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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZNF268-LPAR1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZNF268-LPAR1
FusionPDB ID: 101741
FusionGDB2.0 ID: 101741
HgeneTgene
Gene symbol

ZNF268

LPAR1

Gene ID

10795

1902

Gene namezinc finger protein 268lysophosphatidic acid receptor 1
SynonymsHZF3EDG2|GPR26|Gpcr26|LPA1|Mrec1.3|VZG1|edg-2|rec.1.3|vzg-1
Cytomap

12q24.33

9q31.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 268zinc finger protein 3zinc finger protein HZF3lysophosphatidic acid receptor 1LPA receptor 1LPA-1endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2lysophosphatidic acid receptor Edg-2ventricular zone gene 1
Modification date2020031320200313
UniProtAcc.

Q92633

Ensembl transtripts involved in fusion geneENST idsENST00000537565, ENST00000228289, 
ENST00000416488, ENST00000536435, 
ENST00000536899, ENST00000539248, 
ENST00000541009, ENST00000541211, 
ENST00000542711, ENST00000542986, 
ENST00000592241, 		ENST00000358883, 
ENST00000374430, ENST00000374431, 
ENST00000538760, ENST00000541779, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 4 X 6=16810 X 6 X 6=360
# samples 711
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZNF268 [Title/Abstract] AND LPAR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZNF268(133758616)-LPAR1(113704448), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF268-LPAR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF268-LPAR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF268-LPAR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF268-LPAR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF268

GO:0000122

negative regulation of transcription by RNA polymerase II

12822888

TgeneLPAR1

GO:0007202

activation of phospholipase C activity

19306925


check buttonFusion gene breakpoints across ZNF268 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LPAR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-SI-A71Q-01AZNF268chr12

133758616

+LPAR1chr9

113704448

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000416488ZNF268chr12133758616+ENST00000374431LPAR1chr9113704448-3826618331667544
ENST00000416488ZNF268chr12133758616+ENST00000541779LPAR1chr9113704448-3825618331667544
ENST00000416488ZNF268chr12133758616+ENST00000374430LPAR1chr9113704448-3311618331667544
ENST00000416488ZNF268chr12133758616+ENST00000358883LPAR1chr9113704448-2912618331667544
ENST00000416488ZNF268chr12133758616+ENST00000538760LPAR1chr9113704448-1913618331667544
ENST00000536435ZNF268chr12133758616+ENST00000374431LPAR1chr9113704448-35713631801412410
ENST00000536435ZNF268chr12133758616+ENST00000541779LPAR1chr9113704448-35703631801412410
ENST00000536435ZNF268chr12133758616+ENST00000374430LPAR1chr9113704448-30563631801412410
ENST00000536435ZNF268chr12133758616+ENST00000358883LPAR1chr9113704448-26573631801412410
ENST00000536435ZNF268chr12133758616+ENST00000538760LPAR1chr9113704448-16583631801412410
ENST00000228289ZNF268chr12133758616+ENST00000374431LPAR1chr9113704448-3447239381288416
ENST00000228289ZNF268chr12133758616+ENST00000541779LPAR1chr9113704448-3446239381288416
ENST00000228289ZNF268chr12133758616+ENST00000374430LPAR1chr9113704448-2932239381288416
ENST00000228289ZNF268chr12133758616+ENST00000358883LPAR1chr9113704448-2533239381288416
ENST00000228289ZNF268chr12133758616+ENST00000538760LPAR1chr9113704448-1534239381288416
ENST00000541211ZNF268chr12133758616+ENST00000374431LPAR1chr9113704448-3485277941326410
ENST00000541211ZNF268chr12133758616+ENST00000541779LPAR1chr9113704448-3484277941326410
ENST00000541211ZNF268chr12133758616+ENST00000374430LPAR1chr9113704448-2970277941326410
ENST00000541211ZNF268chr12133758616+ENST00000358883LPAR1chr9113704448-2571277941326410
ENST00000541211ZNF268chr12133758616+ENST00000538760LPAR1chr9113704448-1572277941326410
ENST00000539248ZNF268chr12133758616+ENST00000374431LPAR1chr9113704448-3469261781310410
ENST00000539248ZNF268chr12133758616+ENST00000541779LPAR1chr9113704448-3468261781310410
ENST00000539248ZNF268chr12133758616+ENST00000374430LPAR1chr9113704448-2954261781310410
ENST00000539248ZNF268chr12133758616+ENST00000358883LPAR1chr9113704448-2555261781310410
ENST00000539248ZNF268chr12133758616+ENST00000538760LPAR1chr9113704448-1556261781310410
ENST00000542711ZNF268chr12133758616+ENST00000374431LPAR1chr9113704448-3469261781310410
ENST00000542711ZNF268chr12133758616+ENST00000541779LPAR1chr9113704448-3468261781310410
ENST00000542711ZNF268chr12133758616+ENST00000374430LPAR1chr9113704448-2954261781310410
ENST00000542711ZNF268chr12133758616+ENST00000358883LPAR1chr9113704448-2555261781310410
ENST00000542711ZNF268chr12133758616+ENST00000538760LPAR1chr9113704448-1556261781310410
ENST00000536899ZNF268chr12133758616+ENST00000374431LPAR1chr9113704448-3466258751307410
ENST00000536899ZNF268chr12133758616+ENST00000541779LPAR1chr9113704448-3465258751307410
ENST00000536899ZNF268chr12133758616+ENST00000374430LPAR1chr9113704448-2951258751307410
ENST00000536899ZNF268chr12133758616+ENST00000358883LPAR1chr9113704448-2552258751307410
ENST00000536899ZNF268chr12133758616+ENST00000538760LPAR1chr9113704448-1553258751307410
ENST00000542986ZNF268chr12133758616+ENST00000374431LPAR1chr9113704448-3466258751307410
ENST00000542986ZNF268chr12133758616+ENST00000541779LPAR1chr9113704448-3465258751307410
ENST00000542986ZNF268chr12133758616+ENST00000374430LPAR1chr9113704448-2951258751307410
ENST00000542986ZNF268chr12133758616+ENST00000358883LPAR1chr9113704448-2552258751307410
ENST00000542986ZNF268chr12133758616+ENST00000538760LPAR1chr9113704448-1553258751307410
ENST00000541009ZNF268chr12133758616+ENST00000374431LPAR1chr9113704448-3421213301262410
ENST00000541009ZNF268chr12133758616+ENST00000541779LPAR1chr9113704448-3420213301262410
ENST00000541009ZNF268chr12133758616+ENST00000374430LPAR1chr9113704448-2906213301262410
ENST00000541009ZNF268chr12133758616+ENST00000358883LPAR1chr9113704448-2507213301262410
ENST00000541009ZNF268chr12133758616+ENST00000538760LPAR1chr9113704448-1508213301262410
ENST00000592241ZNF268chr12133758616+ENST00000374431LPAR1chr9113704448-336015221201399
ENST00000592241ZNF268chr12133758616+ENST00000541779LPAR1chr9113704448-335915221201399
ENST00000592241ZNF268chr12133758616+ENST00000374430LPAR1chr9113704448-284515221201399
ENST00000592241ZNF268chr12133758616+ENST00000358883LPAR1chr9113704448-244615221201399
ENST00000592241ZNF268chr12133758616+ENST00000538760LPAR1chr9113704448-144715221201399

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000416488ENST00000374431ZNF268chr12133758616+LPAR1chr9113704448-0.0003468130.9996532
ENST00000416488ENST00000541779ZNF268chr12133758616+LPAR1chr9113704448-0.0003459440.99965405
ENST00000416488ENST00000374430ZNF268chr12133758616+LPAR1chr9113704448-0.000378710.9996213
ENST00000416488ENST00000358883ZNF268chr12133758616+LPAR1chr9113704448-0.0004121270.99958783
ENST00000416488ENST00000538760ZNF268chr12133758616+LPAR1chr9113704448-0.0016043210.9983956
ENST00000536435ENST00000374431ZNF268chr12133758616+LPAR1chr9113704448-0.0003002460.99969983
ENST00000536435ENST00000541779ZNF268chr12133758616+LPAR1chr9113704448-0.0003008760.9996991
ENST00000536435ENST00000374430ZNF268chr12133758616+LPAR1chr9113704448-0.0003154260.9996846
ENST00000536435ENST00000358883ZNF268chr12133758616+LPAR1chr9113704448-0.0003259140.9996741
ENST00000536435ENST00000538760ZNF268chr12133758616+LPAR1chr9113704448-0.0019065130.9980934
ENST00000228289ENST00000374431ZNF268chr12133758616+LPAR1chr9113704448-0.0002815670.99971837
ENST00000228289ENST00000541779ZNF268chr12133758616+LPAR1chr9113704448-0.000282780.9997172
ENST00000228289ENST00000374430ZNF268chr12133758616+LPAR1chr9113704448-0.0002874140.9997125
ENST00000228289ENST00000358883ZNF268chr12133758616+LPAR1chr9113704448-0.0003129290.9996871
ENST00000228289ENST00000538760ZNF268chr12133758616+LPAR1chr9113704448-0.0019832780.9980167
ENST00000541211ENST00000374431ZNF268chr12133758616+LPAR1chr9113704448-0.0002958150.9997042
ENST00000541211ENST00000541779ZNF268chr12133758616+LPAR1chr9113704448-0.0002970120.999703
ENST00000541211ENST00000374430ZNF268chr12133758616+LPAR1chr9113704448-0.0002994280.99970055
ENST00000541211ENST00000358883ZNF268chr12133758616+LPAR1chr9113704448-0.0003233110.9996767
ENST00000541211ENST00000538760ZNF268chr12133758616+LPAR1chr9113704448-0.0019239590.9980761
ENST00000539248ENST00000374431ZNF268chr12133758616+LPAR1chr9113704448-0.0002984140.99970156
ENST00000539248ENST00000541779ZNF268chr12133758616+LPAR1chr9113704448-0.0002996160.9997004
ENST00000539248ENST00000374430ZNF268chr12133758616+LPAR1chr9113704448-0.0003015310.9996985
ENST00000539248ENST00000358883ZNF268chr12133758616+LPAR1chr9113704448-0.0003256120.99967444
ENST00000539248ENST00000538760ZNF268chr12133758616+LPAR1chr9113704448-0.0021070130.99789304
ENST00000542711ENST00000374431ZNF268chr12133758616+LPAR1chr9113704448-0.0002984140.99970156
ENST00000542711ENST00000541779ZNF268chr12133758616+LPAR1chr9113704448-0.0002996160.9997004
ENST00000542711ENST00000374430ZNF268chr12133758616+LPAR1chr9113704448-0.0003015310.9996985
ENST00000542711ENST00000358883ZNF268chr12133758616+LPAR1chr9113704448-0.0003256120.99967444
ENST00000542711ENST00000538760ZNF268chr12133758616+LPAR1chr9113704448-0.0021070130.99789304
ENST00000536899ENST00000374431ZNF268chr12133758616+LPAR1chr9113704448-0.0002987630.9997012
ENST00000536899ENST00000541779ZNF268chr12133758616+LPAR1chr9113704448-0.0002999470.99970007
ENST00000536899ENST00000374430ZNF268chr12133758616+LPAR1chr9113704448-0.000301090.999699
ENST00000536899ENST00000358883ZNF268chr12133758616+LPAR1chr9113704448-0.0003243450.99967563
ENST00000536899ENST00000538760ZNF268chr12133758616+LPAR1chr9113704448-0.0021139840.997886
ENST00000542986ENST00000374431ZNF268chr12133758616+LPAR1chr9113704448-0.0002987630.9997012
ENST00000542986ENST00000541779ZNF268chr12133758616+LPAR1chr9113704448-0.0002999470.99970007
ENST00000542986ENST00000374430ZNF268chr12133758616+LPAR1chr9113704448-0.000301090.999699
ENST00000542986ENST00000358883ZNF268chr12133758616+LPAR1chr9113704448-0.0003243450.99967563
ENST00000542986ENST00000538760ZNF268chr12133758616+LPAR1chr9113704448-0.0021139840.997886
ENST00000541009ENST00000374431ZNF268chr12133758616+LPAR1chr9113704448-0.0002971740.99970275
ENST00000541009ENST00000541779ZNF268chr12133758616+LPAR1chr9113704448-0.0002983420.9997017
ENST00000541009ENST00000374430ZNF268chr12133758616+LPAR1chr9113704448-0.0003073930.9996927
ENST00000541009ENST00000358883ZNF268chr12133758616+LPAR1chr9113704448-0.0003374340.9996625
ENST00000541009ENST00000538760ZNF268chr12133758616+LPAR1chr9113704448-0.0020547310.99794525
ENST00000592241ENST00000374431ZNF268chr12133758616+LPAR1chr9113704448-0.0002928140.99970716
ENST00000592241ENST00000541779ZNF268chr12133758616+LPAR1chr9113704448-0.0002939510.999706
ENST00000592241ENST00000374430ZNF268chr12133758616+LPAR1chr9113704448-0.0003000890.99969995
ENST00000592241ENST00000358883ZNF268chr12133758616+LPAR1chr9113704448-0.000320310.9996797
ENST00000592241ENST00000538760ZNF268chr12133758616+LPAR1chr9113704448-0.0019788210.99802125

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>101741_101741_1_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000228289_LPAR1_chr9_113704448_ENST00000358883_length(amino acids)=416AA_BP=67
MFRADGEILVPQIAFIARRGQRASRVWSGCEPFWLQIWSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSG
KHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLI
DTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTF
VVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNP

--------------------------------------------------------------

>101741_101741_2_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000228289_LPAR1_chr9_113704448_ENST00000374430_length(amino acids)=416AA_BP=67
MFRADGEILVPQIAFIARRGQRASRVWSGCEPFWLQIWSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSG
KHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLI
DTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTF
VVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNP

--------------------------------------------------------------

>101741_101741_3_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000228289_LPAR1_chr9_113704448_ENST00000374431_length(amino acids)=416AA_BP=67
MFRADGEILVPQIAFIARRGQRASRVWSGCEPFWLQIWSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSG
KHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLI
DTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTF
VVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNP

--------------------------------------------------------------

>101741_101741_4_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000228289_LPAR1_chr9_113704448_ENST00000538760_length(amino acids)=416AA_BP=67
MFRADGEILVPQIAFIARRGQRASRVWSGCEPFWLQIWSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSG
KHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLI
DTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTF
VVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNP

--------------------------------------------------------------

>101741_101741_5_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000228289_LPAR1_chr9_113704448_ENST00000541779_length(amino acids)=416AA_BP=67
MFRADGEILVPQIAFIARRGQRASRVWSGCEPFWLQIWSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSG
KHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLI
DTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTF
VVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNP

--------------------------------------------------------------

>101741_101741_6_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000416488_LPAR1_chr9_113704448_ENST00000358883_length(amino acids)=544AA_BP=195
MSPQHSAVTQGSIIKNKEGMDAKSLTAWSRTLVTFKDVFVDFTREEWKLLDTAQQIVYRNVMLENYKNLVSLGYQLTKPDVILRLEKGEE
PWLVEREIHQETHPDSETAFEIKSSVSSRSIFKDKQSCDIKMEGMARNDLWYLSLEEVWKCRDQLDKYQENPERHLSIPRVLSLPARHTK
LTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMAN
LAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIIC
WTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSND

--------------------------------------------------------------

>101741_101741_7_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000416488_LPAR1_chr9_113704448_ENST00000374430_length(amino acids)=544AA_BP=195
MSPQHSAVTQGSIIKNKEGMDAKSLTAWSRTLVTFKDVFVDFTREEWKLLDTAQQIVYRNVMLENYKNLVSLGYQLTKPDVILRLEKGEE
PWLVEREIHQETHPDSETAFEIKSSVSSRSIFKDKQSCDIKMEGMARNDLWYLSLEEVWKCRDQLDKYQENPERHLSIPRVLSLPARHTK
LTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMAN
LAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIIC
WTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSND

--------------------------------------------------------------

>101741_101741_8_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000416488_LPAR1_chr9_113704448_ENST00000374431_length(amino acids)=544AA_BP=195
MSPQHSAVTQGSIIKNKEGMDAKSLTAWSRTLVTFKDVFVDFTREEWKLLDTAQQIVYRNVMLENYKNLVSLGYQLTKPDVILRLEKGEE
PWLVEREIHQETHPDSETAFEIKSSVSSRSIFKDKQSCDIKMEGMARNDLWYLSLEEVWKCRDQLDKYQENPERHLSIPRVLSLPARHTK
LTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMAN
LAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIIC
WTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSND

--------------------------------------------------------------

>101741_101741_9_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000416488_LPAR1_chr9_113704448_ENST00000538760_length(amino acids)=544AA_BP=195
MSPQHSAVTQGSIIKNKEGMDAKSLTAWSRTLVTFKDVFVDFTREEWKLLDTAQQIVYRNVMLENYKNLVSLGYQLTKPDVILRLEKGEE
PWLVEREIHQETHPDSETAFEIKSSVSSRSIFKDKQSCDIKMEGMARNDLWYLSLEEVWKCRDQLDKYQENPERHLSIPRVLSLPARHTK
LTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMAN
LAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIIC
WTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSND

--------------------------------------------------------------

>101741_101741_10_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000416488_LPAR1_chr9_113704448_ENST00000541779_length(amino acids)=544AA_BP=195
MSPQHSAVTQGSIIKNKEGMDAKSLTAWSRTLVTFKDVFVDFTREEWKLLDTAQQIVYRNVMLENYKNLVSLGYQLTKPDVILRLEKGEE
PWLVEREIHQETHPDSETAFEIKSSVSSRSIFKDKQSCDIKMEGMARNDLWYLSLEEVWKCRDQLDKYQENPERHLSIPRVLSLPARHTK
LTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMAN
LAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIIC
WTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSND

--------------------------------------------------------------

>101741_101741_11_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000536435_LPAR1_chr9_113704448_ENST00000358883_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_12_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000536435_LPAR1_chr9_113704448_ENST00000374430_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_13_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000536435_LPAR1_chr9_113704448_ENST00000374431_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_14_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000536435_LPAR1_chr9_113704448_ENST00000538760_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_15_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000536435_LPAR1_chr9_113704448_ENST00000541779_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_16_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000536899_LPAR1_chr9_113704448_ENST00000358883_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_17_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000536899_LPAR1_chr9_113704448_ENST00000374430_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_18_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000536899_LPAR1_chr9_113704448_ENST00000374431_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_19_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000536899_LPAR1_chr9_113704448_ENST00000538760_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_20_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000536899_LPAR1_chr9_113704448_ENST00000541779_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_21_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000539248_LPAR1_chr9_113704448_ENST00000358883_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_22_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000539248_LPAR1_chr9_113704448_ENST00000374430_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_23_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000539248_LPAR1_chr9_113704448_ENST00000374431_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_24_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000539248_LPAR1_chr9_113704448_ENST00000538760_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_25_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000539248_LPAR1_chr9_113704448_ENST00000541779_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_26_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000541009_LPAR1_chr9_113704448_ENST00000358883_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_27_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000541009_LPAR1_chr9_113704448_ENST00000374430_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_28_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000541009_LPAR1_chr9_113704448_ENST00000374431_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_29_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000541009_LPAR1_chr9_113704448_ENST00000538760_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_30_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000541009_LPAR1_chr9_113704448_ENST00000541779_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_31_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000541211_LPAR1_chr9_113704448_ENST00000358883_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_32_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000541211_LPAR1_chr9_113704448_ENST00000374430_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_33_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000541211_LPAR1_chr9_113704448_ENST00000374431_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_34_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000541211_LPAR1_chr9_113704448_ENST00000538760_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_35_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000541211_LPAR1_chr9_113704448_ENST00000541779_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_36_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000542711_LPAR1_chr9_113704448_ENST00000358883_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_37_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000542711_LPAR1_chr9_113704448_ENST00000374430_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_38_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000542711_LPAR1_chr9_113704448_ENST00000374431_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_39_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000542711_LPAR1_chr9_113704448_ENST00000538760_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_40_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000542711_LPAR1_chr9_113704448_ENST00000541779_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_41_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000542986_LPAR1_chr9_113704448_ENST00000358883_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_42_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000542986_LPAR1_chr9_113704448_ENST00000374430_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_43_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000542986_LPAR1_chr9_113704448_ENST00000374431_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_44_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000542986_LPAR1_chr9_113704448_ENST00000538760_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_45_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000542986_LPAR1_chr9_113704448_ENST00000541779_length(amino acids)=410AA_BP=61
MEWLRTLLAADLEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATE
WNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTA
SVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVL
YAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYR

--------------------------------------------------------------

>101741_101741_46_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000592241_LPAR1_chr9_113704448_ENST00000358883_length(amino acids)=399AA_BP=50
LEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGL
GITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIE
RHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQR
TMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQI

--------------------------------------------------------------

>101741_101741_47_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000592241_LPAR1_chr9_113704448_ENST00000374430_length(amino acids)=399AA_BP=50
LEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGL
GITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIE
RHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQR
TMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQI

--------------------------------------------------------------

>101741_101741_48_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000592241_LPAR1_chr9_113704448_ENST00000374431_length(amino acids)=399AA_BP=50
LEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGL
GITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIE
RHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQR
TMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQI

--------------------------------------------------------------

>101741_101741_49_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000592241_LPAR1_chr9_113704448_ENST00000538760_length(amino acids)=399AA_BP=50
LEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGL
GITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIE
RHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQR
TMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQI

--------------------------------------------------------------

>101741_101741_50_ZNF268-LPAR1_ZNF268_chr12_133758616_ENST00000592241_LPAR1_chr9_113704448_ENST00000541779_length(amino acids)=399AA_BP=50
LEVEAVPWTLFCCPFRVWRSRSIPRVLSLPARHTKLTVGMATRVRTASIWFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGL
GITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIE
RHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQR
TMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:133758616/chr9:113704448)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LPAR1

Q92633

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity). {ECO:0000250|UniProtKB:P61793, ECO:0000269|PubMed:18066075, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19656035, ECO:0000269|PubMed:19733258, ECO:0000269|PubMed:25025571, ECO:0000269|PubMed:26091040, ECO:0000269|PubMed:9070858, ECO:0000305|PubMed:11093753, ECO:0000305|PubMed:9069262}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLPAR1chr12:133758616chr9:113704448ENST0000035888314124_12915.0365.0RegionLysophosphatidic acid binding
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443025124_12915.0365.0RegionLysophosphatidic acid binding
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443125124_12915.0365.0RegionLysophosphatidic acid binding
TgeneLPAR1chr12:133758616chr9:113704448ENST0000035888314108_12115.0365.0Topological domainNote=Extracellular
TgeneLPAR1chr12:133758616chr9:113704448ENST0000035888314145_16315.0365.0Topological domainNote=Cytoplasmic
TgeneLPAR1chr12:133758616chr9:113704448ENST0000035888314185_20415.0365.0Topological domainNote=Extracellular
TgeneLPAR1chr12:133758616chr9:113704448ENST0000035888314226_25515.0365.0Topological domainNote=Cytoplasmic
TgeneLPAR1chr12:133758616chr9:113704448ENST0000035888314281_29415.0365.0Topological domainNote=Extracellular
TgeneLPAR1chr12:133758616chr9:113704448ENST0000035888314316_36415.0365.0Topological domainNote=Cytoplasmic
TgeneLPAR1chr12:133758616chr9:113704448ENST000003588831476_8315.0365.0Topological domainNote=Cytoplasmic
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443025108_12115.0365.0Topological domainNote=Extracellular
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443025145_16315.0365.0Topological domainNote=Cytoplasmic
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443025185_20415.0365.0Topological domainNote=Extracellular
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443025226_25515.0365.0Topological domainNote=Cytoplasmic
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443025281_29415.0365.0Topological domainNote=Extracellular
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443025316_36415.0365.0Topological domainNote=Cytoplasmic
TgeneLPAR1chr12:133758616chr9:113704448ENST000003744302576_8315.0365.0Topological domainNote=Cytoplasmic
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443125108_12115.0365.0Topological domainNote=Extracellular
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443125145_16315.0365.0Topological domainNote=Cytoplasmic
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443125185_20415.0365.0Topological domainNote=Extracellular
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443125226_25515.0365.0Topological domainNote=Cytoplasmic
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443125281_29415.0365.0Topological domainNote=Extracellular
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443125316_36415.0365.0Topological domainNote=Cytoplasmic
TgeneLPAR1chr12:133758616chr9:113704448ENST000003744312576_8315.0365.0Topological domainNote=Cytoplasmic
TgeneLPAR1chr12:133758616chr9:113704448ENST0000035888314122_14415.0365.0TransmembraneNote=Helical%3B Name%3D3
TgeneLPAR1chr12:133758616chr9:113704448ENST0000035888314164_18415.0365.0TransmembraneNote=Helical%3B Name%3D4
TgeneLPAR1chr12:133758616chr9:113704448ENST0000035888314205_22515.0365.0TransmembraneNote=Helical%3B Name%3D5
TgeneLPAR1chr12:133758616chr9:113704448ENST0000035888314256_28015.0365.0TransmembraneNote=Helical%3B Name%3D6
TgeneLPAR1chr12:133758616chr9:113704448ENST0000035888314295_31515.0365.0TransmembraneNote=Helical%3B Name%3D7
TgeneLPAR1chr12:133758616chr9:113704448ENST000003588831451_7515.0365.0TransmembraneNote=Helical%3B Name%3D1
TgeneLPAR1chr12:133758616chr9:113704448ENST000003588831484_10715.0365.0TransmembraneNote=Helical%3B Name%3D2
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443025122_14415.0365.0TransmembraneNote=Helical%3B Name%3D3
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443025164_18415.0365.0TransmembraneNote=Helical%3B Name%3D4
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443025205_22515.0365.0TransmembraneNote=Helical%3B Name%3D5
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443025256_28015.0365.0TransmembraneNote=Helical%3B Name%3D6
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443025295_31515.0365.0TransmembraneNote=Helical%3B Name%3D7
TgeneLPAR1chr12:133758616chr9:113704448ENST000003744302551_7515.0365.0TransmembraneNote=Helical%3B Name%3D1
TgeneLPAR1chr12:133758616chr9:113704448ENST000003744302584_10715.0365.0TransmembraneNote=Helical%3B Name%3D2
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443125122_14415.0365.0TransmembraneNote=Helical%3B Name%3D3
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443125164_18415.0365.0TransmembraneNote=Helical%3B Name%3D4
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443125205_22515.0365.0TransmembraneNote=Helical%3B Name%3D5
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443125256_28015.0365.0TransmembraneNote=Helical%3B Name%3D6
TgeneLPAR1chr12:133758616chr9:113704448ENST0000037443125295_31515.0365.0TransmembraneNote=Helical%3B Name%3D7
TgeneLPAR1chr12:133758616chr9:113704448ENST000003744312551_7515.0365.0TransmembraneNote=Helical%3B Name%3D1
TgeneLPAR1chr12:133758616chr9:113704448ENST000003744312584_10715.0365.0TransmembraneNote=Helical%3B Name%3D2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+2681_15211.0948.0DomainKRAB
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+2681_15211.0948.0DomainKRAB
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+2381_1520787.0DomainKRAB
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26276_29811.0948.0Zinc fingerC2H2-type 1
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26304_32611.0948.0Zinc fingerC2H2-type 2
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26332_35411.0948.0Zinc fingerC2H2-type 3
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26360_38211.0948.0Zinc fingerC2H2-type 4
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26388_41011.0948.0Zinc fingerC2H2-type 5
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26416_43811.0948.0Zinc fingerC2H2-type 6
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26444_46611.0948.0Zinc fingerC2H2-type 7
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26472_49411.0948.0Zinc fingerC2H2-type 8
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26500_52211.0948.0Zinc fingerC2H2-type 9
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26528_55011.0948.0Zinc fingerC2H2-type 10
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26556_57811.0948.0Zinc fingerC2H2-type 11
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26584_60611.0948.0Zinc fingerC2H2-type 12
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26612_63411.0948.0Zinc fingerC2H2-type 13
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26640_66211.0948.0Zinc fingerC2H2-type 14
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26668_69011.0948.0Zinc fingerC2H2-type 15
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26696_71811.0948.0Zinc fingerC2H2-type 16
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26724_74611.0948.0Zinc fingerC2H2-type 17
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26752_77411.0948.0Zinc fingerC2H2-type 18
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26780_80211.0948.0Zinc fingerC2H2-type 19
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26808_83011.0948.0Zinc fingerC2H2-type 20
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26836_85811.0948.0Zinc fingerC2H2-type 21
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26864_88611.0948.0Zinc fingerC2H2-type 22
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26892_91411.0948.0Zinc fingerC2H2-type 23
HgeneZNF268chr12:133758616chr9:113704448ENST00000228289+26920_94211.0948.0Zinc fingerC2H2-type 24
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26276_29811.0948.0Zinc fingerC2H2-type 1
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26304_32611.0948.0Zinc fingerC2H2-type 2
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26332_35411.0948.0Zinc fingerC2H2-type 3
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26360_38211.0948.0Zinc fingerC2H2-type 4
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26388_41011.0948.0Zinc fingerC2H2-type 5
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26416_43811.0948.0Zinc fingerC2H2-type 6
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26444_46611.0948.0Zinc fingerC2H2-type 7
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26472_49411.0948.0Zinc fingerC2H2-type 8
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26500_52211.0948.0Zinc fingerC2H2-type 9
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26528_55011.0948.0Zinc fingerC2H2-type 10
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26556_57811.0948.0Zinc fingerC2H2-type 11
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26584_60611.0948.0Zinc fingerC2H2-type 12
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26612_63411.0948.0Zinc fingerC2H2-type 13
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26640_66211.0948.0Zinc fingerC2H2-type 14
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26668_69011.0948.0Zinc fingerC2H2-type 15
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26696_71811.0948.0Zinc fingerC2H2-type 16
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26724_74611.0948.0Zinc fingerC2H2-type 17
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26752_77411.0948.0Zinc fingerC2H2-type 18
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26780_80211.0948.0Zinc fingerC2H2-type 19
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26808_83011.0948.0Zinc fingerC2H2-type 20
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26836_85811.0948.0Zinc fingerC2H2-type 21
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26864_88611.0948.0Zinc fingerC2H2-type 22
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26892_91411.0948.0Zinc fingerC2H2-type 23
HgeneZNF268chr12:133758616chr9:113704448ENST00000536435+26920_94211.0948.0Zinc fingerC2H2-type 24
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23276_2980787.0Zinc fingerC2H2-type 1
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23304_3260787.0Zinc fingerC2H2-type 2
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23332_3540787.0Zinc fingerC2H2-type 3
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23360_3820787.0Zinc fingerC2H2-type 4
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23388_4100787.0Zinc fingerC2H2-type 5
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23416_4380787.0Zinc fingerC2H2-type 6
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23444_4660787.0Zinc fingerC2H2-type 7
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23472_4940787.0Zinc fingerC2H2-type 8
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23500_5220787.0Zinc fingerC2H2-type 9
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23528_5500787.0Zinc fingerC2H2-type 10
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23556_5780787.0Zinc fingerC2H2-type 11
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23584_6060787.0Zinc fingerC2H2-type 12
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23612_6340787.0Zinc fingerC2H2-type 13
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23640_6620787.0Zinc fingerC2H2-type 14
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23668_6900787.0Zinc fingerC2H2-type 15
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23696_7180787.0Zinc fingerC2H2-type 16
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23724_7460787.0Zinc fingerC2H2-type 17
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23752_7740787.0Zinc fingerC2H2-type 18
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23780_8020787.0Zinc fingerC2H2-type 19
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23808_8300787.0Zinc fingerC2H2-type 20
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23836_8580787.0Zinc fingerC2H2-type 21
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23864_8860787.0Zinc fingerC2H2-type 22
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23892_9140787.0Zinc fingerC2H2-type 23
HgeneZNF268chr12:133758616chr9:113704448ENST00000537565+23920_9420787.0Zinc fingerC2H2-type 24
TgeneLPAR1chr12:133758616chr9:113704448ENST00000358883141_5015.0365.0Topological domainNote=Extracellular
TgeneLPAR1chr12:133758616chr9:113704448ENST00000374430251_5015.0365.0Topological domainNote=Extracellular
TgeneLPAR1chr12:133758616chr9:113704448ENST00000374431251_5015.0365.0Topological domainNote=Extracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZNF268
LPAR1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ZNF268-LPAR1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZNF268-LPAR1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource