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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZNF91-CCDC88A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZNF91-CCDC88A
FusionPDB ID: 103101
FusionGDB2.0 ID: 103101
HgeneTgene
Gene symbol

ZNF91

CCDC88A

Gene ID

7644

55704

Gene namezinc finger protein 91coiled-coil domain containing 88A
SynonymsHPF7|HTF10APE|GIRDIN|GIV|GRDN|HkRP1|KIAA1212|PEHO|PEHOL
Cytomap

19p12

2p16.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 91zinc finger protein 91 (HPF7, HTF10)zinc finger protein HPF7zinc finger protein HTF10girdinAKT-phosphorylation enhancerHook-related protein 1g alpha-interacting vesicle-associated proteingirders of actin filaments
Modification date2020031320200329
UniProtAcc.

Q3V6T2

Ensembl transtripts involved in fusion geneENST idsENST00000300619, ENST00000599743, 
ENST00000397082, ENST00000596528, 
ENST00000471947, ENST00000263630, 
ENST00000336838, ENST00000413716, 
ENST00000422883, ENST00000436346, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 8 X 7=61613 X 12 X 5=780
# samples 1114
** MAII scorelog2(11/616*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/780*10)=-2.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZNF91 [Title/Abstract] AND CCDC88A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZNF91(23556544)-CCDC88A(55523659), # samples:3
Anticipated loss of major functional domain due to fusion event.ZNF91-CCDC88A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF91-CCDC88A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF91-CCDC88A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF91-CCDC88A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF91

GO:0045892

negative regulation of transcription, DNA-templated

25274305

HgeneZNF91

GO:0070895

negative regulation of transposon integration

25274305

TgeneCCDC88A

GO:0007264

small GTPase mediated signal transduction

19211784|23509302|27621449|27864364

TgeneCCDC88A

GO:0032147

activation of protein kinase activity

21954290

TgeneCCDC88A

GO:0045742

positive regulation of epidermal growth factor receptor signaling pathway

20462955

TgeneCCDC88A

GO:0061024

membrane organization

15882442

TgeneCCDC88A

GO:0072660

maintenance of protein location in plasma membrane

20462955


check buttonFusion gene breakpoints across ZNF91 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCDC88A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-50-5946-01AZNF91chr19

23556544

-CCDC88Achr2

55523659

-
ChimerDB4LUADTCGA-50-5946-02AZNF91chr19

23556544

-CCDC88Achr2

55523659

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000599743ZNF91chr1923556544-ENST00000336838CCDC88Achr255523659-4505356251146373
ENST00000599743ZNF91chr1923556544-ENST00000263630CCDC88Achr255523659-4505356251146373
ENST00000599743ZNF91chr1923556544-ENST00000436346CCDC88Achr255523659-4500356251146373
ENST00000599743ZNF91chr1923556544-ENST00000413716CCDC88Achr255523659-171535625924299
ENST00000599743ZNF91chr1923556544-ENST00000422883CCDC88Achr255523659-4259356251146373
ENST00000300619ZNF91chr1923556544-ENST00000336838CCDC88Achr255523659-4608459201249409
ENST00000300619ZNF91chr1923556544-ENST00000263630CCDC88Achr255523659-4608459201249409
ENST00000300619ZNF91chr1923556544-ENST00000436346CCDC88Achr255523659-4603459201249409
ENST00000300619ZNF91chr1923556544-ENST00000413716CCDC88Achr255523659-1818459201027335
ENST00000300619ZNF91chr1923556544-ENST00000422883CCDC88Achr255523659-4362459201249409

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000599743ENST00000336838ZNF91chr1923556544-CCDC88Achr255523659-0.0001431670.9998568
ENST00000599743ENST00000263630ZNF91chr1923556544-CCDC88Achr255523659-0.0001431670.9998568
ENST00000599743ENST00000436346ZNF91chr1923556544-CCDC88Achr255523659-0.0001445760.9998554
ENST00000599743ENST00000413716ZNF91chr1923556544-CCDC88Achr255523659-0.0007144950.9992855
ENST00000599743ENST00000422883ZNF91chr1923556544-CCDC88Achr255523659-0.0001499850.99985003
ENST00000300619ENST00000336838ZNF91chr1923556544-CCDC88Achr255523659-0.0001456820.9998543
ENST00000300619ENST00000263630ZNF91chr1923556544-CCDC88Achr255523659-0.0001456820.9998543
ENST00000300619ENST00000436346ZNF91chr1923556544-CCDC88Achr255523659-0.0001472670.99985266
ENST00000300619ENST00000413716ZNF91chr1923556544-CCDC88Achr255523659-0.0006361320.99936384
ENST00000300619ENST00000422883ZNF91chr1923556544-CCDC88Achr255523659-0.0001526820.9998473

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>103101_103101_1_ZNF91-CCDC88A_ZNF91_chr19_23556544_ENST00000300619_CCDC88A_chr2_55523659_ENST00000263630_length(amino acids)=409AA_BP=144
MGTVQSGTKLERTGRLPGCGWAFVSRCRRSFQVSTSLLCVLCSRRPSLCGPVTCRYWRATAKMPGTPGSLEMGLLTFRDVAIEFSPEEWQ
CLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITYLEQGKEPWNMKQHEMVDEPTAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSP
IQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLA
RSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYATLPRASSVISTAEGTTRRTSIH

--------------------------------------------------------------

>103101_103101_2_ZNF91-CCDC88A_ZNF91_chr19_23556544_ENST00000300619_CCDC88A_chr2_55523659_ENST00000336838_length(amino acids)=409AA_BP=144
MGTVQSGTKLERTGRLPGCGWAFVSRCRRSFQVSTSLLCVLCSRRPSLCGPVTCRYWRATAKMPGTPGSLEMGLLTFRDVAIEFSPEEWQ
CLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITYLEQGKEPWNMKQHEMVDEPTAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSP
IQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLA
RSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYATLPRASSVISTAEGTTRRTSIH

--------------------------------------------------------------

>103101_103101_3_ZNF91-CCDC88A_ZNF91_chr19_23556544_ENST00000300619_CCDC88A_chr2_55523659_ENST00000413716_length(amino acids)=335AA_BP=144
MGTVQSGTKLERTGRLPGCGWAFVSRCRRSFQVSTSLLCVLCSRRPSLCGPVTCRYWRATAKMPGTPGSLEMGLLTFRDVAIEFSPEEWQ
CLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITYLEQGKEPWNMKQHEMVDEPTAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSP
IQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLA

--------------------------------------------------------------

>103101_103101_4_ZNF91-CCDC88A_ZNF91_chr19_23556544_ENST00000300619_CCDC88A_chr2_55523659_ENST00000422883_length(amino acids)=409AA_BP=144
MGTVQSGTKLERTGRLPGCGWAFVSRCRRSFQVSTSLLCVLCSRRPSLCGPVTCRYWRATAKMPGTPGSLEMGLLTFRDVAIEFSPEEWQ
CLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITYLEQGKEPWNMKQHEMVDEPTAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSP
IQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLA
RSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYATLPRASSVISTAEGTTRRTSIH

--------------------------------------------------------------

>103101_103101_5_ZNF91-CCDC88A_ZNF91_chr19_23556544_ENST00000300619_CCDC88A_chr2_55523659_ENST00000436346_length(amino acids)=409AA_BP=144
MGTVQSGTKLERTGRLPGCGWAFVSRCRRSFQVSTSLLCVLCSRRPSLCGPVTCRYWRATAKMPGTPGSLEMGLLTFRDVAIEFSPEEWQ
CLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITYLEQGKEPWNMKQHEMVDEPTAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSP
IQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLA
RSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYATLPRASSVISTAEGTTRRTSIH

--------------------------------------------------------------

>103101_103101_6_ZNF91-CCDC88A_ZNF91_chr19_23556544_ENST00000599743_CCDC88A_chr2_55523659_ENST00000263630_length(amino acids)=373AA_BP=108
MLCVLCSRRPSLCGPVTCRYWRATAKMPGTPGSLEMGLLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITY
LEQGKEPWNMKQHEMVDEPTAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGS
EVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDTYFIS
SAGKPTPGTQGKIKLVKESSLSRQSKDSNPYATLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQES

--------------------------------------------------------------

>103101_103101_7_ZNF91-CCDC88A_ZNF91_chr19_23556544_ENST00000599743_CCDC88A_chr2_55523659_ENST00000336838_length(amino acids)=373AA_BP=108
MLCVLCSRRPSLCGPVTCRYWRATAKMPGTPGSLEMGLLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITY
LEQGKEPWNMKQHEMVDEPTAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGS
EVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDTYFIS
SAGKPTPGTQGKIKLVKESSLSRQSKDSNPYATLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQES

--------------------------------------------------------------

>103101_103101_8_ZNF91-CCDC88A_ZNF91_chr19_23556544_ENST00000599743_CCDC88A_chr2_55523659_ENST00000413716_length(amino acids)=299AA_BP=108
MLCVLCSRRPSLCGPVTCRYWRATAKMPGTPGSLEMGLLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITY
LEQGKEPWNMKQHEMVDEPTAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGS
EVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLASVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAA

--------------------------------------------------------------

>103101_103101_9_ZNF91-CCDC88A_ZNF91_chr19_23556544_ENST00000599743_CCDC88A_chr2_55523659_ENST00000422883_length(amino acids)=373AA_BP=108
MLCVLCSRRPSLCGPVTCRYWRATAKMPGTPGSLEMGLLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITY
LEQGKEPWNMKQHEMVDEPTAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGS
EVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDTYFIS
SAGKPTPGTQGKIKLVKESSLSRQSKDSNPYATLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQES

--------------------------------------------------------------

>103101_103101_10_ZNF91-CCDC88A_ZNF91_chr19_23556544_ENST00000599743_CCDC88A_chr2_55523659_ENST00000436346_length(amino acids)=373AA_BP=108
MLCVLCSRRPSLCGPVTCRYWRATAKMPGTPGSLEMGLLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITY
LEQGKEPWNMKQHEMVDEPTAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGS
EVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDTYFIS
SAGKPTPGTQGKIKLVKESSLSRQSKDSNPYATLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQES

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:23556544/chr2:55523659)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCDC88A

Q3V6T2

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (PubMed:19211784, PubMed:27621449). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (PubMed:19211784, PubMed:21954290, PubMed:23509302, PubMed:25187647). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (PubMed:27621449). Essential for cell migration (PubMed:20462955, PubMed:16139227, PubMed:19211784, PubMed:21954290). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (PubMed:20462955). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (PubMed:19211784). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (PubMed:21954290). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (PubMed:27621449). Essential for the integrity of the actin cytoskeleton (PubMed:16139227, PubMed:19211784). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382). {ECO:0000250|UniProtKB:Q5SNZ0, ECO:0000269|PubMed:15882442, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:19211784, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:21954290, ECO:0000269|PubMed:23509302, ECO:0000269|PubMed:25187647, ECO:0000269|PubMed:27621449, ECO:0000269|PubMed:27623382}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-3413_8484.333333333333331192.0DomainKRAB
TgeneCCDC88Achr19:23556544chr2:55523659ENST0000026363027321672_17021580.33333333333332671.3333333333335MotifGBA
TgeneCCDC88Achr19:23556544chr2:55523659ENST0000033683828331672_17021607.33333333333332779.3333333333335MotifGBA
TgeneCCDC88Achr19:23556544chr2:55523659ENST0000041371628341672_17021607.33333333333331961.6666666666667MotifGBA
TgeneCCDC88Achr19:23556544chr2:55523659ENST0000043634628331672_17021608.33333333333332676.0MotifGBA

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-1313_8401160.0DomainKRAB
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-341022_104484.333333333333331192.0Zinc fingerC2H2-type 32
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-341050_107284.333333333333331192.0Zinc fingerC2H2-type 33
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-341078_110084.333333333333331192.0Zinc fingerC2H2-type 34
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-341106_112884.333333333333331192.0Zinc fingerC2H2-type 35
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-341134_115684.333333333333331192.0Zinc fingerC2H2-type 36
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34154_17684.333333333333331192.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34179_20084.333333333333331192.0Zinc fingerC2H2-type 2
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34208_23284.333333333333331192.0Zinc fingerC2H2-type 3
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34238_26084.333333333333331192.0Zinc fingerC2H2-type 4
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34266_28884.333333333333331192.0Zinc fingerC2H2-type 5
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34294_31684.333333333333331192.0Zinc fingerC2H2-type 6
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34322_34484.333333333333331192.0Zinc fingerC2H2-type 7
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34350_37284.333333333333331192.0Zinc fingerC2H2-type 8
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34378_40084.333333333333331192.0Zinc fingerC2H2-type 9
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34406_42884.333333333333331192.0Zinc fingerC2H2-type 10
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34434_45684.333333333333331192.0Zinc fingerC2H2-type 11
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34462_48484.333333333333331192.0Zinc fingerC2H2-type 12
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34490_51284.333333333333331192.0Zinc fingerC2H2-type 13
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34518_54084.333333333333331192.0Zinc fingerC2H2-type 14%3B degenerate
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34546_56884.333333333333331192.0Zinc fingerC2H2-type 15
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34574_59684.333333333333331192.0Zinc fingerC2H2-type 16
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34602_62484.333333333333331192.0Zinc fingerC2H2-type 17
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34630_65284.333333333333331192.0Zinc fingerC2H2-type 18
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34658_68084.333333333333331192.0Zinc fingerC2H2-type 19
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34686_70884.333333333333331192.0Zinc fingerC2H2-type 20
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34714_73684.333333333333331192.0Zinc fingerC2H2-type 21
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34742_76484.333333333333331192.0Zinc fingerC2H2-type 22
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34770_79284.333333333333331192.0Zinc fingerC2H2-type 23
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34798_82084.333333333333331192.0Zinc fingerC2H2-type 24
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34826_84884.333333333333331192.0Zinc fingerC2H2-type 25
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34854_87684.333333333333331192.0Zinc fingerC2H2-type 26
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34885_90484.333333333333331192.0Zinc fingerC2H2-type 27%3B degenerate
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34910_93284.333333333333331192.0Zinc fingerC2H2-type 28
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34938_96084.333333333333331192.0Zinc fingerC2H2-type 29
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34966_98884.333333333333331192.0Zinc fingerC2H2-type 30
HgeneZNF91chr19:23556544chr2:55523659ENST00000300619-34994_101684.333333333333331192.0Zinc fingerC2H2-type 31
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-131022_104401160.0Zinc fingerC2H2-type 32
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-131050_107201160.0Zinc fingerC2H2-type 33
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-131078_110001160.0Zinc fingerC2H2-type 34
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-131106_112801160.0Zinc fingerC2H2-type 35
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-131134_115601160.0Zinc fingerC2H2-type 36
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13154_17601160.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13179_20001160.0Zinc fingerC2H2-type 2
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13208_23201160.0Zinc fingerC2H2-type 3
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13238_26001160.0Zinc fingerC2H2-type 4
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13266_28801160.0Zinc fingerC2H2-type 5
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13294_31601160.0Zinc fingerC2H2-type 6
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13322_34401160.0Zinc fingerC2H2-type 7
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13350_37201160.0Zinc fingerC2H2-type 8
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13378_40001160.0Zinc fingerC2H2-type 9
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13406_42801160.0Zinc fingerC2H2-type 10
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13434_45601160.0Zinc fingerC2H2-type 11
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13462_48401160.0Zinc fingerC2H2-type 12
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13490_51201160.0Zinc fingerC2H2-type 13
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13518_54001160.0Zinc fingerC2H2-type 14%3B degenerate
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13546_56801160.0Zinc fingerC2H2-type 15
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13574_59601160.0Zinc fingerC2H2-type 16
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13602_62401160.0Zinc fingerC2H2-type 17
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13630_65201160.0Zinc fingerC2H2-type 18
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13658_68001160.0Zinc fingerC2H2-type 19
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13686_70801160.0Zinc fingerC2H2-type 20
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13714_73601160.0Zinc fingerC2H2-type 21
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13742_76401160.0Zinc fingerC2H2-type 22
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13770_79201160.0Zinc fingerC2H2-type 23
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13798_82001160.0Zinc fingerC2H2-type 24
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13826_84801160.0Zinc fingerC2H2-type 25
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13854_87601160.0Zinc fingerC2H2-type 26
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13885_90401160.0Zinc fingerC2H2-type 27%3B degenerate
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13910_93201160.0Zinc fingerC2H2-type 28
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13938_96001160.0Zinc fingerC2H2-type 29
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13966_98801160.0Zinc fingerC2H2-type 30
HgeneZNF91chr19:23556544chr2:55523659ENST00000397082-13994_101601160.0Zinc fingerC2H2-type 31
TgeneCCDC88Achr19:23556544chr2:55523659ENST000002636302732196_4251580.33333333333332671.3333333333335Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Achr19:23556544chr2:55523659ENST000002636302732458_13851580.33333333333332671.3333333333335Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Achr19:23556544chr2:55523659ENST000003368382833196_4251607.33333333333332779.3333333333335Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Achr19:23556544chr2:55523659ENST000003368382833458_13851607.33333333333332779.3333333333335Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Achr19:23556544chr2:55523659ENST000004137162834196_4251607.33333333333331961.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Achr19:23556544chr2:55523659ENST000004137162834458_13851607.33333333333331961.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Achr19:23556544chr2:55523659ENST000004363462833196_4251608.33333333333332676.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Achr19:23556544chr2:55523659ENST000004363462833458_13851608.33333333333332676.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC88Achr19:23556544chr2:55523659ENST00000263630273212_1321580.33333333333332671.3333333333335DomainCalponin-homology (CH)
TgeneCCDC88Achr19:23556544chr2:55523659ENST00000336838283312_1321607.33333333333332779.3333333333335DomainCalponin-homology (CH)
TgeneCCDC88Achr19:23556544chr2:55523659ENST00000413716283412_1321607.33333333333331961.6666666666667DomainCalponin-homology (CH)
TgeneCCDC88Achr19:23556544chr2:55523659ENST00000436346283312_1321608.33333333333332676.0DomainCalponin-homology (CH)
TgeneCCDC88Achr19:23556544chr2:55523659ENST0000026363027321390_14081580.33333333333332671.3333333333335RegionPhosphoinositide-binding
TgeneCCDC88Achr19:23556544chr2:55523659ENST0000033683828331390_14081607.33333333333332779.3333333333335RegionPhosphoinositide-binding
TgeneCCDC88Achr19:23556544chr2:55523659ENST0000041371628341390_14081607.33333333333331961.6666666666667RegionPhosphoinositide-binding
TgeneCCDC88Achr19:23556544chr2:55523659ENST0000043634628331390_14081608.33333333333332676.0RegionPhosphoinositide-binding


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>834_ZNF91_23556544_CCDC88A_55523659_834_ZNF91_23556544_CCDC88A_55523659_ranked_0.pdbZNF912355654423556544ENST00000422883CCDC88Achr255523659-
MGTVQSGTKLERTGRLPGCGWAFVSRCRRSFQVSTSLLCVLCSRRPSLCGPVTCRYWRATAKMPGTPGSLEMGLLTFRDVAIEFSPEEWQ
CLDTAQQNLYRNVMLENYRNLAFLGIALSKPDLITYLEQGKEPWNMKQHEMVDEPTAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSP
IQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLA
RSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYATLPRASSVISTAEGTTRRTSIH
409


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ZNF91_pLDDT.png
all structure
all structure
CCDC88A_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZNF91
CCDC88A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ZNF91-CCDC88A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZNF91-CCDC88A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource