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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZNF14-STAT5A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZNF14-STAT5A
FusionPDB ID: 101542
FusionGDB2.0 ID: 101542
HgeneTgene
Gene symbol

ZNF14

STAT5A

Gene ID

7561

6776

Gene namezinc finger protein 14signal transducer and activator of transcription 5A
SynonymsGIOT-4|KOX6MGF|STAT5
Cytomap

19p13.11

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 14gonadotropin inducible transcription repressor-4gonadotropin-inducible ovary transcription repressor 4zinc finger protein 14 (KOX 6)zinc finger protein KOX6signal transducer and activator of transcription 5Aepididymis secretory sperm binding protein
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000344099, ENST00000587646, 
ENST00000345506, ENST00000452307, 
ENST00000546010, ENST00000588868, 
ENST00000590949, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 2 X 5=504 X 5 X 3=60
# samples 55
** MAII scorelog2(5/50*10)=0log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZNF14 [Title/Abstract] AND STAT5A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZNF14(19843765)-STAT5A(40447637), # samples:2
Anticipated loss of major functional domain due to fusion event.ZNF14-STAT5A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF14-STAT5A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF14-STAT5A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF14-STAT5A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTAT5A

GO:0038026

reelin-mediated signaling pathway

29581031


check buttonFusion gene breakpoints across ZNF14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STAT5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-86-7953-01AZNF14chr19

19843765

-STAT5Achr17

40447637

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344099ZNF14chr1919843765-ENST00000345506STAT5Achr1740447637+34261421392151670
ENST00000344099ZNF14chr1919843765-ENST00000590949STAT5Achr1740447637+23431421392151670
ENST00000344099ZNF14chr1919843765-ENST00000546010STAT5Achr1740447637+24101421392151670
ENST00000344099ZNF14chr1919843765-ENST00000452307STAT5Achr1740447637+34121421392142667
ENST00000344099ZNF14chr1919843765-ENST00000588868STAT5Achr1740447637+33301421392058639

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344099ENST00000345506ZNF14chr1919843765-STAT5Achr1740447637+0.0049455870.99505436
ENST00000344099ENST00000590949ZNF14chr1919843765-STAT5Achr1740447637+0.0099188290.99008113
ENST00000344099ENST00000546010ZNF14chr1919843765-STAT5Achr1740447637+0.0101303540.98986965
ENST00000344099ENST00000452307ZNF14chr1919843765-STAT5Achr1740447637+0.0052084810.9947915
ENST00000344099ENST00000588868ZNF14chr1919843765-STAT5Achr1740447637+0.0053375950.99466246

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>101542_101542_1_ZNF14-STAT5A_ZNF14_chr19_19843765_ENST00000344099_STAT5A_chr17_40447637_ENST00000345506_length(amino acids)=670AA_BP=1
MCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAW
LQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLP
IPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSG
EILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLW
DNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWF
DGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLS
YLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDL

--------------------------------------------------------------

>101542_101542_2_ZNF14-STAT5A_ZNF14_chr19_19843765_ENST00000344099_STAT5A_chr17_40447637_ENST00000452307_length(amino acids)=667AA_BP=1
MCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAW
LQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLP
IPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSG
EILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLW
DNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWF
DGVMEVLKKHHKPHWNDGGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLI
YVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDET

--------------------------------------------------------------

>101542_101542_3_ZNF14-STAT5A_ZNF14_chr19_19843765_ENST00000344099_STAT5A_chr17_40447637_ENST00000546010_length(amino acids)=670AA_BP=1
MCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAW
LQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLP
IPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSG
EILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLW
DNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWF
DGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLS
YLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDL

--------------------------------------------------------------

>101542_101542_4_ZNF14-STAT5A_ZNF14_chr19_19843765_ENST00000344099_STAT5A_chr17_40447637_ENST00000588868_length(amino acids)=639AA_BP=1
MCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAW
LQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLP
IPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSG
EILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKGRVPFAVPDKVLWPQLCEALNMKF
KAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHD
LLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYV
KPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSPPAGL

--------------------------------------------------------------

>101542_101542_5_ZNF14-STAT5A_ZNF14_chr19_19843765_ENST00000344099_STAT5A_chr17_40447637_ENST00000590949_length(amino acids)=670AA_BP=1
MCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAW
LQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLP
IPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSG
EILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLW
DNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWF
DGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLS
YLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:19843765/chr17:40447637)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTAT5Achr19:19843765chr17:40447637ENST00000345506420589_686125.0795.0DomainSH2
TgeneSTAT5Achr19:19843765chr17:40447637ENST00000546010218589_68695.0765.0DomainSH2
TgeneSTAT5Achr19:19843765chr17:40447637ENST00000590949319589_686125.0795.0DomainSH2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-144_761.0643.0DomainKRAB
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14103_1251.0643.0Zinc fingerC2H2-type 1
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14141_1631.0643.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14169_1911.0643.0Zinc fingerC2H2-type 3
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14197_2171.0643.0Zinc fingerC2H2-type 4%3B atypical
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14223_2451.0643.0Zinc fingerC2H2-type 5
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14251_2731.0643.0Zinc fingerC2H2-type 6
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14279_3011.0643.0Zinc fingerC2H2-type 7
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14307_3291.0643.0Zinc fingerC2H2-type 8
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14335_3571.0643.0Zinc fingerC2H2-type 9
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14363_3851.0643.0Zinc fingerC2H2-type 10
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14391_4131.0643.0Zinc fingerC2H2-type 11
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14419_4411.0643.0Zinc fingerC2H2-type 12
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14447_4691.0643.0Zinc fingerC2H2-type 13
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14475_4971.0643.0Zinc fingerC2H2-type 14
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14503_5251.0643.0Zinc fingerC2H2-type 15
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14531_5531.0643.0Zinc fingerC2H2-type 16
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14559_5811.0643.0Zinc fingerC2H2-type 17
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14587_6091.0643.0Zinc fingerC2H2-type 18
HgeneZNF14chr19:19843765chr17:40447637ENST00000344099-14615_6371.0643.0Zinc fingerC2H2-type 19


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZNF14
STAT5A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ZNF14-STAT5A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZNF14-STAT5A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource