UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ZNF227-AKAP9

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZNF227-AKAP9
FusionPDB ID: 101651
FusionGDB2.0 ID: 101651
HgeneTgene
Gene symbol

ZNF227

AKAP9

Gene ID

7770

10142

Gene namezinc finger protein 227A-kinase anchoring protein 9
Synonyms-AKAP-9|AKAP350|AKAP450|CG-NAP|HYPERION|LQT11|MU-RMS-40.16A|PPP1R45|PRKA9|YOTIAO
Cytomap

19q13.31

7q21.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 227A-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associ
Modification date2020031320200328
UniProtAcc.

Q99996

Ensembl transtripts involved in fusion geneENST idsENST00000313040, ENST00000586228, 
ENST00000391961, ENST00000589005, 
ENST00000589237, ENST00000589707, 
ENST00000394564, ENST00000491695, 
ENST00000356239, ENST00000358100, 
ENST00000359028, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 6 X 4=9611 X 17 X 7=1309
# samples 715
** MAII scorelog2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1309*10)=-3.12543069144936
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZNF227 [Title/Abstract] AND AKAP9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZNF227(44722005)-AKAP9(91671981), # samples:2
Anticipated loss of major functional domain due to fusion event.ZNF227-AKAP9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF227-AKAP9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF227-AKAP9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF227-AKAP9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAKAP9

GO:0098962

regulation of postsynaptic neurotransmitter receptor activity

10390370

TgeneAKAP9

GO:1903358

regulation of Golgi organization

27666745


check buttonFusion gene breakpoints across ZNF227 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AKAP9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PD-01AZNF227chr19

44722005

+AKAP9chr7

91671360

+
ChimerDB4STADTCGA-BR-A4PD-01AZNF227chr19

44722005

+AKAP9chr7

91671982

+
ChimerDB4STADTCGA-BR-A4PDZNF227chr19

44722005

+AKAP9chr7

91671981

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000586228ZNF227chr1944722005+ENST00000356239AKAP9chr791671981+744526511869302270
ENST00000586228ZNF227chr1944722005+ENST00000358100AKAP9chr791671981+725926511867442208
ENST00000586228ZNF227chr1944722005+ENST00000359028AKAP9chr791671981+742126511869062262
ENST00000313040ZNF227chr1944722005+ENST00000356239AKAP9chr791671981+744526511869302270
ENST00000313040ZNF227chr1944722005+ENST00000358100AKAP9chr791671981+725926511867442208
ENST00000313040ZNF227chr1944722005+ENST00000359028AKAP9chr791671981+742126511869062262
ENST00000586228ZNF227chr1944722005+ENST00000356239AKAP9chr791671360+758626511870712317
ENST00000586228ZNF227chr1944722005+ENST00000358100AKAP9chr791671360+740026511868852255
ENST00000586228ZNF227chr1944722005+ENST00000359028AKAP9chr791671360+756226511870472309
ENST00000313040ZNF227chr1944722005+ENST00000356239AKAP9chr791671360+758626511870712317
ENST00000313040ZNF227chr1944722005+ENST00000358100AKAP9chr791671360+740026511868852255
ENST00000313040ZNF227chr1944722005+ENST00000359028AKAP9chr791671360+756226511870472309
ENST00000586228ZNF227chr1944722005+ENST00000356239AKAP9chr791671982+744526511869302270
ENST00000586228ZNF227chr1944722005+ENST00000358100AKAP9chr791671982+725926511867442208
ENST00000586228ZNF227chr1944722005+ENST00000359028AKAP9chr791671982+742126511869062262
ENST00000313040ZNF227chr1944722005+ENST00000356239AKAP9chr791671982+744526511869302270
ENST00000313040ZNF227chr1944722005+ENST00000358100AKAP9chr791671982+725926511867442208
ENST00000313040ZNF227chr1944722005+ENST00000359028AKAP9chr791671982+742126511869062262

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000586228ENST00000356239ZNF227chr1944722005+AKAP9chr791671981+0.0026398750.99736017
ENST00000586228ENST00000358100ZNF227chr1944722005+AKAP9chr791671981+0.0026447650.9973552
ENST00000586228ENST00000359028ZNF227chr1944722005+AKAP9chr791671981+0.0023492380.9976508
ENST00000313040ENST00000356239ZNF227chr1944722005+AKAP9chr791671981+0.0026398750.99736017
ENST00000313040ENST00000358100ZNF227chr1944722005+AKAP9chr791671981+0.0026447650.9973552
ENST00000313040ENST00000359028ZNF227chr1944722005+AKAP9chr791671981+0.0023492380.9976508
ENST00000586228ENST00000356239ZNF227chr1944722005+AKAP9chr791671360+0.0025617750.9974382
ENST00000586228ENST00000358100ZNF227chr1944722005+AKAP9chr791671360+0.0025577340.99744225
ENST00000586228ENST00000359028ZNF227chr1944722005+AKAP9chr791671360+0.0022656730.9977343
ENST00000313040ENST00000356239ZNF227chr1944722005+AKAP9chr791671360+0.0025617750.9974382
ENST00000313040ENST00000358100ZNF227chr1944722005+AKAP9chr791671360+0.0025577340.99744225
ENST00000313040ENST00000359028ZNF227chr1944722005+AKAP9chr791671360+0.0022656730.9977343
ENST00000586228ENST00000356239ZNF227chr1944722005+AKAP9chr791671982+0.0026398750.99736017
ENST00000586228ENST00000358100ZNF227chr1944722005+AKAP9chr791671982+0.0026447650.9973552
ENST00000586228ENST00000359028ZNF227chr1944722005+AKAP9chr791671982+0.0023492380.9976508
ENST00000313040ENST00000356239ZNF227chr1944722005+AKAP9chr791671982+0.0026398750.99736017
ENST00000313040ENST00000358100ZNF227chr1944722005+AKAP9chr791671982+0.0026447650.9973552
ENST00000313040ENST00000359028ZNF227chr1944722005+AKAP9chr791671982+0.0023492380.9976508

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>101651_101651_1_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000313040_AKAP9_chr7_91671360_ENST00000356239_length(amino acids)=2317AA_BP=49
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN
SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLI
WRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA
ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ
ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL
EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLL
SKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE
NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI
TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ
QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG
KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE
PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVE
VLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE
SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISET
ETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP
KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL
QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE
LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL
ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV
LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT
LQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW
VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGE
EPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL
TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFT
DLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI

--------------------------------------------------------------

>101651_101651_2_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000313040_AKAP9_chr7_91671360_ENST00000358100_length(amino acids)=2255AA_BP=49
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN
SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLI
WRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA
ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ
ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL
EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLL
SKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE
NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI
TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ
QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG
KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE
PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVE
VLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE
SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISET
ETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQ
LQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLS
EIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQ
HKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNE
SQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVEL
LNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREE
KRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETA
DDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDN
SSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYL
LLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDS
FYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQFH

--------------------------------------------------------------

>101651_101651_3_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000313040_AKAP9_chr7_91671360_ENST00000359028_length(amino acids)=2309AA_BP=49
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN
SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLI
WRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA
ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ
ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL
EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLL
SKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE
NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI
TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ
QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG
KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE
PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVE
VLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE
SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISET
ETLKREHYVAVQLLKEECGTLKAVIQCLRSKEVFGFYNMCFSTLCDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLR
AVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEER
SVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ
KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSR
ELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR
IREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEAN
TEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEG
ETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS
TSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKR
AEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNR
PKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQN

--------------------------------------------------------------

>101651_101651_4_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000313040_AKAP9_chr7_91671981_ENST00000356239_length(amino acids)=2270AA_BP=48
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA
NNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE
GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEES
RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE
TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI
QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG
AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE
SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE
KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP
ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ
KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE
QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE
ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN
LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT
REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAY
INTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQA
AMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE
LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL
QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKE
LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQ
GIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQ
VLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLE
EQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLR
AESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININ
RDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQ

--------------------------------------------------------------

>101651_101651_5_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000313040_AKAP9_chr7_91671981_ENST00000358100_length(amino acids)=2208AA_BP=48
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA
NNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE
GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEES
RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE
TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI
QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG
AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE
SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE
KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP
ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ
KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE
QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE
ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN
LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGLLRAVHNEGMQVLS
LTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTEL
TALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE
LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKA
KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRE
RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQ
SKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLI
EMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLL
RQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAE
LRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAV
RVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNP

--------------------------------------------------------------

>101651_101651_6_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000313040_AKAP9_chr7_91671981_ENST00000359028_length(amino acids)=2262AA_BP=48
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA
NNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE
GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEES
RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE
TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI
QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG
AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE
SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE
KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP
ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ
KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE
QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE
ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN
LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEVFGFYNMCFSTLCDS
GSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLK
DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKA
DRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLEL
ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQ
QKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK
HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK
QELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASE
RLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQ
TGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKAL
IYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQ
GAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQS

--------------------------------------------------------------

>101651_101651_7_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000313040_AKAP9_chr7_91671982_ENST00000356239_length(amino acids)=2270AA_BP=48
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA
NNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE
GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEES
RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE
TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI
QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG
AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE
SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE
KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP
ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ
KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE
QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE
ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN
LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT
REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAY
INTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQA
AMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE
LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL
QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKE
LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQ
GIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQ
VLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLE
EQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLR
AESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININ
RDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQ

--------------------------------------------------------------

>101651_101651_8_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000313040_AKAP9_chr7_91671982_ENST00000358100_length(amino acids)=2208AA_BP=48
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA
NNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE
GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEES
RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE
TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI
QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG
AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE
SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE
KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP
ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ
KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE
QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE
ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN
LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGLLRAVHNEGMQVLS
LTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTEL
TALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE
LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKA
KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRE
RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQ
SKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLI
EMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLL
RQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAE
LRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAV
RVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNP

--------------------------------------------------------------

>101651_101651_9_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000313040_AKAP9_chr7_91671982_ENST00000359028_length(amino acids)=2262AA_BP=48
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA
NNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE
GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEES
RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE
TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI
QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG
AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE
SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE
KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP
ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ
KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE
QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE
ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN
LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEVFGFYNMCFSTLCDS
GSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLK
DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKA
DRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLEL
ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQ
QKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK
HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK
QELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASE
RLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQ
TGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKAL
IYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQ
GAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQS

--------------------------------------------------------------

>101651_101651_10_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000586228_AKAP9_chr7_91671360_ENST00000356239_length(amino acids)=2317AA_BP=49
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN
SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLI
WRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA
ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ
ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL
EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLL
SKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE
NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI
TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ
QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG
KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE
PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVE
VLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE
SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISET
ETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP
KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLAL
QQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE
LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTL
ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV
LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT
LQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW
VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGE
EPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL
TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFT
DLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI

--------------------------------------------------------------

>101651_101651_11_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000586228_AKAP9_chr7_91671360_ENST00000358100_length(amino acids)=2255AA_BP=49
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN
SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLI
WRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA
ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ
ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL
EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLL
SKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE
NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI
TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ
QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG
KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE
PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVE
VLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE
SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISET
ETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQ
LQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLS
EIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQ
HKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNE
SQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVEL
LNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREE
KRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETA
DDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDN
SSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYL
LLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDS
FYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQFH

--------------------------------------------------------------

>101651_101651_12_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000586228_AKAP9_chr7_91671360_ENST00000359028_length(amino acids)=2309AA_BP=49
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN
SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLI
WRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA
ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ
ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL
EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLL
SKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE
NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI
TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ
QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG
KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE
PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVE
VLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE
SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISET
ETLKREHYVAVQLLKEECGTLKAVIQCLRSKEVFGFYNMCFSTLCDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLR
AVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEER
SVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ
KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSR
ELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR
IREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEAN
TEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEG
ETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS
TSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKR
AEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNR
PKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQN

--------------------------------------------------------------

>101651_101651_13_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000586228_AKAP9_chr7_91671981_ENST00000356239_length(amino acids)=2270AA_BP=48
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA
NNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE
GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEES
RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE
TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI
QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG
AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE
SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE
KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP
ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ
KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE
QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE
ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN
LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT
REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAY
INTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQA
AMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE
LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL
QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKE
LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQ
GIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQ
VLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLE
EQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLR
AESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININ
RDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQ

--------------------------------------------------------------

>101651_101651_14_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000586228_AKAP9_chr7_91671981_ENST00000358100_length(amino acids)=2208AA_BP=48
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA
NNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE
GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEES
RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE
TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI
QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG
AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE
SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE
KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP
ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ
KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE
QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE
ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN
LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGLLRAVHNEGMQVLS
LTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTEL
TALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE
LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKA
KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRE
RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQ
SKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLI
EMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLL
RQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAE
LRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAV
RVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNP

--------------------------------------------------------------

>101651_101651_15_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000586228_AKAP9_chr7_91671981_ENST00000359028_length(amino acids)=2262AA_BP=48
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA
NNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE
GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEES
RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE
TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI
QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG
AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE
SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE
KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP
ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ
KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE
QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE
ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN
LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEVFGFYNMCFSTLCDS
GSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLK
DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKA
DRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLEL
ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQ
QKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK
HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK
QELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASE
RLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQ
TGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKAL
IYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQ
GAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQS

--------------------------------------------------------------

>101651_101651_16_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000586228_AKAP9_chr7_91671982_ENST00000356239_length(amino acids)=2270AA_BP=48
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA
NNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE
GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEES
RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE
TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI
QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG
AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE
SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE
KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP
ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ
KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE
QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE
ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN
LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT
REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAY
INTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQA
AMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE
LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL
QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKE
LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQ
GIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQ
VLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLE
EQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLR
AESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININ
RDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQ

--------------------------------------------------------------

>101651_101651_17_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000586228_AKAP9_chr7_91671982_ENST00000358100_length(amino acids)=2208AA_BP=48
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA
NNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE
GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEES
RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE
TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI
QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG
AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE
SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE
KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP
ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ
KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE
QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE
ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN
LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGLLRAVHNEGMQVLS
LTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTEL
TALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE
LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKA
KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRE
RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQ
SKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLI
EMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLL
RQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAE
LRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAV
RVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNP

--------------------------------------------------------------

>101651_101651_18_ZNF227-AKAP9_ZNF227_chr19_44722005_ENST00000586228_AKAP9_chr7_91671982_ENST00000359028_length(amino acids)=2262AA_BP=48
MTASFYSPPPNLQRGGRRDFLASPSIAPVMPSQNYDLPQKKQEKMTKFQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA
NNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE
GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEES
RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE
TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI
QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG
AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE
SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE
KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP
ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ
KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE
QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE
ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN
LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEVFGFYNMCFSTLCDS
GSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLK
DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKA
DRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLEL
ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQ
QKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK
HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK
QELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASE
RLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQ
TGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKAL
IYQKKYLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQ
GAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQS

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:44722005/chr7:91671981)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AKAP9

Q99996

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). {ECO:0000269|PubMed:10202149, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.; FUNCTION: [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. {ECO:0000269|PubMed:9482789}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035623917501845_24431639.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035623917502532_25491639.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035623917502591_27641639.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035623917503061_30881639.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035623917503120_34661639.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035623917503583_36851639.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035810018491845_24431651.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035810018492532_25491651.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035810018492591_27641651.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035810018493061_30881651.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035810018493120_34661651.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035810018493583_36851651.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035902818501845_24431651.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035902818502532_25491651.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035902818502591_27641651.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035902818503061_30881651.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035902818503120_34661651.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035902818503583_36851651.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035623918501845_24431686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035623918502532_25491686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035623918502591_27641686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035623918503061_30881686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035623918503120_34661686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035623918503583_36851686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035810019491845_24431698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035810019492532_25491698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035810019492591_27641698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035810019493061_30881698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035810019493120_34661698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035810019493583_36851698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035902819501845_24431698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035902819502532_25491698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035902819502591_27641698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035902819503061_30881698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035902819503120_34661698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035902819503583_36851698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035623918501845_24431686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035623918502532_25491686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035623918502591_27641686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035623918503061_30881686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035623918503120_34661686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035623918503583_36851686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035810019491845_24431698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035810019492532_25491698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035810019492591_27641698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035810019493061_30881698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035810019493120_34661698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035810019493583_36851698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035902819501845_24431698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035902819502532_25491698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035902819502591_27641698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035902819503061_30881698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035902819503120_34661698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035902819503583_36851698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035623917501834_27601639.03908.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035623917503722_37261639.03908.0Compositional biasNote=Poly-Leu
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035810018491834_27601651.03858.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035810018493722_37261651.03858.0Compositional biasNote=Poly-Leu
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035902818501834_27601651.03912.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035902818503722_37261651.03912.0Compositional biasNote=Poly-Leu
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035623918501834_27601686.03908.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035623918503722_37261686.03908.0Compositional biasNote=Poly-Leu
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035810019491834_27601698.03858.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035810019493722_37261698.03858.0Compositional biasNote=Poly-Leu
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035902819501834_27601698.03912.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035902819503722_37261698.03912.0Compositional biasNote=Poly-Leu
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035623918501834_27601686.03908.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035623918503722_37261686.03908.0Compositional biasNote=Poly-Leu
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035810019491834_27601698.03858.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035810019493722_37261698.03858.0Compositional biasNote=Poly-Leu
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035902819501834_27601698.03912.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035902819503722_37261698.03912.0Compositional biasNote=Poly-Leu
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035623917502542_25551639.03908.0RegionNote=PKA-RII subunit binding domain
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035810018492542_25551651.03858.0RegionNote=PKA-RII subunit binding domain
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035902818502542_25551651.03912.0RegionNote=PKA-RII subunit binding domain
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035623918502542_25551686.03908.0RegionNote=PKA-RII subunit binding domain
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035810019492542_25551698.03858.0RegionNote=PKA-RII subunit binding domain
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035902819502542_25551698.03912.0RegionNote=PKA-RII subunit binding domain
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035623918502542_25551686.03908.0RegionNote=PKA-RII subunit binding domain
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035810019492542_25551698.03858.0RegionNote=PKA-RII subunit binding domain
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035902819502542_25551698.03912.0RegionNote=PKA-RII subunit binding domain

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+3623_9420.0800.0DomainKRAB
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+3623_9420.0800.0DomainKRAB
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+3623_9420.0800.0DomainKRAB
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36250_27220.0800.0Zinc fingerC2H2-type 1
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36269_29120.0800.0Zinc fingerC2H2-type 2
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36324_34620.0800.0Zinc fingerC2H2-type 3
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36352_37420.0800.0Zinc fingerC2H2-type 4
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36380_40220.0800.0Zinc fingerC2H2-type 5
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36408_43020.0800.0Zinc fingerC2H2-type 6
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36436_45820.0800.0Zinc fingerC2H2-type 7
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36464_48620.0800.0Zinc fingerC2H2-type 8
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36492_51420.0800.0Zinc fingerC2H2-type 9
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36520_54220.0800.0Zinc fingerC2H2-type 10
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36548_57020.0800.0Zinc fingerC2H2-type 11
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36576_59820.0800.0Zinc fingerC2H2-type 12
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36604_62620.0800.0Zinc fingerC2H2-type 13
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36632_65420.0800.0Zinc fingerC2H2-type 14
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36660_68220.0800.0Zinc fingerC2H2-type 15
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36688_71020.0800.0Zinc fingerC2H2-type 16
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36716_73820.0800.0Zinc fingerC2H2-type 17
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36744_76620.0800.0Zinc fingerC2H2-type 18
HgeneZNF227chr19:44722005chr7:91671360ENST00000313040+36772_79420.0800.0Zinc fingerC2H2-type 19
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36250_27220.0800.0Zinc fingerC2H2-type 1
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36269_29120.0800.0Zinc fingerC2H2-type 2
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36324_34620.0800.0Zinc fingerC2H2-type 3
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36352_37420.0800.0Zinc fingerC2H2-type 4
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36380_40220.0800.0Zinc fingerC2H2-type 5
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36408_43020.0800.0Zinc fingerC2H2-type 6
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36436_45820.0800.0Zinc fingerC2H2-type 7
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36464_48620.0800.0Zinc fingerC2H2-type 8
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36492_51420.0800.0Zinc fingerC2H2-type 9
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36520_54220.0800.0Zinc fingerC2H2-type 10
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36548_57020.0800.0Zinc fingerC2H2-type 11
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36576_59820.0800.0Zinc fingerC2H2-type 12
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36604_62620.0800.0Zinc fingerC2H2-type 13
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36632_65420.0800.0Zinc fingerC2H2-type 14
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36660_68220.0800.0Zinc fingerC2H2-type 15
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36688_71020.0800.0Zinc fingerC2H2-type 16
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36716_73820.0800.0Zinc fingerC2H2-type 17
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36744_76620.0800.0Zinc fingerC2H2-type 18
HgeneZNF227chr19:44722005chr7:91671981ENST00000313040+36772_79420.0800.0Zinc fingerC2H2-type 19
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36250_27220.0800.0Zinc fingerC2H2-type 1
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36269_29120.0800.0Zinc fingerC2H2-type 2
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36324_34620.0800.0Zinc fingerC2H2-type 3
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36352_37420.0800.0Zinc fingerC2H2-type 4
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36380_40220.0800.0Zinc fingerC2H2-type 5
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36408_43020.0800.0Zinc fingerC2H2-type 6
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36436_45820.0800.0Zinc fingerC2H2-type 7
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36464_48620.0800.0Zinc fingerC2H2-type 8
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36492_51420.0800.0Zinc fingerC2H2-type 9
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36520_54220.0800.0Zinc fingerC2H2-type 10
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36548_57020.0800.0Zinc fingerC2H2-type 11
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36576_59820.0800.0Zinc fingerC2H2-type 12
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36604_62620.0800.0Zinc fingerC2H2-type 13
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36632_65420.0800.0Zinc fingerC2H2-type 14
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36660_68220.0800.0Zinc fingerC2H2-type 15
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36688_71020.0800.0Zinc fingerC2H2-type 16
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36716_73820.0800.0Zinc fingerC2H2-type 17
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36744_76620.0800.0Zinc fingerC2H2-type 18
HgeneZNF227chr19:44722005chr7:91671982ENST00000313040+36772_79420.0800.0Zinc fingerC2H2-type 19
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035623917501088_11731639.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035623917501241_12681639.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035623917501324_13801639.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035623917501422_14471639.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST000003562391750152_9021639.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035623917501573_16471639.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST000003562391750932_10101639.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035810018491088_11731651.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035810018491241_12681651.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035810018491324_13801651.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035810018491422_14471651.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST000003581001849152_9021651.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035810018491573_16471651.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST000003581001849932_10101651.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035902818501088_11731651.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035902818501241_12681651.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035902818501324_13801651.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035902818501422_14471651.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST000003590281850152_9021651.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST0000035902818501573_16471651.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST000003590281850932_10101651.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035623918501088_11731686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035623918501241_12681686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035623918501324_13801686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035623918501422_14471686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST000003562391850152_9021686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035623918501573_16471686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST000003562391850932_10101686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035810019491088_11731698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035810019491241_12681698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035810019491324_13801698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035810019491422_14471698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST000003581001949152_9021698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035810019491573_16471698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST000003581001949932_10101698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035902819501088_11731698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035902819501241_12681698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035902819501324_13801698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035902819501422_14471698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST000003590281950152_9021698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST0000035902819501573_16471698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671981ENST000003590281950932_10101698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035623918501088_11731686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035623918501241_12681686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035623918501324_13801686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035623918501422_14471686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST000003562391850152_9021686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035623918501573_16471686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST000003562391850932_10101686.03908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035810019491088_11731698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035810019491241_12681698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035810019491324_13801698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035810019491422_14471698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST000003581001949152_9021698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035810019491573_16471698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST000003581001949932_10101698.03858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035902819501088_11731698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035902819501241_12681698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035902819501324_13801698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035902819501422_14471698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST000003590281950152_9021698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST0000035902819501573_16471698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671982ENST000003590281950932_10101698.03912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr19:44722005chr7:91671360ENST000003562391750191_2801639.03908.0Compositional biasNote=Gln-rich
TgeneAKAP9chr19:44722005chr7:91671360ENST000003562391750309_9981639.03908.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671360ENST000003581001849191_2801651.03858.0Compositional biasNote=Gln-rich
TgeneAKAP9chr19:44722005chr7:91671360ENST000003581001849309_9981651.03858.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671360ENST000003590281850191_2801651.03912.0Compositional biasNote=Gln-rich
TgeneAKAP9chr19:44722005chr7:91671360ENST000003590281850309_9981651.03912.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671981ENST000003562391850191_2801686.03908.0Compositional biasNote=Gln-rich
TgeneAKAP9chr19:44722005chr7:91671981ENST000003562391850309_9981686.03908.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671981ENST000003581001949191_2801698.03858.0Compositional biasNote=Gln-rich
TgeneAKAP9chr19:44722005chr7:91671981ENST000003581001949309_9981698.03858.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671981ENST000003590281950191_2801698.03912.0Compositional biasNote=Gln-rich
TgeneAKAP9chr19:44722005chr7:91671981ENST000003590281950309_9981698.03912.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671982ENST000003562391850191_2801686.03908.0Compositional biasNote=Gln-rich
TgeneAKAP9chr19:44722005chr7:91671982ENST000003562391850309_9981686.03908.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671982ENST000003581001949191_2801698.03858.0Compositional biasNote=Gln-rich
TgeneAKAP9chr19:44722005chr7:91671982ENST000003581001949309_9981698.03858.0Compositional biasNote=Glu-rich
TgeneAKAP9chr19:44722005chr7:91671982ENST000003590281950191_2801698.03912.0Compositional biasNote=Gln-rich
TgeneAKAP9chr19:44722005chr7:91671982ENST000003590281950309_9981698.03912.0Compositional biasNote=Glu-rich


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
AKAP9TACC3, FNBP1, TRIP10, PRKAR2A, KCNQ1, CLIC1, CALM2, CALM1, TUBGCP3, PKN1, Csnk1d, Csnk1e, CSNK1E, CSNK1D, PMS1, CDC5L, DISC1, TNIK, CEBPA, CCNE1, TSG101, gag-pol, CDK5RAP2, KDM1A, TDP2, PCNT, GSK3A, RASSF2, SUV39H2, PRKACA, PRKACB, MAGEA6, HNRNPM, SSX2, BLZF1, USO1, MAGED1, IKZF3, WAC, THAP1, PRDM14, USHBP1, C1orf94, SAMD3, SUZ12, RNF2, BMI1, ROPN1L, MAPRE1, CEP170, CCDC68, PRKAR2B, HERC2, GPC4, DYNLL1, HUWE1, FGFR1OP, THOC2, CEP170P1, Mapre1, Prkacb, Prkar2a, Prkar2b, Uso1, Fgfr1op, Cdk5rap2, PCGF1, NANOG, ATOH1, TPTE2, PDE4DIP, PRKACG, C1orf87, DNAJC10, BIRC6, TPM2, HEY1, PPIE, RBM14, PCM1, RPA2, KIF19, GTSE1, PARD6G, KLC4, CASK, PRC1, FMR1, CTBP1, RBM10, NDEL1, SF3B2, MED1, SLAIN1, FXR2, YWHAE, AKAP9, PKP2, MYO5A, DVL2, AGR2, KIAA1429, nsp13, VPS9D1, THOC1, RSRC2, SNRPB, GLIS2, BEX2, CCDC146, ABI2, FAM46B, SNF8, CCDC116, SCNM1, TLX3, SSX5, SSX3, LMO1, FAM90A1, TCEANC, CTNNA3, HDDC3, PTPN6, HNRNPC, HMGA1, RFC5, HSPD1, DHX9, HNRNPCL2, VDAC2, NONO, SMC3, nsp16, ORF6, TULP3, CIT, KIF14, MTX2, nsp13ab, HDAC1, ACBD5, AP2B1, CAMSAP2, CEP135, DCTN2, GOLGA2, IMPDH2, KRT19, KRT8, LATS1, MAPRE3, NDC80, PFN1, PXN, SEPT10, STIL, LOC338797, CTCFL, EFCAB1, SOGA1, OR10H1, STK11, PIGF, SYCE1, WHAMMP3, COQ3, RAMP1, ABCF3, RNF145, DDX55, DYNLL2, SLU7, BRK1, ZBTB44, FTSJ3, CCDC71, VDR, BNIP1, LINC00346, CEP57, ZNF252P-AS1, CARD9, NDUFAF1, ROPN1, NOLC1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZNF227
AKAP9all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to ZNF227-AKAP9


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ZNF227-AKAP9


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAKAP9C2678483Long Qt Syndrome 114CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneAKAP9C0035828Romano-Ward Syndrome1ORPHANET
TgeneAKAP9C0037274Dermatologic disorders1CTD_human
TgeneAKAP9C0274861Arsenic Poisoning, Inorganic1CTD_human
TgeneAKAP9C0274862Nervous System, Organic Arsenic Poisoning1CTD_human
TgeneAKAP9C0311375Arsenic Poisoning1CTD_human
TgeneAKAP9C0751851Arsenic Encephalopathy1CTD_human
TgeneAKAP9C0751852Arsenic Induced Polyneuropathy1CTD_human
TgeneAKAP9C1142166Brugada Syndrome (disorder)1ORPHANET