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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:BRD9-NUTM1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: BRD9-NUTM1
FusionPDB ID: 10225
FusionGDB2.0 ID: 10225
HgeneTgene
Gene symbol

BRD9

NUTM1

Gene ID

65980

256646

Gene namebromodomain containing 9NUT midline carcinoma family member 1
SynonymsLAVS3040|PRO9856C15orf55|FAM22H|NUT
Cytomap

5p15.33

15q14

Type of geneprotein-codingprotein-coding
Descriptionbromodomain-containing protein 9rhabdomyosarcoma antigen MU-RMS-40.8sarcoma antigen NY-SAR-29NUT family member 1nuclear protein in testis
Modification date2020031520200313
UniProtAcc

Q9H8M2

Q86Y26

Ensembl transtripts involved in fusion geneENST idsENST00000323510, ENST00000388890, 
ENST00000467963, ENST00000483173, 
ENST00000435709, ENST00000494422, 
ENST00000333756, ENST00000438749, 
ENST00000537011, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 15 X 7=10506 X 5 X 4=120
# samples 125
** MAII scorelog2(12/1050*10)=-3.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: BRD9 [Title/Abstract] AND NUTM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across BRD9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NUTM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..BRD9chr5

870588

-NUTM1chr

34640169

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000388890BRD9chr5870588-ENST00000537011NUTM1chr34640169+2105117702102701
ENST00000388890BRD9chr5870588-ENST00000438749NUTM1chr34640169+2105117702102701
ENST00000388890BRD9chr5870588-ENST00000333756NUTM1chr34640169+2105117702102701
ENST00000323510BRD9chr5870588-ENST00000537011NUTM1chr34640169+2165123702162721
ENST00000323510BRD9chr5870588-ENST00000438749NUTM1chr34640169+2165123702162721
ENST00000323510BRD9chr5870588-ENST00000333756NUTM1chr34640169+2165123702162721
ENST00000483173BRD9chr5870588-ENST00000537011NUTM1chr34640169+243415061042431776
ENST00000483173BRD9chr5870588-ENST00000438749NUTM1chr34640169+243415061042431776
ENST00000483173BRD9chr5870588-ENST00000333756NUTM1chr34640169+243415061042431776
ENST00000467963BRD9chr5870588-ENST00000537011NUTM1chr34640169+262016921672617817
ENST00000467963BRD9chr5870588-ENST00000438749NUTM1chr34640169+262016921672617817
ENST00000467963BRD9chr5870588-ENST00000333756NUTM1chr34640169+262016921672617817

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>10225_10225_1_BRD9-NUTM1_BRD9_chr5_870588_ENST00000323510_NUTM1_chr_34640169_ENST00000333756_length(amino acids)=721AA_BP=
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKERLLALKRSMSFMQDMDFSQQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREV
ISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPG
FTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTL
FQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLVLQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICS
GGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFED
RDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLI
MEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPI

--------------------------------------------------------------

>10225_10225_2_BRD9-NUTM1_BRD9_chr5_870588_ENST00000323510_NUTM1_chr_34640169_ENST00000438749_length(amino acids)=721AA_BP=
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKERLLALKRSMSFMQDMDFSQQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREV
ISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPG
FTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTL
FQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLVLQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICS
GGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFED
RDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLI
MEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPI

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>10225_10225_3_BRD9-NUTM1_BRD9_chr5_870588_ENST00000323510_NUTM1_chr_34640169_ENST00000537011_length(amino acids)=721AA_BP=
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKERLLALKRSMSFMQDMDFSQQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREV
ISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPG
FTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTL
FQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLVLQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICS
GGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFED
RDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLI
MEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPI

--------------------------------------------------------------

>10225_10225_4_BRD9-NUTM1_BRD9_chr5_870588_ENST00000388890_NUTM1_chr_34640169_ENST00000333756_length(amino acids)=701AA_BP=
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAE
EHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSA
TTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVG
DTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLVLQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYED
RHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKG
NFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERI

--------------------------------------------------------------

>10225_10225_5_BRD9-NUTM1_BRD9_chr5_870588_ENST00000388890_NUTM1_chr_34640169_ENST00000438749_length(amino acids)=701AA_BP=
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAE
EHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSA
TTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVG
DTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLVLQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYED
RHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKG
NFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERI

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>10225_10225_6_BRD9-NUTM1_BRD9_chr5_870588_ENST00000388890_NUTM1_chr_34640169_ENST00000537011_length(amino acids)=701AA_BP=
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAE
EHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSA
TTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVG
DTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLVLQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYED
RHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKG
NFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERI

--------------------------------------------------------------

>10225_10225_7_BRD9-NUTM1_BRD9_chr5_870588_ENST00000467963_NUTM1_chr_34640169_ENST00000333756_length(amino acids)=817AA_BP=
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKE
EKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHP
MDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSK
KPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLS
SKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGG
DHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLVLQERIPWVPPECIENPKNLNLATDKWSFGTT
LWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGF
SGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGR
RNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKE

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>10225_10225_8_BRD9-NUTM1_BRD9_chr5_870588_ENST00000467963_NUTM1_chr_34640169_ENST00000438749_length(amino acids)=817AA_BP=
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKE
EKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHP
MDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSK
KPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLS
SKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGG
DHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLVLQERIPWVPPECIENPKNLNLATDKWSFGTT
LWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGF
SGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGR
RNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKE

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>10225_10225_9_BRD9-NUTM1_BRD9_chr5_870588_ENST00000467963_NUTM1_chr_34640169_ENST00000537011_length(amino acids)=817AA_BP=
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKE
EKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHP
MDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSK
KPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLS
SKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGG
DHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLVLQERIPWVPPECIENPKNLNLATDKWSFGTT
LWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGF
SGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGR
RNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKE

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>10225_10225_10_BRD9-NUTM1_BRD9_chr5_870588_ENST00000483173_NUTM1_chr_34640169_ENST00000333756_length(amino acids)=776AA_BP=
MNSQDPATTPVTMMTGQTMSERGTKKRKRRRRRSPRRRSIWTMRKEGSERKRRSGSERGSTVTRRERLTTLILGRRWRWSRPQIGQSERA
GHSQPKMRAHLFSNSWNTSSASFRDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTV
YYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEAR
DRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDL
KSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMS
MKSYPDVSVDISMLSSLVLQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANL
INNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQD
NTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKG

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>10225_10225_11_BRD9-NUTM1_BRD9_chr5_870588_ENST00000483173_NUTM1_chr_34640169_ENST00000438749_length(amino acids)=776AA_BP=
MNSQDPATTPVTMMTGQTMSERGTKKRKRRRRRSPRRRSIWTMRKEGSERKRRSGSERGSTVTRRERLTTLILGRRWRWSRPQIGQSERA
GHSQPKMRAHLFSNSWNTSSASFRDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTV
YYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEAR
DRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDL
KSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMS
MKSYPDVSVDISMLSSLVLQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANL
INNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQD
NTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKG

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>10225_10225_12_BRD9-NUTM1_BRD9_chr5_870588_ENST00000483173_NUTM1_chr_34640169_ENST00000537011_length(amino acids)=776AA_BP=
MNSQDPATTPVTMMTGQTMSERGTKKRKRRRRRSPRRRSIWTMRKEGSERKRRSGSERGSTVTRRERLTTLILGRRWRWSRPQIGQSERA
GHSQPKMRAHLFSNSWNTSSASFRDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTV
YYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEAR
DRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDL
KSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMS
MKSYPDVSVDISMLSSLVLQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANL
INNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQD
NTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKG

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:/chr:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRD9

Q9H8M2

NUTM1

Q86Y26

FUNCTION: Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Orchestrates also the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312). {ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:26365797, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:32457312}.FUNCTION: Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. {ECO:0000269|PubMed:30447097}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (572) >>>572.pdbFusion protein BP residue:
CIF file (572) >>>572.cif		BRD9chr5870588-NUTM1chr34640169+
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVT
DAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYN
RPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETA
KKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINR
FLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPG
FTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDE
TGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVP
MKPPDEAKVGDTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLVLQERIPW
VPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYED
RHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTE
NDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRY
DPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCY
SAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLG
TKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPI
701
3D view using mol* of 572 (AA BP:)
PDB file (589) >>>589.pdbFusion protein BP residue:
CIF file (589) >>>589.cif		BRD9chr5870588-NUTM1chr34640169+
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVT
DAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYN
RPDTVYYKLAKKILHAGFKMMSKERLLALKRSMSFMQDMDFSQQAALLGN
EDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAE
EHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDA
DEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNS
VFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQ
ITGGDHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMSMKSYP
DVSVDISMLSSLVLQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICS
GGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSF
RAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERH
LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFERE
IEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERI
DHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLT
721
3D view using mol* of 589 (AA BP:)
PDB file (633) >>>633.pdbFusion protein BP residue:
CIF file (633) >>>633.cif		BRD9chr5870588-NUTM1chr34640169+
MNSQDPATTPVTMMTGQTMSERGTKKRKRRRRRSPRRRSIWTMRKEGSER
KRRSGSERGSTVTRRERLTTLILGRRWRWSRPQIGQSERAGHSQPKMRAH
LFSNSWNTSSASFRDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIV
ANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQA
ALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLT
DSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNT
AEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALS
MQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVD
DLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMS
MKSYPDVSVDISMLSSLVLQERIPWVPPECIENPKNLNLATDKWSFGTTL
WEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPD
FRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQ
FEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLR
DFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQK
HKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIG
776
3D view using mol* of 633 (AA BP:)
PDB file (663) >>>663.pdbFusion protein BP residue:
CIF file (663) >>>663.cif		BRD9chr5870588-NUTM1chr34640169+
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSS
YYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKEEKKRKREREH
CDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLR
QLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTE
FKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTA
VEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVL
ALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEE
THPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGD
LKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGG
DHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMSMKSYPDVSV
DISMLSSLVLQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDK
PLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAII
RDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFL
QQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEIL
KSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIK
LLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLP
817
3D view using mol* of 663 (AA BP:)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
BRD9_pLDDT.png
all structure
all structure
NUTM1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
BRD9_NUTM1_572_pLDDT.png (AA BP:)
all structure
BRD9_NUTM1_572_pLDDT_and_active_sites.png (AA BP:)
all structure
BRD9_NUTM1_572_violinplot.png (AA BP:)
all structure
BRD9_NUTM1_589_pLDDT.png (AA BP:)
all structure
BRD9_NUTM1_589_pLDDT_and_active_sites.png (AA BP:)
all structure
BRD9_NUTM1_589_violinplot.png (AA BP:)
all structure
BRD9_NUTM1_633_pLDDT.png (AA BP:)
all structure
BRD9_NUTM1_633_pLDDT_and_active_sites.png (AA BP:)
all structure
BRD9_NUTM1_663_pLDDT.png (AA BP:)
all structure
BRD9_NUTM1_663_pLDDT_and_active_sites.png (AA BP:)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
BRD9_NUTM1_572.png
all structure
BRD9_NUTM1_589.png
all structure
BRD9_NUTM1_633.png
all structure
BRD9_NUTM1_663.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
5721.1133471.1881357.5940.5170.740.9611.4750.6022.4511.173Chain A: 1,2,4,5,6,8,9,10,12,13,14,17,198,207,208,
210,218,220,222,223,238,240,241,243,244,246,247,24
8,249,250,251,252,253,254,255,257,383,385,386,397,
400,412,417,420,421,424,425,427,428,432,434,480,48
3,484,487
5891.0682011.102526.1620.4830.7590.9821.2240.9011.3590.713Chain A: 557,558,559,560,561,562,563,564,565,582,5
84,586,593,596,597,599,600,604,613,629,631,633,634
,636,637,638,641,645,676,677,678,682,683,685,695,6
96,697,698,699,700,701

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
589ZINC000084668739DB11611Lifitegrast-8.83606-8.83606
589ZINC000068204830DB09102Daclatasvir-7.13416-8.41646
589UpadacitinibDB09102-8.20394-8.20494
589ZINC000003938482DB01263Posaconazole-8.11026-8.12796
589ZINC000028232755DB00385Valrubicin-8.05802-8.05832
589ZINC000001530639DB01095Fluvastatin-7.98817-7.98997
589ZINC000013520815DB00783Estradiol-7.98643-7.98643
589ZINC000253632968DB06290Simeprevir-7.94762-7.95422
589ZINC000053084692DB06654Safinamide-7.11924-7.89734
589ZINC000003944422DB00503Ritonavir-7.64005-7.64005
589ZINC000003920266DB01177Idarubicin-7.60893-7.63603
589ZINC000003830339DB01210Levobunolol-7.49782-7.49892
589ZINC000011681534DB04861Nebivolol-7.47502-7.49482
589ZINC000003918453DB00303Ertapenem-7.41988-7.46888
589ZINC000001530695DB00679Thioridazine-7.44118-7.44158
589ZINC000033965961DB00743Gadobenic acid-6.01271-7.43431
589ZINC000003831151DB00471Montelukast-7.3246-7.3246
589ZINC000000607986DB04861Nebivolol-7.23246-7.25226
589ZINC000043207238DB08907Canagliflozin-7.23847-7.23847
589ZINC000001530697DB00679Thioridazine-7.23697-7.23737

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000084668739DB11611LifitegrastSmall moleculeCS(=O)(=O)C1=CC(C[C@H](NC(=O)C2=C(Cl)C3=C(CN(CC3)C(=O)C3=CC=C4C=COC4=C3)C=C2Cl)C(O)=O)=CC=C1Approved
ZINC000068204830DB09102DaclatasvirSmall moleculeCOC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C1=NC=C(N1)C1=CC=C(C=C1)C1=CC=C(C=C1)C1=CN=C(N1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)CApproved|Investigational
ZINC000003938482DB01263PosaconazoleSmall molecule[H][C@@](C)(O)[C@]([H])(CC)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(OC[C@]2([H])CO[C@](CN3C=NC=N3)(C2)C2=C(F)C=C(F)C=C2)C=C1Approved|Investigational|Vet_approved
ZINC000013520815DB00783EstradiolSmall molecule[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3Approved|Investigational|Vet_approved
ZINC000253632968DB06290SimeprevirSmall molecule[H][C@]12C[C@]1(NC(=O)[C@]1([H])C[C@H](C[C@@]1([H])C(=O)N(C)CCCCC=C/2)OC1=CC(=NC2=C1C=CC(OC)=C2C)C1=NC(=CS1)C(C)C)C(=O)NS(=O)(=O)C1CC1Approved
ZINC000053084692DB06654SafinamideSmall moleculeC[C@H](NCC1=CC=C(OCC2=CC(F)=CC=C2)C=C1)C(N)=OApproved|Investigational
ZINC000003944422DB00503RitonavirSmall moleculeCC(C)[C@H](NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)OCC1=CN=CS1)CC1=CC=CC=C1Approved|Investigational
ZINC000003920266DB01177IdarubicinSmall moleculeC[C@@H]1O[C@H](C[C@H](N)[C@@H]1O)O[C@H]1C[C@@](O)(CC2=C1C(O)=C1C(=O)C3=CC=CC=C3C(=O)C1=C2O)C(C)=OApproved
ZINC000003830339DB01210LevobunololSmall moleculeCC(C)(C)NC[C@H](O)COC1=CC=CC2=C1CCCC2=OApproved
ZINC000011681534DB04861NebivololSmall moleculeOC(CNCC(O)C1CCC2=C(O1)C=CC(F)=C2)C1CCC2=C(O1)C=CC(F)=C2Approved|Investigational
ZINC000003918453DB00303ErtapenemSmall molecule[H][C@]12[C@@H](C)C(S[C@]3([H])CN[C@@]([H])(C3)C(=O)NC3=CC=CC(=C3)C(O)=O)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(O)=OApproved|Investigational
ZINC000001530695DB00679ThioridazineSmall moleculeCSC1=CC2=C(SC3=CC=CC=C3N2CCC2CCCCN2C)C=C1Approved|Withdrawn
ZINC000033965961DB00743Gadobenic acidSmall molecule[Gd+3].OC(=O)CN(CCN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O)C(COCC1=CC=CC=C1)C(O)=OApproved|Investigational
ZINC000003831151DB00471MontelukastSmall moleculeOC(=O)CC1(CC1)CS[C@H](CCC1=CC=CC=C1C(O)(C)C)C1=CC=CC(C=CC2=NC3=C(C=CC(Cl)=C3)C=C2)=C1Approved
ZINC000043207238DB08907CanagliflozinSmall molecule[H][C@]1(O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C1=CC=C(C)C(CC2=CC=C(S2)C2=CC=C(F)C=C2)=C1Approved

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000084668739615.48413.795897.582209.576215.175373.77199.061665.0091.2511.259.285166.22612
ZINC000068204830738.8859.1861185.225698.369189.608297.24802297.4812.512.58.424156.2531
ZINC000068204830738.88512.7281242.653732.724195.462314.46702325.8512.512.58.586156.99331
ZINC000068204830738.8855.6591215.343718.68189.061307.60202308.8542.512.58.456157.66831
ZINC000068204830738.8853.0361238.237724.613189.774323.84902337.4652.512.58.529158.58831
ZINC000068204830738.8856.6121209.345719.031182.477307.83702307.3472.512.58.288159.64831
ZINC000068204830738.8854.8491244.561737.115179.716327.73102332.7592.512.58.571160.79831
ZINC000003938482700.7876.5931133.73453.341130.579474.96374.8482110.183111.28.262182.41731
ZINC000003938482700.7878.5451114.625456.955127.996456.48273.1922101.798111.28.612182.5231
ZINC000028232755723.6532.651042.026492.004317.032110.408122.5811989.623316.69.032227.80723
ZINC000001530639411.4722.606736.515244.402177.684267.60146.8281317.38524.48.258275.70510
ZINC000013520815272.3862.098514.009305.29197.28111.4370912.68722.458.957310000
ZINC000253632968749.9396.9571148.652820.732134.162154.91538.8422228.6291.2513.758.419162.52532
ZINC000253632968749.93911.1351103.653772.655146.278144.58240.1382184.3831.2513.758.499157.80432
ZINC000253632968749.9399.2981114.226794.485125.878154.69239.172200.51.2513.758.41163.80632
ZINC000253632968749.9398.171081.392774.076143.601146.31117.4042179.1541.2513.758.604161.00632
ZINC000053084692302.3486.36612.581156.033105.388304.28646.8741036.21834.759.083376.96100
ZINC000053084692302.3483.053603.233143.432120.534292.3746.8971022.59734.759.137372.68300
ZINC000003944422720.9435.1711056.641444.158125.027430.69256.7642164.0523.2510.959.179172.02532
ZINC000003920266497.5012.725710.728253.475274.61182.64301369.433412.359.091230.11212
ZINC000003920266497.5012.604704.286249.182270.92184.18501372.737412.359.059231.10712
ZINC000003830339291.3894.063611.955402.6193.154116.19101057.8625.459.203386.07900
ZINC000011681534405.4412.335727.789280.70885.7267.62193.761272.95136.49.228395.43300
ZINC000011681534405.4416.385707.131273.32277.744262.30193.7651256.16536.49.073396.54300
ZINC000003918453475.5159.874779.621278.135335.459144.8121.2171402.335411.29.07417.1801
ZINC000003918453475.5159.994771.077279.878329.91144.43916.8511394.363411.28.93918.02501
ZINC000001530695370.573.134614.969295.6996.322232.94480.0041156.758037.924310010
ZINC000001530695370.571.764662.347354.8315.676222.49679.3451195.48037.876310011
ZINC000033965961513.52.418779.845164.862445.111169.87201490.693517.79.5051022
ZINC000033965961513.511.709763.564181.431386.322195.81101467.895517.79.6851022
ZINC000033965961513.54.373821.79193.15432.908195.73301526.715517.79.6721022
ZINC000033965961513.58.818820.356199.676440.476180.20401518.843517.79.6551022
ZINC000033965961513.55.331812.123191.407427.298193.41801519.163517.79.5991022
ZINC000033965961513.56.761787.823203.197382.091202.53501501.995517.79.4871022
ZINC000033965961513.54.323809.291220.875386.145202.27101512.618517.79.5221022
ZINC000003831151586.1872.6511004.488333.455125.421452.35593.2571886.4324.258.788110021
ZINC000000607986405.4415.004705.664273.42884.542253.93193.7631255.21236.49.141395.02900
ZINC000000607986405.4416.242723.401276.42185.145268.0793.7641269.44636.49.103395.44200
ZINC000043207238444.5174.415747.287209.678166.727291.44679.4361342.61848.58.906388.9902
ZINC000001530697370.571.897689.826351.7844.029263.06670.9461232.378037.845310011
ZINC000001530697370.572.15660.267308.5816.715269.02375.9471206.162037.963310011


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000084668739CS(=O)(=O)c1cccc(C[C@H](NC(=O)c2c(Cl)cc3c(c2Cl)CCN(C(=O)c2ccc4ccoc4c2)C3)C(=O)O)c10.0976790350.229936056
ZINC000068204830COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc(-c3ccc(-c4cnc([C@@H]5CCCN5C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]4)cc3)cc2)[nH]1)C(C)C0.0399710920.226481814
ZINC000003938482CC[C@@H]([C@H](C)O)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@@H]5CO[C@@](Cn6cncn6)(c6ccc(F)cc6F)C5)cc4)CC3)cc2)c1=O0.0317243810.429306683
ZINC000028232755CCCCC(=O)OCC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](NC(=O)C(F)(F)F)[C@@H](O)[C@@H](C)O2)C1)C(=O)c1c(OC)cccc1C3=O0.0230569920.246049783
ZINC000001530639CC(C)n1c(/C=C/[C@H](O)C[C@H](O)CC(=O)O)c(-c2ccc(F)cc2)c2ccccc210.1011703060.183209327
ZINC000013520815C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2O0.0753697940.351201784
ZINC000253632968COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6CC6)C[C@H]5C=CCCCCN(C)C(=O)[C@@H]4C3)cc(-c3nc(C(C)C)cs3)nc2c1C0.0148452150.273382605
ZINC000053084692C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O0.2799554790.265373208
ZINC000003944422CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs10.0411619360.407340083
ZINC000003920266CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O0.035530410.335010792
ZINC000003830339CC(C)(C)NC[C@H](O)COc1cccc2c1CCCC2=O0.1733436360.14827061
ZINC000011681534O[C@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000003918453C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](C(=O)Nc4cccc(C(=O)O)c4)C3)[C@H](C)[C@H]120.0433370410.30139698
ZINC000001530695CSc1ccc2c(c1)N(CC[C@@H]1CCCCN1C)c1ccccc1S20.1432805140.391555547
ZINC000033965961O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)[C@H](COCc1ccccc1)C(=O)O0.106773660.316603347
ZINC000003831151CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c10.0799984550.32708243
ZINC000000607986O[C@@H](CNC[C@@H](O)[C@H]1CCc2cc(F)ccc2O1)[C@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000043207238Cc1ccc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1Cc1ccc(-c2ccc(F)cc2)s10.0682111610.161061761
ZINC000001530697CSc1ccc2c(c1)N(CC[C@H]1CCCCN1C)c1ccccc1S20.1432805140.391555547


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
BRD9BRD4, WHSC1L1, CATIP, SS18, SMARCD1, MUS81, NFE2L1, CXXC4, BCL7C, BCL7A, SMARCC2, TRIM25, UBE2A, RUNX1, DPF2, INO80, INO80E, THAP3, WDR5, MED8, TRRAP, GEMIN5, ACTL6A, MCM2, CNOT1, CENPA, MED14, PSME3, ATG16L1, NR2C2, GLTSCR1, SMARCA4, GLTSCR1L, ESR1, CHMP4B, ECT2, PRC1, BRD2, BRD3, SMARCC1, SMARCA2, NOLC1, CKAP4, RCN2, SLC25A13, PGAM5, SLC25A11, TCOF1, MSH6, SLC25A12, DNAJA2, SLC16A1, LBR, TUFM, CSNK2A1, RIN3, DPF1, SMARCD3, BRD7, ARID1A, ARID2, ARID1B, DPF3, STK11IP, SMARCD2, SMARCB1, SS18L1, PBRM1, PHF10, SMARCE1, ACTC1, RAD51, ATRX, ZCCHC10, SS18L2, RNPS1, MAPKAPK2, PPARG, HSPBP1, SRRM2, JMJD6, AP3B1, PNN, RDH13, EPB41L2, CWC22, NAF1, RANBP6, TUBA1B, JMY,
NUTM1EP300, ALOX5, IFIT2, KPNA2, LMO1, LMO2, PRKAA2, TP53BP2, NEBL, ZNF277, SAMD4A, PSME4, ZMYND10, CCHCR1, LMO3, RIC8A, SH2D4A, HSPBAP1, FAM161A, MORN4, P4HA3, KANSL1, LHX8, AXIN1, SMARCD1, MBD3, TXN2, TTC23, AES, CHCHD3, CDK18, RCOR3, ENKD1, ARHGEF6, PRKAB2, OSTF1, SOGA1, ALS2CR11, CCDC116, SCNM1, CDC20B, PRPF18, METTL17, TBC1D21, LRRC8E, TSGA10IP, PLEKHF2, CCDC185, SAMD4B, GADD45GIP1, KANK2, TEAD4, SH2D1B, GPANK1, AQP1, E7, nsp8,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
BRD9all structure
NUTM1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to BRD9-NUTM1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to BRD9-NUTM1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRD9C0036920Sezary Syndrome1CTD_human
TgeneNUTM1C1707291NUT midline carcinoma1ORPHANET