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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:C11orf54-EPB41

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: C11orf54-EPB41
	FusionPDB ID: 10738
	FusionGDB2.0 ID: 10738
		Hgene	Tgene
	Gene symbol	C11orf54	EPB41
	Gene ID	28970	2035
	Gene name	chromosome 11 open reading frame 54	erythrocyte membrane protein band 4.1
	Synonyms	PTD012\|PTOD012	4.1R\|EL1\|HE
	Cytomap	11q21	1p35.3
	Type of gene	protein-coding	protein-coding
	Description	ester hydrolase C11orf54epididymis secretory sperm binding protein	protein 4.1EPB4.1P4.1band 4.1elliptocytosis 1, RH-linkederythrocyte surface protein band 4.1
	Modification date	20200327	20200320
	UniProtAcc	Q9H0W9	Q9HCM4
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000331239, ENST00000354421, ENST00000528099, ENST00000528288, ENST00000540113, ENST00000531516,	ENST00000460378, ENST00000343067, ENST00000347529, ENST00000349460, ENST00000356093, ENST00000373797, ENST00000373798, ENST00000373800, ENST00000398863,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	5 X 4 X 3=60	13 X 13 X 6=1014
	# samples	4	15
	** MAII score	log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1014*10)=-2.75702324650746 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: C11orf54 [Title/Abstract] AND EPB41 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	C11orf54(93480614)-EPB41(29379616), # samples:1
Anticipated loss of major functional domain due to fusion event.	C11orf54-EPB41 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. C11orf54-EPB41 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. C11orf54-EPB41 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. C11orf54-EPB41 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	EPB41	GO:0032092	positive regulation of protein binding	3693401

Fusion gene breakpoints across C11orf54 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EPB41 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4GN-01A	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000528288	C11orf54	chr11	93480614	+	ENST00000356093	EPB41	chr1	29379616	+	4358	290	235	1149	304
ENST00000528288	C11orf54	chr11	93480614	+	ENST00000398863	EPB41	chr1	29379616	+	4166	290	235	957	240
ENST00000528288	C11orf54	chr11	93480614	+	ENST00000343067	EPB41	chr1	29379616	+	4457	290	235	1248	337
ENST00000528288	C11orf54	chr11	93480614	+	ENST00000349460	EPB41	chr1	29379616	+	1509	290	235	1206	323
ENST00000528288	C11orf54	chr11	93480614	+	ENST00000373800	EPB41	chr1	29379616	+	1350	290	235	1047	270
ENST00000528288	C11orf54	chr11	93480614	+	ENST00000347529	EPB41	chr1	29379616	+	1389	290	235	1086	283
ENST00000528288	C11orf54	chr11	93480614	+	ENST00000373798	EPB41	chr1	29379616	+	4478	290	235	1248	337
ENST00000528288	C11orf54	chr11	93480614	+	ENST00000373797	EPB41	chr1	29379616	+	859	290	235	816	193
ENST00000331239	C11orf54	chr11	93480614	+	ENST00000356093	EPB41	chr1	29379616	+	4302	234	179	1093	304
ENST00000331239	C11orf54	chr11	93480614	+	ENST00000398863	EPB41	chr1	29379616	+	4110	234	179	901	240
ENST00000331239	C11orf54	chr11	93480614	+	ENST00000343067	EPB41	chr1	29379616	+	4401	234	179	1192	337
ENST00000331239	C11orf54	chr11	93480614	+	ENST00000349460	EPB41	chr1	29379616	+	1453	234	179	1150	323
ENST00000331239	C11orf54	chr11	93480614	+	ENST00000373800	EPB41	chr1	29379616	+	1294	234	179	991	270
ENST00000331239	C11orf54	chr11	93480614	+	ENST00000347529	EPB41	chr1	29379616	+	1333	234	179	1030	283
ENST00000331239	C11orf54	chr11	93480614	+	ENST00000373798	EPB41	chr1	29379616	+	4422	234	179	1192	337
ENST00000331239	C11orf54	chr11	93480614	+	ENST00000373797	EPB41	chr1	29379616	+	803	234	179	760	193
ENST00000528099	C11orf54	chr11	93480614	+	ENST00000356093	EPB41	chr1	29379616	+	4422	354	299	1213	304
ENST00000528099	C11orf54	chr11	93480614	+	ENST00000398863	EPB41	chr1	29379616	+	4230	354	299	1021	240
ENST00000528099	C11orf54	chr11	93480614	+	ENST00000343067	EPB41	chr1	29379616	+	4521	354	299	1312	337
ENST00000528099	C11orf54	chr11	93480614	+	ENST00000349460	EPB41	chr1	29379616	+	1573	354	299	1270	323
ENST00000528099	C11orf54	chr11	93480614	+	ENST00000373800	EPB41	chr1	29379616	+	1414	354	299	1111	270
ENST00000528099	C11orf54	chr11	93480614	+	ENST00000347529	EPB41	chr1	29379616	+	1453	354	299	1150	283
ENST00000528099	C11orf54	chr11	93480614	+	ENST00000373798	EPB41	chr1	29379616	+	4542	354	299	1312	337
ENST00000528099	C11orf54	chr11	93480614	+	ENST00000373797	EPB41	chr1	29379616	+	923	354	299	880	193
ENST00000354421	C11orf54	chr11	93480614	+	ENST00000356093	EPB41	chr1	29379616	+	4280	212	157	1071	304
ENST00000354421	C11orf54	chr11	93480614	+	ENST00000398863	EPB41	chr1	29379616	+	4088	212	157	879	240
ENST00000354421	C11orf54	chr11	93480614	+	ENST00000343067	EPB41	chr1	29379616	+	4379	212	157	1170	337
ENST00000354421	C11orf54	chr11	93480614	+	ENST00000349460	EPB41	chr1	29379616	+	1431	212	157	1128	323
ENST00000354421	C11orf54	chr11	93480614	+	ENST00000373800	EPB41	chr1	29379616	+	1272	212	157	969	270
ENST00000354421	C11orf54	chr11	93480614	+	ENST00000347529	EPB41	chr1	29379616	+	1311	212	157	1008	283
ENST00000354421	C11orf54	chr11	93480614	+	ENST00000373798	EPB41	chr1	29379616	+	4400	212	157	1170	337
ENST00000354421	C11orf54	chr11	93480614	+	ENST00000373797	EPB41	chr1	29379616	+	781	212	157	738	193

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000528288	ENST00000356093	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.002730284	0.9972697
ENST00000528288	ENST00000398863	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.002532742	0.9974673
ENST00000528288	ENST00000343067	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.001796195	0.99820375
ENST00000528288	ENST00000349460	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.002368462	0.99763155
ENST00000528288	ENST00000373800	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.004362676	0.99563736
ENST00000528288	ENST00000347529	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.003383745	0.9966163
ENST00000528288	ENST00000373798	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.001702425	0.99829763
ENST00000528288	ENST00000373797	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.003144756	0.99685526
ENST00000331239	ENST00000356093	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.002757442	0.99724257
ENST00000331239	ENST00000398863	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.002602436	0.99739754
ENST00000331239	ENST00000343067	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.001801166	0.9981988
ENST00000331239	ENST00000349460	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.002502132	0.99749786
ENST00000331239	ENST00000373800	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.004532953	0.99546707
ENST00000331239	ENST00000347529	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.003814822	0.9961851
ENST00000331239	ENST00000373798	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.001708711	0.9982913
ENST00000331239	ENST00000373797	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.003749586	0.99625045
ENST00000528099	ENST00000356093	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.00247856	0.99752146
ENST00000528099	ENST00000398863	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.002332689	0.9976673
ENST00000528099	ENST00000343067	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.001551008	0.99844897
ENST00000528099	ENST00000349460	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.001601711	0.99839824
ENST00000528099	ENST00000373800	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.002993293	0.9970067
ENST00000528099	ENST00000347529	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.002295818	0.9977042
ENST00000528099	ENST00000373798	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.001464426	0.9985355
ENST00000528099	ENST00000373797	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.002105979	0.997894
ENST00000354421	ENST00000356093	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.002662954	0.99733704
ENST00000354421	ENST00000398863	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.002517788	0.99748224
ENST00000354421	ENST00000343067	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.001740806	0.99825925
ENST00000354421	ENST00000349460	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.002402411	0.99759763
ENST00000354421	ENST00000373800	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.004495035	0.99550503
ENST00000354421	ENST00000347529	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.003513842	0.9964862
ENST00000354421	ENST00000373798	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.001650405	0.99834967
ENST00000354421	ENST00000373797	C11orf54	chr11	93480614	+	EPB41	chr1	29379616	+	0.004356318	0.99564373

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>10738_10738_1_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000331239_EPB41_chr1_29379616_ENST00000343067_length(amino acids)=337AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKR
LSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSS

--------------------------------------------------------------

>10738_10738_2_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000331239_EPB41_chr1_29379616_ENST00000347529_length(amino acids)=283AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDL
DKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTE
TKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVT

--------------------------------------------------------------

>10738_10738_3_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000331239_EPB41_chr1_29379616_ENST00000349460_length(amino acids)=323AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNING
QIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGI

--------------------------------------------------------------

>10738_10738_4_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000331239_EPB41_chr1_29379616_ENST00000356093_length(amino acids)=304AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKK
RERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTIS
DNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDH

--------------------------------------------------------------

>10738_10738_5_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000331239_EPB41_chr1_29379616_ENST00000373797_length(amino acids)=193AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNING

--------------------------------------------------------------

>10738_10738_6_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000331239_EPB41_chr1_29379616_ENST00000373798_length(amino acids)=337AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKR
LSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSS

--------------------------------------------------------------

>10738_10738_7_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000331239_EPB41_chr1_29379616_ENST00000373800_length(amino acids)=270AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKK
RERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTIS
DNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE

--------------------------------------------------------------

>10738_10738_8_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000331239_EPB41_chr1_29379616_ENST00000398863_length(amino acids)=240AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDL
DKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGTDDNSGDLDPGVLLTAQTITSETPSSTTTTQIT

--------------------------------------------------------------

>10738_10738_9_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000354421_EPB41_chr1_29379616_ENST00000343067_length(amino acids)=337AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKR
LSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSS

--------------------------------------------------------------

>10738_10738_10_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000354421_EPB41_chr1_29379616_ENST00000347529_length(amino acids)=283AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDL
DKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTE
TKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVT

--------------------------------------------------------------

>10738_10738_11_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000354421_EPB41_chr1_29379616_ENST00000349460_length(amino acids)=323AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNING
QIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGI

--------------------------------------------------------------

>10738_10738_12_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000354421_EPB41_chr1_29379616_ENST00000356093_length(amino acids)=304AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKK
RERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTIS
DNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDH

--------------------------------------------------------------

>10738_10738_13_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000354421_EPB41_chr1_29379616_ENST00000373797_length(amino acids)=193AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNING

--------------------------------------------------------------

>10738_10738_14_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000354421_EPB41_chr1_29379616_ENST00000373798_length(amino acids)=337AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKR
LSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSS

--------------------------------------------------------------

>10738_10738_15_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000354421_EPB41_chr1_29379616_ENST00000373800_length(amino acids)=270AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKK
RERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTIS
DNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE

--------------------------------------------------------------

>10738_10738_16_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000354421_EPB41_chr1_29379616_ENST00000398863_length(amino acids)=240AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDL
DKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGTDDNSGDLDPGVLLTAQTITSETPSSTTTTQIT

--------------------------------------------------------------

>10738_10738_17_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528099_EPB41_chr1_29379616_ENST00000343067_length(amino acids)=337AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKR
LSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSS

--------------------------------------------------------------

>10738_10738_18_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528099_EPB41_chr1_29379616_ENST00000347529_length(amino acids)=283AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDL
DKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTE
TKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVT

--------------------------------------------------------------

>10738_10738_19_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528099_EPB41_chr1_29379616_ENST00000349460_length(amino acids)=323AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNING
QIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGI

--------------------------------------------------------------

>10738_10738_20_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528099_EPB41_chr1_29379616_ENST00000356093_length(amino acids)=304AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKK
RERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTIS
DNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDH

--------------------------------------------------------------

>10738_10738_21_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528099_EPB41_chr1_29379616_ENST00000373797_length(amino acids)=193AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNING

--------------------------------------------------------------

>10738_10738_22_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528099_EPB41_chr1_29379616_ENST00000373798_length(amino acids)=337AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKR
LSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSS

--------------------------------------------------------------

>10738_10738_23_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528099_EPB41_chr1_29379616_ENST00000373800_length(amino acids)=270AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKK
RERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTIS
DNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE

--------------------------------------------------------------

>10738_10738_24_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528099_EPB41_chr1_29379616_ENST00000398863_length(amino acids)=240AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDL
DKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGTDDNSGDLDPGVLLTAQTITSETPSSTTTTQIT

--------------------------------------------------------------

>10738_10738_25_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528288_EPB41_chr1_29379616_ENST00000343067_length(amino acids)=337AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKR
LSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSS

--------------------------------------------------------------

>10738_10738_26_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528288_EPB41_chr1_29379616_ENST00000347529_length(amino acids)=283AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDL
DKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTE
TKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVT

--------------------------------------------------------------

>10738_10738_27_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528288_EPB41_chr1_29379616_ENST00000349460_length(amino acids)=323AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNING
QIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGI

--------------------------------------------------------------

>10738_10738_28_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528288_EPB41_chr1_29379616_ENST00000356093_length(amino acids)=304AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKK
RERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTIS
DNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDH

--------------------------------------------------------------

>10738_10738_29_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528288_EPB41_chr1_29379616_ENST00000373797_length(amino acids)=193AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNING

--------------------------------------------------------------

>10738_10738_30_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528288_EPB41_chr1_29379616_ENST00000373798_length(amino acids)=337AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVE
KTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKR
LSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSS

--------------------------------------------------------------

>10738_10738_31_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528288_EPB41_chr1_29379616_ENST00000373800_length(amino acids)=270AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKK
RERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTIS
DNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE

--------------------------------------------------------------

>10738_10738_32_C11orf54-EPB41_C11orf54_chr11_93480614_ENST00000528288_EPB41_chr1_29379616_ENST00000398863_length(amino acids)=240AA_BP=18
MACAEFSFHVPSLEELAGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDL
DKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGTDDNSGDLDPGVLLTAQTITSETPSSTTTTQIT

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:93480614/chr1:29379616)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
C11orf54 Q9H0W9	EPB41 Q9HCM4
FUNCTION: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate. {ECO:0000269\|PubMed:16522806}.	FUNCTION: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269\|PubMed:17920587}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000343067

615_713

545.3333333333334

1892.3333333333333

Region

Note=Spectrin--actin-binding

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000343067

714_864

545.3333333333334

1892.3333333333333

Region

Note=C-terminal (CTD)

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000347529

615_713

510.3333333333333

861.6666666666666

Region

Note=Spectrin--actin-binding

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000347529

714_864

510.3333333333333

861.6666666666666

Region

Note=C-terminal (CTD)

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000349460

494_614

336.3333333333333

711.6666666666666

Region

Note=Hydrophilic

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000349460

615_713

336.3333333333333

711.6666666666666

Region

Note=Spectrin--actin-binding

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000349460

714_864

336.3333333333333

711.6666666666666

Region

Note=C-terminal (CTD)

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000356093

615_713

545.3333333333334

1859.3333333333333

Region

Note=Spectrin--actin-binding

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000356093

714_864

545.3333333333334

1859.3333333333333

Region

Note=C-terminal (CTD)

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000373797

615_713

545.3333333333334

721.0

Region

Note=Spectrin--actin-binding

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000373797

714_864

545.3333333333334

721.0

Region

Note=C-terminal (CTD)

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000373798

615_713

545.3333333333334

1907.0

Region

Note=Spectrin--actin-binding

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000373798

714_864

545.3333333333334

1907.0

Region

Note=C-terminal (CTD)

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000373800

494_614

336.3333333333333

658.6666666666666

Region

Note=Hydrophilic

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000373800

615_713

336.3333333333333

658.6666666666666

Region

Note=Spectrin--actin-binding

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000373800

714_864

336.3333333333333

658.6666666666666

Region

Note=C-terminal (CTD)

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000343067

210_491

545.3333333333334

1892.3333333333333

Domain

FERM

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000347529

210_491

510.3333333333333

861.6666666666666

Domain

FERM

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000349460

210_491

336.3333333333333

711.6666666666666

Domain

FERM

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000356093

210_491

545.3333333333334

1859.3333333333333

Domain

FERM

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000373797

210_491

545.3333333333334

721.0

Domain

FERM

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000373798

210_491

545.3333333333334

1907.0

Domain

FERM

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000373800

210_491

336.3333333333333

658.6666666666666

Domain

FERM

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000343067

494_614

545.3333333333334

1892.3333333333333

Region

Note=Hydrophilic

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000347529

494_614

510.3333333333333

861.6666666666666

Region

Note=Hydrophilic

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000356093

494_614

545.3333333333334

1859.3333333333333

Region

Note=Hydrophilic

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000373797

494_614

545.3333333333334

721.0

Region

Note=Hydrophilic

Tgene

EPB41

chr11:93480614

chr1:29379616

ENST00000373798

494_614

545.3333333333334

1907.0

Region

Note=Hydrophilic

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
C11orf54
EPB41

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to C11orf54-EPB41

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to C11orf54-EPB41

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source