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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ACAP2-TP63

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ACAP2-TP63
FusionPDB ID: 1225
FusionGDB2.0 ID: 1225
HgeneTgene
Gene symbol

ACAP2

TP63

Gene ID

23527

8626

Gene nameArfGAP with coiled-coil, ankyrin repeat and PH domains 2tumor protein p63
SynonymsCENTB2|CNT-B2AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L
Cytomap

3q29

3q28

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2Arf GAP with coiled coil, ANK repeat and PH domains 2centaurin-beta-2tumor protein 63amplified in squamous cell carcinomachronic ulcerative stomatitis proteinkeratinocyte transcription factor KETtransformation-related protein 63tumor protein p53-competing protein
Modification date2020031320200329
UniProtAcc

Q15057

.
Ensembl transtripts involved in fusion geneENST idsENST00000326793, ENST00000472860, 
ENST00000354600, ENST00000392461, 
ENST00000392463, ENST00000437221, 
ENST00000449992, ENST00000456148, 
ENST00000264731, ENST00000320472, 
ENST00000382063, ENST00000392460, 
ENST00000418709, ENST00000440651, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 14 X 11=246413 X 11 X 8=1144
# samples 2215
** MAII scorelog2(22/2464*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1144*10)=-2.93105264628251
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ACAP2 [Title/Abstract] AND TP63 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ACAP2(195065988)-TP63(189455529), # samples:1
Anticipated loss of major functional domain due to fusion event.ACAP2-TP63 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACAP2-TP63 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACAP2-TP63 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACAP2-TP63 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACAP2

GO:0030029

actin filament-based process

11062263

TgeneTP63

GO:0045747

positive regulation of Notch signaling pathway

11641404

TgeneTP63

GO:0045892

negative regulation of transcription, DNA-templated

12446784

TgeneTP63

GO:0045893

positive regulation of transcription, DNA-templated

12446784|16343436

TgeneTP63

GO:0045944

positive regulation of transcription by RNA polymerase II

22521434

TgeneTP63

GO:2000271

positive regulation of fibroblast apoptotic process

9774969


check buttonFusion gene breakpoints across ACAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TP63 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-GD-A2C5-11AACAP2chr3

195065988

-TP63chr3

189455529

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000326793ACAP2chr3195065988-ENST00000264731TP63chr3189455529+53335752132555780
ENST00000326793ACAP2chr3195065988-ENST00000382063TP63chr3189455529+50785752132300695
ENST00000326793ACAP2chr3195065988-ENST00000418709TP63chr3189455529+32955752131976587
ENST00000326793ACAP2chr3195065988-ENST00000320472TP63chr3189455529+25175752132045610
ENST00000326793ACAP2chr3195065988-ENST00000392460TP63chr3189455529+21815752132180655
ENST00000326793ACAP2chr3195065988-ENST00000440651TP63chr3189455529+25445752132543776

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000326793ENST00000264731ACAP2chr3195065988-TP63chr3189455529+0.0002927250.9997073
ENST00000326793ENST00000382063ACAP2chr3195065988-TP63chr3189455529+0.0003559450.99964404
ENST00000326793ENST00000418709ACAP2chr3195065988-TP63chr3189455529+0.0004043910.9995956
ENST00000326793ENST00000320472ACAP2chr3195065988-TP63chr3189455529+0.0055002680.9944997
ENST00000326793ENST00000392460ACAP2chr3195065988-TP63chr3189455529+0.0069191850.9930808
ENST00000326793ENST00000440651ACAP2chr3195065988-TP63chr3189455529+0.0069528060.9930472

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>1225_1225_1_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000264731_length(amino acids)=780AA_BP=121
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTILFDQTQRSIKAQLQNFVKDFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEP
SEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTD
YPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAP
PSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGR
DRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQ
QQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLS
MPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTP

--------------------------------------------------------------

>1225_1225_2_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000320472_length(amino acids)=610AA_BP=121
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTILFDQTQRSIKAQLQNFVKDFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEP
SEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTD
YPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAP
PSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGR
DRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQ

--------------------------------------------------------------

>1225_1225_3_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000382063_length(amino acids)=695AA_BP=121
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTILFDQTQRSIKAQLQNFVKDFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEP
SEDGATNKIEISMDCIRMQDSDLSDPMWYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNE
GQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARIC
ACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETY
RQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQAL
PPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSH

--------------------------------------------------------------

>1225_1225_4_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000392460_length(amino acids)=655AA_BP=121
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTILFDQTQRSIKAQLQNFVKDFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEP
SEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTD
YPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAP
PSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGR
DRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQ
QQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLS

--------------------------------------------------------------

>1225_1225_5_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000418709_length(amino acids)=587AA_BP=121
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTILFDQTQRSIKAQLQNFVKDFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEP
SEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTD
YPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAP
PSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGR
DRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQ

--------------------------------------------------------------

>1225_1225_6_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000440651_length(amino acids)=776AA_BP=121
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTILFDQTQRSIKAQLQNFVKDFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEP
SEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTD
YPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAP
PSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGR
DRKADEDSIRKQQVSDSTKNGDAFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQ
HLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPST
SHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTPSSAS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:195065988/chr3:189455529)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACAP2

Q15057

.
FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). {ECO:0000269|PubMed:11062263}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTP63chr3:195065988chr3:189455529ENST00000264731014437_44420.666666666666668681.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000320472012437_44420.666666666666668511.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000354600012437_4440587.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000382063013437_44420.666666666666668596.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000392460013437_44420.666666666666668556.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000392461010437_4440.0417.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000392463011437_4440.0462.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000418709011437_44420.666666666666668488.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST0000043722109437_4440.0394.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000440651014437_44420.666666666666668677.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000449992011437_4440.0502.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000456148012437_4440.0583.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000264731014170_36220.666666666666668681.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000320472012170_36220.666666666666668511.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000354600012170_3620587.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000382063013170_36220.666666666666668596.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000392460013170_36220.666666666666668556.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000392461010170_3620.0417.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000392463011170_3620.0462.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000418709011170_36220.666666666666668488.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST0000043722109170_3620.0394.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000440651014170_36220.666666666666668677.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000449992011170_3620.0502.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000456148012170_3620.0583.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000264731014541_60720.666666666666668681.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000320472012541_60720.666666666666668511.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000354600012541_6070587.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000382063013541_60720.666666666666668596.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000392460013541_60720.666666666666668556.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000392461010541_6070.0417.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000392463011541_6070.0462.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000418709011541_60720.666666666666668488.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST0000043722109541_6070.0394.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000440651014541_60720.666666666666668677.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000449992011541_6070.0502.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000456148012541_6070.0583.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000264731014394_44320.666666666666668681.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000264731014610_68020.666666666666668681.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST00000320472012394_44320.666666666666668511.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000320472012610_68020.666666666666668511.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST000003546000121_1070587.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST00000354600012394_4430587.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000354600012610_6800587.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST00000382063013394_44320.666666666666668596.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000382063013610_68020.666666666666668596.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST00000392460013394_44320.666666666666668556.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000392460013610_68020.666666666666668556.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST000003924610101_1070.0417.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST00000392461010394_4430.0417.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000392461010610_6800.0417.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST000003924630111_1070.0462.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST00000392463011394_4430.0462.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000392463011610_6800.0462.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST00000418709011394_44320.666666666666668488.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000418709011610_68020.666666666666668488.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST00000437221091_1070.0394.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST0000043722109394_4430.0394.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST0000043722109610_6800.0394.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST00000440651014394_44320.666666666666668677.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000440651014610_68020.666666666666668677.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST000004499920111_1070.0502.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST00000449992011394_4430.0502.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000449992011610_6800.0502.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST000004561480121_1070.0583.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST00000456148012394_4430.0583.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000456148012610_6800.0583.0RegionNote=Transactivation inhibition

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACAP2chr3:195065988chr3:189455529ENST00000326793-5231_226114.66666666666667779.0DomainNote=BAR
HgeneACAP2chr3:195065988chr3:189455529ENST00000326793-523266_361114.66666666666667779.0DomainPH
HgeneACAP2chr3:195065988chr3:189455529ENST00000326793-523399_520114.66666666666667779.0DomainArf-GAP
HgeneACAP2chr3:195065988chr3:189455529ENST00000326793-523640_669114.66666666666667779.0RepeatNote=ANK 1
HgeneACAP2chr3:195065988chr3:189455529ENST00000326793-523673_702114.66666666666667779.0RepeatNote=ANK 2
HgeneACAP2chr3:195065988chr3:189455529ENST00000326793-523706_735114.66666666666667779.0RepeatNote=ANK 3
HgeneACAP2chr3:195065988chr3:189455529ENST00000326793-523414_437114.66666666666667779.0Zinc fingerC4-type
TgeneTP63chr3:195065988chr3:189455529ENST000002647310141_10720.666666666666668681.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST000003204720121_10720.666666666666668511.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST000003820630131_10720.666666666666668596.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST000003924600131_10720.666666666666668556.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST000004187090111_10720.666666666666668488.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST000004406510141_10720.666666666666668677.0RegionNote=Transcription activation


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ACAP2
TP63


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ACAP2-TP63


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ACAP2-TP63


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource