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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ZNF532-NEDD4L

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ZNF532-NEDD4L
	FusionPDB ID: 102301
	FusionGDB2.0 ID: 102301
		Hgene	Tgene
	Gene symbol	ZNF532	NEDD4L
	Gene ID	55205	23327
	Gene name	zinc finger protein 532	NEDD4 like E3 ubiquitin protein ligase
	Synonyms	-	NEDD4-2\|NEDD4.2\|PVNH7\|RSP5\|hNEDD4-2
	Cytomap	18q21.32	18q21.31
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 532	E3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseubiquitin-protein ligase Rsp5
	Modification date	20200313	20200329
	UniProtAcc	.	Q96PU5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000336078, ENST00000589288, ENST00000591083, ENST00000591230, ENST00000591808, ENST00000588956,	ENST00000588516, ENST00000256830, ENST00000256832, ENST00000357895, ENST00000382850, ENST00000435432, ENST00000456986, ENST00000586263, ENST00000431212, ENST00000456173, ENST00000589054, ENST00000356462, ENST00000400345,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	12 X 11 X 10=1320	27 X 28 X 6=4536
	# samples	16	32
	** MAII score	log2(16/1320*10)=-3.04439411935845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(32/4536*10)=-3.82527683005487 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ZNF532 [Title/Abstract] AND NEDD4L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ZNF532(56585954)-NEDD4L(56018223), # samples:2
Anticipated loss of major functional domain due to fusion event.	ZNF532-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF532-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF532-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ZNF532-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NEDD4L	GO:0003254	regulation of membrane depolarization	15217910
Tgene	NEDD4L	GO:0006511	ubiquitin-dependent protein catabolic process	21463633
Tgene	NEDD4L	GO:0010038	response to metal ion	11244092
Tgene	NEDD4L	GO:0016567	protein ubiquitination	15217910\|25631046
Tgene	NEDD4L	GO:0034765	regulation of ion transmembrane transport	17289006
Tgene	NEDD4L	GO:0042391	regulation of membrane potential	17289006
Tgene	NEDD4L	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21463633
Tgene	NEDD4L	GO:0060306	regulation of membrane repolarization	21463633
Tgene	NEDD4L	GO:0070936	protein K48-linked ubiquitination	21463633
Tgene	NEDD4L	GO:1901016	regulation of potassium ion transmembrane transporter activity	17289006
Tgene	NEDD4L	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	21463633
Tgene	NEDD4L	GO:1901380	negative regulation of potassium ion transmembrane transport	21463633
Tgene	NEDD4L	GO:1902306	negative regulation of sodium ion transmembrane transport	15217910
Tgene	NEDD4L	GO:1903861	positive regulation of dendrite extension	23999003
Tgene	NEDD4L	GO:2000009	negative regulation of protein localization to cell surface	21463633
Tgene	NEDD4L	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	15217910

Fusion gene breakpoints across ZNF532 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NEDD4L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-KK-A8ID-01A	ZNF532	chr18	56587865	+	NEDD4L	chr18	55833020	+
ChimerDB4	UCEC	TCGA-AJ-A3BF-01A	ZNF532	chr18	56585954	+	NEDD4L	chr18	56018223	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000336078	ZNF532	chr18	56587865	+	ENST00000356462	NEDD4L	chr18	55833020	+	6115	3122	764	5809	1681
ENST00000336078	ZNF532	chr18	56587865	+	ENST00000400345	NEDD4L	chr18	55833020	+	6438	3122	764	6001	1745
ENST00000591083	ZNF532	chr18	56587865	+	ENST00000356462	NEDD4L	chr18	55833020	+	5685	2692	334	5379	1681
ENST00000591083	ZNF532	chr18	56587865	+	ENST00000400345	NEDD4L	chr18	55833020	+	6008	2692	334	5571	1745
ENST00000589288	ZNF532	chr18	56587865	+	ENST00000356462	NEDD4L	chr18	55833020	+	5540	2547	189	5234	1681
ENST00000589288	ZNF532	chr18	56587865	+	ENST00000400345	NEDD4L	chr18	55833020	+	5863	2547	189	5426	1745
ENST00000591230	ZNF532	chr18	56587865	+	ENST00000356462	NEDD4L	chr18	55833020	+	5693	2700	342	5387	1681
ENST00000591230	ZNF532	chr18	56587865	+	ENST00000400345	NEDD4L	chr18	55833020	+	6016	2700	342	5579	1745
ENST00000591808	ZNF532	chr18	56587865	+	ENST00000356462	NEDD4L	chr18	55833020	+	6228	3235	877	5922	1681
ENST00000591808	ZNF532	chr18	56587865	+	ENST00000400345	NEDD4L	chr18	55833020	+	6551	3235	877	6114	1745
ENST00000336078	ZNF532	chr18	56585954	+	ENST00000356462	NEDD4L	chr18	56018223	+	4250	2670	714	3944	1076
ENST00000336078	ZNF532	chr18	56585954	+	ENST00000400345	NEDD4L	chr18	56018223	+	4381	2670	714	3944	1076
ENST00000591083	ZNF532	chr18	56585954	+	ENST00000356462	NEDD4L	chr18	56018223	+	3820	2240	284	3514	1076
ENST00000591083	ZNF532	chr18	56585954	+	ENST00000400345	NEDD4L	chr18	56018223	+	3951	2240	284	3514	1076
ENST00000589288	ZNF532	chr18	56585954	+	ENST00000356462	NEDD4L	chr18	56018223	+	3675	2095	139	3369	1076
ENST00000589288	ZNF532	chr18	56585954	+	ENST00000400345	NEDD4L	chr18	56018223	+	3806	2095	139	3369	1076
ENST00000591230	ZNF532	chr18	56585954	+	ENST00000356462	NEDD4L	chr18	56018223	+	3828	2248	292	3522	1076
ENST00000591230	ZNF532	chr18	56585954	+	ENST00000400345	NEDD4L	chr18	56018223	+	3959	2248	292	3522	1076
ENST00000591808	ZNF532	chr18	56585954	+	ENST00000356462	NEDD4L	chr18	56018223	+	4363	2783	827	4057	1076
ENST00000591808	ZNF532	chr18	56585954	+	ENST00000400345	NEDD4L	chr18	56018223	+	4494	2783	827	4057	1076

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000336078	ENST00000356462	ZNF532	chr18	56587865	+	NEDD4L	chr18	55833020	+	0.001262635	0.9987374
ENST00000336078	ENST00000400345	ZNF532	chr18	56587865	+	NEDD4L	chr18	55833020	+	0.000624994	0.99937505
ENST00000591083	ENST00000356462	ZNF532	chr18	56587865	+	NEDD4L	chr18	55833020	+	0.001043044	0.9989569
ENST00000591083	ENST00000400345	ZNF532	chr18	56587865	+	NEDD4L	chr18	55833020	+	0.000519101	0.9994809
ENST00000589288	ENST00000356462	ZNF532	chr18	56587865	+	NEDD4L	chr18	55833020	+	0.001149568	0.99885046
ENST00000589288	ENST00000400345	ZNF532	chr18	56587865	+	NEDD4L	chr18	55833020	+	0.000564323	0.9994356
ENST00000591230	ENST00000356462	ZNF532	chr18	56587865	+	NEDD4L	chr18	55833020	+	0.001038653	0.9989613
ENST00000591230	ENST00000400345	ZNF532	chr18	56587865	+	NEDD4L	chr18	55833020	+	0.000506686	0.99949324
ENST00000591808	ENST00000356462	ZNF532	chr18	56587865	+	NEDD4L	chr18	55833020	+	0.001762206	0.9982377
ENST00000591808	ENST00000400345	ZNF532	chr18	56587865	+	NEDD4L	chr18	55833020	+	0.000850032	0.9991499
ENST00000336078	ENST00000356462	ZNF532	chr18	56585954	+	NEDD4L	chr18	56018223	+	0.00099493	0.99900514
ENST00000336078	ENST00000400345	ZNF532	chr18	56585954	+	NEDD4L	chr18	56018223	+	0.000873406	0.9991266
ENST00000591083	ENST00000356462	ZNF532	chr18	56585954	+	NEDD4L	chr18	56018223	+	0.000841571	0.9991584
ENST00000591083	ENST00000400345	ZNF532	chr18	56585954	+	NEDD4L	chr18	56018223	+	0.000718187	0.9992818
ENST00000589288	ENST00000356462	ZNF532	chr18	56585954	+	NEDD4L	chr18	56018223	+	0.001014194	0.9989858
ENST00000589288	ENST00000400345	ZNF532	chr18	56585954	+	NEDD4L	chr18	56018223	+	0.000839452	0.9991605
ENST00000591230	ENST00000356462	ZNF532	chr18	56585954	+	NEDD4L	chr18	56018223	+	0.000827163	0.99917287
ENST00000591230	ENST00000400345	ZNF532	chr18	56585954	+	NEDD4L	chr18	56018223	+	0.000696915	0.9993031
ENST00000591808	ENST00000356462	ZNF532	chr18	56585954	+	NEDD4L	chr18	56018223	+	0.00144869	0.9985513
ENST00000591808	ENST00000400345	ZNF532	chr18	56585954	+	NEDD4L	chr18	56018223	+	0.001256793	0.99874324

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>102301_102301_1_ZNF532-NEDD4L_ZNF532_chr18_56585954_ENST00000336078_NEDD4L_chr18_56018223_ENST00000356462_length(amino acids)=1076AA_BP=652
MNIGLKSFQKVKVHKVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKLKALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKV
RKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSKLSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRA
ADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVM
ASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIKPVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSAS
SAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSV
VEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFALEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKE
KGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTVTKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECN
EVFQDETSLATHFQQAADTSGQPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFE
MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY
FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMV
TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLL

--------------------------------------------------------------

>102301_102301_2_ZNF532-NEDD4L_ZNF532_chr18_56585954_ENST00000336078_NEDD4L_chr18_56018223_ENST00000400345_length(amino acids)=1076AA_BP=652
MNIGLKSFQKVKVHKVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKLKALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKV
RKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSKLSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRA
ADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVM
ASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIKPVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSAS
SAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSV
VEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFALEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKE
KGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTVTKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECN
EVFQDETSLATHFQQAADTSGQPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFE
MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY
FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMV
TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLL

--------------------------------------------------------------

>102301_102301_3_ZNF532-NEDD4L_ZNF532_chr18_56585954_ENST00000589288_NEDD4L_chr18_56018223_ENST00000356462_length(amino acids)=1076AA_BP=652
MNIGLKSFQKVKVHKVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKLKALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKV
RKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSKLSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRA
ADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVM
ASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIKPVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSAS
SAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSV
VEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFALEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKE
KGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTVTKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECN
EVFQDETSLATHFQQAADTSGQPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFE
MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY
FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMV
TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLL

--------------------------------------------------------------

>102301_102301_4_ZNF532-NEDD4L_ZNF532_chr18_56585954_ENST00000589288_NEDD4L_chr18_56018223_ENST00000400345_length(amino acids)=1076AA_BP=652
MNIGLKSFQKVKVHKVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKLKALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKV
RKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSKLSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRA
ADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVM
ASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIKPVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSAS
SAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSV
VEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFALEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKE
KGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTVTKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECN
EVFQDETSLATHFQQAADTSGQPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFE
MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY
FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMV
TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLL

--------------------------------------------------------------

>102301_102301_5_ZNF532-NEDD4L_ZNF532_chr18_56585954_ENST00000591083_NEDD4L_chr18_56018223_ENST00000356462_length(amino acids)=1076AA_BP=652
MNIGLKSFQKVKVHKVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKLKALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKV
RKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSKLSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRA
ADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVM
ASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIKPVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSAS
SAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSV
VEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFALEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKE
KGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTVTKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECN
EVFQDETSLATHFQQAADTSGQPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFE
MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY
FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMV
TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLL

--------------------------------------------------------------

>102301_102301_6_ZNF532-NEDD4L_ZNF532_chr18_56585954_ENST00000591083_NEDD4L_chr18_56018223_ENST00000400345_length(amino acids)=1076AA_BP=652
MNIGLKSFQKVKVHKVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKLKALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKV
RKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSKLSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRA
ADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVM
ASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIKPVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSAS
SAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSV
VEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFALEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKE
KGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTVTKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECN
EVFQDETSLATHFQQAADTSGQPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFE
MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY
FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMV
TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLL

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>102301_102301_7_ZNF532-NEDD4L_ZNF532_chr18_56585954_ENST00000591230_NEDD4L_chr18_56018223_ENST00000356462_length(amino acids)=1076AA_BP=652
MNIGLKSFQKVKVHKVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKLKALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKV
RKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSKLSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRA
ADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVM
ASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIKPVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSAS
SAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSV
VEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFALEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKE
KGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTVTKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECN
EVFQDETSLATHFQQAADTSGQPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFE
MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY
FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMV
TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLL

--------------------------------------------------------------

>102301_102301_8_ZNF532-NEDD4L_ZNF532_chr18_56585954_ENST00000591230_NEDD4L_chr18_56018223_ENST00000400345_length(amino acids)=1076AA_BP=652
MNIGLKSFQKVKVHKVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKLKALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKV
RKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSKLSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRA
ADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVM
ASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIKPVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSAS
SAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSV
VEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFALEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKE
KGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTVTKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECN
EVFQDETSLATHFQQAADTSGQPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFE
MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY
FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMV
TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLL

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>102301_102301_9_ZNF532-NEDD4L_ZNF532_chr18_56585954_ENST00000591808_NEDD4L_chr18_56018223_ENST00000356462_length(amino acids)=1076AA_BP=652
MNIGLKSFQKVKVHKVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKLKALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKV
RKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSKLSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRA
ADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVM
ASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIKPVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSAS
SAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSV
VEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFALEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKE
KGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTVTKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECN
EVFQDETSLATHFQQAADTSGQPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFE
MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY
FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMV
TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLL

--------------------------------------------------------------

>102301_102301_10_ZNF532-NEDD4L_ZNF532_chr18_56585954_ENST00000591808_NEDD4L_chr18_56018223_ENST00000400345_length(amino acids)=1076AA_BP=652
MNIGLKSFQKVKVHKVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKLKALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKV
RKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSKLSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRA
ADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVM
ASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIKPVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSAS
SAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSV
VEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFALEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKE
KGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTVTKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECN
EVFQDETSLATHFQQAADTSGQPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFE
MKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSY
FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMV
TNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLL

--------------------------------------------------------------

>102301_102301_11_ZNF532-NEDD4L_ZNF532_chr18_56587865_ENST00000336078_NEDD4L_chr18_55833020_ENST00000356462_length(amino acids)=1681AA_BP=785
MLKLMTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHMKQNAHGEDDSHAPSSSDVGVSVIVKNVRNIDSSEGGEKDGHNPTG
NGLHNGFLTASSLDSYSKDGAKSLKGDVPASEVTLKDSTFSQFSPISSAEEFDDDEKIEVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKL
KALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKVRKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSK
LSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRAADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTP
AIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVMASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIK
PVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQA
TSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFA
LEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTV
TKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECNEVFQDETSLATHFQQAADTSGQGESRILRVKVVSGIDLAKKDIFGA
SDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKD
FLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQ
WHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEE
LSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDS
PVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW
EERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVL
KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRP
FYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQM
NAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFA

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>102301_102301_12_ZNF532-NEDD4L_ZNF532_chr18_56587865_ENST00000336078_NEDD4L_chr18_55833020_ENST00000400345_length(amino acids)=1745AA_BP=785
MLKLMTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHMKQNAHGEDDSHAPSSSDVGVSVIVKNVRNIDSSEGGEKDGHNPTG
NGLHNGFLTASSLDSYSKDGAKSLKGDVPASEVTLKDSTFSQFSPISSAEEFDDDEKIEVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKL
KALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKVRKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSK
LSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRAADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTP
AIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVMASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIK
PVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQA
TSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFA
LEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTV
TKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECNEVFQDETSLATHFQQAADTSGQGESRILRVKVVSGIDLAKKDIFGA
SDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKD
FLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQ
WHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEE
LSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGR
TYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKP
QHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR
LQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFL
LSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSL
KWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELEL
LMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAH

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>102301_102301_13_ZNF532-NEDD4L_ZNF532_chr18_56587865_ENST00000589288_NEDD4L_chr18_55833020_ENST00000356462_length(amino acids)=1681AA_BP=785
MLKLMTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHMKQNAHGEDDSHAPSSSDVGVSVIVKNVRNIDSSEGGEKDGHNPTG
NGLHNGFLTASSLDSYSKDGAKSLKGDVPASEVTLKDSTFSQFSPISSAEEFDDDEKIEVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKL
KALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKVRKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSK
LSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRAADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTP
AIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVMASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIK
PVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQA
TSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFA
LEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTV
TKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECNEVFQDETSLATHFQQAADTSGQGESRILRVKVVSGIDLAKKDIFGA
SDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKD
FLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQ
WHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEE
LSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDS
PVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW
EERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVL
KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRP
FYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQM
NAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFA

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>102301_102301_14_ZNF532-NEDD4L_ZNF532_chr18_56587865_ENST00000589288_NEDD4L_chr18_55833020_ENST00000400345_length(amino acids)=1745AA_BP=785
MLKLMTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHMKQNAHGEDDSHAPSSSDVGVSVIVKNVRNIDSSEGGEKDGHNPTG
NGLHNGFLTASSLDSYSKDGAKSLKGDVPASEVTLKDSTFSQFSPISSAEEFDDDEKIEVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKL
KALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKVRKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSK
LSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRAADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTP
AIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVMASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIK
PVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQA
TSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFA
LEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTV
TKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECNEVFQDETSLATHFQQAADTSGQGESRILRVKVVSGIDLAKKDIFGA
SDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKD
FLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQ
WHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEE
LSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGR
TYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKP
QHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR
LQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFL
LSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSL
KWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELEL
LMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAH

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>102301_102301_15_ZNF532-NEDD4L_ZNF532_chr18_56587865_ENST00000591083_NEDD4L_chr18_55833020_ENST00000356462_length(amino acids)=1681AA_BP=785
MLKLMTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHMKQNAHGEDDSHAPSSSDVGVSVIVKNVRNIDSSEGGEKDGHNPTG
NGLHNGFLTASSLDSYSKDGAKSLKGDVPASEVTLKDSTFSQFSPISSAEEFDDDEKIEVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKL
KALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKVRKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSK
LSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRAADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTP
AIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVMASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIK
PVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQA
TSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFA
LEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTV
TKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECNEVFQDETSLATHFQQAADTSGQGESRILRVKVVSGIDLAKKDIFGA
SDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKD
FLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQ
WHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEE
LSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDS
PVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW
EERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVL
KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRP
FYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQM
NAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFA

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>102301_102301_16_ZNF532-NEDD4L_ZNF532_chr18_56587865_ENST00000591083_NEDD4L_chr18_55833020_ENST00000400345_length(amino acids)=1745AA_BP=785
MLKLMTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHMKQNAHGEDDSHAPSSSDVGVSVIVKNVRNIDSSEGGEKDGHNPTG
NGLHNGFLTASSLDSYSKDGAKSLKGDVPASEVTLKDSTFSQFSPISSAEEFDDDEKIEVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKL
KALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKVRKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSK
LSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRAADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTP
AIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVMASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIK
PVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQA
TSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFA
LEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTV
TKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECNEVFQDETSLATHFQQAADTSGQGESRILRVKVVSGIDLAKKDIFGA
SDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKD
FLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQ
WHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEE
LSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGR
TYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKP
QHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR
LQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFL
LSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSL
KWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELEL
LMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAH

--------------------------------------------------------------

>102301_102301_17_ZNF532-NEDD4L_ZNF532_chr18_56587865_ENST00000591230_NEDD4L_chr18_55833020_ENST00000356462_length(amino acids)=1681AA_BP=785
MLKLMTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHMKQNAHGEDDSHAPSSSDVGVSVIVKNVRNIDSSEGGEKDGHNPTG
NGLHNGFLTASSLDSYSKDGAKSLKGDVPASEVTLKDSTFSQFSPISSAEEFDDDEKIEVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKL
KALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKVRKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSK
LSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRAADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTP
AIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVMASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIK
PVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQA
TSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFA
LEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTV
TKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECNEVFQDETSLATHFQQAADTSGQGESRILRVKVVSGIDLAKKDIFGA
SDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKD
FLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQ
WHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEE
LSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDS
PVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW
EERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVL
KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRP
FYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQM
NAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFA

--------------------------------------------------------------

>102301_102301_18_ZNF532-NEDD4L_ZNF532_chr18_56587865_ENST00000591230_NEDD4L_chr18_55833020_ENST00000400345_length(amino acids)=1745AA_BP=785
MLKLMTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHMKQNAHGEDDSHAPSSSDVGVSVIVKNVRNIDSSEGGEKDGHNPTG
NGLHNGFLTASSLDSYSKDGAKSLKGDVPASEVTLKDSTFSQFSPISSAEEFDDDEKIEVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKL
KALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKVRKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSK
LSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRAADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTP
AIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVMASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIK
PVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQA
TSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFA
LEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTV
TKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECNEVFQDETSLATHFQQAADTSGQGESRILRVKVVSGIDLAKKDIFGA
SDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKD
FLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQ
WHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEE
LSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGR
TYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKP
QHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR
LQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFL
LSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSL
KWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELEL
LMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAH

--------------------------------------------------------------

>102301_102301_19_ZNF532-NEDD4L_ZNF532_chr18_56587865_ENST00000591808_NEDD4L_chr18_55833020_ENST00000356462_length(amino acids)=1681AA_BP=785
MLKLMTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHMKQNAHGEDDSHAPSSSDVGVSVIVKNVRNIDSSEGGEKDGHNPTG
NGLHNGFLTASSLDSYSKDGAKSLKGDVPASEVTLKDSTFSQFSPISSAEEFDDDEKIEVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKL
KALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKVRKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSK
LSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRAADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTP
AIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVMASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIK
PVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQA
TSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFA
LEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTV
TKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECNEVFQDETSLATHFQQAADTSGQGESRILRVKVVSGIDLAKKDIFGA
SDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKD
FLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQ
WHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEE
LSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDS
PVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW
EERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVL
KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRP
FYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQM
NAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFA

--------------------------------------------------------------

>102301_102301_20_ZNF532-NEDD4L_ZNF532_chr18_56587865_ENST00000591808_NEDD4L_chr18_55833020_ENST00000400345_length(amino acids)=1745AA_BP=785
MLKLMTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHMKQNAHGEDDSHAPSSSDVGVSVIVKNVRNIDSSEGGEKDGHNPTG
NGLHNGFLTASSLDSYSKDGAKSLKGDVPASEVTLKDSTFSQFSPISSAEEFDDDEKIEVDDPPDKEDMRSSFRSNVLTGSAPQQDYDKL
KALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPFKVRKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSK
LSSCIAAIAALSAKKAASDSCKEPVANSRESSPLPKEVNDSPRAADKSPESQNLIDGTKKPSLKQPDSPRSISSENSSKGSPSSPAGSTP
AIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKPSEQTASVMASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIK
PVATAFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVPASSLANAKLVPKTVHLANLNLLPQGAQA
TSELRQVLTKPQQQIKQAIINAAASQPPKKVSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDSFA
LEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLILKPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTV
TKIQSGITGTVISAPSSTPITPAMPLDEDPSKLCRHSLKCLECNEVFQDETSLATHFQQAADTSGQGESRILRVKVVSGIDLAKKDIFGA
SDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKD
FLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQ
WHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEE
LSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGR
TYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKP
QHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPR
LQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFL
LSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSL
KWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELEL
LMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAH

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:56585954/chr18:56018223)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NEDD4L Q96PU5
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). {ECO:0000250\|UniProtKB:Q8CFI0, ECO:0000269\|PubMed:12911626, ECO:0000269\|PubMed:15040001, ECO:0000269\|PubMed:15217910, ECO:0000269\|PubMed:15489223, ECO:0000269\|PubMed:15496141, ECO:0000269\|PubMed:15576372, ECO:0000269\|PubMed:19144635, ECO:0000269\|PubMed:23999003, ECO:0000269\|PubMed:25631046, ECO:0000269\|PubMed:26363003, ECO:0000269\|PubMed:27445338, ECO:0000269\|PubMed:27694961}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000336078

616_635

782.0

1302.0

Zinc finger

C2H2-type 1%3B degenerate

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000336078

754_779

782.0

1302.0

Zinc finger

C2H2-type 2%3B degenerate

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000589288

616_635

782.0

1302.0

Zinc finger

C2H2-type 1%3B degenerate

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000589288

754_779

782.0

1302.0

Zinc finger

C2H2-type 2%3B degenerate

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591083

616_635

782.0

1302.0

Zinc finger

C2H2-type 1%3B degenerate

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591083

754_779

782.0

1302.0

Zinc finger

C2H2-type 2%3B degenerate

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591230

616_635

782.0

1302.0

Zinc finger

C2H2-type 1%3B degenerate

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591230

754_779

782.0

1302.0

Zinc finger

C2H2-type 2%3B degenerate

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591808

616_635

782.0

1302.0

Zinc finger

C2H2-type 1%3B degenerate

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591808

754_779

782.0

1302.0

Zinc finger

C2H2-type 2%3B degenerate

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000256830

497_530

447.0

872.0

Domain

WW 3

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000256830

548_581

447.0

872.0

Domain

WW 4

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000256830

640_974

447.0

872.0

Domain

HECT

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000356462

497_530

487.0

912.0

Domain

WW 3

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000356462

548_581

487.0

912.0

Domain

WW 4

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000356462

640_974

487.0

912.0

Domain

HECT

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000357895

548_581

543.0

968.0

Domain

WW 4

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000357895

640_974

543.0

968.0

Domain

HECT

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000382850

548_581

531.0

956.0

Domain

WW 4

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000382850

640_974

531.0

956.0

Domain

HECT

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000400345

548_581

551.0

976.0

Domain

WW 4

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000400345

640_974

551.0

976.0

Domain

HECT

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000431212

497_530

430.0

855.0

Domain

WW 3

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000431212

548_581

430.0

855.0

Domain

WW 4

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000431212

640_974

430.0

855.0

Domain

HECT

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000435432

497_530

410.0

835.0

Domain

WW 3

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000435432

548_581

410.0

835.0

Domain

WW 4

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000435432

640_974

410.0

835.0

Domain

HECT

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000456173

497_530

410.0

835.0

Domain

WW 3

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000456173

548_581

410.0

835.0

Domain

WW 4

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000456173

640_974

410.0

835.0

Domain

HECT

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000456986

497_530

430.0

855.0

Domain

WW 3

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000456986

548_581

430.0

855.0

Domain

WW 4

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000456986

640_974

430.0

855.0

Domain

HECT

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000586263

548_581

523.0

948.0

Domain

WW 4

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000586263

640_974

523.0

948.0

Domain

HECT

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000256830

193_226

16.0

872.0

Domain

WW 1

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000256830

385_418

16.0

872.0

Domain

WW 2

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000256830

497_530

16.0

872.0

Domain

WW 3

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000256830

548_581

16.0

872.0

Domain

WW 4

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000256830

640_974

16.0

872.0

Domain

HECT

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000356462

193_226

16.0

912.0

Domain

WW 1

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000356462

385_418

16.0

912.0

Domain

WW 2

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000356462

497_530

16.0

912.0

Domain

WW 3

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000356462

548_581

16.0

912.0

Domain

WW 4

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000356462

640_974

16.0

912.0

Domain

HECT

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000357895

193_226

8.0

968.0

Domain

WW 1

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000357895

385_418

8.0

968.0

Domain

WW 2

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000357895

497_530

8.0

968.0

Domain

WW 3

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000357895

548_581

8.0

968.0

Domain

WW 4

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000357895

640_974

8.0

968.0

Domain

HECT

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000382850

193_226

16.0

956.0

Domain

WW 1

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000382850

385_418

16.0

956.0

Domain

WW 2

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000382850

497_530

16.0

956.0

Domain

WW 3

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000382850

548_581

16.0

956.0

Domain

WW 4

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000382850

640_974

16.0

956.0

Domain

HECT

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000400345

193_226

16.0

976.0

Domain

WW 1

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000400345

385_418

16.0

976.0

Domain

WW 2

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000400345

497_530

16.0

976.0

Domain

WW 3

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000400345

548_581

16.0

976.0

Domain

WW 4

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000400345

640_974

16.0

976.0

Domain

HECT

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000431212

193_226

855.0

Domain

WW 1

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000431212

385_418

855.0

Domain

WW 2

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000431212

497_530

855.0

Domain

WW 3

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000431212

4_126

855.0

Domain

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000431212

548_581

855.0

Domain

WW 4

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000431212

640_974

855.0

Domain

HECT

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000435432

193_226

835.0

Domain

WW 1

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000435432

385_418

835.0

Domain

WW 2

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000435432

497_530

835.0

Domain

WW 3

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000435432

4_126

835.0

Domain

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000435432

548_581

835.0

Domain

WW 4

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000435432

640_974

835.0

Domain

HECT

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000456173

193_226

835.0

Domain

WW 1

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000456173

385_418

835.0

Domain

WW 2

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000456173

497_530

835.0

Domain

WW 3

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000456173

4_126

835.0

Domain

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000456173

548_581

835.0

Domain

WW 4

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000456173

640_974

835.0

Domain

HECT

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000456986

193_226

855.0

Domain

WW 1

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000456986

385_418

855.0

Domain

WW 2

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000456986

497_530

855.0

Domain

WW 3

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000456986

4_126

855.0

Domain

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000456986

548_581

855.0

Domain

WW 4

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000456986

640_974

855.0

Domain

HECT

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000586263

193_226

8.0

948.0

Domain

WW 1

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000586263

385_418

8.0

948.0

Domain

WW 2

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000586263

497_530

8.0

948.0

Domain

WW 3

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000586263

548_581

8.0

948.0

Domain

WW 4

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000586263

640_974

8.0

948.0

Domain

HECT

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000336078

1025_1048

1302.0

Zinc finger

C2H2-type 8

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000336078

1055_1078

1302.0

Zinc finger

C2H2-type 9

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000336078

1085_1111

1302.0

Zinc finger

C2H2-type 10%3B degenerate

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000336078

1203_1226

1302.0

Zinc finger

C2H2-type 11

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000336078

1264_1286

1302.0

Zinc finger

C2H2-type 12

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000336078

616_635

1302.0

Zinc finger

C2H2-type 1%3B degenerate

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000336078

754_779

1302.0

Zinc finger

C2H2-type 2%3B degenerate

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000336078

783_805

1302.0

Zinc finger

C2H2-type 3

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000336078

842_865

1302.0

Zinc finger

C2H2-type 4

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000336078

870_893

1302.0

Zinc finger

C2H2-type 5

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000336078

905_927

1302.0

Zinc finger

C2H2-type 6

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000336078

936_959

1302.0

Zinc finger

C2H2-type 7

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000589288

1025_1048

1302.0

Zinc finger

C2H2-type 8

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000589288

1055_1078

1302.0

Zinc finger

C2H2-type 9

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000589288

1085_1111

1302.0

Zinc finger

C2H2-type 10%3B degenerate

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000589288

1203_1226

1302.0

Zinc finger

C2H2-type 11

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000589288

1264_1286

1302.0

Zinc finger

C2H2-type 12

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000589288

616_635

1302.0

Zinc finger

C2H2-type 1%3B degenerate

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000589288

754_779

1302.0

Zinc finger

C2H2-type 2%3B degenerate

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000589288

783_805

1302.0

Zinc finger

C2H2-type 3

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000589288

842_865

1302.0

Zinc finger

C2H2-type 4

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000589288

870_893

1302.0

Zinc finger

C2H2-type 5

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000589288

905_927

1302.0

Zinc finger

C2H2-type 6

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000589288

936_959

1302.0

Zinc finger

C2H2-type 7

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591083

1025_1048

1302.0

Zinc finger

C2H2-type 8

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591083

1055_1078

1302.0

Zinc finger

C2H2-type 9

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591083

1085_1111

1302.0

Zinc finger

C2H2-type 10%3B degenerate

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591083

1203_1226

1302.0

Zinc finger

C2H2-type 11

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591083

1264_1286

1302.0

Zinc finger

C2H2-type 12

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591083

616_635

1302.0

Zinc finger

C2H2-type 1%3B degenerate

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591083

754_779

1302.0

Zinc finger

C2H2-type 2%3B degenerate

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591083

783_805

1302.0

Zinc finger

C2H2-type 3

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591083

842_865

1302.0

Zinc finger

C2H2-type 4

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591083

870_893

1302.0

Zinc finger

C2H2-type 5

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591083

905_927

1302.0

Zinc finger

C2H2-type 6

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591083

936_959

1302.0

Zinc finger

C2H2-type 7

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591230

1025_1048

1302.0

Zinc finger

C2H2-type 8

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591230

1055_1078

1302.0

Zinc finger

C2H2-type 9

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591230

1085_1111

1302.0

Zinc finger

C2H2-type 10%3B degenerate

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591230

1203_1226

1302.0

Zinc finger

C2H2-type 11

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591230

1264_1286

1302.0

Zinc finger

C2H2-type 12

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591230

616_635

1302.0

Zinc finger

C2H2-type 1%3B degenerate

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591230

754_779

1302.0

Zinc finger

C2H2-type 2%3B degenerate

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591230

783_805

1302.0

Zinc finger

C2H2-type 3

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591230

842_865

1302.0

Zinc finger

C2H2-type 4

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591230

870_893

1302.0

Zinc finger

C2H2-type 5

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591230

905_927

1302.0

Zinc finger

C2H2-type 6

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591230

936_959

1302.0

Zinc finger

C2H2-type 7

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591808

1025_1048

1302.0

Zinc finger

C2H2-type 8

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591808

1055_1078

1302.0

Zinc finger

C2H2-type 9

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591808

1085_1111

1302.0

Zinc finger

C2H2-type 10%3B degenerate

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591808

1203_1226

1302.0

Zinc finger

C2H2-type 11

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591808

1264_1286

1302.0

Zinc finger

C2H2-type 12

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591808

616_635

1302.0

Zinc finger

C2H2-type 1%3B degenerate

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591808

754_779

1302.0

Zinc finger

C2H2-type 2%3B degenerate

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591808

783_805

1302.0

Zinc finger

C2H2-type 3

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591808

842_865

1302.0

Zinc finger

C2H2-type 4

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591808

870_893

1302.0

Zinc finger

C2H2-type 5

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591808

905_927

1302.0

Zinc finger

C2H2-type 6

Hgene

ZNF532

chr18:56585954

chr18:56018223

ENST00000591808

936_959

1302.0

Zinc finger

C2H2-type 7

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000336078

1025_1048

782.0

1302.0

Zinc finger

C2H2-type 8

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000336078

1055_1078

782.0

1302.0

Zinc finger

C2H2-type 9

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000336078

1085_1111

782.0

1302.0

Zinc finger

C2H2-type 10%3B degenerate

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000336078

1203_1226

782.0

1302.0

Zinc finger

C2H2-type 11

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000336078

1264_1286

782.0

1302.0

Zinc finger

C2H2-type 12

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000336078

783_805

782.0

1302.0

Zinc finger

C2H2-type 3

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000336078

842_865

782.0

1302.0

Zinc finger

C2H2-type 4

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000336078

870_893

782.0

1302.0

Zinc finger

C2H2-type 5

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000336078

905_927

782.0

1302.0

Zinc finger

C2H2-type 6

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000336078

936_959

782.0

1302.0

Zinc finger

C2H2-type 7

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000589288

1025_1048

782.0

1302.0

Zinc finger

C2H2-type 8

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000589288

1055_1078

782.0

1302.0

Zinc finger

C2H2-type 9

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000589288

1085_1111

782.0

1302.0

Zinc finger

C2H2-type 10%3B degenerate

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000589288

1203_1226

782.0

1302.0

Zinc finger

C2H2-type 11

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000589288

1264_1286

782.0

1302.0

Zinc finger

C2H2-type 12

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000589288

783_805

782.0

1302.0

Zinc finger

C2H2-type 3

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000589288

842_865

782.0

1302.0

Zinc finger

C2H2-type 4

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000589288

870_893

782.0

1302.0

Zinc finger

C2H2-type 5

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000589288

905_927

782.0

1302.0

Zinc finger

C2H2-type 6

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000589288

936_959

782.0

1302.0

Zinc finger

C2H2-type 7

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591083

1025_1048

782.0

1302.0

Zinc finger

C2H2-type 8

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591083

1055_1078

782.0

1302.0

Zinc finger

C2H2-type 9

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591083

1085_1111

782.0

1302.0

Zinc finger

C2H2-type 10%3B degenerate

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591083

1203_1226

782.0

1302.0

Zinc finger

C2H2-type 11

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591083

1264_1286

782.0

1302.0

Zinc finger

C2H2-type 12

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591083

783_805

782.0

1302.0

Zinc finger

C2H2-type 3

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591083

842_865

782.0

1302.0

Zinc finger

C2H2-type 4

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591083

870_893

782.0

1302.0

Zinc finger

C2H2-type 5

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591083

905_927

782.0

1302.0

Zinc finger

C2H2-type 6

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591083

936_959

782.0

1302.0

Zinc finger

C2H2-type 7

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591230

1025_1048

782.0

1302.0

Zinc finger

C2H2-type 8

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591230

1055_1078

782.0

1302.0

Zinc finger

C2H2-type 9

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591230

1085_1111

782.0

1302.0

Zinc finger

C2H2-type 10%3B degenerate

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591230

1203_1226

782.0

1302.0

Zinc finger

C2H2-type 11

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591230

1264_1286

782.0

1302.0

Zinc finger

C2H2-type 12

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591230

783_805

782.0

1302.0

Zinc finger

C2H2-type 3

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591230

842_865

782.0

1302.0

Zinc finger

C2H2-type 4

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591230

870_893

782.0

1302.0

Zinc finger

C2H2-type 5

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591230

905_927

782.0

1302.0

Zinc finger

C2H2-type 6

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591230

936_959

782.0

1302.0

Zinc finger

C2H2-type 7

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591808

1025_1048

782.0

1302.0

Zinc finger

C2H2-type 8

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591808

1055_1078

782.0

1302.0

Zinc finger

C2H2-type 9

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591808

1085_1111

782.0

1302.0

Zinc finger

C2H2-type 10%3B degenerate

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591808

1203_1226

782.0

1302.0

Zinc finger

C2H2-type 11

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591808

1264_1286

782.0

1302.0

Zinc finger

C2H2-type 12

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591808

783_805

782.0

1302.0

Zinc finger

C2H2-type 3

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591808

842_865

782.0

1302.0

Zinc finger

C2H2-type 4

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591808

870_893

782.0

1302.0

Zinc finger

C2H2-type 5

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591808

905_927

782.0

1302.0

Zinc finger

C2H2-type 6

Hgene

ZNF532

chr18:56587865

chr18:55833020

ENST00000591808

936_959

782.0

1302.0

Zinc finger

C2H2-type 7

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000256830

193_226

447.0

872.0

Domain

WW 1

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000256830

385_418

447.0

872.0

Domain

WW 2

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000256830

4_126

447.0

872.0

Domain

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000356462

193_226

487.0

912.0

Domain

WW 1

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000356462

385_418

487.0

912.0

Domain

WW 2

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000356462

4_126

487.0

912.0

Domain

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000357895

193_226

543.0

968.0

Domain

WW 1

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000357895

385_418

543.0

968.0

Domain

WW 2

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000357895

497_530

543.0

968.0

Domain

WW 3

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000357895

4_126

543.0

968.0

Domain

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000382850

193_226

531.0

956.0

Domain

WW 1

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000382850

385_418

531.0

956.0

Domain

WW 2

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000382850

497_530

531.0

956.0

Domain

WW 3

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000382850

4_126

531.0

956.0

Domain

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000400345

193_226

551.0

976.0

Domain

WW 1

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000400345

385_418

551.0

976.0

Domain

WW 2

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000400345

497_530

551.0

976.0

Domain

WW 3

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000400345

4_126

551.0

976.0

Domain

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000431212

193_226

430.0

855.0

Domain

WW 1

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000431212

385_418

430.0

855.0

Domain

WW 2

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000431212

4_126

430.0

855.0

Domain

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000435432

193_226

410.0

835.0

Domain

WW 1

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000435432

385_418

410.0

835.0

Domain

WW 2

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000435432

4_126

410.0

835.0

Domain

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000456173

193_226

410.0

835.0

Domain

WW 1

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000456173

385_418

410.0

835.0

Domain

WW 2

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000456173

4_126

410.0

835.0

Domain

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000456986

193_226

430.0

855.0

Domain

WW 1

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000456986

385_418

430.0

855.0

Domain

WW 2

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000456986

4_126

430.0

855.0

Domain

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000586263

193_226

523.0

948.0

Domain

WW 1

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000586263

385_418

523.0

948.0

Domain

WW 2

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000586263

497_530

523.0

948.0

Domain

WW 3

Tgene

NEDD4L

chr18:56585954

chr18:56018223

ENST00000586263

4_126

523.0

948.0

Domain

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000256830

4_126

16.0

872.0

Domain

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000356462

4_126

16.0

912.0

Domain

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000357895

4_126

8.0

968.0

Domain

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000382850

4_126

16.0

956.0

Domain

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000400345

4_126

16.0

976.0

Domain

Tgene

NEDD4L

chr18:56587865

chr18:55833020

ENST00000586263

4_126

8.0

948.0

Domain

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ZNF532
NEDD4L

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ZNF532-NEDD4L

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ZNF532-NEDD4L

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source