UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ZNF577-GRIK5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZNF577-GRIK5
FusionPDB ID: 102429
FusionGDB2.0 ID: 102429
HgeneTgene
Gene symbol

ZNF577

GRIK5

Gene ID

84765

2901

Gene namezinc finger protein 577glutamate ionotropic receptor kainate type subunit 5
Synonyms-EAA2|GRIK2|GluK5|KA2
Cytomap

19q13.41

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 577glutamate receptor ionotropic, kainate 5excitatory amino acid receptor 2glutamate receptor KA2
Modification date2020031320200313
UniProtAcc.

Q16478

Ensembl transtripts involved in fusion geneENST idsENST00000485702, ENST00000301399, 
ENST00000412216, ENST00000420592, 
ENST00000451628, 		ENST00000262895, 
ENST00000301218, ENST00000593562, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 2 X 2=86 X 6 X 5=180
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZNF577 [Title/Abstract] AND GRIK5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZNF577(52380535)-GRIK5(42510962), # samples:1
ZNF577(52380535)-GRIK5(42526506), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF577-GRIK5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF577-GRIK5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF577-GRIK5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF577-GRIK5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF577-GRIK5 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF577-GRIK5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ZNF577-GRIK5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZNF577 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRIK5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-CS-4943-01AZNF577chr19

52380535

-GRIK5chr19

42510962

-
ChimerDB4LGGTCGA-CS-4943-01AZNF577chr19

52380535

-GRIK5chr19

42526506

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000451628ZNF577chr1952380535-ENST00000262895GRIK5chr1942510962-232069812372319361
ENST00000451628ZNF577chr1952380535-ENST00000593562GRIK5chr1942510962-18276986901769359
ENST00000451628ZNF577chr1952380535-ENST00000301218GRIK5chr1942510962-21026986901772360
ENST00000412216ZNF577chr1952380535-ENST00000262895GRIK5chr1942526506-3652163216413101486
ENST00000412216ZNF577chr1952380535-ENST00000593562GRIK5chr1942526506-3159163216413101486
ENST00000412216ZNF577chr1952380535-ENST00000301218GRIK5chr1942526506-3434163216413104487
ENST00000420592ZNF577chr1952380535-ENST00000262895GRIK5chr1942526506-3637161716263086486
ENST00000420592ZNF577chr1952380535-ENST00000593562GRIK5chr1942526506-3144161716263086486
ENST00000420592ZNF577chr1952380535-ENST00000301218GRIK5chr1942526506-3419161716263089487

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000451628ENST00000262895ZNF577chr1952380535-GRIK5chr1942510962-0.121643310.87835675
ENST00000451628ENST00000593562ZNF577chr1952380535-GRIK5chr1942510962-0.097637070.90236294
ENST00000451628ENST00000301218ZNF577chr1952380535-GRIK5chr1942510962-0.069644390.9303556
ENST00000412216ENST00000262895ZNF577chr1952380535-GRIK5chr1942526506-0.026382580.97361743
ENST00000412216ENST00000593562ZNF577chr1952380535-GRIK5chr1942526506-0.0261449680.973855
ENST00000412216ENST00000301218ZNF577chr1952380535-GRIK5chr1942526506-0.029763080.9702369
ENST00000420592ENST00000262895ZNF577chr1952380535-GRIK5chr1942526506-0.0265280380.97347194
ENST00000420592ENST00000593562ZNF577chr1952380535-GRIK5chr1942526506-0.0262178890.9737821
ENST00000420592ENST00000301218ZNF577chr1952380535-GRIK5chr1942526506-0.029612920.97038704

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>102429_102429_1_ZNF577-GRIK5_ZNF577_chr19_52380535_ENST00000412216_GRIK5_chr19_42526506_ENST00000262895_length(amino acids)=486AA_BP=
MAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPH
ILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGST
MTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITL
AILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVS
CRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGSAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRA

--------------------------------------------------------------

>102429_102429_2_ZNF577-GRIK5_ZNF577_chr19_52380535_ENST00000412216_GRIK5_chr19_42526506_ENST00000301218_length(amino acids)=487AA_BP=
MAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPH
ILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGST
MTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITL
AILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEETPALHPAACQCSALGP
RTPLKEPSMLLVKVPSTRVQVAFSRTSLRQVCPFLLQHQLSSLYWIQATNVQICCHFSSLKPSPDLTFPPSHRPLSSLLFTALAAVGGLP

--------------------------------------------------------------

>102429_102429_3_ZNF577-GRIK5_ZNF577_chr19_52380535_ENST00000412216_GRIK5_chr19_42526506_ENST00000593562_length(amino acids)=486AA_BP=
MAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPH
ILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGST
MTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITL
AILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVS
CRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGSAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRA

--------------------------------------------------------------

>102429_102429_4_ZNF577-GRIK5_ZNF577_chr19_52380535_ENST00000420592_GRIK5_chr19_42526506_ENST00000262895_length(amino acids)=486AA_BP=
MAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPH
ILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGST
MTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITL
AILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVS
CRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGSAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRA

--------------------------------------------------------------

>102429_102429_5_ZNF577-GRIK5_ZNF577_chr19_52380535_ENST00000420592_GRIK5_chr19_42526506_ENST00000301218_length(amino acids)=487AA_BP=
MAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPH
ILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGST
MTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITL
AILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEETPALHPAACQCSALGP
RTPLKEPSMLLVKVPSTRVQVAFSRTSLRQVCPFLLQHQLSSLYWIQATNVQICCHFSSLKPSPDLTFPPSHRPLSSLLFTALAAVGGLP

--------------------------------------------------------------

>102429_102429_6_ZNF577-GRIK5_ZNF577_chr19_52380535_ENST00000420592_GRIK5_chr19_42526506_ENST00000593562_length(amino acids)=486AA_BP=
MAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPH
ILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGST
MTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITL
AILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVS
CRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGSAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRA

--------------------------------------------------------------

>102429_102429_7_ZNF577-GRIK5_ZNF577_chr19_52380535_ENST00000451628_GRIK5_chr19_42510962_ENST00000262895_length(amino acids)=361AA_BP=
MVAFLSCSSVASSLLSSWRSWNSYGPHGGQLSPRRCRCARRCCRSCATPFLAARRRVPAGADARAARAGPCCHCARSARCASATASSTRP
ARAGMRAARTGARSASWTTRGPPAEPDPPPPPPAPTCASARSAGASRRCGPRGPARLRVAWASPPKPPARPGRGLAPPAPGSWRSTSDHG
RGCAGARTDRRDGARPRPQQSPLPQRARDRTCAPAPRTPRFCLWFPAKSEAWLWSPPAPPSGLARGCRGREGRRNRGLQGLGTSGAALGS
GKQSAERTPFWDCSGSPRLDAAPHASGGGEGLWTDGCPLVPLHSSLPLFFGGRNLGISMRPPPGRGSVGPPSLPLPHRSPCWNKKKNKTP

--------------------------------------------------------------

>102429_102429_8_ZNF577-GRIK5_ZNF577_chr19_52380535_ENST00000451628_GRIK5_chr19_42510962_ENST00000301218_length(amino acids)=360AA_BP=2
MSRWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIAR
VLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGM
ENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEETPALHPAACQCSALGPRTPLKEPSMLLVKVPSTRVQVAFSRTSLRQVCPFLLQ
HQLSSLYWIQATNVQICCHFSSLKPSPDLTFPPSHRPLSSLLFTALAAVGGLPDASSFFFPPISSCPPLQSGIGPCHSTEATLVTSNFHV

--------------------------------------------------------------

>102429_102429_9_ZNF577-GRIK5_ZNF577_chr19_52380535_ENST00000451628_GRIK5_chr19_42510962_ENST00000593562_length(amino acids)=359AA_BP=2
MSRWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIAR
VLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGM
ENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLY

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:52380535/chr19:42510962)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GRIK5

Q16478

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF577chr19:52380535chr19:42510962ENST00000301399-6723_9494.33333333333333486.0DomainKRAB
HgeneZNF577chr19:52380535chr19:42510962ENST00000420592-5623_9494.33333333333333427.0DomainKRAB
HgeneZNF577chr19:52380535chr19:42510962ENST00000451628-6723_9494.33333333333333427.0DomainKRAB
HgeneZNF577chr19:52380535chr19:42526506ENST00000301399-6723_9494.33333333333333486.0DomainKRAB
HgeneZNF577chr19:52380535chr19:42526506ENST00000420592-5623_9494.33333333333333427.0DomainKRAB
HgeneZNF577chr19:52380535chr19:42526506ENST00000451628-6723_9494.33333333333333427.0DomainKRAB
TgeneGRIK5chr19:52380535chr19:42510962ENST000002628951319860_866623.6666666666666981.0Compositional biasNote=Poly-Arg
TgeneGRIK5chr19:52380535chr19:42510962ENST000003012181319860_866623.6666666666666982.0Compositional biasNote=Poly-Arg
TgeneGRIK5chr19:52380535chr19:42510962ENST000005935621420860_866623.6666666666666981.0Compositional biasNote=Poly-Arg
TgeneGRIK5chr19:52380535chr19:42526506ENST000002628951019860_866491.0981.0Compositional biasNote=Poly-Arg
TgeneGRIK5chr19:52380535chr19:42526506ENST000003012181019860_866491.0982.0Compositional biasNote=Poly-Arg
TgeneGRIK5chr19:52380535chr19:42526506ENST000005935621120860_866491.0981.0Compositional biasNote=Poly-Arg
TgeneGRIK5chr19:52380535chr19:42510962ENST000002628951319644_803623.6666666666666981.0Topological domainExtracellular
TgeneGRIK5chr19:52380535chr19:42510962ENST000002628951319825_980623.6666666666666981.0Topological domainCytoplasmic
TgeneGRIK5chr19:52380535chr19:42510962ENST000003012181319644_803623.6666666666666982.0Topological domainExtracellular
TgeneGRIK5chr19:52380535chr19:42510962ENST000003012181319825_980623.6666666666666982.0Topological domainCytoplasmic
TgeneGRIK5chr19:52380535chr19:42510962ENST000005935621420644_803623.6666666666666981.0Topological domainExtracellular
TgeneGRIK5chr19:52380535chr19:42510962ENST000005935621420825_980623.6666666666666981.0Topological domainCytoplasmic
TgeneGRIK5chr19:52380535chr19:42526506ENST000002628951019566_622491.0981.0Topological domainCytoplasmic
TgeneGRIK5chr19:52380535chr19:42526506ENST000002628951019644_803491.0981.0Topological domainExtracellular
TgeneGRIK5chr19:52380535chr19:42526506ENST000002628951019825_980491.0981.0Topological domainCytoplasmic
TgeneGRIK5chr19:52380535chr19:42526506ENST000003012181019566_622491.0982.0Topological domainCytoplasmic
TgeneGRIK5chr19:52380535chr19:42526506ENST000003012181019644_803491.0982.0Topological domainExtracellular
TgeneGRIK5chr19:52380535chr19:42526506ENST000003012181019825_980491.0982.0Topological domainCytoplasmic
TgeneGRIK5chr19:52380535chr19:42526506ENST000005935621120566_622491.0981.0Topological domainCytoplasmic
TgeneGRIK5chr19:52380535chr19:42526506ENST000005935621120644_803491.0981.0Topological domainExtracellular
TgeneGRIK5chr19:52380535chr19:42526506ENST000005935621120825_980491.0981.0Topological domainCytoplasmic
TgeneGRIK5chr19:52380535chr19:42510962ENST000002628951319623_643623.6666666666666981.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42510962ENST000002628951319804_824623.6666666666666981.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42510962ENST000003012181319623_643623.6666666666666982.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42510962ENST000003012181319804_824623.6666666666666982.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42510962ENST000005935621420623_643623.6666666666666981.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42510962ENST000005935621420804_824623.6666666666666981.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42526506ENST000002628951019545_565491.0981.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42526506ENST000002628951019623_643491.0981.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42526506ENST000002628951019804_824491.0981.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42526506ENST000003012181019545_565491.0982.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42526506ENST000003012181019623_643491.0982.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42526506ENST000003012181019804_824491.0982.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42526506ENST000005935621120545_565491.0981.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42526506ENST000005935621120623_643491.0981.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42526506ENST000005935621120804_824491.0981.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF577chr19:52380535chr19:42510962ENST00000301399-67158_18094.33333333333333486.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF577chr19:52380535chr19:42510962ENST00000301399-67186_20894.33333333333333486.0Zinc fingerC2H2-type 2
HgeneZNF577chr19:52380535chr19:42510962ENST00000301399-67214_23694.33333333333333486.0Zinc fingerC2H2-type 3
HgeneZNF577chr19:52380535chr19:42510962ENST00000301399-67242_26494.33333333333333486.0Zinc fingerC2H2-type 4
HgeneZNF577chr19:52380535chr19:42510962ENST00000301399-67270_29294.33333333333333486.0Zinc fingerC2H2-type 5
HgeneZNF577chr19:52380535chr19:42510962ENST00000301399-67298_32094.33333333333333486.0Zinc fingerC2H2-type 6
HgeneZNF577chr19:52380535chr19:42510962ENST00000301399-67326_34894.33333333333333486.0Zinc fingerC2H2-type 7
HgeneZNF577chr19:52380535chr19:42510962ENST00000301399-67354_37694.33333333333333486.0Zinc fingerC2H2-type 8
HgeneZNF577chr19:52380535chr19:42510962ENST00000420592-56158_18094.33333333333333427.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF577chr19:52380535chr19:42510962ENST00000420592-56186_20894.33333333333333427.0Zinc fingerC2H2-type 2
HgeneZNF577chr19:52380535chr19:42510962ENST00000420592-56214_23694.33333333333333427.0Zinc fingerC2H2-type 3
HgeneZNF577chr19:52380535chr19:42510962ENST00000420592-56242_26494.33333333333333427.0Zinc fingerC2H2-type 4
HgeneZNF577chr19:52380535chr19:42510962ENST00000420592-56270_29294.33333333333333427.0Zinc fingerC2H2-type 5
HgeneZNF577chr19:52380535chr19:42510962ENST00000420592-56298_32094.33333333333333427.0Zinc fingerC2H2-type 6
HgeneZNF577chr19:52380535chr19:42510962ENST00000420592-56326_34894.33333333333333427.0Zinc fingerC2H2-type 7
HgeneZNF577chr19:52380535chr19:42510962ENST00000420592-56354_37694.33333333333333427.0Zinc fingerC2H2-type 8
HgeneZNF577chr19:52380535chr19:42510962ENST00000451628-67158_18094.33333333333333427.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF577chr19:52380535chr19:42510962ENST00000451628-67186_20894.33333333333333427.0Zinc fingerC2H2-type 2
HgeneZNF577chr19:52380535chr19:42510962ENST00000451628-67214_23694.33333333333333427.0Zinc fingerC2H2-type 3
HgeneZNF577chr19:52380535chr19:42510962ENST00000451628-67242_26494.33333333333333427.0Zinc fingerC2H2-type 4
HgeneZNF577chr19:52380535chr19:42510962ENST00000451628-67270_29294.33333333333333427.0Zinc fingerC2H2-type 5
HgeneZNF577chr19:52380535chr19:42510962ENST00000451628-67298_32094.33333333333333427.0Zinc fingerC2H2-type 6
HgeneZNF577chr19:52380535chr19:42510962ENST00000451628-67326_34894.33333333333333427.0Zinc fingerC2H2-type 7
HgeneZNF577chr19:52380535chr19:42510962ENST00000451628-67354_37694.33333333333333427.0Zinc fingerC2H2-type 8
HgeneZNF577chr19:52380535chr19:42526506ENST00000301399-67158_18094.33333333333333486.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF577chr19:52380535chr19:42526506ENST00000301399-67186_20894.33333333333333486.0Zinc fingerC2H2-type 2
HgeneZNF577chr19:52380535chr19:42526506ENST00000301399-67214_23694.33333333333333486.0Zinc fingerC2H2-type 3
HgeneZNF577chr19:52380535chr19:42526506ENST00000301399-67242_26494.33333333333333486.0Zinc fingerC2H2-type 4
HgeneZNF577chr19:52380535chr19:42526506ENST00000301399-67270_29294.33333333333333486.0Zinc fingerC2H2-type 5
HgeneZNF577chr19:52380535chr19:42526506ENST00000301399-67298_32094.33333333333333486.0Zinc fingerC2H2-type 6
HgeneZNF577chr19:52380535chr19:42526506ENST00000301399-67326_34894.33333333333333486.0Zinc fingerC2H2-type 7
HgeneZNF577chr19:52380535chr19:42526506ENST00000301399-67354_37694.33333333333333486.0Zinc fingerC2H2-type 8
HgeneZNF577chr19:52380535chr19:42526506ENST00000420592-56158_18094.33333333333333427.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF577chr19:52380535chr19:42526506ENST00000420592-56186_20894.33333333333333427.0Zinc fingerC2H2-type 2
HgeneZNF577chr19:52380535chr19:42526506ENST00000420592-56214_23694.33333333333333427.0Zinc fingerC2H2-type 3
HgeneZNF577chr19:52380535chr19:42526506ENST00000420592-56242_26494.33333333333333427.0Zinc fingerC2H2-type 4
HgeneZNF577chr19:52380535chr19:42526506ENST00000420592-56270_29294.33333333333333427.0Zinc fingerC2H2-type 5
HgeneZNF577chr19:52380535chr19:42526506ENST00000420592-56298_32094.33333333333333427.0Zinc fingerC2H2-type 6
HgeneZNF577chr19:52380535chr19:42526506ENST00000420592-56326_34894.33333333333333427.0Zinc fingerC2H2-type 7
HgeneZNF577chr19:52380535chr19:42526506ENST00000420592-56354_37694.33333333333333427.0Zinc fingerC2H2-type 8
HgeneZNF577chr19:52380535chr19:42526506ENST00000451628-67158_18094.33333333333333427.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF577chr19:52380535chr19:42526506ENST00000451628-67186_20894.33333333333333427.0Zinc fingerC2H2-type 2
HgeneZNF577chr19:52380535chr19:42526506ENST00000451628-67214_23694.33333333333333427.0Zinc fingerC2H2-type 3
HgeneZNF577chr19:52380535chr19:42526506ENST00000451628-67242_26494.33333333333333427.0Zinc fingerC2H2-type 4
HgeneZNF577chr19:52380535chr19:42526506ENST00000451628-67270_29294.33333333333333427.0Zinc fingerC2H2-type 5
HgeneZNF577chr19:52380535chr19:42526506ENST00000451628-67298_32094.33333333333333427.0Zinc fingerC2H2-type 6
HgeneZNF577chr19:52380535chr19:42526506ENST00000451628-67326_34894.33333333333333427.0Zinc fingerC2H2-type 7
HgeneZNF577chr19:52380535chr19:42526506ENST00000451628-67354_37694.33333333333333427.0Zinc fingerC2H2-type 8
TgeneGRIK5chr19:52380535chr19:42510962ENST00000262895131915_544623.6666666666666981.0Topological domainExtracellular
TgeneGRIK5chr19:52380535chr19:42510962ENST000002628951319566_622623.6666666666666981.0Topological domainCytoplasmic
TgeneGRIK5chr19:52380535chr19:42510962ENST00000301218131915_544623.6666666666666982.0Topological domainExtracellular
TgeneGRIK5chr19:52380535chr19:42510962ENST000003012181319566_622623.6666666666666982.0Topological domainCytoplasmic
TgeneGRIK5chr19:52380535chr19:42510962ENST00000593562142015_544623.6666666666666981.0Topological domainExtracellular
TgeneGRIK5chr19:52380535chr19:42510962ENST000005935621420566_622623.6666666666666981.0Topological domainCytoplasmic
TgeneGRIK5chr19:52380535chr19:42526506ENST00000262895101915_544491.0981.0Topological domainExtracellular
TgeneGRIK5chr19:52380535chr19:42526506ENST00000301218101915_544491.0982.0Topological domainExtracellular
TgeneGRIK5chr19:52380535chr19:42526506ENST00000593562112015_544491.0981.0Topological domainExtracellular
TgeneGRIK5chr19:52380535chr19:42510962ENST000002628951319545_565623.6666666666666981.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42510962ENST000003012181319545_565623.6666666666666982.0TransmembraneHelical
TgeneGRIK5chr19:52380535chr19:42510962ENST000005935621420545_565623.6666666666666981.0TransmembraneHelical


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZNF577
GRIK5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to ZNF577-GRIK5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ZNF577-GRIK5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource