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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CACNA2D3-DAP3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CACNA2D3-DAP3
	FusionPDB ID: 12362
	FusionGDB2.0 ID: 12362
		Hgene	Tgene
	Gene symbol	CACNA2D3	DAP3
	Gene ID	55799	58512
	Gene name	calcium voltage-gated channel auxiliary subunit alpha2delta 3	DLG associated protein 3
	Synonyms	HSA272268	DAP3\|SAPAP3
	Cytomap	3p21.1-p14.3	1p34.3
	Type of gene	protein-coding	protein-coding
	Description	voltage-dependent calcium channel subunit alpha-2/delta-3calcium channel alpha2-delta3 subunitcalcium channel, voltage-dependent, alpha 2/delta 3 subunitcalcium channel, voltage-dependent, alpha 2/delta subunit 3voltage-gated calcium channel subunit a	disks large-associated protein 3DAP-3PSD-95/SAP90-binding protein 3SAP90/PSD-95-associated protein 3discs large homolog associated protein 3
	Modification date	20200313	20200313
	UniProtAcc	Q8IZS8	P51398
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000288197, ENST00000415676, ENST00000474759, ENST00000490478, ENST00000478261,	ENST00000421487, ENST00000465375, ENST00000496863, ENST00000535183, ENST00000343043, ENST00000471642, ENST00000368336,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 12 X 6=1008	16 X 12 X 6=1152
	# samples	15	18
	** MAII score	log2(15/1008*10)=-2.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1152*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CACNA2D3 [Title/Abstract] AND DAP3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CACNA2D3(54676268)-DAP3(155707948), # samples:2
Anticipated loss of major functional domain due to fusion event.	CACNA2D3-DAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CACNA2D3-DAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CACNA2D3-DAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CACNA2D3-DAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CACNA2D3-DAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CACNA2D3-DAP3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. CACNA2D3-DAP3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CACNA2D3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DAP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-20-1684-01A	CACNA2D3	chr3	54676268	+	DAP3	chr1	155706737	+
ChimerDB4	OV	TCGA-20-1684-01A	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+
ChimerDB4	OV	TCGA-20-1684	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707947	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000415676	CACNA2D3	chr3	54676268	+	ENST00000368336	DAP3	chr1	155707948	+	2139	1285	118	1323	401
ENST00000288197	CACNA2D3	chr3	54676268	+	ENST00000368336	DAP3	chr1	155707948	+	2069	1215	48	1253	401
ENST00000474759	CACNA2D3	chr3	54676268	+	ENST00000368336	DAP3	chr1	155707948	+	2069	1215	48	1253	401
ENST00000490478	CACNA2D3	chr3	54676268	+	ENST00000368336	DAP3	chr1	155707948	+	1951	1097	125	1135	336
ENST00000415676	CACNA2D3	chr3	54676268	+	ENST00000368336	DAP3	chr1	155707947	+	2139	1285	118	1323	401
ENST00000288197	CACNA2D3	chr3	54676268	+	ENST00000368336	DAP3	chr1	155707947	+	2069	1215	48	1253	401
ENST00000474759	CACNA2D3	chr3	54676268	+	ENST00000368336	DAP3	chr1	155707947	+	2069	1215	48	1253	401
ENST00000490478	CACNA2D3	chr3	54676268	+	ENST00000368336	DAP3	chr1	155707947	+	1951	1097	125	1135	336
ENST00000415676	CACNA2D3	chr3	54676268	+	ENST00000471642	DAP3	chr1	155706737	+	1773	1285	118	1488	456
ENST00000415676	CACNA2D3	chr3	54676268	+	ENST00000368336	DAP3	chr1	155706737	+	2257	1285	118	1488	456
ENST00000415676	CACNA2D3	chr3	54676268	+	ENST00000343043	DAP3	chr1	155706737	+	1773	1285	118	1488	456
ENST00000288197	CACNA2D3	chr3	54676268	+	ENST00000471642	DAP3	chr1	155706737	+	1703	1215	48	1418	456
ENST00000288197	CACNA2D3	chr3	54676268	+	ENST00000368336	DAP3	chr1	155706737	+	2187	1215	48	1418	456
ENST00000288197	CACNA2D3	chr3	54676268	+	ENST00000343043	DAP3	chr1	155706737	+	1703	1215	48	1418	456
ENST00000474759	CACNA2D3	chr3	54676268	+	ENST00000471642	DAP3	chr1	155706737	+	1703	1215	48	1418	456
ENST00000474759	CACNA2D3	chr3	54676268	+	ENST00000368336	DAP3	chr1	155706737	+	2187	1215	48	1418	456
ENST00000474759	CACNA2D3	chr3	54676268	+	ENST00000343043	DAP3	chr1	155706737	+	1703	1215	48	1418	456
ENST00000490478	CACNA2D3	chr3	54676268	+	ENST00000471642	DAP3	chr1	155706737	+	1585	1097	125	1300	391
ENST00000490478	CACNA2D3	chr3	54676268	+	ENST00000368336	DAP3	chr1	155706737	+	2069	1097	125	1300	391
ENST00000490478	CACNA2D3	chr3	54676268	+	ENST00000343043	DAP3	chr1	155706737	+	1585	1097	125	1300	391

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000415676	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+	0.00104183	0.9989581
ENST00000288197	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+	0.000851891	0.99914813
ENST00000474759	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+	0.000851891	0.99914813
ENST00000490478	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707948	+	0.000837163	0.9991628
ENST00000415676	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707947	+	0.00104183	0.9989581
ENST00000288197	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707947	+	0.000851891	0.99914813
ENST00000474759	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707947	+	0.000851891	0.99914813
ENST00000490478	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155707947	+	0.000837163	0.9991628
ENST00000415676	ENST00000471642	CACNA2D3	chr3	54676268	+	DAP3	chr1	155706737	+	0.000887646	0.9991123
ENST00000415676	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155706737	+	0.000920179	0.9990798
ENST00000415676	ENST00000343043	CACNA2D3	chr3	54676268	+	DAP3	chr1	155706737	+	0.000887646	0.9991123
ENST00000288197	ENST00000471642	CACNA2D3	chr3	54676268	+	DAP3	chr1	155706737	+	0.000661522	0.99933845
ENST00000288197	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155706737	+	0.000758313	0.9992417
ENST00000288197	ENST00000343043	CACNA2D3	chr3	54676268	+	DAP3	chr1	155706737	+	0.000661522	0.99933845
ENST00000474759	ENST00000471642	CACNA2D3	chr3	54676268	+	DAP3	chr1	155706737	+	0.000661522	0.99933845
ENST00000474759	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155706737	+	0.000758313	0.9992417
ENST00000474759	ENST00000343043	CACNA2D3	chr3	54676268	+	DAP3	chr1	155706737	+	0.000661522	0.99933845
ENST00000490478	ENST00000471642	CACNA2D3	chr3	54676268	+	DAP3	chr1	155706737	+	0.000433828	0.99956614
ENST00000490478	ENST00000368336	CACNA2D3	chr3	54676268	+	DAP3	chr1	155706737	+	0.000554225	0.99944574
ENST00000490478	ENST00000343043	CACNA2D3	chr3	54676268	+	DAP3	chr1	155706737	+	0.000433828	0.99956614

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>12362_12362_1_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000288197_DAP3_chr1_155706737_ENST00000343043_length(amino acids)=456AA_BP=389
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKEGFDALDPFIPILVSNYNPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLE

--------------------------------------------------------------

>12362_12362_2_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000288197_DAP3_chr1_155706737_ENST00000368336_length(amino acids)=456AA_BP=389
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKEGFDALDPFIPILVSNYNPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLE

--------------------------------------------------------------

>12362_12362_3_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000288197_DAP3_chr1_155706737_ENST00000471642_length(amino acids)=456AA_BP=389
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKEGFDALDPFIPILVSNYNPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLE

--------------------------------------------------------------

>12362_12362_4_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000288197_DAP3_chr1_155707947_ENST00000368336_length(amino acids)=401AA_BP=
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI

--------------------------------------------------------------

>12362_12362_5_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000288197_DAP3_chr1_155707948_ENST00000368336_length(amino acids)=401AA_BP=
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI

--------------------------------------------------------------

>12362_12362_6_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000415676_DAP3_chr1_155706737_ENST00000343043_length(amino acids)=456AA_BP=389
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKEGFDALDPFIPILVSNYNPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLE

--------------------------------------------------------------

>12362_12362_7_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000415676_DAP3_chr1_155706737_ENST00000368336_length(amino acids)=456AA_BP=389
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKEGFDALDPFIPILVSNYNPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLE

--------------------------------------------------------------

>12362_12362_8_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000415676_DAP3_chr1_155706737_ENST00000471642_length(amino acids)=456AA_BP=389
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKEGFDALDPFIPILVSNYNPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLE

--------------------------------------------------------------

>12362_12362_9_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000415676_DAP3_chr1_155707947_ENST00000368336_length(amino acids)=401AA_BP=
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI

--------------------------------------------------------------

>12362_12362_10_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000415676_DAP3_chr1_155707948_ENST00000368336_length(amino acids)=401AA_BP=
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI

--------------------------------------------------------------

>12362_12362_11_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000474759_DAP3_chr1_155706737_ENST00000343043_length(amino acids)=456AA_BP=389
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKEGFDALDPFIPILVSNYNPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLE

--------------------------------------------------------------

>12362_12362_12_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000474759_DAP3_chr1_155706737_ENST00000368336_length(amino acids)=456AA_BP=389
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKEGFDALDPFIPILVSNYNPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLE

--------------------------------------------------------------

>12362_12362_13_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000474759_DAP3_chr1_155706737_ENST00000471642_length(amino acids)=456AA_BP=389
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKEGFDALDPFIPILVSNYNPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLE

--------------------------------------------------------------

>12362_12362_14_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000474759_DAP3_chr1_155707947_ENST00000368336_length(amino acids)=401AA_BP=
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI

--------------------------------------------------------------

>12362_12362_15_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000474759_DAP3_chr1_155707948_ENST00000368336_length(amino acids)=401AA_BP=
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI

--------------------------------------------------------------

>12362_12362_16_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000490478_DAP3_chr1_155706737_ENST00000343043_length(amino acids)=391AA_BP=324
MQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILA
PNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRK
WYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGI
GMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKEGFDALDPFIPILVSNYNPKEFESCIQYYLENNWLQ

--------------------------------------------------------------

>12362_12362_17_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000490478_DAP3_chr1_155706737_ENST00000368336_length(amino acids)=391AA_BP=324
MQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILA
PNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRK
WYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGI
GMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKEGFDALDPFIPILVSNYNPKEFESCIQYYLENNWLQ

--------------------------------------------------------------

>12362_12362_18_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000490478_DAP3_chr1_155706737_ENST00000471642_length(amino acids)=391AA_BP=324
MQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILA
PNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRK
WYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGI
GMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKEGFDALDPFIPILVSNYNPKEFESCIQYYLENNWLQ

--------------------------------------------------------------

>12362_12362_19_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000490478_DAP3_chr1_155707947_ENST00000368336_length(amino acids)=336AA_BP=
MQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILA
PNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRK
WYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGI

--------------------------------------------------------------

>12362_12362_20_CACNA2D3-DAP3_CACNA2D3_chr3_54676268_ENST00000490478_DAP3_chr1_155707948_ENST00000368336_length(amino acids)=336AA_BP=
MQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILA
PNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRK
WYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGI

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:54676268/chr1:155707948)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CACNA2D3 Q8IZS8	DAP3 P51398
FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO:0000250}.	FUNCTION: Involved in mediating interferon-gamma-induced cell death.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000288197

262_266

389.0

1092.0

Motif

Note=MIDAS-like motif

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000415676

262_266

389.0

1092.0

Motif

Note=MIDAS-like motif

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000474759

262_266

389.0

1092.0

Motif

Note=MIDAS-like motif

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000490478

262_266

295.0

998.0

Motif

Note=MIDAS-like motif

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000288197

262_266

389.0

1092.0

Motif

Note=MIDAS-like motif

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000415676

262_266

389.0

1092.0

Motif

Note=MIDAS-like motif

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000474759

262_266

389.0

1092.0

Motif

Note=MIDAS-like motif

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000490478

262_266

295.0

998.0

Motif

Note=MIDAS-like motif

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000288197

262_266

389.0

1092.0

Motif

Note=MIDAS-like motif

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000415676

262_266

389.0

1092.0

Motif

Note=MIDAS-like motif

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000474759

262_266

389.0

1092.0

Motif

Note=MIDAS-like motif

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000490478

262_266

295.0

998.0

Motif

Note=MIDAS-like motif

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000288197

256_438

389.0

1092.0

Domain

VWFA

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000288197

452_549

389.0

1092.0

Domain

Note=Cache

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000415676

256_438

389.0

1092.0

Domain

VWFA

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000415676

452_549

389.0

1092.0

Domain

Note=Cache

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000474759

256_438

389.0

1092.0

Domain

VWFA

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000474759

452_549

389.0

1092.0

Domain

Note=Cache

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000490478

256_438

295.0

998.0

Domain

VWFA

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000490478

452_549

295.0

998.0

Domain

Note=Cache

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000288197

256_438

389.0

1092.0

Domain

VWFA

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000288197

452_549

389.0

1092.0

Domain

Note=Cache

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000415676

256_438

389.0

1092.0

Domain

VWFA

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000415676

452_549

389.0

1092.0

Domain

Note=Cache

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000474759

256_438

389.0

1092.0

Domain

VWFA

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000474759

452_549

389.0

1092.0

Domain

Note=Cache

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000490478

256_438

295.0

998.0

Domain

VWFA

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000490478

452_549

295.0

998.0

Domain

Note=Cache

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000288197

256_438

389.0

1092.0

Domain

VWFA

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000288197

452_549

389.0

1092.0

Domain

Note=Cache

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000415676

256_438

389.0

1092.0

Domain

VWFA

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000415676

452_549

389.0

1092.0

Domain

Note=Cache

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000474759

256_438

389.0

1092.0

Domain

VWFA

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000474759

452_549

389.0

1092.0

Domain

Note=Cache

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000490478

256_438

295.0

998.0

Domain

VWFA

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000490478

452_549

295.0

998.0

Domain

Note=Cache

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000288197

1090_1091

389.0

1092.0

Topological domain

Cytoplasmic

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000288197

29_1068

389.0

1092.0

Topological domain

Extracellular

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000415676

1090_1091

389.0

1092.0

Topological domain

Cytoplasmic

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000415676

29_1068

389.0

1092.0

Topological domain

Extracellular

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000474759

1090_1091

389.0

1092.0

Topological domain

Cytoplasmic

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000474759

29_1068

389.0

1092.0

Topological domain

Extracellular

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000490478

1090_1091

295.0

998.0

Topological domain

Cytoplasmic

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000490478

29_1068

295.0

998.0

Topological domain

Extracellular

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000288197

1090_1091

389.0

1092.0

Topological domain

Cytoplasmic

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000288197

29_1068

389.0

1092.0

Topological domain

Extracellular

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000415676

1090_1091

389.0

1092.0

Topological domain

Cytoplasmic

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000415676

29_1068

389.0

1092.0

Topological domain

Extracellular

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000474759

1090_1091

389.0

1092.0

Topological domain

Cytoplasmic

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000474759

29_1068

389.0

1092.0

Topological domain

Extracellular

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000490478

1090_1091

295.0

998.0

Topological domain

Cytoplasmic

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000490478

29_1068

295.0

998.0

Topological domain

Extracellular

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000288197

1090_1091

389.0

1092.0

Topological domain

Cytoplasmic

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000288197

29_1068

389.0

1092.0

Topological domain

Extracellular

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000415676

1090_1091

389.0

1092.0

Topological domain

Cytoplasmic

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000415676

29_1068

389.0

1092.0

Topological domain

Extracellular

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000474759

1090_1091

389.0

1092.0

Topological domain

Cytoplasmic

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000474759

29_1068

389.0

1092.0

Topological domain

Extracellular

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000490478

1090_1091

295.0

998.0

Topological domain

Cytoplasmic

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000490478

29_1068

295.0

998.0

Topological domain

Extracellular

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000288197

1069_1089

389.0

1092.0

Transmembrane

Helical

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000415676

1069_1089

389.0

1092.0

Transmembrane

Helical

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000474759

1069_1089

389.0

1092.0

Transmembrane

Helical

Hgene

CACNA2D3

chr3:54676268

chr1:155706737

ENST00000490478

1069_1089

295.0

998.0

Transmembrane

Helical

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000288197

1069_1089

389.0

1092.0

Transmembrane

Helical

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000415676

1069_1089

389.0

1092.0

Transmembrane

Helical

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000474759

1069_1089

389.0

1092.0

Transmembrane

Helical

Hgene

CACNA2D3

chr3:54676268

chr1:155707947

ENST00000490478

1069_1089

295.0

998.0

Transmembrane

Helical

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000288197

1069_1089

389.0

1092.0

Transmembrane

Helical

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000415676

1069_1089

389.0

1092.0

Transmembrane

Helical

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000474759

1069_1089

389.0

1092.0

Transmembrane

Helical

Hgene

CACNA2D3

chr3:54676268

chr1:155707948

ENST00000490478

1069_1089

295.0

998.0

Transmembrane

Helical

Tgene

DAP3

chr3:54676268

chr1:155706737

ENST00000343043

128_135

331.0

399.0

Nucleotide binding

GTP

Tgene

DAP3

chr3:54676268

chr1:155706737

ENST00000368336

128_135

331.0

399.0

Nucleotide binding

GTP

Tgene

DAP3

chr3:54676268

chr1:155706737

ENST00000421487

128_135

297.0

365.0

Nucleotide binding

GTP

Tgene

DAP3

chr3:54676268

chr1:155706737

ENST00000535183

128_135

290.0

358.0

Nucleotide binding

GTP

Tgene

DAP3

chr3:54676268

chr1:155707947

ENST00000343043

128_135

370.3333333333333

399.0

Nucleotide binding

GTP

Tgene

DAP3

chr3:54676268

chr1:155707947

ENST00000368336

128_135

370.3333333333333

399.0

Nucleotide binding

GTP

Tgene

DAP3

chr3:54676268

chr1:155707947

ENST00000421487

128_135

336.3333333333333

365.0

Nucleotide binding

GTP

Tgene

DAP3

chr3:54676268

chr1:155707947

ENST00000535183

128_135

329.3333333333333

358.0

Nucleotide binding

GTP

Tgene

DAP3

chr3:54676268

chr1:155707948

ENST00000343043

128_135

370.3333333333333

399.0

Nucleotide binding

GTP

Tgene

DAP3

chr3:54676268

chr1:155707948

ENST00000368336

128_135

370.3333333333333

399.0

Nucleotide binding

GTP

Tgene

DAP3

chr3:54676268

chr1:155707948

ENST00000421487

128_135

336.3333333333333

365.0

Nucleotide binding

GTP

Tgene

DAP3

chr3:54676268

chr1:155707948

ENST00000535183

128_135

329.3333333333333

358.0

Nucleotide binding

GTP

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CACNA2D3
DAP3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to CACNA2D3-DAP3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CACNA2D3-DAP3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source