UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:C15orf40-HOMER2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: C15orf40-HOMER2
	FusionPDB ID: 10945
	FusionGDB2.0 ID: 10945
		Hgene	Tgene
	Gene symbol	C15orf40	HOMER2
	Gene ID	123207	9455
	Gene name	chromosome 15 open reading frame 40	homer scaffold protein 2
	Synonyms	-	ACPD\|CPD\|DFNA68\|HOMER-2\|VESL-2
	Cytomap	15q25.2	15q25.2
	Type of gene	protein-coding	protein-coding
	Description	UPF0235 protein C15orf40	homer protein homolog 2cupidinhomer homolog 2homer homolog 3homer scaffolding protein 2homer, neuronal immediate early gene, 2
	Modification date	20200313	20200313
	UniProtAcc	Q8WUR7	Q9NSB8
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000304177, ENST00000451195, ENST00000513601, ENST00000538348, ENST00000565712,	ENST00000500334, ENST00000304231, ENST00000399166, ENST00000426485, ENST00000450735,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 3 X 3=27	8 X 6 X 3=144
	# samples	3	8
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: C15orf40 [Title/Abstract] AND HOMER2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	C15orf40(83677300)-HOMER2(83544156), # samples:1
Anticipated loss of major functional domain due to fusion event.	C15orf40-HOMER2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. C15orf40-HOMER2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across C15orf40 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HOMER2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A0D1-01A	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000538348	C15orf40	chr15	83677300	-	ENST00000450735	HOMER2	chr15	83544156	-	1968	366	0	1235	411
ENST00000538348	C15orf40	chr15	83677300	-	ENST00000304231	HOMER2	chr15	83544156	-	2001	366	0	1268	422
ENST00000538348	C15orf40	chr15	83677300	-	ENST00000399166	HOMER2	chr15	83544156	-	1800	366	0	1070	356
ENST00000538348	C15orf40	chr15	83677300	-	ENST00000426485	HOMER2	chr15	83544156	-	1833	366	0	1103	367
ENST00000451195	C15orf40	chr15	83677300	-	ENST00000450735	HOMER2	chr15	83544156	-	1968	366	0	1235	411
ENST00000451195	C15orf40	chr15	83677300	-	ENST00000304231	HOMER2	chr15	83544156	-	2001	366	0	1268	422
ENST00000451195	C15orf40	chr15	83677300	-	ENST00000399166	HOMER2	chr15	83544156	-	1800	366	0	1070	356
ENST00000451195	C15orf40	chr15	83677300	-	ENST00000426485	HOMER2	chr15	83544156	-	1833	366	0	1103	367
ENST00000304177	C15orf40	chr15	83677300	-	ENST00000450735	HOMER2	chr15	83544156	-	2002	400	34	1269	411
ENST00000304177	C15orf40	chr15	83677300	-	ENST00000304231	HOMER2	chr15	83544156	-	2035	400	34	1302	422
ENST00000304177	C15orf40	chr15	83677300	-	ENST00000399166	HOMER2	chr15	83544156	-	1834	400	34	1104	356
ENST00000304177	C15orf40	chr15	83677300	-	ENST00000426485	HOMER2	chr15	83544156	-	1867	400	34	1137	367
ENST00000513601	C15orf40	chr15	83677300	-	ENST00000450735	HOMER2	chr15	83544156	-	1976	374	8	1243	411
ENST00000513601	C15orf40	chr15	83677300	-	ENST00000304231	HOMER2	chr15	83544156	-	2009	374	8	1276	422
ENST00000513601	C15orf40	chr15	83677300	-	ENST00000399166	HOMER2	chr15	83544156	-	1808	374	8	1078	356
ENST00000513601	C15orf40	chr15	83677300	-	ENST00000426485	HOMER2	chr15	83544156	-	1841	374	8	1111	367

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000538348	ENST00000450735	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.009241383	0.99075866
ENST00000538348	ENST00000304231	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.010742573	0.9892574
ENST00000538348	ENST00000399166	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.005251196	0.9947488
ENST00000538348	ENST00000426485	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.006258701	0.99374133
ENST00000451195	ENST00000450735	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.009241383	0.99075866
ENST00000451195	ENST00000304231	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.010742573	0.9892574
ENST00000451195	ENST00000399166	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.005251196	0.9947488
ENST00000451195	ENST00000426485	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.006258701	0.99374133
ENST00000304177	ENST00000450735	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.009127802	0.9908722
ENST00000304177	ENST00000304231	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.010750253	0.9892497
ENST00000304177	ENST00000399166	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.005195307	0.9948047
ENST00000304177	ENST00000426485	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.006193148	0.99380684
ENST00000513601	ENST00000450735	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.009475719	0.99052435
ENST00000513601	ENST00000304231	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.011022197	0.98897785
ENST00000513601	ENST00000399166	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.005301824	0.99469817
ENST00000513601	ENST00000426485	C15orf40	chr15	83677300	-	HOMER2	chr15	83544156	-	0.00637046	0.9936295

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>10945_10945_1_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000304177_HOMER2_chr15_83544156_ENST00000304231_length(amino acids)=422AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQ
ESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLE

--------------------------------------------------------------

>10945_10945_2_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000304177_HOMER2_chr15_83544156_ENST00000399166_length(amino acids)=356AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELK

--------------------------------------------------------------

>10945_10945_3_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000304177_HOMER2_chr15_83544156_ENST00000426485_length(amino acids)=367AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELE
AELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGL

--------------------------------------------------------------

>10945_10945_4_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000304177_HOMER2_chr15_83544156_ENST00000450735_length(amino acids)=411AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKR
QFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLED

--------------------------------------------------------------

>10945_10945_5_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000451195_HOMER2_chr15_83544156_ENST00000304231_length(amino acids)=422AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQ
ESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLE

--------------------------------------------------------------

>10945_10945_6_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000451195_HOMER2_chr15_83544156_ENST00000399166_length(amino acids)=356AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELK

--------------------------------------------------------------

>10945_10945_7_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000451195_HOMER2_chr15_83544156_ENST00000426485_length(amino acids)=367AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELE
AELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGL

--------------------------------------------------------------

>10945_10945_8_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000451195_HOMER2_chr15_83544156_ENST00000450735_length(amino acids)=411AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKR
QFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLED

--------------------------------------------------------------

>10945_10945_9_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000513601_HOMER2_chr15_83544156_ENST00000304231_length(amino acids)=422AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQ
ESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLE

--------------------------------------------------------------

>10945_10945_10_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000513601_HOMER2_chr15_83544156_ENST00000399166_length(amino acids)=356AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELK

--------------------------------------------------------------

>10945_10945_11_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000513601_HOMER2_chr15_83544156_ENST00000426485_length(amino acids)=367AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELE
AELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGL

--------------------------------------------------------------

>10945_10945_12_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000513601_HOMER2_chr15_83544156_ENST00000450735_length(amino acids)=411AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKR
QFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLED

--------------------------------------------------------------

>10945_10945_13_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000538348_HOMER2_chr15_83544156_ENST00000304231_length(amino acids)=422AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQ
ESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLE

--------------------------------------------------------------

>10945_10945_14_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000538348_HOMER2_chr15_83544156_ENST00000399166_length(amino acids)=356AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELK

--------------------------------------------------------------

>10945_10945_15_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000538348_HOMER2_chr15_83544156_ENST00000426485_length(amino acids)=367AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELE
AELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGL

--------------------------------------------------------------

>10945_10945_16_C15orf40-HOMER2_C15orf40_chr15_83677300_ENST00000538348_HOMER2_chr15_83544156_ENST00000450735_length(amino acids)=411AA_BP=0
MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAI
AAPPSEGEANAELCRYLSKVLELRKSDVVLDKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKI
AKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKR
QFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLED

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:83677300/chr15:83544156)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
C15orf40 Q8WUR7	HOMER2 Q9NSB8
	FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269\|PubMed:18218901, ECO:0000269\|PubMed:25816005, ECO:0000269\|PubMed:9808459}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

HOMER2

chr15:83677300

chr15:83544156

ENST00000304231

160_329

54.0

355.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HOMER2

chr15:83677300

chr15:83544156

ENST00000304231

92_122

54.0

355.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HOMER2

chr15:83677300

chr15:83544156

ENST00000450735

160_329

54.0

344.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HOMER2

chr15:83677300

chr15:83544156

ENST00000450735

92_122

54.0

344.0

Coiled coil

Ontology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

HOMER2

chr15:83677300

chr15:83544156

ENST00000304231

1_110

54.0

355.0

Domain

WH1

Tgene

HOMER2

chr15:83677300

chr15:83544156

ENST00000450735

1_110

54.0

344.0

Domain

WH1

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
C15orf40
HOMER2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to C15orf40-HOMER2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to C15orf40-HOMER2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source