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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ZNF141-NUP98

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ZNF141-NUP98
	FusionPDB ID: 101496
	FusionGDB2.0 ID: 101496
		Hgene	Tgene
	Gene symbol	ZNF141	NUP98
	Gene ID	7700	4928
	Gene name	zinc finger protein 141	nucleoporin 98 and 96 precursor
	Synonyms	D4S90\|pHZ-44	ADIR2\|NUP196\|NUP96\|Nup98-96
	Cytomap	4p16.3	11p15.4
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 141zinc finger protein 141 (clone pHZ-44)	nuclear pore complex protein Nup98-Nup96nuclear pore complex protein Nup98GLFG-repeat containing nucleoporinNUP98/PHF23 fusion 2 proteinNup98-Nup96nucleoporin 96nucleoporin 98kDnucleoporin 98kDa
	Modification date	20200313	20200313
	UniProtAcc	.	P52948
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000240499, ENST00000505939, ENST00000512994, ENST00000579770,	ENST00000488828, ENST00000324932, ENST00000355260, ENST00000359171, ENST00000397004, ENST00000397007,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 4 X 1=16	17 X 18 X 10=3060
	# samples	7	18
	** MAII score	log2(7/16*10)=2.12928301694497 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(18/3060*10)=-4.08746284125034 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ZNF141 [Title/Abstract] AND NUP98 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ZNF141(337645)-NUP98(3756511), # samples:1
Anticipated loss of major functional domain due to fusion event.	ZNF141-NUP98 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF141-NUP98 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF141-NUP98 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF141-NUP98 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ZNF141 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NUP98 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	DA817816	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000512994	ZNF141	chr4	337645	+	ENST00000324932	NUP98	chr11	3756511	-	5320	219	3006	3695	229
ENST00000512994	ZNF141	chr4	337645	+	ENST00000359171	NUP98	chr11	3756511	-	5117	219	2803	3492	229
ENST00000512994	ZNF141	chr4	337645	+	ENST00000355260	NUP98	chr11	3756511	-	4309	219	1995	2684	229
ENST00000512994	ZNF141	chr4	337645	+	ENST00000397004	NUP98	chr11	3756511	-	2521	219	2295	1924	123
ENST00000512994	ZNF141	chr4	337645	+	ENST00000397007	NUP98	chr11	3756511	-	2239	219	2013	1642	123
ENST00000505939	ZNF141	chr4	337645	+	ENST00000324932	NUP98	chr11	3756511	-	5306	205	2992	3681	229
ENST00000505939	ZNF141	chr4	337645	+	ENST00000359171	NUP98	chr11	3756511	-	5103	205	2789	3478	229
ENST00000505939	ZNF141	chr4	337645	+	ENST00000355260	NUP98	chr11	3756511	-	4295	205	1981	2670	229
ENST00000505939	ZNF141	chr4	337645	+	ENST00000397004	NUP98	chr11	3756511	-	2507	205	2281	1910	123
ENST00000505939	ZNF141	chr4	337645	+	ENST00000397007	NUP98	chr11	3756511	-	2225	205	1999	1628	123
ENST00000240499	ZNF141	chr4	337645	+	ENST00000324932	NUP98	chr11	3756511	-	5305	204	2991	3680	229
ENST00000240499	ZNF141	chr4	337645	+	ENST00000359171	NUP98	chr11	3756511	-	5102	204	2788	3477	229
ENST00000240499	ZNF141	chr4	337645	+	ENST00000355260	NUP98	chr11	3756511	-	4294	204	1980	2669	229
ENST00000240499	ZNF141	chr4	337645	+	ENST00000397004	NUP98	chr11	3756511	-	2506	204	2280	1909	123
ENST00000240499	ZNF141	chr4	337645	+	ENST00000397007	NUP98	chr11	3756511	-	2224	204	1998	1627	123

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000512994	ENST00000324932	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-	0.0266743	0.9733257
ENST00000512994	ENST00000359171	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-	0.02559697	0.97440296
ENST00000512994	ENST00000355260	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-	0.02338946	0.97661054
ENST00000512994	ENST00000397004	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-	0.869554	0.13044599
ENST00000512994	ENST00000397007	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-	0.6512268	0.3487732
ENST00000505939	ENST00000324932	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-	0.026309118	0.97369087
ENST00000505939	ENST00000359171	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-	0.025252167	0.97474784
ENST00000505939	ENST00000355260	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-	0.022954205	0.9770458
ENST00000505939	ENST00000397004	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-	0.82543784	0.17456217
ENST00000505939	ENST00000397007	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-	0.8004245	0.19957548
ENST00000240499	ENST00000324932	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-	0.026353886	0.97364616
ENST00000240499	ENST00000359171	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-	0.025263365	0.97473663
ENST00000240499	ENST00000355260	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-	0.022977917	0.97702205
ENST00000240499	ENST00000397004	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-	0.8655262	0.13447385
ENST00000240499	ENST00000397007	ZNF141	chr4	337645	+	NUP98	chr11	3756511	-	0.8128297	0.18717034

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>101496_101496_1_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000240499_NUP98_chr11_3756511_ENST00000324932_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_2_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000240499_NUP98_chr11_3756511_ENST00000355260_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_3_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000240499_NUP98_chr11_3756511_ENST00000359171_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_4_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000240499_NUP98_chr11_3756511_ENST00000397004_length(amino acids)=123AA_BP=
MSRCSKSLLGCWICWFQSLSPFSGYSDGEARFSESRLTGEKRLLLLRFFKTNFLMLFLLGAYGKNYFLFLLGHPEVTHHEKTFLHCFLPA

--------------------------------------------------------------

>101496_101496_5_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000240499_NUP98_chr11_3756511_ENST00000397007_length(amino acids)=123AA_BP=
MSRCSKSLLGCWICWFQSLSPFSGYSDGEARFSESRLTGEKRLLLLRFFKTNFLMLFLLGAYGKNYFLFLLGHPEVTHHEKTFLHCFLPA

--------------------------------------------------------------

>101496_101496_6_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000505939_NUP98_chr11_3756511_ENST00000324932_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_7_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000505939_NUP98_chr11_3756511_ENST00000355260_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_8_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000505939_NUP98_chr11_3756511_ENST00000359171_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_9_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000505939_NUP98_chr11_3756511_ENST00000397004_length(amino acids)=123AA_BP=
MSRCSKSLLGCWICWFQSLSPFSGYSDGEARFSESRLTGEKRLLLLRFFKTNFLMLFLLGAYGKNYFLFLLGHPEVTHHEKTFLHCFLPA

--------------------------------------------------------------

>101496_101496_10_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000505939_NUP98_chr11_3756511_ENST00000397007_length(amino acids)=123AA_BP=
MSRCSKSLLGCWICWFQSLSPFSGYSDGEARFSESRLTGEKRLLLLRFFKTNFLMLFLLGAYGKNYFLFLLGHPEVTHHEKTFLHCFLPA

--------------------------------------------------------------

>101496_101496_11_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000512994_NUP98_chr11_3756511_ENST00000324932_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_12_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000512994_NUP98_chr11_3756511_ENST00000355260_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_13_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000512994_NUP98_chr11_3756511_ENST00000359171_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_14_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000512994_NUP98_chr11_3756511_ENST00000397004_length(amino acids)=123AA_BP=
MSRCSKSLLGCWICWFQSLSPFSGYSDGEARFSESRLTGEKRLLLLRFFKTNFLMLFLLGAYGKNYFLFLLGHPEVTHHEKTFLHCFLPA

--------------------------------------------------------------

>101496_101496_15_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000512994_NUP98_chr11_3756511_ENST00000397007_length(amino acids)=123AA_BP=
MSRCSKSLLGCWICWFQSLSPFSGYSDGEARFSESRLTGEKRLLLLRFFKTNFLMLFLLGAYGKNYFLFLLGHPEVTHHEKTFLHCFLPA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:337645/chr11:3756511)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NUP98 P52948
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269\|PubMed:15229283, ECO:0000269\|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change ASN-74-ASP is reduced (in vitro) (PubMed:23523133). {ECO:0000269\|PubMed:23523133}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000324932

7_480

1801.0

Compositional bias

Note=Gly/Thr-rich

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000324932

890_894

1801.0

Compositional bias

Note=Poly-Glu

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000355260

7_480

1727.0

Compositional bias

Note=Gly/Thr-rich

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000355260

890_894

1727.0

Compositional bias

Note=Poly-Glu

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000397004

7_480

921.0

Compositional bias

Note=Gly/Thr-rich

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000397004

890_894

921.0

Compositional bias

Note=Poly-Glu

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000397007

7_480

938.0

Compositional bias

Note=Gly/Thr-rich

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000397007

890_894

938.0

Compositional bias

Note=Poly-Glu

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000324932

738_880

1801.0

Domain

Peptidase S59

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000355260

738_880

1727.0

Domain

Peptidase S59

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000397004

738_880

921.0

Domain

Peptidase S59

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000397007

738_880

938.0

Domain

Peptidase S59

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000324932

1_156

1801.0

Region

Note=FG repeats 1

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000324932

214_480

1801.0

Region

Note=FG repeats 2

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000355260

1_156

1727.0

Region

Note=FG repeats 1

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000355260

214_480

1727.0

Region

Note=FG repeats 2

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000397004

1_156

921.0

Region

Note=FG repeats 1

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000397004

214_480

921.0

Region

Note=FG repeats 2

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000397007

1_156

938.0

Region

Note=FG repeats 1

Tgene

NUP98

chr4:337645

chr11:3756511

ENST00000397007

214_480

938.0

Region

Note=FG repeats 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF141

chr4:337645

chr11:3756511

ENST00000240499

4_75

475.0

Domain

KRAB

Hgene

ZNF141

chr4:337645

chr11:3756511

ENST00000240499

171_193

475.0

Zinc finger

C2H2-type 1%3B atypical

Hgene

ZNF141

chr4:337645

chr11:3756511

ENST00000240499

199_221

475.0

Zinc finger

C2H2-type 2

Hgene

ZNF141

chr4:337645

chr11:3756511

ENST00000240499

227_249

475.0

Zinc finger

C2H2-type 3

Hgene

ZNF141

chr4:337645

chr11:3756511

ENST00000240499

255_277

475.0

Zinc finger

C2H2-type 4

Hgene

ZNF141

chr4:337645

chr11:3756511

ENST00000240499

283_305

475.0

Zinc finger

C2H2-type 5

Hgene

ZNF141

chr4:337645

chr11:3756511

ENST00000240499

311_333

475.0

Zinc finger

C2H2-type 6

Hgene

ZNF141

chr4:337645

chr11:3756511

ENST00000240499

339_361

475.0

Zinc finger

C2H2-type 7

Hgene

ZNF141

chr4:337645

chr11:3756511

ENST00000240499

367_389

475.0

Zinc finger

C2H2-type 8

Hgene

ZNF141

chr4:337645

chr11:3756511

ENST00000240499

395_417

475.0

Zinc finger

C2H2-type 9

Hgene

ZNF141

chr4:337645

chr11:3756511

ENST00000240499

423_445

475.0

Zinc finger

C2H2-type 10

Hgene

ZNF141

chr4:337645

chr11:3756511

ENST00000240499

451_473

475.0

Zinc finger

C2H2-type 11

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

NUP98

MOB1A, PARP11, QRICH2, TPR, NUP88, CREBBP, EP300, NUP133, Rae1, KPNB1, RAE1, TNPO2, CRM1, KAP104, NXF1, TNPO1, USP7, NPM1, PTTG1, APC, HDAC1, tat, NUP82, NUP159, Nup188, Nup98, Nup107, Nup214, SIRT7, NUP107, RAPGEF3, rev, NUMA1, ECT2, CSNK2A1, HNRNPUL1, LMNA, HDAC8, HDAC11, FBXO6, ARFGEF2, CDC73, PAF1, CDC37, CUL7, OBSL1, EED, MAPK8, COMTD1, SEC13, PNKD, NUP43, CLEC11A, RNF166, UNK, NUP54, NUP85, SEH1L, XPO5, KRAS, IFI16, NUP160, NUP35, B9D2, UBE2I, NUPL1, NUP153, PIM2, NUDT21, NCBP2, CHMP4B, GTF2H5, Ranbp2, Ube2i, Ssna1, Rcc1, Xpo1, Kifc1, Nup155, FOXI2, FOXL1, FOXQ1, FAF1, C11orf30, DUSP13, SPAST, FAM136A, UXS1, CD70, VASN, TRIM25, G3BP1, ORF10, CDC27, ANAPC4, ANAPC10, MAD2L1, CDC20, FZR1, PIN1, CTNNB1, TGFB1, NKX2-1, ESR2, NUP155, EZH2, DCPS, CDK9, DYNLT1, TOMM20, KIAA1429, DISC1, NR2C2, AGRN, HIST1H4A, PTPMT1, ORF6, BIRC3, LMBR1L, FAM105A, PLEKHA4, TTC9, HIST1H2BH, HIST3H3, M, nsp16, nsp4, nsp6, ORF7b, GLE1, NEK4, CIT, KIF14, KIF20A, PRC1, ARHGEF19, MYO9A, PTPN1, SEC61B, NFX1, HULC, NUPR1, BRD4, LGALS9, DYRK1A, NUP37, DDX58, CKAP4, DERL1, EMD, HSD17B11, HSD3B7, LMNB1, LRRC59, METTL7A, NUP50, REEP5, SEC62, SSR1, STIM1, SYNE3, TMPO, WDR5, NAA40, OCIAD1, CADPS, TACSTD2, RGPD1, TPST2, CD40, SLFN11, FBXO32, RCHY1, SIRT6, ETV6,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ZNF141
NUP98

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ZNF141-NUP98

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ZNF141-NUP98

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	NUP98	C0002871	Anemia	1	CTD_human
Tgene	NUP98	C0023467	Leukemia, Myelocytic, Acute	1	CTD_human
Tgene	NUP98	C0024312	Lymphopenia	1	CTD_human
Tgene	NUP98	C0026998	Acute Myeloid Leukemia, M1	1	CTD_human
Tgene	NUP98	C0027947	Neutropenia	1	CTD_human
Tgene	NUP98	C1879321	Acute Myeloid Leukemia (AML-M2)	1	CTD_human
Tgene	NUP98	C2930974	Acute erythroleukemia	1	CTD_human
Tgene	NUP98	C2930975	Acute erythroleukemia - M6a subtype	1	CTD_human
Tgene	NUP98	C2930976	Acute myeloid leukemia FAB-M6	1	CTD_human
Tgene	NUP98	C2930977	Acute erythroleukemia - M6b subtype	1	CTD_human