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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:BTBD18-KMT2A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: BTBD18-KMT2A
FusionPDB ID: 10438
FusionGDB2.0 ID: 10438
HgeneTgene
Gene symbol

BTBD18

KMT2A

Gene ID

643376

4297

Gene nameBTB domain containing 18lysine methyltransferase 2A
Synonyms-ALL-1|CXXC7|HRX|HTRX1|MLL|MLL1|MLL1A|TRX1|WDSTS
Cytomap

11q12.1

11q23.3

Type of geneprotein-codingprotein-coding
DescriptionBTB/POZ domain-containing protein 18BTB (POZ) domain containing 18hCG1730474histone-lysine N-methyltransferase 2ACXXC-type zinc finger protein 7lysine (K)-specific methyltransferase 2Alysine N-methyltransferase 2Amixed lineage leukemia 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)trithorax-like
Modification date2020031320200319
UniProtAcc

B2RXH4

Q03164

Ensembl transtripts involved in fusion geneENST idsENST00000422652, ENST00000436147, 
ENST00000354520, ENST00000389506, 
ENST00000420751, ENST00000534358, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score1 X 1 X 1=131 X 72 X 3=6696
# samples 179
** MAII scorelog2(1/1*10)=3.32192809488736log2(79/6696*10)=-3.08337496948588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: BTBD18 [Title/Abstract] AND KMT2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KMT2A(118354935)-BTBD18(57513451), # samples:2
Anticipated loss of major functional domain due to fusion event.BTBD18-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD18-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD18-KMT2A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD18-KMT2A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD18-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD18-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD18-KMT2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD18-KMT2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD18-KMT2A seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD18-KMT2A seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF.
BTBD18-KMT2A seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
BTBD18-KMT2A seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
BTBD18-KMT2A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
BTBD18-KMT2A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
BTBD18-KMT2A seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
KMT2A-BTBD18 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KMT2A-BTBD18 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KMT2A-BTBD18 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KMT2A-BTBD18 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KMT2A-BTBD18 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKMT2A

GO:0044648

histone H3-K4 dimethylation

25561738

TgeneKMT2A

GO:0045944

positive regulation of transcription by RNA polymerase II

20861184

TgeneKMT2A

GO:0051568

histone H3-K4 methylation

19556245

TgeneKMT2A

GO:0065003

protein-containing complex assembly

15199122

TgeneKMT2A

GO:0080182

histone H3-K4 trimethylation

20861184

TgeneKMT2A

GO:0097692

histone H3-K4 monomethylation

25561738|26324722


check buttonFusion gene breakpoints across BTBD18 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KMT2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..BTBD18chr11

57510985

-KMT2Achr11

118355576

ChimerKB3..BTBD18chr11

57510985

-KMT2Achr11

118377361



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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000422652BTBD18chr1157510985-ENST00000534358KMT2Achr111183555761539730443074107442556
ENST00000422652BTBD18chr1157510985-ENST00000389506KMT2Achr111183555761248130443074107352553

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>10438_10438_1_BTBD18-KMT2A_BTBD18_chr11_57510985_ENST00000422652_KMT2A_chr11_118355576_ENST00000389506_length(amino acids)=2553AA_BP=
MGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYH
PECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVH
SKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSP
EGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRF
WEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPG
IEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHF
MCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFP
IGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYY
HVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSS
VSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSS
EGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSG
MSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPG
VPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSN
NYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDE
DDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEH
VTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKN
TPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNP
SRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVS
PTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMG
GGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSS
GLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSV
GGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQP
VALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQT
VDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTS
LTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPK
KGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEP
PLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCK
RNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYR

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>10438_10438_2_BTBD18-KMT2A_BTBD18_chr11_57510985_ENST00000422652_KMT2A_chr11_118355576_ENST00000534358_length(amino acids)=2556AA_BP=
MGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYH
PECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVH
SKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSR
SSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKK
SRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNP
PPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSN
YHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDK
LFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGS
CYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNN
VSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSS
KSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLK
LSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLS
MPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDS
QSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLST
SDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGE
KEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFV
LKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPS
QNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQV
PVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLG
PMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVAT
PSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLP
QSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQ
DQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNF
TQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQE
TTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEK
KPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEA
NEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGL
FCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRK

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:118354935/chr11:57513451)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BTBD18

B2RXH4

KMT2A

Q03164

FUNCTION: Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene. {ECO:0000250|UniProtKB:A0A0A6YY25}.FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBTBD18chr11:57510985chr11:118355576ENST0000042265233270_293918.3333333333334713.0Compositional biasPolar residues
HgeneBTBD18chr11:57510985chr11:118355576ENST0000042265233299_313918.3333333333334713.0Compositional biasBasic and acidic residues
HgeneBTBD18chr11:57510985chr11:118355576ENST0000042265233318_332918.3333333333334713.0Compositional biasPolar residues
HgeneBTBD18chr11:57510985chr11:118355576ENST0000042265233396_410918.3333333333334713.0Compositional biasPolar residues
HgeneBTBD18chr11:57510985chr11:118355576ENST0000042265233695_712918.3333333333334713.0Compositional biasPolar residues
HgeneBTBD18chr11:57510985chr11:118355576ENST0000043614722270_293919.6666666666666713.0Compositional biasPolar residues
HgeneBTBD18chr11:57510985chr11:118355576ENST0000043614722299_313919.6666666666666713.0Compositional biasBasic and acidic residues
HgeneBTBD18chr11:57510985chr11:118355576ENST0000043614722318_332919.6666666666666713.0Compositional biasPolar residues
HgeneBTBD18chr11:57510985chr11:118355576ENST0000043614722396_410919.6666666666666713.0Compositional biasPolar residues
HgeneBTBD18chr11:57510985chr11:118355576ENST0000043614722695_712919.6666666666666713.0Compositional biasPolar residues
HgeneBTBD18chr11:57510985chr11:118355576ENST000004226523334_102918.3333333333334713.0DomainBTB
HgeneBTBD18chr11:57510985chr11:118355576ENST000004361472234_102919.6666666666666713.0DomainBTB
HgeneBTBD18chr11:57510985chr11:118355576ENST0000042265233157_176918.3333333333334713.0RegionDisordered
HgeneBTBD18chr11:57510985chr11:118355576ENST0000042265233212_355918.3333333333334713.0RegionDisordered
HgeneBTBD18chr11:57510985chr11:118355576ENST0000042265233374_410918.3333333333334713.0RegionDisordered
HgeneBTBD18chr11:57510985chr11:118355576ENST0000042265233653_676918.3333333333334713.0RegionDisordered
HgeneBTBD18chr11:57510985chr11:118355576ENST0000042265233691_712918.3333333333334713.0RegionDisordered
HgeneBTBD18chr11:57510985chr11:118355576ENST0000043614722157_176919.6666666666666713.0RegionDisordered
HgeneBTBD18chr11:57510985chr11:118355576ENST0000043614722212_355919.6666666666666713.0RegionDisordered
HgeneBTBD18chr11:57510985chr11:118355576ENST0000043614722374_410919.6666666666666713.0RegionDisordered
HgeneBTBD18chr11:57510985chr11:118355576ENST0000043614722653_676919.6666666666666713.0RegionDisordered
HgeneBTBD18chr11:57510985chr11:118355576ENST0000043614722691_712919.6666666666666713.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351046_10610.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351249_12720.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351278_13020.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351303_13170.03932.0Compositional biasPro residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351822_18470.03932.0Compositional biasPro residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035184_2030.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035204_2260.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352096_21180.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352146_21740.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352189_22320.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352275_23200.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035236_2530.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352402_24180.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352419_24450.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352526_25940.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352721_27460.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352747_27840.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352785_28210.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200353011_30640.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200353166_31830.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200353195_32220.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200353230_32440.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035325_3510.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200353464_35300.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200353563_36060.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST0000035452003537_580.03932.0Compositional biasPro residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035445_4950.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035535_5560.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035557_5760.03932.0Compositional biasPro residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035713_7310.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035747_7800.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035798_8450.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST0000035452003581_1030.03932.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035846_8980.03932.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361822_18471406.03970.0Compositional biasPro residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362096_21181406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362146_21741406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362189_22321406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362275_23201406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362402_24181406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362419_24451406.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362526_25941406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362721_27461406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362747_27841406.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362785_28211406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068363011_30641406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068363166_31831406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068363195_32221406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068363230_32441406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068363464_35301406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068363563_36061406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361822_18471406.03973.0Compositional biasPro residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362096_21181406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362146_21741406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362189_22321406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362275_23201406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362402_24181406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362419_24451406.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362526_25941406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362721_27461406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362747_27841406.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362785_28211406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588363011_30641406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588363166_31831406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588363195_32221406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588363230_32441406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588363464_35301406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588363563_36061406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035169_1800.03932.0DNA bindingNote=A.T hook 1
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035217_2270.03932.0DNA bindingNote=A.T hook 2
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035301_3090.03932.0DNA bindingNote=A.T hook 3
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351703_17480.03932.0DomainBromo%3B divergent
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352018_20740.03932.0DomainFYR N-terminal
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200353666_37470.03932.0DomainFYR C-terminal
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200353829_39450.03932.0DomainSET
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200353953_39690.03932.0DomainPost-SET
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361703_17481406.03970.0DomainBromo%3B divergent
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362018_20741406.03970.0DomainFYR N-terminal
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068363666_37471406.03970.0DomainFYR C-terminal
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068363829_39451406.03970.0DomainSET
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068363953_39691406.03970.0DomainPost-SET
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361703_17481406.03973.0DomainBromo%3B divergent
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362018_20741406.03973.0DomainFYR N-terminal
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588363666_37471406.03973.0DomainFYR C-terminal
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588363829_39451406.03973.0DomainSET
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588363953_39691406.03973.0DomainPost-SET
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035123_1340.03932.0MotifIntegrase domain-binding motif 1 (IBM1)
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035147_1520.03932.0MotifIntegrase domain-binding motif 2 (IBM2)
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200356_250.03932.0MotifMenin-binding motif (MBM)
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351038_10660.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351106_11660.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351200_13750.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035132_2530.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351663_17130.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351806_18690.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351_1080.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352081_21330.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352145_22320.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352275_23330.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352373_24600.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352475_26180.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352647_26750.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352713_28210.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200352961_30640.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035301_3520.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200353166_32440.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200353464_36080.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200353620_36430.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200353785_38080.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200353906_39070.03932.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035445_5850.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035713_7800.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST00000354520035798_9490.03932.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361663_17131406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361806_18691406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362081_21331406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362145_22321406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362275_23331406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362373_24601406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362475_26181406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362647_26751406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362713_28211406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068362961_30641406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068363166_32441406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068363464_36081406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068363620_36431406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068363785_38081406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068363906_39071406.03970.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361663_17131406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361806_18691406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362081_21331406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362145_22321406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362275_23331406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362373_24601406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362475_26181406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362647_26751406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362713_28211406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588362961_30641406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588363166_32441406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588363464_36081406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588363620_36431406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588363785_38081406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588363906_39071406.03973.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351147_11950.03932.0Zinc fingerCXXC-type
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351431_14820.03932.0Zinc fingerPHD-type 1
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351479_15330.03932.0Zinc fingerPHD-type 2
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351566_16270.03932.0Zinc fingerPHD-type 3
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351870_19100.03932.0Zinc fingerC2HC pre-PHD-type
TgeneKMT2Achr11:57510985chr11:118355576ENST000003545200351931_19780.03932.0Zinc fingerPHD-type 4
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361431_14821406.03970.0Zinc fingerPHD-type 1
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361479_15331406.03970.0Zinc fingerPHD-type 2
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361566_16271406.03970.0Zinc fingerPHD-type 3
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361870_19101406.03970.0Zinc fingerC2HC pre-PHD-type
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361931_19781406.03970.0Zinc fingerPHD-type 4
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361431_14821406.03973.0Zinc fingerPHD-type 1
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361479_15331406.03973.0Zinc fingerPHD-type 2
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361566_16271406.03973.0Zinc fingerPHD-type 3
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361870_19101406.03973.0Zinc fingerC2HC pre-PHD-type
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361931_19781406.03973.0Zinc fingerPHD-type 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361046_10611406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361249_12721406.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361278_13021406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361303_13171406.03970.0Compositional biasPro residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836184_2031406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836204_2261406.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836236_2531406.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836325_3511406.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST0000038950683637_581406.03970.0Compositional biasPro residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836445_4951406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836535_5561406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836557_5761406.03970.0Compositional biasPro residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836713_7311406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836747_7801406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836798_8451406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST0000038950683681_1031406.03970.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836846_8981406.03970.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361046_10611406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361249_12721406.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361278_13021406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361303_13171406.03973.0Compositional biasPro residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836184_2031406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836204_2261406.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836236_2531406.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836325_3511406.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST0000053435883637_581406.03973.0Compositional biasPro residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836445_4951406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836535_5561406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836557_5761406.03973.0Compositional biasPro residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836713_7311406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836747_7801406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836798_8451406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST0000053435883681_1031406.03973.0Compositional biasPolar residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836846_8981406.03973.0Compositional biasBasic and acidic residues
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836169_1801406.03970.0DNA bindingNote=A.T hook 1
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836217_2271406.03970.0DNA bindingNote=A.T hook 2
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836301_3091406.03970.0DNA bindingNote=A.T hook 3
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836169_1801406.03973.0DNA bindingNote=A.T hook 1
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836217_2271406.03973.0DNA bindingNote=A.T hook 2
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836301_3091406.03973.0DNA bindingNote=A.T hook 3
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836123_1341406.03970.0MotifIntegrase domain-binding motif 1 (IBM1)
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836147_1521406.03970.0MotifIntegrase domain-binding motif 2 (IBM2)
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068366_251406.03970.0MotifMenin-binding motif (MBM)
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836123_1341406.03973.0MotifIntegrase domain-binding motif 1 (IBM1)
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836147_1521406.03973.0MotifIntegrase domain-binding motif 2 (IBM2)
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588366_251406.03973.0MotifMenin-binding motif (MBM)
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361038_10661406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361106_11661406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361200_13751406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836132_2531406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361_1081406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836301_3521406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836445_5851406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836713_7801406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST00000389506836798_9491406.03970.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361038_10661406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361106_11661406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361200_13751406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836132_2531406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361_1081406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836301_3521406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836445_5851406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836713_7801406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST00000534358836798_9491406.03973.0RegionDisordered
TgeneKMT2Achr11:57510985chr11:118355576ENST000003895068361147_11951406.03970.0Zinc fingerCXXC-type
TgeneKMT2Achr11:57510985chr11:118355576ENST000005343588361147_11951406.03973.0Zinc fingerCXXC-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (1141)BTBD18chr1157510985-KMT2Achr11118355576
MGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERP
LEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPT
KPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKG
NFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPES
VAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQA
AKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMD
QGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVF
PWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQ
PPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPG
IEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDG
SLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVF
LDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEP
ENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCV
YTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEI
ISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAG
SPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTG
NTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNL
QRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSS
EGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALS
FPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINE
HMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMD
EVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPR
KRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPG
DGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRY
PRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVD
GADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQ
LDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEH
VTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPS
DKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGES
PESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSIS
AEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKS
VASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGH
GNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQT
TPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVME
TNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFP
AATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSS
GLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHP
SLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGT
STISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTN
PRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPS
TAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIH
SSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSP
SSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSE
AHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPE
VQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPK
KGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNG
LRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARA
EVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPM
PMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSI
QTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSR
VINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRK
2553
PDB file (1142) >>>1142.pdbFusion protein BP residue:
CIF file (1142) >>>1142.cif		BTBD18chr1157510985-KMT2Achr11118355576
MGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERP
LEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPT
KPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKG
NFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNL
PESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRY
RQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKR
KMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQME
RVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSH
TEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNP
PPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFED
DDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKN
CVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNG
LEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARK
RCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNT
AEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLP
SAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPM
RTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTS
SNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSS
KSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKE
ALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSI
INEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPE
FMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQ
APRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASE
NPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFK
RRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEG
QVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPK
ISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGE
KEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTS
TPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQAL
GESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSS
SISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTIT
EKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVE
QGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAA
VQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPS
VMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLH
SFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVAT
PSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLP
NHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATA
AGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVT
LTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQ
TPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKT
GIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPG
GSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTS
SSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAV
LPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEK
KPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAG
VNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGS
ARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMD
LPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVI
RSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNC
YSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKK
2556
3D view using mol* of 1142 (AA BP:)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
BTBD18_pLDDT.png
all structure
KMT2A_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
BTBD18_KMT2A_1141_pLDDT_and_active_sites.png (AA BP:)
all structure
BTBD18_KMT2A_1141_violinplot.png (AA BP:)
all structure
BTBD18_KMT2A_1142_pLDDT.png (AA BP:)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
BTBD18_KMT2A_1141.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
11411.0741331.05300.4680.4010.8091.0970.8031.1510.6970.534Chain A: 21,22,23,24,28,31,32,33,37,38,39,41,55,56
,57,59,60,61,62,2265,2266,2267,2268
11411.0432561.007539.5390.4020.7621.0260.3961.1970.3310.795Chain A: 34,45,46,47,48,49,50,51,54,57,58,59,61,64
,65,67,73,78,79,80,81,83,85,86,87,88,102,107,108,1
09,2291,2292,2293,2294

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
1141ZINC000026664090DB01232Saquinavir-8.19378-8.20698
1141ZINC000043206370DB11793Niraparib-8.11682-8.11682
1141ZINC000028639340DB01263Posaconazole-6.0032-8.0918
1141ZINC000004228257DB00360Sapropterin-7.93876-7.95846
1141ZINC000013585233DB00360Sapropterin-7.78713-7.80683
1141ZINC000000895154DB00360Sapropterin-7.62242-7.64212
1141ZINC000004228258DB00360Sapropterin-7.46795-7.48765
1141ZINC000002036848DB00140Riboflavin-7.4713-7.4717
1141ZINC000002169830DB00194Vidarabine-7.42384-7.42384
1141ZINC000001481815DB01609Deferasirox-7.31341-7.31921
1141ZINC000003802690DB00442Entecavir-7.23715-7.23715
1141ZINC000003806262DB00552Pentostatin-7.19662-7.22622
1141ZINC000009164421DB09050Ceftolozane-7.20481-7.20641
1141ZINC000022116612DB00800Fenoldopam-7.09928-7.12518
1141ZINC000040899447DB08828Vismodegib-7.0932-7.0932
1141ZINC000000004724DB00776Oxcarbazepine-7.07465-7.07465
1141ZINC000000968328DB00412Rosiglitazone-5.71505-7.04955
1141ZINC000001482184DB00853Temozolomide-7.01998-7.02158
1141ZINC000003604264DB00480Lenalidomide-6.97215-6.97215
1141ZINC000000020220DB00537Ciprofloxacin-6.84624-6.94604

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000043206370DB11793NiraparibSmall moleculeNC(=O)C1=CC=CC2=CN(N=C12)C1=CC=C(C=C1)[C@@H]1CCCNC1Approved|Investigational
ZINC000000895154DB00360SapropterinSmall molecule[H][C@@]1(CNC2=C(N1)C(=O)NC(N)=N2)[C@@H](O)[C@H](C)OApproved|Investigational
ZINC000002036848DB00140RiboflavinSmall moleculeCC1=C(C)C=C2N(C[C@H](O)[C@H](O)[C@H](O)CO)C3=NC(=O)NC(=O)C3=NC2=C1Approved|Investigational|Nutraceutical|Vet_approved
ZINC000002169830DB00194VidarabineSmall moleculeNC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1OApproved|Investigational
ZINC000001481815DB01609DeferasiroxSmall moleculeOC(=O)C1=CC=C(C=C1)N1N=C(N=C1C1=CC=CC=C1O)C1=CC=CC=C1OApproved|Investigational
ZINC000003802690DB00442EntecavirSmall moleculeNC1=NC(=O)C2=C(N1)N(C=N2)[C@H]1C[C@H](O)[C@@H](CO)C1=CApproved|Investigational
ZINC000003806262DB00552PentostatinSmall moleculeOC[C@H]1O[C@H](C[C@@H]1O)N1C=NC2=C1N=CNC[C@H]2OApproved|Investigational
ZINC000009164421DB09050CeftolozaneSmall moleculeCN1C(N)=C(NC(=O)NCCN)C=[N+]1CC1=C(N2[C@H](SC1)[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)C1=NSC(N)=N1)C2=O)C([O-])=OApproved|Investigational
ZINC000022116612DB00800FenoldopamSmall moleculeOC1=CC=C(C=C1)C1CNCCC2=C(Cl)C(O)=C(O)C=C12Approved
ZINC000040899447DB08828VismodegibSmall moleculeCS(=O)(=O)C1=CC(Cl)=C(C=C1)C(=O)NC1=CC=C(Cl)C(=C1)C1=CC=CC=N1Approved|Investigational
ZINC000000004724DB00776OxcarbazepineSmall moleculeNC(=O)N1C2=CC=CC=C2CC(=O)C2=C1C=CC=C2Approved
ZINC000001482184DB00853TemozolomideSmall moleculeCN1N=NC2=C(N=CN2C1=O)C(N)=OApproved|Investigational
ZINC000000020220DB00537CiprofloxacinSmall moleculeOC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=OApproved|Investigational

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000026664090670.858.1761065.378519.173193.936352.26902081.598513.78.874224.52832
ZINC000026664090670.857.1381070.742492.821201.426376.49502080.089513.79.102219.95232
ZINC000026664090670.858.4911112.722519.438188.94404.34302123.763513.78.939226.75332
ZINC000043206370320.3933.754607.688185.794143.417278.47601055.805358.546376.7200
ZINC000028639340700.7877.4041124.08472.765117.692460.37673.2482110.438111.28.362185.02331
ZINC000028639340700.7879.0091124.607459.294130.195459.08576.0332100.905111.28.651182.08231
ZINC000004228257241.2497.058447.535159.775268.53619.2230742.97178.97.522229.42710
ZINC000004228257241.24910.846445.922159.81267.19618.9150744.46278.97.661229.81310
ZINC000013585233241.2497.548455.149158.349273.98222.8190749.38778.97.637228.32310
ZINC000013585233241.24911.056455.167158.05274.48622.6310750.26378.97.777228.24910
ZINC000000895154241.2496.373456.659158.621275.2722.7690751.10678.97.413228.07410
ZINC000000895154241.24911.58456.496158.427275.45422.6150751.97778.97.547228.07210
ZINC000004228258241.2497.543455.16158.34273.99922.820749.39578.97.636228.3210
ZINC000004228258241.24911.054455.161158.04274.4922.6310750.2578.97.777228.24810
ZINC000002036848376.3688.767609.496261.237282.58265.67701115.69512.39.092245.8601
ZINC000002169830267.2443.396469.3695.245259.374114.7410784.03510.88.527244.32700
ZINC000001481815373.3676.655632.9870203.176429.81201121.431368.881271.63600
ZINC000003802690277.2826.742504.225143.129289.37471.7210851.66258.98.512242.61301
ZINC000003806262268.2721.452502.362225.071237.12940.1620835.80349.88.337251.84800
ZINC000003806262268.2721.378469.669223.737214.90231.030809.61749.88.34256.16400
ZINC000022116612305.762.648518.975117.225175.946169.41556.388904.72343.758.656366.48200
ZINC000022116612305.763.982521.194119.203176.013170.00555.972907.32143.758.911366.54600
ZINC000040899447421.2977.41693.16182.41131.553361.984117.2131198.28317.58.97310001
ZINC000000004724252.2724.767462.65934.19134.85293.6190794.353249.343377.84800
ZINC000000968328357.4261.444634.074175.676137.918287.73532.7451113.73115.258.373396.01200
ZINC000000968328357.4262.563632.369175.708136.258287.71932.6841111.85315.258.348396.29400
ZINC000000968328357.4261.098615.115188.498120.189271.1535.2791101.06815.258.417310000
ZINC000000968328357.4264.059637.846177.05121.495296.23443.0671111.87615.258.521310000
ZINC000001482184194.1523.411379.12887.887235.05156.190597.216279.649251.42500
ZINC000003604264259.2647.929464.201117.081210.677136.4420792.1542.578.452363.0800
ZINC000000020220331.3468.67578.412299.833178.53968.48731.5531017.371168.925248.3301
ZINC000000020220331.3468.111575.511298.04176.66769.24631.5581012.813168.79248.64801


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000026664090CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n10.0392487760.333476835
ZINC000043206370NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc120.158103060.243905197
ZINC000028639340CC[C@@H]([C@H](C)O)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@H]5CO[C@@](Cn6cncn6)(c6ccc(F)cc6F)C5)cc4)CC3)cc2)c1=O0.0317243810.429306683
ZINC000004228257C[C@H](O)[C@@H](O)[C@@H]1CNc2nc(N)[nH]c(=O)c2N10.0314105690.318425003
ZINC000013585233C[C@H](O)[C@H](O)[C@H]1CNc2nc(N)[nH]c(=O)c2N10.0314105690.318425003
ZINC000000895154C[C@@H](O)[C@H](O)[C@@H]1CNc2[nH]c(N)nc(=O)c2N10.0371845340.22690944
ZINC000004228258C[C@@H](O)[C@@H](O)[C@@H]1CNc2[nH]c(N)nc(=O)c2N10.0371845340.22690944
ZINC000002036848Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(C[C@H](O)[C@H](O)[C@H](O)CO)c2cc1C0.0613904940.448129596
ZINC000002169830Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O0.0795547680.347763769
ZINC000001481815O=C(O)c1ccc(-n2nc(-c3ccccc3O)nc2-c2ccccc2O)cc10.2844524210.360361492
ZINC000003802690C=C1[C@@H](n2cnc3c(=O)[nH]c(N)nc32)C[C@H](O)[C@H]1CO0.0456937720.309972869
ZINC000003806262OC[C@H]1O[C@@H](n2cnc3c2N=CNC[C@H]3O)C[C@@H]1O0.0242366470.504660299
ZINC000009164421Cn1c(N)c(NC(=O)NCCN)c[n+]1CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)/C(=NOC(C)(C)C(=O)O)c3nsc(N)n3)[C@H]2SC10.0281256130.175846017
ZINC000022116612Oc1ccc([C@H]2CNCCc3c2cc(O)c(O)c3Cl)cc10.1281071130.261427946
ZINC000040899447CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)c(Cl)c10.352692980.346729393
ZINC000000004724NC(=O)N1c2ccccc2CC(=O)c2ccccc210.3140267360.439183728
ZINC000000968328CN(CCOc1ccc(C[C@@H]2SC(=O)NC2=O)cc1)c1ccccn10.1553268710.273380926
ZINC000001482184Cn1nnc2c(C(N)=O)ncn2c1=O0.1608864090.261932701
ZINC000003604264Nc1cccc2c1CN([C@@H]1CCC(=O)NC1=O)C2=O0.1395805520.287500053
ZINC000000020220O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O0.2310316290.323908212


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
BTBD18EGFR, NXF1, TRIM33, DDX39A,
KMT2APPIE, PPP1R15A, KMT2A, ASH2L, HCFC1, HCFC2, MEN1, RBBP5, WDR5, AVP, INS, OXT, MAP3K5, HDAC1, CTBP1, CBX4, BMI1, CREBBP, SMARCB1, CXXC1, MYB, CTNNB1, SNW1, E2F2, E2F4, E2F6, PSIP1, MLLT4, POLR2A, KAT8, RNF2, TP53, tat, SBF1, MTM1, SET, HIST1H3A, HIST1H4A, KAT6A, ELL, AFF1, AFF4, CDK9, CCNT1, CTR9, LEO1, PAF1, CDC73, WDR61, MLLT3, DOT1L, SKP2, HIST3H3, SVIL, HIST2H3C, SIN3A, MLLT1, RUNX1, CBFB, H3F3A, SIRT7, ASB2, TCEB1, TCEB2, CBX8, TOP1, TAF6, NCL, HECW2, LGR4, CSNK2A2, SENP3, SYMPK, PKN1, PIH1D1, KRAS, TAF1, CHD3, SMARCA2, SMARCC2, SMARCC1, HDAC2, RBBP4, RBBP7, TBP, MBD3, SAP30, RAN, TAF9, TASP1, HIST1H2BG, EWSR1, DYNLT1, KIF11, ING4, Cbx1, Set, ZNF131, ASB7, AR, CSNK2A1, OGT, BRD4, KDM5B, KDM5D, KDM6B, CKS1B, CKS2, CHD4, ESR2, AGR2, EZH2, FBXW7, SOX2, MED17, WDR82, ACTR8, GEMIN5, RUVBL1, MCM2, RTF1, MED15, MED8, MRGBP, MED14, HIST1H2BB, HIST1H2AB, KIAA1429, SP1, MYC, NR2C2, IRF2, PLEKHA4, DPY30, PTEN, NPM1, RPL13, CCT6A, TMCO1, ITGB1, ESR1, MYCN, SUPT5H, CIT, Pik3r2, FASN, LDLR, CDC27, KMT2B, SETD1A, KDM6A, KANSL2, BUB3, SETD1B, KANSL1, RERE, MCRS1, KMT2C, ZZZ3, MBIP, YEATS2, PAXIP1, KANSL3, KMT2D, BOD1L1, CSRP2BP, ZNF608, ATN1, PHF20L1, PHF20, NCOA6, TADA3, APEX1, ASF1A, CBX3, CD3EAP, CENPA, NUP50, POLR1E, TERF2IP, ZNF330, NAA40, PRKRA, SRSF4, KRR1, RPL13A, ABT1, CSNK2B, OASL, SRSF5, SRSF6, RPS9, FGFBP1, RPLP0, RPL36, KAL1, RPL3, PML, ELF1, ELF2, FEV, NHLH1, EN1, KLF12, KLF3, NFIX, NFYC, YY1, BRD3,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
BTBD18all structure
KMT2Aall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to BTBD18-KMT2A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to BTBD18-KMT2A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKMT2AC2826025Mixed phenotype acute leukemia3ORPHANET
TgeneKMT2AC0023418leukemia2CTD_human
TgeneKMT2AC0023452Childhood Acute Lymphoblastic Leukemia2CTD_human
TgeneKMT2AC0023453L2 Acute Lymphoblastic Leukemia2CTD_human
TgeneKMT2AC0023466Leukemia, Monocytic, Chronic2CTD_human
TgeneKMT2AC0023467Leukemia, Myelocytic, Acute2CTD_human
TgeneKMT2AC0023470Myeloid Leukemia2CTD_human
TgeneKMT2AC0026998Acute Myeloid Leukemia, M12CTD_human
TgeneKMT2AC1854630Growth Deficiency and Mental Retardation with Facial Dysmorphism2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneKMT2AC1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
TgeneKMT2AC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human
TgeneKMT2AC0001418Adenocarcinoma1CTD_human
TgeneKMT2AC0004403Autosome Abnormalities1CTD_human
TgeneKMT2AC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneKMT2AC0005695Bladder Neoplasm1CTD_human
TgeneKMT2AC0007138Carcinoma, Transitional Cell1CTD_human
TgeneKMT2AC0008625Chromosome Aberrations1CTD_human
TgeneKMT2AC0023448Lymphoid leukemia1CTD_human
TgeneKMT2AC0023465Acute monocytic leukemia1CTD_human
TgeneKMT2AC0023479Acute myelomonocytic leukemia1CTD_human
TgeneKMT2AC0024623Malignant neoplasm of stomach1CTD_human
TgeneKMT2AC0033578Prostatic Neoplasms1CTD_human
TgeneKMT2AC0036341Schizophrenia1PSYGENET
TgeneKMT2AC0038356Stomach Neoplasms1CTD_human
TgeneKMT2AC0149925Small cell carcinoma of lung1CTD_human
TgeneKMT2AC0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneKMT2AC0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneKMT2AC0205643Carcinoma, Cribriform1CTD_human
TgeneKMT2AC0205644Carcinoma, Granular Cell1CTD_human
TgeneKMT2AC0205645Adenocarcinoma, Tubular1CTD_human
TgeneKMT2AC0270972Cornelia De Lange Syndrome1ORPHANET
TgeneKMT2AC0280141Acute Undifferentiated Leukemia1ORPHANET
TgeneKMT2AC0376358Malignant neoplasm of prostate1CTD_human
TgeneKMT2AC0856823Undifferentiated type acute leukemia1ORPHANET
TgeneKMT2AC1535926Neurodevelopmental Disorders1CTD_human
TgeneKMT2AC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneKMT2AC2239176Liver carcinoma1CTD_human
TgeneKMT2AC2930974Acute erythroleukemia1CTD_human
TgeneKMT2AC2930975Acute erythroleukemia - M6a subtype1CTD_human
TgeneKMT2AC2930976Acute myeloid leukemia FAB-M61CTD_human
TgeneKMT2AC2930977Acute erythroleukemia - M6b subtype1CTD_human