
	Gene symbol	ZFYVE21	BIN1
	Gene ID	79038	274
	Gene name	zinc finger FYVE-type containing 21	bridging integrator 1
	Synonyms	HCVP7TP1\|ZF21	AMPH2\|AMPHL\|CNM2\|SH3P9
	Cytomap	14q32.33	2q14.3
	Type of gene	protein-coding	protein-coding
	Description	zinc finger FYVE domain-containing protein 21FYVE domain containing 21HCV p7-transactivated protein 1zinc finger, FYVE domain containing 21	myc box-dependent-interacting protein 1amphiphysin IIamphiphysin-like proteinbox dependant MYC interacting protein 1box-dependent myc-interacting protein 1
	Modification date	20200313	20200322
	UniProtAcc	.	O00499
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000216602, ENST00000311141,	ENST00000466111, ENST00000259238, ENST00000316724, ENST00000346226, ENST00000348750, ENST00000351659, ENST00000352848, ENST00000357970, ENST00000376113, ENST00000393040, ENST00000393041, ENST00000409400,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 4 X 2=32	8 X 8 X 4=256
	# samples	4	8
	** MAII score	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ZFYVE21 [Title/Abstract] AND BIN1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ZFYVE21(104182318)-BIN1(127834284), # samples:1
Anticipated loss of major functional domain due to fusion event.	ZFYVE21-BIN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZFYVE21-BIN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZFYVE21-BIN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ZFYVE21-BIN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	BIN1	GO:0033292	T-tubule organization	24755653
Tgene	BIN1	GO:0043065	positive regulation of apoptotic process	16530520
Tgene	BIN1	GO:0071156	regulation of cell cycle arrest	10412034

Fusion gene breakpoints across ZFYVE21 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BIN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BQ068183	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000216602	ZFYVE21	chr14	104182318	+	ENST00000376113	BIN1	chr2	127834284	-	1940	250	112	1440	442
ENST00000216602	ZFYVE21	chr14	104182318	+	ENST00000346226	BIN1	chr2	127834284	-	2222	250	112	1722	536
ENST00000216602	ZFYVE21	chr14	104182318	+	ENST00000352848	BIN1	chr2	127834284	-	2030	250	112	1530	472
ENST00000216602	ZFYVE21	chr14	104182318	+	ENST00000393041	BIN1	chr2	127834284	-	2093	250	112	1593	493
ENST00000216602	ZFYVE21	chr14	104182318	+	ENST00000348750	BIN1	chr2	127834284	-	1895	250	112	1395	427
ENST00000216602	ZFYVE21	chr14	104182318	+	ENST00000357970	BIN1	chr2	127834284	-	2318	250	112	1818	568
ENST00000216602	ZFYVE21	chr14	104182318	+	ENST00000259238	BIN1	chr2	127834284	-	2159	250	112	1659	515
ENST00000216602	ZFYVE21	chr14	104182318	+	ENST00000393040	BIN1	chr2	127834284	-	2114	250	112	1614	500
ENST00000216602	ZFYVE21	chr14	104182318	+	ENST00000351659	BIN1	chr2	127834284	-	2186	250	112	1686	524
ENST00000216602	ZFYVE21	chr14	104182318	+	ENST00000316724	BIN1	chr2	127834284	-	2447	250	112	1947	611
ENST00000216602	ZFYVE21	chr14	104182318	+	ENST00000409400	BIN1	chr2	127834284	-	1974	250	112	1485	457
ENST00000311141	ZFYVE21	chr14	104182318	+	ENST00000376113	BIN1	chr2	127834284	-	1862	172	34	1362	442
ENST00000311141	ZFYVE21	chr14	104182318	+	ENST00000346226	BIN1	chr2	127834284	-	2144	172	34	1644	536
ENST00000311141	ZFYVE21	chr14	104182318	+	ENST00000352848	BIN1	chr2	127834284	-	1952	172	34	1452	472
ENST00000311141	ZFYVE21	chr14	104182318	+	ENST00000393041	BIN1	chr2	127834284	-	2015	172	34	1515	493
ENST00000311141	ZFYVE21	chr14	104182318	+	ENST00000348750	BIN1	chr2	127834284	-	1817	172	34	1317	427
ENST00000311141	ZFYVE21	chr14	104182318	+	ENST00000357970	BIN1	chr2	127834284	-	2240	172	34	1740	568
ENST00000311141	ZFYVE21	chr14	104182318	+	ENST00000259238	BIN1	chr2	127834284	-	2081	172	34	1581	515
ENST00000311141	ZFYVE21	chr14	104182318	+	ENST00000393040	BIN1	chr2	127834284	-	2036	172	34	1536	500
ENST00000311141	ZFYVE21	chr14	104182318	+	ENST00000351659	BIN1	chr2	127834284	-	2108	172	34	1608	524
ENST00000311141	ZFYVE21	chr14	104182318	+	ENST00000316724	BIN1	chr2	127834284	-	2369	172	34	1869	611
ENST00000311141	ZFYVE21	chr14	104182318	+	ENST00000409400	BIN1	chr2	127834284	-	1896	172	34	1407	457

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000216602	ENST00000376113	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.003522861	0.9964772
ENST00000216602	ENST00000346226	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.004874338	0.9951257
ENST00000216602	ENST00000352848	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.003771716	0.99622834
ENST00000216602	ENST00000393041	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.004413863	0.99558616
ENST00000216602	ENST00000348750	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.003045487	0.99695456
ENST00000216602	ENST00000357970	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.006850007	0.99315006
ENST00000216602	ENST00000259238	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.004315987	0.995684
ENST00000216602	ENST00000393040	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.003803027	0.996197
ENST00000216602	ENST00000351659	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.005889166	0.99411076
ENST00000216602	ENST00000316724	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.006421516	0.99357843
ENST00000216602	ENST00000409400	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.003506755	0.9964933
ENST00000311141	ENST00000376113	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.003956554	0.99604344
ENST00000311141	ENST00000346226	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.005564634	0.9944353
ENST00000311141	ENST00000352848	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.004277133	0.9957229
ENST00000311141	ENST00000393041	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.00511459	0.9948854
ENST00000311141	ENST00000348750	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.003370091	0.9966299
ENST00000311141	ENST00000357970	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.007684811	0.9923152
ENST00000311141	ENST00000259238	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.005012315	0.9949877
ENST00000311141	ENST00000393040	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.004317167	0.99568284
ENST00000311141	ENST00000351659	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.006832699	0.99316734
ENST00000311141	ENST00000316724	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.007385455	0.9926145
ENST00000311141	ENST00000409400	ZFYVE21	chr14	104182318	+	BIN1	chr2	127834284	-	0.00399956	0.99600047

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>101164_101164_1_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000216602_BIN1_chr2_127834284_ENST00000259238_length(amino acids)=515AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPRKKSKLFSRLRRKKNSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQI
LSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQ

--------------------------------------------------------------

>101164_101164_2_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000216602_BIN1_chr2_127834284_ENST00000316724_length(amino acids)=611AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENF
HKEMSKLNQNLNDVLVGLEKQHGSNTFTVKAQPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVP
PPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQFEAPGPFSEQASLLDLDFDPLPPVTSPVKAPTPSGQSIPWDLWEPTESPAGSLPS
GEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFM

--------------------------------------------------------------

>101164_101164_3_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000216602_BIN1_chr2_127834284_ENST00000346226_length(amino acids)=536AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVT
TPSQPTESPAGSLPSGEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVE

--------------------------------------------------------------

>101164_101164_4_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000216602_BIN1_chr2_127834284_ENST00000348750_length(amino acids)=427AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQ

--------------------------------------------------------------

>101164_101164_5_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000216602_BIN1_chr2_127834284_ENST00000351659_length(amino acids)=524AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENF
HKEMSKLNQNLNDVLVGLEKQHGSNTFTVKAQPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQPTESPAGS
LPSGEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPP

--------------------------------------------------------------

>101164_101164_6_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000216602_BIN1_chr2_127834284_ENST00000352848_length(amino acids)=472AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPRKKSKLFSRLRRKKNSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQPAEASEVAGGTQPAAGAQEPGETA
ASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDW

--------------------------------------------------------------

>101164_101164_7_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000216602_BIN1_chr2_127834284_ENST00000357970_length(amino acids)=568AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENF
HKEMSKLNQNLNDVLVGLEKQHGSNTFTVKAQPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQFEAPGPFS
EQASLLDLDFDPLPPVTSPVKAPTPSGQSIPWDLWEPTESPAGSLPSGEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQPAAGAQ
EPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMG

--------------------------------------------------------------

>101164_101164_8_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000216602_BIN1_chr2_127834284_ENST00000376113_length(amino acids)=442AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPRKKSKLFSRLRRKKNSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQSSLPAVVVETFPATVNGTVEGGSG

--------------------------------------------------------------

>101164_101164_9_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000216602_BIN1_chr2_127834284_ENST00000393040_length(amino acids)=500AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVT
TPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKA

--------------------------------------------------------------

>101164_101164_10_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000216602_BIN1_chr2_127834284_ENST00000393041_length(amino acids)=493AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQPTESPAGSLPSGEPSAAEGTFAVSWPSQTAEPGPAQPAE
ASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVI

--------------------------------------------------------------

>101164_101164_11_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000216602_BIN1_chr2_127834284_ENST00000409400_length(amino acids)=457AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVE
TFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPE

--------------------------------------------------------------

>101164_101164_12_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000311141_BIN1_chr2_127834284_ENST00000259238_length(amino acids)=515AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPRKKSKLFSRLRRKKNSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQI
LSLFEDTFVPEISVTTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQ

--------------------------------------------------------------

>101164_101164_13_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000311141_BIN1_chr2_127834284_ENST00000316724_length(amino acids)=611AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENF
HKEMSKLNQNLNDVLVGLEKQHGSNTFTVKAQPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVP
PPPKHTPSKEVKQEQILSLFEDTFVPEISVTTPSQFEAPGPFSEQASLLDLDFDPLPPVTSPVKAPTPSGQSIPWDLWEPTESPAGSLPS
GEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFM

--------------------------------------------------------------

>101164_101164_14_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000311141_BIN1_chr2_127834284_ENST00000346226_length(amino acids)=536AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVT
TPSQPTESPAGSLPSGEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVE

--------------------------------------------------------------

>101164_101164_15_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000311141_BIN1_chr2_127834284_ENST00000348750_length(amino acids)=427AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQ

--------------------------------------------------------------

>101164_101164_16_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000311141_BIN1_chr2_127834284_ENST00000351659_length(amino acids)=524AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENF
HKEMSKLNQNLNDVLVGLEKQHGSNTFTVKAQPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQPTESPAGS
LPSGEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPP

--------------------------------------------------------------

>101164_101164_17_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000311141_BIN1_chr2_127834284_ENST00000352848_length(amino acids)=472AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPRKKSKLFSRLRRKKNSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQPAEASEVAGGTQPAAGAQEPGETA
ASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDW

--------------------------------------------------------------

>101164_101164_18_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000311141_BIN1_chr2_127834284_ENST00000357970_length(amino acids)=568AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENF
HKEMSKLNQNLNDVLVGLEKQHGSNTFTVKAQPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQFEAPGPFS
EQASLLDLDFDPLPPVTSPVKAPTPSGQSIPWDLWEPTESPAGSLPSGEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQPAAGAQ
EPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMG

--------------------------------------------------------------

>101164_101164_19_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000311141_BIN1_chr2_127834284_ENST00000376113_length(amino acids)=442AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPRKKSKLFSRLRRKKNSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQSSLPAVVVETFPATVNGTVEGGSG

--------------------------------------------------------------

>101164_101164_20_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000311141_BIN1_chr2_127834284_ENST00000393040_length(amino acids)=500AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQEQILSLFEDTFVPEISVT
TPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKA

--------------------------------------------------------------

>101164_101164_21_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000311141_BIN1_chr2_127834284_ENST00000393041_length(amino acids)=493AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQPTESPAGSLPSGEPSAAEGTFAVSWPSQTAEPGPAQPAE
ASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVI

--------------------------------------------------------------

>101164_101164_22_ZFYVE21-BIN1_ZFYVE21_chr14_104182318_ENST00000311141_BIN1_chr2_127834284_ENST00000409400_length(amino acids)=457AA_BP=46
MSSEVSARRDAKKLVRSPSGLRMVPEHRAFGSPFGLEEPQWVPDKEVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASV
KAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQT
AKKKDEAKIAKAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKA
QPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVE
TFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:104182318/chr2:127834284)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	BIN1 O00499
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863). {ECO:0000250\|UniProtKB:O08839, ECO:0000269\|PubMed:24755653, ECO:0000269\|PubMed:27179792, ECO:0000269\|PubMed:28893863, ECO:0000269\|PubMed:8782822}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000259238

193_267

28.0

498.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000316724

193_267

28.0

594.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000346226

193_267

28.0

519.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000348750

193_267

28.0

410.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000351659

193_267

28.0

507.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000352848

193_267

28.0

455.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000357970

193_267

28.0

551.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000376113

193_267

28.0

425.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000393040

193_267

28.0

483.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000393041

193_267

28.0

476.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000409400

193_267

28.0

440.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000259238

29_276

28.0

498.0

Domain

BAR

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000259238

520_593

28.0

498.0

Domain

SH3

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000316724

29_276

28.0

594.0

Domain

BAR

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000316724

520_593

28.0

594.0

Domain

SH3

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000346226

29_276

28.0

519.0

Domain

BAR

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000346226

520_593

28.0

519.0

Domain

SH3

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000348750

29_276

28.0

410.0

Domain

BAR

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000348750

520_593

28.0

410.0

Domain

SH3

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000351659

29_276

28.0

507.0

Domain

BAR

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000351659

520_593

28.0

507.0

Domain

SH3

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000352848

29_276

28.0

455.0

Domain

BAR

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000352848

520_593

28.0

455.0

Domain

SH3

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000357970

29_276

28.0

551.0

Domain

BAR

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000357970

520_593

28.0

551.0

Domain

SH3

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000376113

29_276

28.0

425.0

Domain

BAR

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000376113

520_593

28.0

425.0

Domain

SH3

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000393040

29_276

28.0

483.0

Domain

BAR

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000393040

520_593

28.0

483.0

Domain

SH3

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000393041

29_276

28.0

476.0

Domain

BAR

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000393041

520_593

28.0

476.0

Domain

SH3

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000409400

29_276

28.0

440.0

Domain

BAR

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000409400

520_593

28.0

440.0

Domain

SH3

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZFYVE21

chr14:104182318

chr2:127834284

ENST00000216602

107_234

46.0

253.0

Region

Note=PH-like

Hgene

ZFYVE21

chr14:104182318

chr2:127834284

ENST00000311141

107_234

46.0

235.0

Region

Note=PH-like

Hgene

ZFYVE21

chr14:104182318

chr2:127834284

ENST00000216602

44_104

46.0

253.0

Zinc finger

FYVE-type

Hgene

ZFYVE21

chr14:104182318

chr2:127834284

ENST00000311141

44_104

46.0

235.0

Zinc finger

FYVE-type

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000259238

15_42

28.0

498.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000316724

15_42

28.0

594.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000346226

15_42

28.0

519.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000348750

15_42

28.0

410.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000351659

15_42

28.0

507.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000352848

15_42

28.0

455.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000357970

15_42

28.0

551.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000376113

15_42

28.0

425.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000393040

15_42

28.0

483.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000393041

15_42

28.0

476.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

BIN1

chr14:104182318

chr2:127834284

ENST00000409400

15_42

28.0

440.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ZFYVE21
BIN1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	BIN1	chr14:104182318	chr2:127834284	ENST00000259238		0	16	2_122	28.0	498.0	BIN2
Tgene	BIN1	chr14:104182318	chr2:127834284	ENST00000316724		0	19	2_122	28.0	594.0	BIN2
Tgene	BIN1	chr14:104182318	chr2:127834284	ENST00000346226		0	16	2_122	28.0	519.0	BIN2
Tgene	BIN1	chr14:104182318	chr2:127834284	ENST00000348750		0	13	2_122	28.0	410.0	BIN2
Tgene	BIN1	chr14:104182318	chr2:127834284	ENST00000351659		0	16	2_122	28.0	507.0	BIN2
Tgene	BIN1	chr14:104182318	chr2:127834284	ENST00000352848		0	15	2_122	28.0	455.0	BIN2
Tgene	BIN1	chr14:104182318	chr2:127834284	ENST00000357970		0	18	2_122	28.0	551.0	BIN2
Tgene	BIN1	chr14:104182318	chr2:127834284	ENST00000376113		0	14	2_122	28.0	425.0	BIN2
Tgene	BIN1	chr14:104182318	chr2:127834284	ENST00000393040		0	15	2_122	28.0	483.0	BIN2
Tgene	BIN1	chr14:104182318	chr2:127834284	ENST00000393041		0	15	2_122	28.0	476.0	BIN2
Tgene	BIN1	chr14:104182318	chr2:127834284	ENST00000409400		0	14	2_122	28.0	440.0	BIN2

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Related Drugs to ZFYVE21-BIN1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ZFYVE21-BIN1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source