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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZNF141-NUP98

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZNF141-NUP98
FusionPDB ID: 101496
FusionGDB2.0 ID: 101496
HgeneTgene
Gene symbol

ZNF141

NUP98

Gene ID

7700

4928

Gene namezinc finger protein 141nucleoporin 98 and 96 precursor
SynonymsD4S90|pHZ-44ADIR2|NUP196|NUP96|Nup98-96
Cytomap

4p16.3

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 141zinc finger protein 141 (clone pHZ-44)nuclear pore complex protein Nup98-Nup96nuclear pore complex protein Nup98GLFG-repeat containing nucleoporinNUP98/PHF23 fusion 2 proteinNup98-Nup96nucleoporin 96nucleoporin 98kDnucleoporin 98kDa
Modification date2020031320200313
UniProtAcc.

P52948

Ensembl transtripts involved in fusion geneENST idsENST00000240499, ENST00000505939, 
ENST00000512994, ENST00000579770, 
ENST00000488828, ENST00000324932, 
ENST00000355260, ENST00000359171, 
ENST00000397004, ENST00000397007, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 1=1617 X 18 X 10=3060
# samples 718
** MAII scorelog2(7/16*10)=2.12928301694497
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(18/3060*10)=-4.08746284125034
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZNF141 [Title/Abstract] AND NUP98 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZNF141(337645)-NUP98(3756511), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF141-NUP98 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF141-NUP98 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF141-NUP98 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF141-NUP98 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF141 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NUP98 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA817816ZNF141chr4

337645

+NUP98chr11

3756511

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000512994ZNF141chr4337645+ENST00000324932NUP98chr113756511-532021930063695229
ENST00000512994ZNF141chr4337645+ENST00000359171NUP98chr113756511-511721928033492229
ENST00000512994ZNF141chr4337645+ENST00000355260NUP98chr113756511-430921919952684229
ENST00000512994ZNF141chr4337645+ENST00000397004NUP98chr113756511-252121922951924123
ENST00000512994ZNF141chr4337645+ENST00000397007NUP98chr113756511-223921920131642123
ENST00000505939ZNF141chr4337645+ENST00000324932NUP98chr113756511-530620529923681229
ENST00000505939ZNF141chr4337645+ENST00000359171NUP98chr113756511-510320527893478229
ENST00000505939ZNF141chr4337645+ENST00000355260NUP98chr113756511-429520519812670229
ENST00000505939ZNF141chr4337645+ENST00000397004NUP98chr113756511-250720522811910123
ENST00000505939ZNF141chr4337645+ENST00000397007NUP98chr113756511-222520519991628123
ENST00000240499ZNF141chr4337645+ENST00000324932NUP98chr113756511-530520429913680229
ENST00000240499ZNF141chr4337645+ENST00000359171NUP98chr113756511-510220427883477229
ENST00000240499ZNF141chr4337645+ENST00000355260NUP98chr113756511-429420419802669229
ENST00000240499ZNF141chr4337645+ENST00000397004NUP98chr113756511-250620422801909123
ENST00000240499ZNF141chr4337645+ENST00000397007NUP98chr113756511-222420419981627123

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000512994ENST00000324932ZNF141chr4337645+NUP98chr113756511-0.02667430.9733257
ENST00000512994ENST00000359171ZNF141chr4337645+NUP98chr113756511-0.025596970.97440296
ENST00000512994ENST00000355260ZNF141chr4337645+NUP98chr113756511-0.023389460.97661054
ENST00000512994ENST00000397004ZNF141chr4337645+NUP98chr113756511-0.8695540.13044599
ENST00000512994ENST00000397007ZNF141chr4337645+NUP98chr113756511-0.65122680.3487732
ENST00000505939ENST00000324932ZNF141chr4337645+NUP98chr113756511-0.0263091180.97369087
ENST00000505939ENST00000359171ZNF141chr4337645+NUP98chr113756511-0.0252521670.97474784
ENST00000505939ENST00000355260ZNF141chr4337645+NUP98chr113756511-0.0229542050.9770458
ENST00000505939ENST00000397004ZNF141chr4337645+NUP98chr113756511-0.825437840.17456217
ENST00000505939ENST00000397007ZNF141chr4337645+NUP98chr113756511-0.80042450.19957548
ENST00000240499ENST00000324932ZNF141chr4337645+NUP98chr113756511-0.0263538860.97364616
ENST00000240499ENST00000359171ZNF141chr4337645+NUP98chr113756511-0.0252633650.97473663
ENST00000240499ENST00000355260ZNF141chr4337645+NUP98chr113756511-0.0229779170.97702205
ENST00000240499ENST00000397004ZNF141chr4337645+NUP98chr113756511-0.86552620.13447385
ENST00000240499ENST00000397007ZNF141chr4337645+NUP98chr113756511-0.81282970.18717034

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>101496_101496_1_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000240499_NUP98_chr11_3756511_ENST00000324932_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_2_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000240499_NUP98_chr11_3756511_ENST00000355260_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_3_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000240499_NUP98_chr11_3756511_ENST00000359171_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_4_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000240499_NUP98_chr11_3756511_ENST00000397004_length(amino acids)=123AA_BP=
MSRCSKSLLGCWICWFQSLSPFSGYSDGEARFSESRLTGEKRLLLLRFFKTNFLMLFLLGAYGKNYFLFLLGHPEVTHHEKTFLHCFLPA

--------------------------------------------------------------

>101496_101496_5_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000240499_NUP98_chr11_3756511_ENST00000397007_length(amino acids)=123AA_BP=
MSRCSKSLLGCWICWFQSLSPFSGYSDGEARFSESRLTGEKRLLLLRFFKTNFLMLFLLGAYGKNYFLFLLGHPEVTHHEKTFLHCFLPA

--------------------------------------------------------------

>101496_101496_6_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000505939_NUP98_chr11_3756511_ENST00000324932_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_7_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000505939_NUP98_chr11_3756511_ENST00000355260_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_8_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000505939_NUP98_chr11_3756511_ENST00000359171_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_9_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000505939_NUP98_chr11_3756511_ENST00000397004_length(amino acids)=123AA_BP=
MSRCSKSLLGCWICWFQSLSPFSGYSDGEARFSESRLTGEKRLLLLRFFKTNFLMLFLLGAYGKNYFLFLLGHPEVTHHEKTFLHCFLPA

--------------------------------------------------------------

>101496_101496_10_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000505939_NUP98_chr11_3756511_ENST00000397007_length(amino acids)=123AA_BP=
MSRCSKSLLGCWICWFQSLSPFSGYSDGEARFSESRLTGEKRLLLLRFFKTNFLMLFLLGAYGKNYFLFLLGHPEVTHHEKTFLHCFLPA

--------------------------------------------------------------

>101496_101496_11_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000512994_NUP98_chr11_3756511_ENST00000324932_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_12_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000512994_NUP98_chr11_3756511_ENST00000355260_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_13_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000512994_NUP98_chr11_3756511_ENST00000359171_length(amino acids)=229AA_BP=
MLSGPAVSLTESPFKVHLEKLSLRQRKPDEDMKLYQTPLELKLKHSTVHVDELCPLIVPNLGVAVIHDYADWVKEASGDLPEAQIGGLLQ
SKFTSGAFLSPSVSVQECRTPRAASLMNIPSTSSWSVPPPLTSVFTMPSPAPEVPLKTVGTRRQLGLVPREKSVTYGKGKLLMDMALFMG

--------------------------------------------------------------

>101496_101496_14_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000512994_NUP98_chr11_3756511_ENST00000397004_length(amino acids)=123AA_BP=
MSRCSKSLLGCWICWFQSLSPFSGYSDGEARFSESRLTGEKRLLLLRFFKTNFLMLFLLGAYGKNYFLFLLGHPEVTHHEKTFLHCFLPA

--------------------------------------------------------------

>101496_101496_15_ZNF141-NUP98_ZNF141_chr4_337645_ENST00000512994_NUP98_chr11_3756511_ENST00000397007_length(amino acids)=123AA_BP=
MSRCSKSLLGCWICWFQSLSPFSGYSDGEARFSESRLTGEKRLLLLRFFKTNFLMLFLLGAYGKNYFLFLLGHPEVTHHEKTFLHCFLPA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:337645/chr11:3756511)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NUP98

P52948

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}.; FUNCTION: (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change ASN-74-ASP is reduced (in vitro) (PubMed:23523133). {ECO:0000269|PubMed:23523133}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNUP98chr4:337645chr11:3756511ENST000003249320337_48001801.0Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr4:337645chr11:3756511ENST00000324932033890_89401801.0Compositional biasNote=Poly-Glu
TgeneNUP98chr4:337645chr11:3756511ENST000003552600327_48001727.0Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr4:337645chr11:3756511ENST00000355260032890_89401727.0Compositional biasNote=Poly-Glu
TgeneNUP98chr4:337645chr11:3756511ENST000003970040207_4800921.0Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr4:337645chr11:3756511ENST00000397004020890_8940921.0Compositional biasNote=Poly-Glu
TgeneNUP98chr4:337645chr11:3756511ENST000003970070207_4800938.0Compositional biasNote=Gly/Thr-rich
TgeneNUP98chr4:337645chr11:3756511ENST00000397007020890_8940938.0Compositional biasNote=Poly-Glu
TgeneNUP98chr4:337645chr11:3756511ENST00000324932033738_88001801.0DomainPeptidase S59
TgeneNUP98chr4:337645chr11:3756511ENST00000355260032738_88001727.0DomainPeptidase S59
TgeneNUP98chr4:337645chr11:3756511ENST00000397004020738_8800921.0DomainPeptidase S59
TgeneNUP98chr4:337645chr11:3756511ENST00000397007020738_8800938.0DomainPeptidase S59
TgeneNUP98chr4:337645chr11:3756511ENST000003249320331_15601801.0RegionNote=FG repeats 1
TgeneNUP98chr4:337645chr11:3756511ENST00000324932033214_48001801.0RegionNote=FG repeats 2
TgeneNUP98chr4:337645chr11:3756511ENST000003552600321_15601727.0RegionNote=FG repeats 1
TgeneNUP98chr4:337645chr11:3756511ENST00000355260032214_48001727.0RegionNote=FG repeats 2
TgeneNUP98chr4:337645chr11:3756511ENST000003970040201_1560921.0RegionNote=FG repeats 1
TgeneNUP98chr4:337645chr11:3756511ENST00000397004020214_4800921.0RegionNote=FG repeats 2
TgeneNUP98chr4:337645chr11:3756511ENST000003970070201_1560938.0RegionNote=FG repeats 1
TgeneNUP98chr4:337645chr11:3756511ENST00000397007020214_4800938.0RegionNote=FG repeats 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF141chr4:337645chr11:3756511ENST00000240499+144_750475.0DomainKRAB
HgeneZNF141chr4:337645chr11:3756511ENST00000240499+14171_1930475.0Zinc fingerC2H2-type 1%3B atypical
HgeneZNF141chr4:337645chr11:3756511ENST00000240499+14199_2210475.0Zinc fingerC2H2-type 2
HgeneZNF141chr4:337645chr11:3756511ENST00000240499+14227_2490475.0Zinc fingerC2H2-type 3
HgeneZNF141chr4:337645chr11:3756511ENST00000240499+14255_2770475.0Zinc fingerC2H2-type 4
HgeneZNF141chr4:337645chr11:3756511ENST00000240499+14283_3050475.0Zinc fingerC2H2-type 5
HgeneZNF141chr4:337645chr11:3756511ENST00000240499+14311_3330475.0Zinc fingerC2H2-type 6
HgeneZNF141chr4:337645chr11:3756511ENST00000240499+14339_3610475.0Zinc fingerC2H2-type 7
HgeneZNF141chr4:337645chr11:3756511ENST00000240499+14367_3890475.0Zinc fingerC2H2-type 8
HgeneZNF141chr4:337645chr11:3756511ENST00000240499+14395_4170475.0Zinc fingerC2H2-type 9
HgeneZNF141chr4:337645chr11:3756511ENST00000240499+14423_4450475.0Zinc fingerC2H2-type 10
HgeneZNF141chr4:337645chr11:3756511ENST00000240499+14451_4730475.0Zinc fingerC2H2-type 11


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NUP98MOB1A, PARP11, QRICH2, TPR, NUP88, CREBBP, EP300, NUP133, Rae1, KPNB1, RAE1, TNPO2, CRM1, KAP104, NXF1, TNPO1, USP7, NPM1, PTTG1, APC, HDAC1, tat, NUP82, NUP159, Nup188, Nup98, Nup107, Nup214, SIRT7, NUP107, RAPGEF3, rev, NUMA1, ECT2, CSNK2A1, HNRNPUL1, LMNA, HDAC8, HDAC11, FBXO6, ARFGEF2, CDC73, PAF1, CDC37, CUL7, OBSL1, EED, MAPK8, COMTD1, SEC13, PNKD, NUP43, CLEC11A, RNF166, UNK, NUP54, NUP85, SEH1L, XPO5, KRAS, IFI16, NUP160, NUP35, B9D2, UBE2I, NUPL1, NUP153, PIM2, NUDT21, NCBP2, CHMP4B, GTF2H5, Ranbp2, Ube2i, Ssna1, Rcc1, Xpo1, Kifc1, Nup155, FOXI2, FOXL1, FOXQ1, FAF1, C11orf30, DUSP13, SPAST, FAM136A, UXS1, CD70, VASN, TRIM25, G3BP1, ORF10, CDC27, ANAPC4, ANAPC10, MAD2L1, CDC20, FZR1, PIN1, CTNNB1, TGFB1, NKX2-1, ESR2, NUP155, EZH2, DCPS, CDK9, DYNLT1, TOMM20, KIAA1429, DISC1, NR2C2, AGRN, HIST1H4A, PTPMT1, ORF6, BIRC3, LMBR1L, FAM105A, PLEKHA4, TTC9, HIST1H2BH, HIST3H3, M, nsp16, nsp4, nsp6, ORF7b, GLE1, NEK4, CIT, KIF14, KIF20A, PRC1, ARHGEF19, MYO9A, PTPN1, SEC61B, NFX1, HULC, NUPR1, BRD4, LGALS9, DYRK1A, NUP37, DDX58, CKAP4, DERL1, EMD, HSD17B11, HSD3B7, LMNB1, LRRC59, METTL7A, NUP50, REEP5, SEC62, SSR1, STIM1, SYNE3, TMPO, WDR5, NAA40, OCIAD1, CADPS, TACSTD2, RGPD1, TPST2, CD40, SLFN11, FBXO32, RCHY1, SIRT6, ETV6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZNF141
NUP98all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ZNF141-NUP98


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZNF141-NUP98


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUP98C0002871Anemia1CTD_human
TgeneNUP98C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneNUP98C0024312Lymphopenia1CTD_human
TgeneNUP98C0026998Acute Myeloid Leukemia, M11CTD_human
TgeneNUP98C0027947Neutropenia1CTD_human
TgeneNUP98C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneNUP98C2930974Acute erythroleukemia1CTD_human
TgeneNUP98C2930975Acute erythroleukemia - M6a subtype1CTD_human
TgeneNUP98C2930976Acute myeloid leukemia FAB-M61CTD_human
TgeneNUP98C2930977Acute erythroleukemia - M6b subtype1CTD_human