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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:C9orf3-TNC

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: C9orf3-TNC
FusionPDB ID: 12130
FusionGDB2.0 ID: 12130
HgeneTgene
Gene symbol

C9orf3

TNC

Gene ID

84909

7134

Gene nameaminopeptidase O (putative)troponin C1, slow skeletal and cardiac type
SynonymsAP-O|APO|C90RF3|C9orf3|ONPEPCMD1Z|CMH13|TN-C|TNC|TNNC
Cytomap

9q22.32

3p21.1

Type of geneprotein-codingprotein-coding
Descriptionaminopeptidase Otroponin C, slow skeletal and cardiac musclescardiac troponin Cslow twitch skeletal/cardiac muscle troponin Ctroponin C type 1 (slow)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000297979, ENST00000375315, 
ENST00000425634, ENST00000433691, 
ENST00000277198, ENST00000395357, 
ENST00000473778, 		ENST00000481475, 
ENST00000340094, ENST00000341037, 
ENST00000345230, ENST00000346706, 
ENST00000350763, ENST00000423613, 
ENST00000535648, ENST00000537320, 
ENST00000542877, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 15 X 11=28058 X 8 X 4=256
# samples 2111
** MAII scorelog2(21/2805*10)=-3.73953953783003
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/256*10)=-1.21864028647534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: C9orf3 [Title/Abstract] AND TNC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)C9orf3(97767898)-TNC(117793964), # samples:1
Anticipated loss of major functional domain due to fusion event.C9orf3-TNC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C9orf3-TNC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C9orf3-TNC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C9orf3-TNC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNC

GO:0006937

regulation of muscle contraction

18092822

TgeneTNC

GO:0060048

cardiac muscle contraction

25771144


check buttonFusion gene breakpoints across C9orf3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TNC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0725-01AC9orf3chr9

97767898

+TNCchr9

117793964

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000297979C9orf3chr997767898+ENST00000535648TNCchr9117793964-344219931752811878
ENST00000297979C9orf3chr997767898+ENST00000346706TNCchr9117793964-344219931752811878
ENST00000297979C9orf3chr997767898+ENST00000340094TNCchr9117793964-344219931752811878
ENST00000297979C9orf3chr997767898+ENST00000345230TNCchr9117793964-344219931752811878
ENST00000297979C9orf3chr997767898+ENST00000350763TNCchr9117793964-343519931752811878
ENST00000297979C9orf3chr997767898+ENST00000341037TNCchr9117793964-340919931752811878
ENST00000297979C9orf3chr997767898+ENST00000423613TNCchr9117793964-302319931752811878
ENST00000297979C9orf3chr997767898+ENST00000537320TNCchr9117793964-294019931752811878
ENST00000297979C9orf3chr997767898+ENST00000542877TNCchr9117793964-281219931752811879
ENST00000375315C9orf3chr997767898+ENST00000535648TNCchr9117793964-3564211502933977
ENST00000375315C9orf3chr997767898+ENST00000346706TNCchr9117793964-3564211502933977
ENST00000375315C9orf3chr997767898+ENST00000340094TNCchr9117793964-3564211502933977
ENST00000375315C9orf3chr997767898+ENST00000345230TNCchr9117793964-3564211502933977
ENST00000375315C9orf3chr997767898+ENST00000350763TNCchr9117793964-3557211502933977
ENST00000375315C9orf3chr997767898+ENST00000341037TNCchr9117793964-3531211502933977
ENST00000375315C9orf3chr997767898+ENST00000423613TNCchr9117793964-3145211502933977
ENST00000375315C9orf3chr997767898+ENST00000537320TNCchr9117793964-3062211502933977
ENST00000375315C9orf3chr997767898+ENST00000542877TNCchr9117793964-2934211502933977
ENST00000425634C9orf3chr997767898+ENST00000535648TNCchr9117793964-1741292851110341
ENST00000425634C9orf3chr997767898+ENST00000346706TNCchr9117793964-1741292851110341
ENST00000425634C9orf3chr997767898+ENST00000340094TNCchr9117793964-1741292851110341
ENST00000425634C9orf3chr997767898+ENST00000345230TNCchr9117793964-1741292851110341
ENST00000425634C9orf3chr997767898+ENST00000350763TNCchr9117793964-1734292851110341
ENST00000425634C9orf3chr997767898+ENST00000341037TNCchr9117793964-1708292851110341
ENST00000425634C9orf3chr997767898+ENST00000423613TNCchr9117793964-1322292851110341
ENST00000425634C9orf3chr997767898+ENST00000537320TNCchr9117793964-1239292851110341
ENST00000425634C9orf3chr997767898+ENST00000542877TNCchr9117793964-1111292851110342
ENST00000433691C9orf3chr997767898+ENST00000535648TNCchr9117793964-15871380956318
ENST00000433691C9orf3chr997767898+ENST00000346706TNCchr9117793964-15871380956318
ENST00000433691C9orf3chr997767898+ENST00000340094TNCchr9117793964-15871380956318
ENST00000433691C9orf3chr997767898+ENST00000345230TNCchr9117793964-15871380956318
ENST00000433691C9orf3chr997767898+ENST00000350763TNCchr9117793964-15801380956318
ENST00000433691C9orf3chr997767898+ENST00000341037TNCchr9117793964-15541380956318
ENST00000433691C9orf3chr997767898+ENST00000423613TNCchr9117793964-11681380956318
ENST00000433691C9orf3chr997767898+ENST00000537320TNCchr9117793964-10851380956318
ENST00000433691C9orf3chr997767898+ENST00000542877TNCchr9117793964-9571380956318

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000297979ENST00000535648C9orf3chr997767898+TNCchr9117793964-0.0008089280.9991911
ENST00000297979ENST00000346706C9orf3chr997767898+TNCchr9117793964-0.0008089280.9991911
ENST00000297979ENST00000340094C9orf3chr997767898+TNCchr9117793964-0.0008089280.9991911
ENST00000297979ENST00000345230C9orf3chr997767898+TNCchr9117793964-0.0008089280.9991911
ENST00000297979ENST00000350763C9orf3chr997767898+TNCchr9117793964-0.0008238120.9991762
ENST00000297979ENST00000341037C9orf3chr997767898+TNCchr9117793964-0.0008662510.99913377
ENST00000297979ENST00000423613C9orf3chr997767898+TNCchr9117793964-0.001363290.99863666
ENST00000297979ENST00000537320C9orf3chr997767898+TNCchr9117793964-0.0012982450.9987017
ENST00000297979ENST00000542877C9orf3chr997767898+TNCchr9117793964-0.0014918530.99850816
ENST00000375315ENST00000535648C9orf3chr997767898+TNCchr9117793964-0.00052030.9994797
ENST00000375315ENST00000346706C9orf3chr997767898+TNCchr9117793964-0.00052030.9994797
ENST00000375315ENST00000340094C9orf3chr997767898+TNCchr9117793964-0.00052030.9994797
ENST00000375315ENST00000345230C9orf3chr997767898+TNCchr9117793964-0.00052030.9994797
ENST00000375315ENST00000350763C9orf3chr997767898+TNCchr9117793964-0.0005325640.99946743
ENST00000375315ENST00000341037C9orf3chr997767898+TNCchr9117793964-0.0005688690.9994311
ENST00000375315ENST00000423613C9orf3chr997767898+TNCchr9117793964-0.000999030.99900097
ENST00000375315ENST00000537320C9orf3chr997767898+TNCchr9117793964-0.0009347030.99906534
ENST00000375315ENST00000542877C9orf3chr997767898+TNCchr9117793964-0.001119950.9988801
ENST00000425634ENST00000535648C9orf3chr997767898+TNCchr9117793964-0.0013089620.998691
ENST00000425634ENST00000346706C9orf3chr997767898+TNCchr9117793964-0.0013089620.998691
ENST00000425634ENST00000340094C9orf3chr997767898+TNCchr9117793964-0.0013089620.998691
ENST00000425634ENST00000345230C9orf3chr997767898+TNCchr9117793964-0.0013089620.998691
ENST00000425634ENST00000350763C9orf3chr997767898+TNCchr9117793964-0.0013255050.9986745
ENST00000425634ENST00000341037C9orf3chr997767898+TNCchr9117793964-0.0014295790.99857044
ENST00000425634ENST00000423613C9orf3chr997767898+TNCchr9117793964-0.0045963660.99540365
ENST00000425634ENST00000537320C9orf3chr997767898+TNCchr9117793964-0.0045217070.99547833
ENST00000425634ENST00000542877C9orf3chr997767898+TNCchr9117793964-0.0047570810.9952429
ENST00000433691ENST00000535648C9orf3chr997767898+TNCchr9117793964-0.000917590.99908245
ENST00000433691ENST00000346706C9orf3chr997767898+TNCchr9117793964-0.000917590.99908245
ENST00000433691ENST00000340094C9orf3chr997767898+TNCchr9117793964-0.000917590.99908245
ENST00000433691ENST00000345230C9orf3chr997767898+TNCchr9117793964-0.000917590.99908245
ENST00000433691ENST00000350763C9orf3chr997767898+TNCchr9117793964-0.0009366350.99906343
ENST00000433691ENST00000341037C9orf3chr997767898+TNCchr9117793964-0.0010032640.9989968
ENST00000433691ENST00000423613C9orf3chr997767898+TNCchr9117793964-0.0034664320.9965335
ENST00000433691ENST00000537320C9orf3chr997767898+TNCchr9117793964-0.0034507070.99654925
ENST00000433691ENST00000542877C9orf3chr997767898+TNCchr9117793964-0.0028406950.99715936

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>12130_12130_1_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000297979_TNC_chr9_117793964_ENST00000340094_length(amino acids)=878AA_BP=606
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMARPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKR
LELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTA
KIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAY
AAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAI

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>12130_12130_2_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000297979_TNC_chr9_117793964_ENST00000341037_length(amino acids)=878AA_BP=606
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMARPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKR
LELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTA
KIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAY
AAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAI

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>12130_12130_3_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000297979_TNC_chr9_117793964_ENST00000345230_length(amino acids)=878AA_BP=606
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMARPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKR
LELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTA
KIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAY
AAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAI

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>12130_12130_4_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000297979_TNC_chr9_117793964_ENST00000346706_length(amino acids)=878AA_BP=606
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMARPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKR
LELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTA
KIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAY
AAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAI

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>12130_12130_5_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000297979_TNC_chr9_117793964_ENST00000350763_length(amino acids)=878AA_BP=606
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMARPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKR
LELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTA
KIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAY
AAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAI

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>12130_12130_6_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000297979_TNC_chr9_117793964_ENST00000423613_length(amino acids)=878AA_BP=606
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMARPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKR
LELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTA
KIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAY
AAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAI

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>12130_12130_7_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000297979_TNC_chr9_117793964_ENST00000535648_length(amino acids)=878AA_BP=606
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMARPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKR
LELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTA
KIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAY
AAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAI

--------------------------------------------------------------

>12130_12130_8_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000297979_TNC_chr9_117793964_ENST00000537320_length(amino acids)=878AA_BP=606
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMARPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKR
LELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTA
KIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAY
AAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAI

--------------------------------------------------------------

>12130_12130_9_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000297979_TNC_chr9_117793964_ENST00000542877_length(amino acids)=879AA_BP=606
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMARPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKR
LELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTA
KIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAY
AAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAI

--------------------------------------------------------------

>12130_12130_10_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000375315_TNC_chr9_117793964_ENST00000340094_length(amino acids)=977AA_BP=705
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWATAQQLAPYEAREQQELRACLRWRRLQ
DEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQML
LENIPEEKRLELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLAD
LSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRE
NFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFST

--------------------------------------------------------------

>12130_12130_11_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000375315_TNC_chr9_117793964_ENST00000341037_length(amino acids)=977AA_BP=705
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWATAQQLAPYEAREQQELRACLRWRRLQ
DEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQML
LENIPEEKRLELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLAD
LSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRE
NFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFST

--------------------------------------------------------------

>12130_12130_12_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000375315_TNC_chr9_117793964_ENST00000345230_length(amino acids)=977AA_BP=705
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWATAQQLAPYEAREQQELRACLRWRRLQ
DEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQML
LENIPEEKRLELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLAD
LSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRE
NFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFST

--------------------------------------------------------------

>12130_12130_13_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000375315_TNC_chr9_117793964_ENST00000346706_length(amino acids)=977AA_BP=705
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWATAQQLAPYEAREQQELRACLRWRRLQ
DEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQML
LENIPEEKRLELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLAD
LSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRE
NFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFST

--------------------------------------------------------------

>12130_12130_14_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000375315_TNC_chr9_117793964_ENST00000350763_length(amino acids)=977AA_BP=705
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWATAQQLAPYEAREQQELRACLRWRRLQ
DEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQML
LENIPEEKRLELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLAD
LSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRE
NFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFST

--------------------------------------------------------------

>12130_12130_15_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000375315_TNC_chr9_117793964_ENST00000423613_length(amino acids)=977AA_BP=705
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWATAQQLAPYEAREQQELRACLRWRRLQ
DEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQML
LENIPEEKRLELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLAD
LSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRE
NFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFST

--------------------------------------------------------------

>12130_12130_16_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000375315_TNC_chr9_117793964_ENST00000535648_length(amino acids)=977AA_BP=705
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWATAQQLAPYEAREQQELRACLRWRRLQ
DEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQML
LENIPEEKRLELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLAD
LSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRE
NFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFST

--------------------------------------------------------------

>12130_12130_17_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000375315_TNC_chr9_117793964_ENST00000537320_length(amino acids)=977AA_BP=705
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWATAQQLAPYEAREQQELRACLRWRRLQ
DEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQML
LENIPEEKRLELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLAD
LSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRE
NFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFST

--------------------------------------------------------------

>12130_12130_18_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000375315_TNC_chr9_117793964_ENST00000542877_length(amino acids)=977AA_BP=705
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTF
SSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVY
TVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPS
LGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWATAQQLAPYEAREQQELRACLRWRRLQ
DEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQML
LENIPEEKRLELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLAD
LSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRE
NFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFST

--------------------------------------------------------------

>12130_12130_19_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000425634_TNC_chr9_117793964_ENST00000340094_length(amino acids)=341AA_BP=69
MLMRMRRPLAGGGKSWGIAHFYKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTH
YTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNW
KAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTD

--------------------------------------------------------------

>12130_12130_20_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000425634_TNC_chr9_117793964_ENST00000341037_length(amino acids)=341AA_BP=69
MLMRMRRPLAGGGKSWGIAHFYKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTH
YTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNW
KAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTD

--------------------------------------------------------------

>12130_12130_21_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000425634_TNC_chr9_117793964_ENST00000345230_length(amino acids)=341AA_BP=69
MLMRMRRPLAGGGKSWGIAHFYKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTH
YTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNW
KAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTD

--------------------------------------------------------------

>12130_12130_22_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000425634_TNC_chr9_117793964_ENST00000346706_length(amino acids)=341AA_BP=69
MLMRMRRPLAGGGKSWGIAHFYKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTH
YTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNW
KAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTD

--------------------------------------------------------------

>12130_12130_23_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000425634_TNC_chr9_117793964_ENST00000350763_length(amino acids)=341AA_BP=69
MLMRMRRPLAGGGKSWGIAHFYKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTH
YTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNW
KAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTD

--------------------------------------------------------------

>12130_12130_24_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000425634_TNC_chr9_117793964_ENST00000423613_length(amino acids)=341AA_BP=69
MLMRMRRPLAGGGKSWGIAHFYKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTH
YTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNW
KAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTD

--------------------------------------------------------------

>12130_12130_25_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000425634_TNC_chr9_117793964_ENST00000535648_length(amino acids)=341AA_BP=69
MLMRMRRPLAGGGKSWGIAHFYKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTH
YTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNW
KAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTD

--------------------------------------------------------------

>12130_12130_26_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000425634_TNC_chr9_117793964_ENST00000537320_length(amino acids)=341AA_BP=69
MLMRMRRPLAGGGKSWGIAHFYKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTH
YTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNW
KAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTD

--------------------------------------------------------------

>12130_12130_27_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000425634_TNC_chr9_117793964_ENST00000542877_length(amino acids)=342AA_BP=69
MLMRMRRPLAGGGKSWGIAHFYKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTH
YTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNW
KAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTD

--------------------------------------------------------------

>12130_12130_28_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000433691_TNC_chr9_117793964_ENST00000340094_length(amino acids)=318AA_BP=46
MRMRRPLAGGGKSWGIAHFYKVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTT
IGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNK
ITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVN

--------------------------------------------------------------

>12130_12130_29_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000433691_TNC_chr9_117793964_ENST00000341037_length(amino acids)=318AA_BP=46
MRMRRPLAGGGKSWGIAHFYKVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTT
IGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNK
ITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVN

--------------------------------------------------------------

>12130_12130_30_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000433691_TNC_chr9_117793964_ENST00000345230_length(amino acids)=318AA_BP=46
MRMRRPLAGGGKSWGIAHFYKVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTT
IGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNK
ITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVN

--------------------------------------------------------------

>12130_12130_31_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000433691_TNC_chr9_117793964_ENST00000346706_length(amino acids)=318AA_BP=46
MRMRRPLAGGGKSWGIAHFYKVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTT
IGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNK
ITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVN

--------------------------------------------------------------

>12130_12130_32_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000433691_TNC_chr9_117793964_ENST00000350763_length(amino acids)=318AA_BP=46
MRMRRPLAGGGKSWGIAHFYKVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTT
IGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNK
ITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVN

--------------------------------------------------------------

>12130_12130_33_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000433691_TNC_chr9_117793964_ENST00000423613_length(amino acids)=318AA_BP=46
MRMRRPLAGGGKSWGIAHFYKVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTT
IGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNK
ITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVN

--------------------------------------------------------------

>12130_12130_34_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000433691_TNC_chr9_117793964_ENST00000535648_length(amino acids)=318AA_BP=46
MRMRRPLAGGGKSWGIAHFYKVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTT
IGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNK
ITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVN

--------------------------------------------------------------

>12130_12130_35_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000433691_TNC_chr9_117793964_ENST00000537320_length(amino acids)=318AA_BP=46
MRMRRPLAGGGKSWGIAHFYKVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTT
IGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNK
ITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVN

--------------------------------------------------------------

>12130_12130_36_C9orf3-TNC_C9orf3_chr9_97767898_ENST00000433691_TNC_chr9_117793964_ENST00000542877_length(amino acids)=318AA_BP=46
MRMRRPLAGGGKSWGIAHFYKVTKWIGVNRRPRKRKRREKEEVFEKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTT
IGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNK
ITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVN

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:97767898/chr9:117793964)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC9orf3chr9:97767898chr9:117793964ENST00000375315+1216689_699705.0713.3333333333334MotifNucleolar localization signal
TgeneTNCchr9:97767898chr9:117793964ENST0000034009417241622_17111565.01838.0DomainFibronectin type-III 12
TgeneTNCchr9:97767898chr9:117793964ENST0000034009417241712_18011565.01838.0DomainFibronectin type-III 13
TgeneTNCchr9:97767898chr9:117793964ENST0000034009417241802_18881565.01838.0DomainFibronectin type-III 14
TgeneTNCchr9:97767898chr9:117793964ENST0000034009417241889_19771565.01838.0DomainFibronectin type-III 15
TgeneTNCchr9:97767898chr9:117793964ENST0000034009417241975_21901565.01838.0DomainFibrinogen C-terminal
TgeneTNCchr9:97767898chr9:117793964ENST0000034523014211351_14391292.01565.0DomainFibronectin type-III 9
TgeneTNCchr9:97767898chr9:117793964ENST0000034523014211440_15311292.01565.0DomainFibronectin type-III 10
TgeneTNCchr9:97767898chr9:117793964ENST0000034523014211533_16211292.01565.0DomainFibronectin type-III 11
TgeneTNCchr9:97767898chr9:117793964ENST0000034523014211622_17111292.01565.0DomainFibronectin type-III 12
TgeneTNCchr9:97767898chr9:117793964ENST0000034523014211712_18011292.01565.0DomainFibronectin type-III 13
TgeneTNCchr9:97767898chr9:117793964ENST0000034523014211802_18881292.01565.0DomainFibronectin type-III 14
TgeneTNCchr9:97767898chr9:117793964ENST0000034523014211889_19771292.01565.0DomainFibronectin type-III 15
TgeneTNCchr9:97767898chr9:117793964ENST0000034523014211975_21901292.01565.0DomainFibrinogen C-terminal
TgeneTNCchr9:97767898chr9:117793964ENST0000034670615221440_15311383.01656.0DomainFibronectin type-III 10
TgeneTNCchr9:97767898chr9:117793964ENST0000034670615221533_16211383.01656.0DomainFibronectin type-III 11
TgeneTNCchr9:97767898chr9:117793964ENST0000034670615221622_17111383.01656.0DomainFibronectin type-III 12
TgeneTNCchr9:97767898chr9:117793964ENST0000034670615221712_18011383.01656.0DomainFibronectin type-III 13
TgeneTNCchr9:97767898chr9:117793964ENST0000034670615221802_18881383.01656.0DomainFibronectin type-III 14
TgeneTNCchr9:97767898chr9:117793964ENST0000034670615221889_19771383.01656.0DomainFibronectin type-III 15
TgeneTNCchr9:97767898chr9:117793964ENST0000034670615221975_21901383.01656.0DomainFibrinogen C-terminal
TgeneTNCchr9:97767898chr9:117793964ENST0000035076321281975_21901929.02202.0DomainFibrinogen C-terminal
TgeneTNCchr9:97767898chr9:117793964ENST0000053564816231533_16211474.01747.0DomainFibronectin type-III 11
TgeneTNCchr9:97767898chr9:117793964ENST0000053564816231622_17111474.01747.0DomainFibronectin type-III 12
TgeneTNCchr9:97767898chr9:117793964ENST0000053564816231712_18011474.01747.0DomainFibronectin type-III 13
TgeneTNCchr9:97767898chr9:117793964ENST0000053564816231802_18881474.01747.0DomainFibronectin type-III 14
TgeneTNCchr9:97767898chr9:117793964ENST0000053564816231889_19771474.01747.0DomainFibronectin type-III 15
TgeneTNCchr9:97767898chr9:117793964ENST0000053564816231975_21901474.01747.0DomainFibrinogen C-terminal
TgeneTNCchr9:97767898chr9:117793964ENST0000053732013201351_14391292.01565.0DomainFibronectin type-III 9
TgeneTNCchr9:97767898chr9:117793964ENST0000053732013201440_15311292.01565.0DomainFibronectin type-III 10
TgeneTNCchr9:97767898chr9:117793964ENST0000053732013201533_16211292.01565.0DomainFibronectin type-III 11
TgeneTNCchr9:97767898chr9:117793964ENST0000053732013201622_17111292.01565.0DomainFibronectin type-III 12
TgeneTNCchr9:97767898chr9:117793964ENST0000053732013201712_18011292.01565.0DomainFibronectin type-III 13
TgeneTNCchr9:97767898chr9:117793964ENST0000053732013201802_18881292.01565.0DomainFibronectin type-III 14
TgeneTNCchr9:97767898chr9:117793964ENST0000053732013201889_19771292.01565.0DomainFibronectin type-III 15
TgeneTNCchr9:97767898chr9:117793964ENST0000053732013201975_21901292.01565.0DomainFibrinogen C-terminal

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC9orf3chr9:97767898chr9:117793964ENST00000277198+18689_6990567.0MotifNucleolar localization signal
HgeneC9orf3chr9:97767898chr9:117793964ENST00000297979+1115689_699606.0867.0MotifNucleolar localization signal
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724118_1451565.01838.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421118_1451292.01565.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522118_1451383.01656.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128118_1451929.02202.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623118_1451474.01747.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320118_1451292.01565.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr9:97767898chr9:117793964ENST0000034009417241076_11651565.01838.0DomainFibronectin type-III 6
TgeneTNCchr9:97767898chr9:117793964ENST0000034009417241167_12561565.01838.0DomainFibronectin type-III 7
TgeneTNCchr9:97767898chr9:117793964ENST0000034009417241258_13501565.01838.0DomainFibronectin type-III 8
TgeneTNCchr9:97767898chr9:117793964ENST0000034009417241351_14391565.01838.0DomainFibronectin type-III 9
TgeneTNCchr9:97767898chr9:117793964ENST0000034009417241440_15311565.01838.0DomainFibronectin type-III 10
TgeneTNCchr9:97767898chr9:117793964ENST0000034009417241533_16211565.01838.0DomainFibronectin type-III 11
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724174_1861565.01838.0DomainEGF-like 1%3B incomplete
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724186_2171565.01838.0DomainEGF-like 2
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724217_2481565.01838.0DomainEGF-like 3
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724248_2801565.01838.0DomainEGF-like 4
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724280_3111565.01838.0DomainEGF-like 5
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724311_3421565.01838.0DomainEGF-like 6
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724342_3731565.01838.0DomainEGF-like 7
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724373_4041565.01838.0DomainEGF-like 8
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724404_4351565.01838.0DomainEGF-like 9
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724435_4661565.01838.0DomainEGF-like 10
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724466_4971565.01838.0DomainEGF-like 11
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724497_5281565.01838.0DomainEGF-like 12
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724528_5591565.01838.0DomainEGF-like 13
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724559_5901565.01838.0DomainEGF-like 14
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724590_6211565.01838.0DomainEGF-like 15
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724625_7151565.01838.0DomainFibronectin type-III 1
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724716_8041565.01838.0DomainFibronectin type-III 2
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724805_8941565.01838.0DomainFibronectin type-III 3
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724895_9901565.01838.0DomainFibronectin type-III 4
TgeneTNCchr9:97767898chr9:117793964ENST000003400941724991_10751565.01838.0DomainFibronectin type-III 5
TgeneTNCchr9:97767898chr9:117793964ENST0000034523014211076_11651292.01565.0DomainFibronectin type-III 6
TgeneTNCchr9:97767898chr9:117793964ENST0000034523014211167_12561292.01565.0DomainFibronectin type-III 7
TgeneTNCchr9:97767898chr9:117793964ENST0000034523014211258_13501292.01565.0DomainFibronectin type-III 8
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421174_1861292.01565.0DomainEGF-like 1%3B incomplete
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421186_2171292.01565.0DomainEGF-like 2
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421217_2481292.01565.0DomainEGF-like 3
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421248_2801292.01565.0DomainEGF-like 4
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421280_3111292.01565.0DomainEGF-like 5
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421311_3421292.01565.0DomainEGF-like 6
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421342_3731292.01565.0DomainEGF-like 7
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421373_4041292.01565.0DomainEGF-like 8
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421404_4351292.01565.0DomainEGF-like 9
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421435_4661292.01565.0DomainEGF-like 10
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421466_4971292.01565.0DomainEGF-like 11
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421497_5281292.01565.0DomainEGF-like 12
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421528_5591292.01565.0DomainEGF-like 13
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421559_5901292.01565.0DomainEGF-like 14
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421590_6211292.01565.0DomainEGF-like 15
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421625_7151292.01565.0DomainFibronectin type-III 1
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421716_8041292.01565.0DomainFibronectin type-III 2
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421805_8941292.01565.0DomainFibronectin type-III 3
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421895_9901292.01565.0DomainFibronectin type-III 4
TgeneTNCchr9:97767898chr9:117793964ENST000003452301421991_10751292.01565.0DomainFibronectin type-III 5
TgeneTNCchr9:97767898chr9:117793964ENST0000034670615221076_11651383.01656.0DomainFibronectin type-III 6
TgeneTNCchr9:97767898chr9:117793964ENST0000034670615221167_12561383.01656.0DomainFibronectin type-III 7
TgeneTNCchr9:97767898chr9:117793964ENST0000034670615221258_13501383.01656.0DomainFibronectin type-III 8
TgeneTNCchr9:97767898chr9:117793964ENST0000034670615221351_14391383.01656.0DomainFibronectin type-III 9
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522174_1861383.01656.0DomainEGF-like 1%3B incomplete
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522186_2171383.01656.0DomainEGF-like 2
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522217_2481383.01656.0DomainEGF-like 3
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522248_2801383.01656.0DomainEGF-like 4
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522280_3111383.01656.0DomainEGF-like 5
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522311_3421383.01656.0DomainEGF-like 6
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522342_3731383.01656.0DomainEGF-like 7
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522373_4041383.01656.0DomainEGF-like 8
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522404_4351383.01656.0DomainEGF-like 9
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522435_4661383.01656.0DomainEGF-like 10
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522466_4971383.01656.0DomainEGF-like 11
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522497_5281383.01656.0DomainEGF-like 12
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522528_5591383.01656.0DomainEGF-like 13
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522559_5901383.01656.0DomainEGF-like 14
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522590_6211383.01656.0DomainEGF-like 15
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522625_7151383.01656.0DomainFibronectin type-III 1
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522716_8041383.01656.0DomainFibronectin type-III 2
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522805_8941383.01656.0DomainFibronectin type-III 3
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522895_9901383.01656.0DomainFibronectin type-III 4
TgeneTNCchr9:97767898chr9:117793964ENST000003467061522991_10751383.01656.0DomainFibronectin type-III 5
TgeneTNCchr9:97767898chr9:117793964ENST0000035076321281076_11651929.02202.0DomainFibronectin type-III 6
TgeneTNCchr9:97767898chr9:117793964ENST0000035076321281167_12561929.02202.0DomainFibronectin type-III 7
TgeneTNCchr9:97767898chr9:117793964ENST0000035076321281258_13501929.02202.0DomainFibronectin type-III 8
TgeneTNCchr9:97767898chr9:117793964ENST0000035076321281351_14391929.02202.0DomainFibronectin type-III 9
TgeneTNCchr9:97767898chr9:117793964ENST0000035076321281440_15311929.02202.0DomainFibronectin type-III 10
TgeneTNCchr9:97767898chr9:117793964ENST0000035076321281533_16211929.02202.0DomainFibronectin type-III 11
TgeneTNCchr9:97767898chr9:117793964ENST0000035076321281622_17111929.02202.0DomainFibronectin type-III 12
TgeneTNCchr9:97767898chr9:117793964ENST0000035076321281712_18011929.02202.0DomainFibronectin type-III 13
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128174_1861929.02202.0DomainEGF-like 1%3B incomplete
TgeneTNCchr9:97767898chr9:117793964ENST0000035076321281802_18881929.02202.0DomainFibronectin type-III 14
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128186_2171929.02202.0DomainEGF-like 2
TgeneTNCchr9:97767898chr9:117793964ENST0000035076321281889_19771929.02202.0DomainFibronectin type-III 15
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128217_2481929.02202.0DomainEGF-like 3
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128248_2801929.02202.0DomainEGF-like 4
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128280_3111929.02202.0DomainEGF-like 5
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128311_3421929.02202.0DomainEGF-like 6
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128342_3731929.02202.0DomainEGF-like 7
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128373_4041929.02202.0DomainEGF-like 8
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128404_4351929.02202.0DomainEGF-like 9
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128435_4661929.02202.0DomainEGF-like 10
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128466_4971929.02202.0DomainEGF-like 11
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128497_5281929.02202.0DomainEGF-like 12
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128528_5591929.02202.0DomainEGF-like 13
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128559_5901929.02202.0DomainEGF-like 14
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128590_6211929.02202.0DomainEGF-like 15
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128625_7151929.02202.0DomainFibronectin type-III 1
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128716_8041929.02202.0DomainFibronectin type-III 2
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128805_8941929.02202.0DomainFibronectin type-III 3
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128895_9901929.02202.0DomainFibronectin type-III 4
TgeneTNCchr9:97767898chr9:117793964ENST000003507632128991_10751929.02202.0DomainFibronectin type-III 5
TgeneTNCchr9:97767898chr9:117793964ENST0000053564816231076_11651474.01747.0DomainFibronectin type-III 6
TgeneTNCchr9:97767898chr9:117793964ENST0000053564816231167_12561474.01747.0DomainFibronectin type-III 7
TgeneTNCchr9:97767898chr9:117793964ENST0000053564816231258_13501474.01747.0DomainFibronectin type-III 8
TgeneTNCchr9:97767898chr9:117793964ENST0000053564816231351_14391474.01747.0DomainFibronectin type-III 9
TgeneTNCchr9:97767898chr9:117793964ENST0000053564816231440_15311474.01747.0DomainFibronectin type-III 10
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623174_1861474.01747.0DomainEGF-like 1%3B incomplete
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623186_2171474.01747.0DomainEGF-like 2
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623217_2481474.01747.0DomainEGF-like 3
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623248_2801474.01747.0DomainEGF-like 4
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623280_3111474.01747.0DomainEGF-like 5
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623311_3421474.01747.0DomainEGF-like 6
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623342_3731474.01747.0DomainEGF-like 7
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623373_4041474.01747.0DomainEGF-like 8
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623404_4351474.01747.0DomainEGF-like 9
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623435_4661474.01747.0DomainEGF-like 10
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623466_4971474.01747.0DomainEGF-like 11
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623497_5281474.01747.0DomainEGF-like 12
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623528_5591474.01747.0DomainEGF-like 13
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623559_5901474.01747.0DomainEGF-like 14
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623590_6211474.01747.0DomainEGF-like 15
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623625_7151474.01747.0DomainFibronectin type-III 1
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623716_8041474.01747.0DomainFibronectin type-III 2
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623805_8941474.01747.0DomainFibronectin type-III 3
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623895_9901474.01747.0DomainFibronectin type-III 4
TgeneTNCchr9:97767898chr9:117793964ENST000005356481623991_10751474.01747.0DomainFibronectin type-III 5
TgeneTNCchr9:97767898chr9:117793964ENST0000053732013201076_11651292.01565.0DomainFibronectin type-III 6
TgeneTNCchr9:97767898chr9:117793964ENST0000053732013201167_12561292.01565.0DomainFibronectin type-III 7
TgeneTNCchr9:97767898chr9:117793964ENST0000053732013201258_13501292.01565.0DomainFibronectin type-III 8
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320174_1861292.01565.0DomainEGF-like 1%3B incomplete
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320186_2171292.01565.0DomainEGF-like 2
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320217_2481292.01565.0DomainEGF-like 3
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320248_2801292.01565.0DomainEGF-like 4
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320280_3111292.01565.0DomainEGF-like 5
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320311_3421292.01565.0DomainEGF-like 6
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320342_3731292.01565.0DomainEGF-like 7
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320373_4041292.01565.0DomainEGF-like 8
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320404_4351292.01565.0DomainEGF-like 9
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320435_4661292.01565.0DomainEGF-like 10
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320466_4971292.01565.0DomainEGF-like 11
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320497_5281292.01565.0DomainEGF-like 12
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320528_5591292.01565.0DomainEGF-like 13
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320559_5901292.01565.0DomainEGF-like 14
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320590_6211292.01565.0DomainEGF-like 15
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320625_7151292.01565.0DomainFibronectin type-III 1
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320716_8041292.01565.0DomainFibronectin type-III 2
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320805_8941292.01565.0DomainFibronectin type-III 3
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320895_9901292.01565.0DomainFibronectin type-III 4
TgeneTNCchr9:97767898chr9:117793964ENST000005373201320991_10751292.01565.0DomainFibronectin type-III 5


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
C9orf3
TNC


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to C9orf3-TNC


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to C9orf3-TNC


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource