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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZNF586-SRC

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZNF586-SRC
FusionPDB ID: 102458
FusionGDB2.0 ID: 102458
HgeneTgene
Gene symbol

ZNF586

SRC

Gene ID

54807

6714

Gene namezinc finger protein 586SRC proto-oncogene, non-receptor tyrosine kinase
Synonyms-ASV|SRC1|THC6|c-SRC|p60-Src
Cytomap

19q13.43

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 586proto-oncogene tyrosine-protein kinase Srcproto-oncogene c-Srcprotooncogene SRC, Rous sarcomatyrosine kinase pp60c-srctyrosine-protein kinase SRC-1v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Modification date2020031320200327
UniProtAcc.

SLA2

Ensembl transtripts involved in fusion geneENST idsENST00000391702, ENST00000396150, 
ENST00000396154, ENST00000598183, 
ENST00000598885, ENST00000599802, 
ENST00000477066, ENST00000358208, 
ENST00000360723, ENST00000373558, 
ENST00000373567, ENST00000373578, 
ENST00000445403, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 5 X 5=1509 X 7 X 5=315
# samples 78
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/315*10)=-1.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZNF586 [Title/Abstract] AND SRC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZNF586(58301768)-SRC(36028518), # samples:2
Anticipated loss of major functional domain due to fusion event.ZNF586-SRC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF586-SRC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF586-SRC seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF586-SRC seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ZNF586-SRC seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ZNF586-SRC seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSRC

GO:0018108

peptidyl-tyrosine phosphorylation

12051764|22732588

TgeneSRC

GO:0035306

positive regulation of dephosphorylation

23159740

TgeneSRC

GO:0035556

intracellular signal transduction

15248232

TgeneSRC

GO:0046777

protein autophosphorylation

16441665

TgeneSRC

GO:0071902

positive regulation of protein serine/threonine kinase activity

19059439


check buttonFusion gene breakpoints across ZNF586 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SRC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A03V-01AZNF586chr19

58281246

-SRCchr20

36028518

+
ChimerDB4BRCATCGA-AO-A03V-01AZNF586chr19

58288037

+SRCchr20

36028518

+
ChimerDB4BRCATCGA-AO-A03V-01AZNF586chr19

58301768

+SRCchr20

36028518

+
ChimerDB4BRCATCGA-AO-A03V-01AZNF586chr19

58331313

+SRCchr20

36028518

+
ChimerDB4BRCATCGA-AO-A03V-01AZNF586chr19

58331917

+SRCchr20

36028518

+
ChimerDB4BRCATCGA-AO-A03VZNF586chr19

58288037

+SRCchr20

36028517

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000598885ZNF586chr1958301768+ENST00000445403SRCchr2036028518+3132345171096359
ENST00000598885ZNF586chr1958301768+ENST00000373578SRCchr2036028518+3768345171096359
ENST00000598885ZNF586chr1958301768+ENST00000360723SRCchr2036028518+3132345171096359
ENST00000598885ZNF586chr1958301768+ENST00000358208SRCchr2036028518+3132345171096359
ENST00000598885ZNF586chr1958301768+ENST00000373567SRCchr2036028518+3768345171096359
ENST00000598885ZNF586chr1958301768+ENST00000373558SRCchr2036028518+3768345171096359
ENST00000598183ZNF586chr1958301768+ENST00000445403SRCchr2036028518+3126339111090359
ENST00000598183ZNF586chr1958301768+ENST00000373578SRCchr2036028518+3762339111090359
ENST00000598183ZNF586chr1958301768+ENST00000360723SRCchr2036028518+3126339111090359
ENST00000598183ZNF586chr1958301768+ENST00000358208SRCchr2036028518+3126339111090359
ENST00000598183ZNF586chr1958301768+ENST00000373567SRCchr2036028518+3762339111090359
ENST00000598183ZNF586chr1958301768+ENST00000373558SRCchr2036028518+3762339111090359
ENST00000391702ZNF586chr1958288037+ENST00000445403SRCchr2036028517+31884013131152279
ENST00000391702ZNF586chr1958288037+ENST00000373578SRCchr2036028517+38244013131152279
ENST00000391702ZNF586chr1958288037+ENST00000360723SRCchr2036028517+31884013131152279
ENST00000391702ZNF586chr1958288037+ENST00000358208SRCchr2036028517+31884013131152279
ENST00000391702ZNF586chr1958288037+ENST00000373567SRCchr2036028517+38244013131152279
ENST00000391702ZNF586chr1958288037+ENST00000373558SRCchr2036028517+38244013131152279
ENST00000396154ZNF586chr1958288037+ENST00000445403SRCchr2036028517+312333681087359
ENST00000396154ZNF586chr1958288037+ENST00000373578SRCchr2036028517+375933681087359
ENST00000396154ZNF586chr1958288037+ENST00000360723SRCchr2036028517+312333681087359
ENST00000396154ZNF586chr1958288037+ENST00000358208SRCchr2036028517+312333681087359
ENST00000396154ZNF586chr1958288037+ENST00000373567SRCchr2036028517+375933681087359
ENST00000396154ZNF586chr1958288037+ENST00000373558SRCchr2036028517+375933681087359
ENST00000391702ZNF586chr1958288037+ENST00000445403SRCchr2036028518+31884013131152279
ENST00000391702ZNF586chr1958288037+ENST00000373578SRCchr2036028518+38244013131152279
ENST00000391702ZNF586chr1958288037+ENST00000360723SRCchr2036028518+31884013131152279
ENST00000391702ZNF586chr1958288037+ENST00000358208SRCchr2036028518+31884013131152279
ENST00000391702ZNF586chr1958288037+ENST00000373567SRCchr2036028518+38244013131152279
ENST00000391702ZNF586chr1958288037+ENST00000373558SRCchr2036028518+38244013131152279
ENST00000396154ZNF586chr1958288037+ENST00000445403SRCchr2036028518+312333681087359
ENST00000396154ZNF586chr1958288037+ENST00000373578SRCchr2036028518+375933681087359
ENST00000396154ZNF586chr1958288037+ENST00000360723SRCchr2036028518+312333681087359
ENST00000396154ZNF586chr1958288037+ENST00000358208SRCchr2036028518+312333681087359
ENST00000396154ZNF586chr1958288037+ENST00000373567SRCchr2036028518+375933681087359
ENST00000396154ZNF586chr1958288037+ENST00000373558SRCchr2036028518+375933681087359

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000598885ENST00000445403ZNF586chr1958301768+SRCchr2036028518+0.0048271520.9951729
ENST00000598885ENST00000373578ZNF586chr1958301768+SRCchr2036028518+0.0041078880.99589205
ENST00000598885ENST00000360723ZNF586chr1958301768+SRCchr2036028518+0.0048271520.9951729
ENST00000598885ENST00000358208ZNF586chr1958301768+SRCchr2036028518+0.0048271520.9951729
ENST00000598885ENST00000373567ZNF586chr1958301768+SRCchr2036028518+0.0041078880.99589205
ENST00000598885ENST00000373558ZNF586chr1958301768+SRCchr2036028518+0.0041078880.99589205
ENST00000598183ENST00000445403ZNF586chr1958301768+SRCchr2036028518+0.0047844480.99521554
ENST00000598183ENST00000373578ZNF586chr1958301768+SRCchr2036028518+0.0040706010.9959294
ENST00000598183ENST00000360723ZNF586chr1958301768+SRCchr2036028518+0.0047844480.99521554
ENST00000598183ENST00000358208ZNF586chr1958301768+SRCchr2036028518+0.0047844480.99521554
ENST00000598183ENST00000373567ZNF586chr1958301768+SRCchr2036028518+0.0040706010.9959294
ENST00000598183ENST00000373558ZNF586chr1958301768+SRCchr2036028518+0.0040706010.9959294
ENST00000391702ENST00000445403ZNF586chr1958288037+SRCchr2036028517+0.0075432710.9924568
ENST00000391702ENST00000373578ZNF586chr1958288037+SRCchr2036028517+0.0061924530.9938075
ENST00000391702ENST00000360723ZNF586chr1958288037+SRCchr2036028517+0.0075432710.9924568
ENST00000391702ENST00000358208ZNF586chr1958288037+SRCchr2036028517+0.0075432710.9924568
ENST00000391702ENST00000373567ZNF586chr1958288037+SRCchr2036028517+0.0061924530.9938075
ENST00000391702ENST00000373558ZNF586chr1958288037+SRCchr2036028517+0.0061924530.9938075
ENST00000396154ENST00000445403ZNF586chr1958288037+SRCchr2036028517+0.0049766710.99502337
ENST00000396154ENST00000373578ZNF586chr1958288037+SRCchr2036028517+0.004230290.99576974
ENST00000396154ENST00000360723ZNF586chr1958288037+SRCchr2036028517+0.0049766710.99502337
ENST00000396154ENST00000358208ZNF586chr1958288037+SRCchr2036028517+0.0049766710.99502337
ENST00000396154ENST00000373567ZNF586chr1958288037+SRCchr2036028517+0.004230290.99576974
ENST00000396154ENST00000373558ZNF586chr1958288037+SRCchr2036028517+0.004230290.99576974
ENST00000391702ENST00000445403ZNF586chr1958288037+SRCchr2036028518+0.0075432710.9924568
ENST00000391702ENST00000373578ZNF586chr1958288037+SRCchr2036028518+0.0061924530.9938075
ENST00000391702ENST00000360723ZNF586chr1958288037+SRCchr2036028518+0.0075432710.9924568
ENST00000391702ENST00000358208ZNF586chr1958288037+SRCchr2036028518+0.0075432710.9924568
ENST00000391702ENST00000373567ZNF586chr1958288037+SRCchr2036028518+0.0061924530.9938075
ENST00000391702ENST00000373558ZNF586chr1958288037+SRCchr2036028518+0.0061924530.9938075
ENST00000396154ENST00000445403ZNF586chr1958288037+SRCchr2036028518+0.0049766710.99502337
ENST00000396154ENST00000373578ZNF586chr1958288037+SRCchr2036028518+0.004230290.99576974
ENST00000396154ENST00000360723ZNF586chr1958288037+SRCchr2036028518+0.0049766710.99502337
ENST00000396154ENST00000358208ZNF586chr1958288037+SRCchr2036028518+0.0049766710.99502337
ENST00000396154ENST00000373567ZNF586chr1958288037+SRCchr2036028518+0.004230290.99576974
ENST00000396154ENST00000373558ZNF586chr1958288037+SRCchr2036028518+0.004230290.99576974

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>102458_102458_1_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000391702_SRC_chr20_36028517_ENST00000358208_length(amino acids)=279AA_BP=26
MEEWSLLNEAQRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKG
SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA
LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE

--------------------------------------------------------------

>102458_102458_2_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000391702_SRC_chr20_36028517_ENST00000360723_length(amino acids)=279AA_BP=26
MEEWSLLNEAQRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKG
SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA
LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE

--------------------------------------------------------------

>102458_102458_3_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000391702_SRC_chr20_36028517_ENST00000373558_length(amino acids)=279AA_BP=26
MEEWSLLNEAQRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKG
SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA
LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE

--------------------------------------------------------------

>102458_102458_4_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000391702_SRC_chr20_36028517_ENST00000373567_length(amino acids)=279AA_BP=26
MEEWSLLNEAQRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKG
SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA
LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE

--------------------------------------------------------------

>102458_102458_5_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000391702_SRC_chr20_36028517_ENST00000373578_length(amino acids)=279AA_BP=26
MEEWSLLNEAQRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKG
SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA
LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE

--------------------------------------------------------------

>102458_102458_6_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000391702_SRC_chr20_36028517_ENST00000445403_length(amino acids)=279AA_BP=26
MEEWSLLNEAQRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKG
SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA
LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE

--------------------------------------------------------------

>102458_102458_7_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000391702_SRC_chr20_36028518_ENST00000358208_length(amino acids)=279AA_BP=26
MEEWSLLNEAQRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKG
SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA
LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE

--------------------------------------------------------------

>102458_102458_8_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000391702_SRC_chr20_36028518_ENST00000360723_length(amino acids)=279AA_BP=26
MEEWSLLNEAQRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKG
SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA
LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE

--------------------------------------------------------------

>102458_102458_9_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000391702_SRC_chr20_36028518_ENST00000373558_length(amino acids)=279AA_BP=26
MEEWSLLNEAQRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKG
SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA
LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE

--------------------------------------------------------------

>102458_102458_10_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000391702_SRC_chr20_36028518_ENST00000373567_length(amino acids)=279AA_BP=26
MEEWSLLNEAQRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKG
SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA
LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE

--------------------------------------------------------------

>102458_102458_11_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000391702_SRC_chr20_36028518_ENST00000373578_length(amino acids)=279AA_BP=26
MEEWSLLNEAQRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKG
SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA
LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE

--------------------------------------------------------------

>102458_102458_12_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000391702_SRC_chr20_36028518_ENST00000445403_length(amino acids)=279AA_BP=26
MEEWSLLNEAQRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKG
SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA
LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE

--------------------------------------------------------------

>102458_102458_13_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000396154_SRC_chr20_36028517_ENST00000358208_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_14_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000396154_SRC_chr20_36028517_ENST00000360723_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_15_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000396154_SRC_chr20_36028517_ENST00000373558_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_16_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000396154_SRC_chr20_36028517_ENST00000373567_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_17_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000396154_SRC_chr20_36028517_ENST00000373578_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_18_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000396154_SRC_chr20_36028517_ENST00000445403_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_19_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000396154_SRC_chr20_36028518_ENST00000358208_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_20_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000396154_SRC_chr20_36028518_ENST00000360723_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_21_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000396154_SRC_chr20_36028518_ENST00000373558_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_22_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000396154_SRC_chr20_36028518_ENST00000373567_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_23_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000396154_SRC_chr20_36028518_ENST00000373578_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_24_ZNF586-SRC_ZNF586_chr19_58288037_ENST00000396154_SRC_chr20_36028518_ENST00000445403_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QRCLYRDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_25_ZNF586-SRC_ZNF586_chr19_58301768_ENST00000598183_SRC_chr20_36028518_ENST00000358208_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_26_ZNF586-SRC_ZNF586_chr19_58301768_ENST00000598183_SRC_chr20_36028518_ENST00000360723_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_27_ZNF586-SRC_ZNF586_chr19_58301768_ENST00000598183_SRC_chr20_36028518_ENST00000373558_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_28_ZNF586-SRC_ZNF586_chr19_58301768_ENST00000598183_SRC_chr20_36028518_ENST00000373567_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_29_ZNF586-SRC_ZNF586_chr19_58301768_ENST00000598183_SRC_chr20_36028518_ENST00000373578_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_30_ZNF586-SRC_ZNF586_chr19_58301768_ENST00000598183_SRC_chr20_36028518_ENST00000445403_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_31_ZNF586-SRC_ZNF586_chr19_58301768_ENST00000598885_SRC_chr20_36028518_ENST00000358208_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_32_ZNF586-SRC_ZNF586_chr19_58301768_ENST00000598885_SRC_chr20_36028518_ENST00000360723_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_33_ZNF586-SRC_ZNF586_chr19_58301768_ENST00000598885_SRC_chr20_36028518_ENST00000373558_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_34_ZNF586-SRC_ZNF586_chr19_58301768_ENST00000598885_SRC_chr20_36028518_ENST00000373567_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_35_ZNF586-SRC_ZNF586_chr19_58301768_ENST00000598885_SRC_chr20_36028518_ENST00000373578_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>102458_102458_36_ZNF586-SRC_ZNF586_chr19_58301768_ENST00000598885_SRC_chr20_36028518_ENST00000445403_length(amino acids)=359AA_BP=106
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:58301768/chr20:36028518)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.SRC

SLA2

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.261

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF586chr19:58288037chr20:36028517ENST00000391702+3415_8711.333333333333334360.0DomainKRAB
HgeneZNF586chr19:58288037chr20:36028517ENST00000396150+1215_870211.0DomainKRAB
HgeneZNF586chr19:58288037chr20:36028517ENST00000396154+2315_8754.333333333333336403.0DomainKRAB
HgeneZNF586chr19:58288037chr20:36028518ENST00000391702+3415_8711.333333333333334360.0DomainKRAB
HgeneZNF586chr19:58288037chr20:36028518ENST00000396150+1215_870211.0DomainKRAB
HgeneZNF586chr19:58288037chr20:36028518ENST00000396154+2315_8754.333333333333336403.0DomainKRAB
HgeneZNF586chr19:58301768chr20:36028518ENST00000391702+1415_870360.0DomainKRAB
HgeneZNF586chr19:58301768chr20:36028518ENST00000396150+1215_870211.0DomainKRAB
HgeneZNF586chr19:58301768chr20:36028518ENST00000396154+1315_870403.0DomainKRAB
HgeneZNF586chr19:58288037chr20:36028517ENST00000391702+34122_14411.333333333333334360.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58288037chr20:36028517ENST00000391702+34150_17211.333333333333334360.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58288037chr20:36028517ENST00000391702+34178_20011.333333333333334360.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58288037chr20:36028517ENST00000391702+34206_22811.333333333333334360.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58288037chr20:36028517ENST00000391702+34234_25611.333333333333334360.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58288037chr20:36028517ENST00000391702+34262_28411.333333333333334360.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58288037chr20:36028517ENST00000391702+34290_31211.333333333333334360.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58288037chr20:36028517ENST00000391702+34317_33911.333333333333334360.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58288037chr20:36028517ENST00000391702+34345_36711.333333333333334360.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58288037chr20:36028517ENST00000391702+34373_39511.333333333333334360.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58288037chr20:36028517ENST00000391702+3488_11611.333333333333334360.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58288037chr20:36028517ENST00000396150+12122_1440211.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58288037chr20:36028517ENST00000396150+12150_1720211.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58288037chr20:36028517ENST00000396150+12178_2000211.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58288037chr20:36028517ENST00000396150+12206_2280211.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58288037chr20:36028517ENST00000396150+12234_2560211.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58288037chr20:36028517ENST00000396150+12262_2840211.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58288037chr20:36028517ENST00000396150+12290_3120211.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58288037chr20:36028517ENST00000396150+12317_3390211.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58288037chr20:36028517ENST00000396150+12345_3670211.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58288037chr20:36028517ENST00000396150+12373_3950211.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58288037chr20:36028517ENST00000396150+1288_1160211.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58288037chr20:36028517ENST00000396154+23122_14454.333333333333336403.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58288037chr20:36028517ENST00000396154+23150_17254.333333333333336403.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58288037chr20:36028517ENST00000396154+23178_20054.333333333333336403.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58288037chr20:36028517ENST00000396154+23206_22854.333333333333336403.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58288037chr20:36028517ENST00000396154+23234_25654.333333333333336403.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58288037chr20:36028517ENST00000396154+23262_28454.333333333333336403.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58288037chr20:36028517ENST00000396154+23290_31254.333333333333336403.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58288037chr20:36028517ENST00000396154+23317_33954.333333333333336403.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58288037chr20:36028517ENST00000396154+23345_36754.333333333333336403.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58288037chr20:36028517ENST00000396154+23373_39554.333333333333336403.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58288037chr20:36028517ENST00000396154+2388_11654.333333333333336403.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58288037chr20:36028518ENST00000391702+34122_14411.333333333333334360.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58288037chr20:36028518ENST00000391702+34150_17211.333333333333334360.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58288037chr20:36028518ENST00000391702+34178_20011.333333333333334360.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58288037chr20:36028518ENST00000391702+34206_22811.333333333333334360.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58288037chr20:36028518ENST00000391702+34234_25611.333333333333334360.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58288037chr20:36028518ENST00000391702+34262_28411.333333333333334360.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58288037chr20:36028518ENST00000391702+34290_31211.333333333333334360.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58288037chr20:36028518ENST00000391702+34317_33911.333333333333334360.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58288037chr20:36028518ENST00000391702+34345_36711.333333333333334360.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58288037chr20:36028518ENST00000391702+34373_39511.333333333333334360.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58288037chr20:36028518ENST00000391702+3488_11611.333333333333334360.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58288037chr20:36028518ENST00000396150+12122_1440211.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58288037chr20:36028518ENST00000396150+12150_1720211.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58288037chr20:36028518ENST00000396150+12178_2000211.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58288037chr20:36028518ENST00000396150+12206_2280211.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58288037chr20:36028518ENST00000396150+12234_2560211.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58288037chr20:36028518ENST00000396150+12262_2840211.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58288037chr20:36028518ENST00000396150+12290_3120211.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58288037chr20:36028518ENST00000396150+12317_3390211.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58288037chr20:36028518ENST00000396150+12345_3670211.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58288037chr20:36028518ENST00000396150+12373_3950211.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58288037chr20:36028518ENST00000396150+1288_1160211.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58288037chr20:36028518ENST00000396154+23122_14454.333333333333336403.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58288037chr20:36028518ENST00000396154+23150_17254.333333333333336403.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58288037chr20:36028518ENST00000396154+23178_20054.333333333333336403.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58288037chr20:36028518ENST00000396154+23206_22854.333333333333336403.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58288037chr20:36028518ENST00000396154+23234_25654.333333333333336403.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58288037chr20:36028518ENST00000396154+23262_28454.333333333333336403.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58288037chr20:36028518ENST00000396154+23290_31254.333333333333336403.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58288037chr20:36028518ENST00000396154+23317_33954.333333333333336403.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58288037chr20:36028518ENST00000396154+23345_36754.333333333333336403.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58288037chr20:36028518ENST00000396154+23373_39554.333333333333336403.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58288037chr20:36028518ENST00000396154+2388_11654.333333333333336403.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58301768chr20:36028518ENST00000391702+14122_1440360.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58301768chr20:36028518ENST00000391702+14150_1720360.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58301768chr20:36028518ENST00000391702+14178_2000360.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58301768chr20:36028518ENST00000391702+14206_2280360.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58301768chr20:36028518ENST00000391702+14234_2560360.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58301768chr20:36028518ENST00000391702+14262_2840360.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58301768chr20:36028518ENST00000391702+14290_3120360.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58301768chr20:36028518ENST00000391702+14317_3390360.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58301768chr20:36028518ENST00000391702+14345_3670360.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58301768chr20:36028518ENST00000391702+14373_3950360.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58301768chr20:36028518ENST00000391702+1488_1160360.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58301768chr20:36028518ENST00000396150+12122_1440211.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58301768chr20:36028518ENST00000396150+12150_1720211.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58301768chr20:36028518ENST00000396150+12178_2000211.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58301768chr20:36028518ENST00000396150+12206_2280211.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58301768chr20:36028518ENST00000396150+12234_2560211.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58301768chr20:36028518ENST00000396150+12262_2840211.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58301768chr20:36028518ENST00000396150+12290_3120211.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58301768chr20:36028518ENST00000396150+12317_3390211.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58301768chr20:36028518ENST00000396150+12345_3670211.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58301768chr20:36028518ENST00000396150+12373_3950211.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58301768chr20:36028518ENST00000396150+1288_1160211.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58301768chr20:36028518ENST00000396154+13122_1440403.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58301768chr20:36028518ENST00000396154+13150_1720403.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58301768chr20:36028518ENST00000396154+13178_2000403.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58301768chr20:36028518ENST00000396154+13206_2280403.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58301768chr20:36028518ENST00000396154+13234_2560403.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58301768chr20:36028518ENST00000396154+13262_2840403.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58301768chr20:36028518ENST00000396154+13290_3120403.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58301768chr20:36028518ENST00000396154+13317_3390403.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58301768chr20:36028518ENST00000396154+13345_3670403.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58301768chr20:36028518ENST00000396154+13373_3950403.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58301768chr20:36028518ENST00000396154+1388_1160403.0Zinc fingerC2H2-type 1%3B degenerate
TgeneSRCchr19:58288037chr20:36028517ENST00000358208612151_248286.3333333333333537.0DomainSH2
TgeneSRCchr19:58288037chr20:36028517ENST00000358208612270_523286.3333333333333537.0DomainProtein kinase
TgeneSRCchr19:58288037chr20:36028517ENST0000035820861284_145286.3333333333333537.0DomainSH3
TgeneSRCchr19:58288037chr20:36028517ENST00000360723713151_248292.3333333333333543.0DomainSH2
TgeneSRCchr19:58288037chr20:36028517ENST00000360723713270_523292.3333333333333543.0DomainProtein kinase
TgeneSRCchr19:58288037chr20:36028517ENST0000036072371384_145292.3333333333333543.0DomainSH3
TgeneSRCchr19:58288037chr20:36028517ENST00000373558612151_248292.3333333333333543.0DomainSH2
TgeneSRCchr19:58288037chr20:36028517ENST00000373558612270_523292.3333333333333543.0DomainProtein kinase
TgeneSRCchr19:58288037chr20:36028517ENST0000037355861284_145292.3333333333333543.0DomainSH3
TgeneSRCchr19:58288037chr20:36028517ENST00000373567612151_248286.3333333333333537.0DomainSH2
TgeneSRCchr19:58288037chr20:36028517ENST00000373567612270_523286.3333333333333537.0DomainProtein kinase
TgeneSRCchr19:58288037chr20:36028517ENST0000037356761284_145286.3333333333333537.0DomainSH3
TgeneSRCchr19:58288037chr20:36028517ENST00000373578814151_248286.3333333333333537.0DomainSH2
TgeneSRCchr19:58288037chr20:36028517ENST00000373578814270_523286.3333333333333537.0DomainProtein kinase
TgeneSRCchr19:58288037chr20:36028517ENST0000037357881484_145286.3333333333333537.0DomainSH3
TgeneSRCchr19:58288037chr20:36028517ENST00000445403713151_248286.3333333333333537.0DomainSH2
TgeneSRCchr19:58288037chr20:36028517ENST00000445403713270_523286.3333333333333537.0DomainProtein kinase
TgeneSRCchr19:58288037chr20:36028517ENST0000044540371384_145286.3333333333333537.0DomainSH3
TgeneSRCchr19:58288037chr20:36028518ENST00000358208612151_248286.3333333333333537.0DomainSH2
TgeneSRCchr19:58288037chr20:36028518ENST00000358208612270_523286.3333333333333537.0DomainProtein kinase
TgeneSRCchr19:58288037chr20:36028518ENST0000035820861284_145286.3333333333333537.0DomainSH3
TgeneSRCchr19:58288037chr20:36028518ENST00000360723713151_248292.3333333333333543.0DomainSH2
TgeneSRCchr19:58288037chr20:36028518ENST00000360723713270_523292.3333333333333543.0DomainProtein kinase
TgeneSRCchr19:58288037chr20:36028518ENST0000036072371384_145292.3333333333333543.0DomainSH3
TgeneSRCchr19:58288037chr20:36028518ENST00000373558612151_248292.3333333333333543.0DomainSH2
TgeneSRCchr19:58288037chr20:36028518ENST00000373558612270_523292.3333333333333543.0DomainProtein kinase
TgeneSRCchr19:58288037chr20:36028518ENST0000037355861284_145292.3333333333333543.0DomainSH3
TgeneSRCchr19:58288037chr20:36028518ENST00000373567612151_248286.3333333333333537.0DomainSH2
TgeneSRCchr19:58288037chr20:36028518ENST00000373567612270_523286.3333333333333537.0DomainProtein kinase
TgeneSRCchr19:58288037chr20:36028518ENST0000037356761284_145286.3333333333333537.0DomainSH3
TgeneSRCchr19:58288037chr20:36028518ENST00000373578814151_248286.3333333333333537.0DomainSH2
TgeneSRCchr19:58288037chr20:36028518ENST00000373578814270_523286.3333333333333537.0DomainProtein kinase
TgeneSRCchr19:58288037chr20:36028518ENST0000037357881484_145286.3333333333333537.0DomainSH3
TgeneSRCchr19:58288037chr20:36028518ENST00000445403713151_248286.3333333333333537.0DomainSH2
TgeneSRCchr19:58288037chr20:36028518ENST00000445403713270_523286.3333333333333537.0DomainProtein kinase
TgeneSRCchr19:58288037chr20:36028518ENST0000044540371384_145286.3333333333333537.0DomainSH3
TgeneSRCchr19:58301768chr20:36028518ENST00000358208612151_248286.3333333333333537.0DomainSH2
TgeneSRCchr19:58301768chr20:36028518ENST00000358208612270_523286.3333333333333537.0DomainProtein kinase
TgeneSRCchr19:58301768chr20:36028518ENST0000035820861284_145286.3333333333333537.0DomainSH3
TgeneSRCchr19:58301768chr20:36028518ENST00000360723713151_248292.3333333333333543.0DomainSH2
TgeneSRCchr19:58301768chr20:36028518ENST00000360723713270_523292.3333333333333543.0DomainProtein kinase
TgeneSRCchr19:58301768chr20:36028518ENST0000036072371384_145292.3333333333333543.0DomainSH3
TgeneSRCchr19:58301768chr20:36028518ENST00000373558612151_248292.3333333333333543.0DomainSH2
TgeneSRCchr19:58301768chr20:36028518ENST00000373558612270_523292.3333333333333543.0DomainProtein kinase
TgeneSRCchr19:58301768chr20:36028518ENST0000037355861284_145292.3333333333333543.0DomainSH3
TgeneSRCchr19:58301768chr20:36028518ENST00000373567612151_248286.3333333333333537.0DomainSH2
TgeneSRCchr19:58301768chr20:36028518ENST00000373567612270_523286.3333333333333537.0DomainProtein kinase
TgeneSRCchr19:58301768chr20:36028518ENST0000037356761284_145286.3333333333333537.0DomainSH3
TgeneSRCchr19:58301768chr20:36028518ENST00000373578814151_248286.3333333333333537.0DomainSH2
TgeneSRCchr19:58301768chr20:36028518ENST00000373578814270_523286.3333333333333537.0DomainProtein kinase
TgeneSRCchr19:58301768chr20:36028518ENST0000037357881484_145286.3333333333333537.0DomainSH3
TgeneSRCchr19:58301768chr20:36028518ENST00000445403713151_248286.3333333333333537.0DomainSH2
TgeneSRCchr19:58301768chr20:36028518ENST00000445403713270_523286.3333333333333537.0DomainProtein kinase
TgeneSRCchr19:58301768chr20:36028518ENST0000044540371384_145286.3333333333333537.0DomainSH3
TgeneSRCchr19:58288037chr20:36028517ENST00000358208612276_284286.3333333333333537.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58288037chr20:36028517ENST00000360723713276_284292.3333333333333543.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58288037chr20:36028517ENST00000373558612276_284292.3333333333333543.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58288037chr20:36028517ENST00000373567612276_284286.3333333333333537.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58288037chr20:36028517ENST00000373578814276_284286.3333333333333537.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58288037chr20:36028517ENST00000445403713276_284286.3333333333333537.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58288037chr20:36028518ENST00000358208612276_284286.3333333333333537.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58288037chr20:36028518ENST00000360723713276_284292.3333333333333543.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58288037chr20:36028518ENST00000373558612276_284292.3333333333333543.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58288037chr20:36028518ENST00000373567612276_284286.3333333333333537.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58288037chr20:36028518ENST00000373578814276_284286.3333333333333537.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58288037chr20:36028518ENST00000445403713276_284286.3333333333333537.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58301768chr20:36028518ENST00000358208612276_284286.3333333333333537.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58301768chr20:36028518ENST00000360723713276_284292.3333333333333543.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58301768chr20:36028518ENST00000373558612276_284292.3333333333333543.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58301768chr20:36028518ENST00000373567612276_284286.3333333333333537.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58301768chr20:36028518ENST00000373578814276_284286.3333333333333537.0Nucleotide bindingNote=ATP
TgeneSRCchr19:58301768chr20:36028518ENST00000445403713276_284286.3333333333333537.0Nucleotide bindingNote=ATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZNF586
SRC


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ZNF586-SRC


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZNF586-SRC


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource