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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZNF292-FIG4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZNF292-FIG4
FusionPDB ID: 101818
FusionGDB2.0 ID: 101818
HgeneTgene
Gene symbol

ZNF292

FIG4

Gene ID

23036

9896

Gene namezinc finger protein 292FIG4 phosphoinositide 5-phosphatase
SynonymsNbla00365|ZFP292|ZN-16|Zn-15|bA393I2.3ALS11|BTOP|CMT4J|KIAA0274|SAC3|YVS|dJ249I4.1
Cytomap

6q14.3

6q21

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 29216 zinc-finger domain proteinputative protein product of Nbla00365polyphosphoinositide phosphataseFIG4 homolog, SAC domain containing lipid phosphataseFIG4 homolog, SAC1 domain containing lipid phosphataseFIG4 homolog, SAC1 lipid phosphatase domain containingSAC domain-containing protein 3Sac domain-containing inos
Modification date2020031320200328
UniProtAcc.

Q92562

Ensembl transtripts involved in fusion geneENST idsENST00000369578, ENST00000339907, 
ENST00000369577, ENST00000392985, 
ENST00000230124, ENST00000441478, 
ENST00000368941, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score24 X 7 X 12=20166 X 10 X 5=300
# samples 277
** MAII scorelog2(27/2016*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/300*10)=-2.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZNF292 [Title/Abstract] AND FIG4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZNF292(87865477)-FIG4(110098125), # samples:3
Anticipated loss of major functional domain due to fusion event.ZNF292-FIG4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF292-FIG4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF292-FIG4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZNF292-FIG4 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF292-FIG4 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ZNF292-FIG4 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF292 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FIG4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A0J2-01AZNF292chr6

87865477

-FIG4chr6

110098125

+
ChimerDB4BRCATCGA-AO-A0J2-01AZNF292chr6

87865477

+FIG4chr6

110098125

+
ChimerDB4BRCATCGA-AO-A0J2-01AZNF292chr6

87865477

+FIG4chr6

110106173

+
ChimerDB4BRCATCGA-AO-A0J2-01AZNF292chr6

87865477

+FIG4chr6

110113785

+
ChimerDB4BRCATCGA-AO-A0J2ZNF292chr6

87865477

+FIG4chr6

110098124

+
ChimerDB4BRCATCGA-AO-A0J2ZNF292chr6

87865477

+FIG4chr6

110106172

+
ChimerDB4BRCATCGA-AO-A0J2ZNF292chr6

87865477

+FIG4chr6

110113784

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000369577ZNF292chr687865477+ENST00000441478FIG4chr6110113784+63121143471142
ENST00000369577ZNF292chr687865477+ENST00000230124FIG4chr6110113784+72221143558171
ENST00000339907ZNF292chr687865477+ENST00000441478FIG4chr6110113784+59917911439142
ENST00000339907ZNF292chr687865477+ENST00000230124FIG4chr6110113784+69017911526171
ENST00000392985ZNF292chr687865477+ENST00000441478FIG4chr6110113784+825405237665142
ENST00000392985ZNF292chr687865477+ENST00000230124FIG4chr6110113784+916405237752171
ENST00000369577ZNF292chr687865477+ENST00000441478FIG4chr6110113785+63121143471142
ENST00000369577ZNF292chr687865477+ENST00000230124FIG4chr6110113785+72221143558171
ENST00000339907ZNF292chr687865477+ENST00000441478FIG4chr6110113785+59917911439142
ENST00000339907ZNF292chr687865477+ENST00000230124FIG4chr6110113785+69017911526171
ENST00000392985ZNF292chr687865477+ENST00000441478FIG4chr6110113785+825405237665142
ENST00000392985ZNF292chr687865477+ENST00000230124FIG4chr6110113785+916405237752171

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369577ENST00000441478ZNF292chr687865477+FIG4chr6110113784+0.0112904520.9887095
ENST00000369577ENST00000230124ZNF292chr687865477+FIG4chr6110113784+0.0073974580.9926025
ENST00000339907ENST00000441478ZNF292chr687865477+FIG4chr6110113784+0.009555950.990444
ENST00000339907ENST00000230124ZNF292chr687865477+FIG4chr6110113784+0.0077152690.99228466
ENST00000392985ENST00000441478ZNF292chr687865477+FIG4chr6110113784+0.0106541340.98934585
ENST00000392985ENST00000230124ZNF292chr687865477+FIG4chr6110113784+0.006750090.9932499
ENST00000369577ENST00000441478ZNF292chr687865477+FIG4chr6110113785+0.0112904520.9887095
ENST00000369577ENST00000230124ZNF292chr687865477+FIG4chr6110113785+0.0073974580.9926025
ENST00000339907ENST00000441478ZNF292chr687865477+FIG4chr6110113785+0.009555950.990444
ENST00000339907ENST00000230124ZNF292chr687865477+FIG4chr6110113785+0.0077152690.99228466
ENST00000392985ENST00000441478ZNF292chr687865477+FIG4chr6110113785+0.0106541340.98934585
ENST00000392985ENST00000230124ZNF292chr687865477+FIG4chr6110113785+0.006750090.9932499

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>101818_101818_1_ZNF292-FIG4_ZNF292_chr6_87865477_ENST00000339907_FIG4_chr6_110113784_ENST00000230124_length(amino acids)=171AA_BP=55
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQNVVQPMKELYGINLSDGLSEEDFSIYSRFVQLGQ

--------------------------------------------------------------

>101818_101818_2_ZNF292-FIG4_ZNF292_chr6_87865477_ENST00000339907_FIG4_chr6_110113784_ENST00000441478_length(amino acids)=142AA_BP=55
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQNVVQPMKELYGINLSDGLSEEDFSIYSRTPISAF

--------------------------------------------------------------

>101818_101818_3_ZNF292-FIG4_ZNF292_chr6_87865477_ENST00000339907_FIG4_chr6_110113785_ENST00000230124_length(amino acids)=171AA_BP=55
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQNVVQPMKELYGINLSDGLSEEDFSIYSRFVQLGQ

--------------------------------------------------------------

>101818_101818_4_ZNF292-FIG4_ZNF292_chr6_87865477_ENST00000339907_FIG4_chr6_110113785_ENST00000441478_length(amino acids)=142AA_BP=55
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQNVVQPMKELYGINLSDGLSEEDFSIYSRTPISAF

--------------------------------------------------------------

>101818_101818_5_ZNF292-FIG4_ZNF292_chr6_87865477_ENST00000369577_FIG4_chr6_110113784_ENST00000230124_length(amino acids)=171AA_BP=55
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQNVVQPMKELYGINLSDGLSEEDFSIYSRFVQLGQ

--------------------------------------------------------------

>101818_101818_6_ZNF292-FIG4_ZNF292_chr6_87865477_ENST00000369577_FIG4_chr6_110113784_ENST00000441478_length(amino acids)=142AA_BP=55
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQNVVQPMKELYGINLSDGLSEEDFSIYSRTPISAF

--------------------------------------------------------------

>101818_101818_7_ZNF292-FIG4_ZNF292_chr6_87865477_ENST00000369577_FIG4_chr6_110113785_ENST00000230124_length(amino acids)=171AA_BP=55
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQNVVQPMKELYGINLSDGLSEEDFSIYSRFVQLGQ

--------------------------------------------------------------

>101818_101818_8_ZNF292-FIG4_ZNF292_chr6_87865477_ENST00000369577_FIG4_chr6_110113785_ENST00000441478_length(amino acids)=142AA_BP=55
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQNVVQPMKELYGINLSDGLSEEDFSIYSRTPISAF

--------------------------------------------------------------

>101818_101818_9_ZNF292-FIG4_ZNF292_chr6_87865477_ENST00000392985_FIG4_chr6_110113784_ENST00000230124_length(amino acids)=171AA_BP=55
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQNVVQPMKELYGINLSDGLSEEDFSIYSRFVQLGQ

--------------------------------------------------------------

>101818_101818_10_ZNF292-FIG4_ZNF292_chr6_87865477_ENST00000392985_FIG4_chr6_110113784_ENST00000441478_length(amino acids)=142AA_BP=55
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQNVVQPMKELYGINLSDGLSEEDFSIYSRTPISAF

--------------------------------------------------------------

>101818_101818_11_ZNF292-FIG4_ZNF292_chr6_87865477_ENST00000392985_FIG4_chr6_110113785_ENST00000230124_length(amino acids)=171AA_BP=55
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQNVVQPMKELYGINLSDGLSEEDFSIYSRFVQLGQ

--------------------------------------------------------------

>101818_101818_12_ZNF292-FIG4_ZNF292_chr6_87865477_ENST00000392985_FIG4_chr6_110113785_ENST00000441478_length(amino acids)=142AA_BP=55
MADEEAEQERLSCGEGGCVAELQRLGERLQELELQLRESRVPAVEAATDYCQQLCQNVVQPMKELYGINLSDGLSEEDFSIYSRTPISAF

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:87865477/chr6:110098125)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FIG4

Q92562

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:17556371}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+181827_185456.02724.0Coiled coilOntology_term=ECO:0000255
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+181827_185456.02724.0Coiled coilOntology_term=ECO:0000255
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+181098_112356.02724.0Zinc fingerC2H2-type 7
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+181375_139756.02724.0Zinc fingerC2H2-type 8%3B degenerate
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+181902_192756.02724.0Zinc fingerC2H2-type 9
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+181947_197256.02724.0Zinc fingerC2H2-type 10
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+182114_213956.02724.0Zinc fingerC2H2-type 11
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+182172_219756.02724.0Zinc fingerC2H2-type 12
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+182216_224156.02724.0Zinc fingerC2H2-type 13
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+182256_228156.02724.0Zinc fingerC2H2-type 14
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+182386_241056.02724.0Zinc fingerC2H2-type 15
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+18569_59156.02724.0Zinc fingerC2H2-type 1
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+18681_70556.02724.0Zinc fingerC2H2-type 2
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+18722_74456.02724.0Zinc fingerC2H2-type 3
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+18750_77456.02724.0Zinc fingerC2H2-type 4
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+18779_80356.02724.0Zinc fingerC2H2-type 5
HgeneZNF292chr6:87865477chr6:110113784ENST00000369577+18807_83156.02724.0Zinc fingerC2H2-type 6
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+181098_112356.02724.0Zinc fingerC2H2-type 7
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+181375_139756.02724.0Zinc fingerC2H2-type 8%3B degenerate
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+181902_192756.02724.0Zinc fingerC2H2-type 9
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+181947_197256.02724.0Zinc fingerC2H2-type 10
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+182114_213956.02724.0Zinc fingerC2H2-type 11
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+182172_219756.02724.0Zinc fingerC2H2-type 12
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+182216_224156.02724.0Zinc fingerC2H2-type 13
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+182256_228156.02724.0Zinc fingerC2H2-type 14
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+182386_241056.02724.0Zinc fingerC2H2-type 15
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+18569_59156.02724.0Zinc fingerC2H2-type 1
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+18681_70556.02724.0Zinc fingerC2H2-type 2
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+18722_74456.02724.0Zinc fingerC2H2-type 3
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+18750_77456.02724.0Zinc fingerC2H2-type 4
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+18779_80356.02724.0Zinc fingerC2H2-type 5
HgeneZNF292chr6:87865477chr6:110113785ENST00000369577+18807_83156.02724.0Zinc fingerC2H2-type 6
TgeneFIG4chr6:87865477chr6:110113784ENST000002301241923746_749792.0908.0Compositional biasNote=Poly-Pro
TgeneFIG4chr6:87865477chr6:110113784ENST000002301241923755_758792.0908.0Compositional biasNote=Poly-Ser
TgeneFIG4chr6:87865477chr6:110113785ENST000002301241923746_749792.0908.0Compositional biasNote=Poly-Pro
TgeneFIG4chr6:87865477chr6:110113785ENST000002301241923755_758792.0908.0Compositional biasNote=Poly-Ser
TgeneFIG4chr6:87865477chr6:110113784ENST000002301241923154_547792.0908.0DomainSAC
TgeneFIG4chr6:87865477chr6:110113785ENST000002301241923154_547792.0908.0DomainSAC


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZNF292
FIG4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ZNF292-FIG4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZNF292-FIG4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource