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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CALU-LAP3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CALU-LAP3
FusionPDB ID: 12626
FusionGDB2.0 ID: 12626
HgeneTgene
Gene symbol

CALU

LAP3

Gene ID

813

51056

Gene namecalumeninleucine aminopeptidase 3
Synonyms-HEL-S-106|LAP|LAPEP|PEPS
Cytomap

7q32.1

4p15.32

Type of geneprotein-codingprotein-coding
DescriptioncalumeninIEF SSP 9302crocalbin-like proteinmultiple EF-hand proteincytosol aminopeptidaseLAP-3epididymis secretory protein Li 106leucyl aminopeptidasepeptidase Sproline aminopeptidaseprolyl aminopeptidase
Modification date2020031320200313
UniProtAcc

O43852

P28838

Ensembl transtripts involved in fusion geneENST idsENST00000535623, ENST00000249364, 
ENST00000449187, ENST00000479257, 
ENST00000538546, ENST00000542996, 
ENST00000535011, 		ENST00000226299, 
ENST00000606142, ENST00000503467, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 13 X 3=4688 X 7 X 7=392
# samples 188
** MAII scorelog2(18/468*10)=-1.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/392*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CALU [Title/Abstract] AND LAP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CALU(128407709)-LAP3(17600079), # samples:1
Anticipated loss of major functional domain due to fusion event.CALU-LAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CALU-LAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CALU-LAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CALU-LAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CALU (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LAP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-PJ-A5Z8-01ACALUchr7

128407709

+LAP3chr4

17600079

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000538546CALUchr7128407709+ENST00000226299LAP3chr417600079+14315691791051290
ENST00000538546CALUchr7128407709+ENST00000606142LAP3chr417600079+13975691791051290
ENST00000542996CALUchr7128407709+ENST00000226299LAP3chr417600079+267218108742292472
ENST00000542996CALUchr7128407709+ENST00000606142LAP3chr417600079+263818108742292472
ENST00000249364CALUchr7128407709+ENST00000226299LAP3chr417600079+18079451021427441
ENST00000249364CALUchr7128407709+ENST00000606142LAP3chr417600079+17739451021427441
ENST00000449187CALUchr7128407709+ENST00000226299LAP3chr417600079+1786924811406441
ENST00000449187CALUchr7128407709+ENST00000606142LAP3chr417600079+1752924811406441
ENST00000479257CALUchr7128407709+ENST00000226299LAP3chr417600079+256016987622180472
ENST00000479257CALUchr7128407709+ENST00000606142LAP3chr417600079+252616987622180472

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000538546ENST00000226299CALUchr7128407709+LAP3chr417600079+0.0005585830.99944144
ENST00000538546ENST00000606142CALUchr7128407709+LAP3chr417600079+0.0005599370.99944
ENST00000542996ENST00000226299CALUchr7128407709+LAP3chr417600079+0.0001724260.9998275
ENST00000542996ENST00000606142CALUchr7128407709+LAP3chr417600079+0.0001737930.99982625
ENST00000249364ENST00000226299CALUchr7128407709+LAP3chr417600079+0.0005926160.9994074
ENST00000249364ENST00000606142CALUchr7128407709+LAP3chr417600079+0.0005885390.99941146
ENST00000449187ENST00000226299CALUchr7128407709+LAP3chr417600079+0.0005423790.99945766
ENST00000449187ENST00000606142CALUchr7128407709+LAP3chr417600079+0.0005471850.99945277
ENST00000479257ENST00000226299CALUchr7128407709+LAP3chr417600079+0.0001892550.99981076
ENST00000479257ENST00000606142CALUchr7128407709+LAP3chr417600079+0.0001953680.9998047

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>12626_12626_1_CALU-LAP3_CALU_chr7_128407709_ENST00000249364_LAP3_chr4_17600079_ENST00000226299_length(amino acids)=441AA_BP=281
MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESKERLGKIVSKIDGDKDGFVTV
DELKDWIKFAQKRWIYEDVERQWKGHDLNEDGLVSWEEYKNATYGYVLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFL
HPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEA
RHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHY

--------------------------------------------------------------

>12626_12626_2_CALU-LAP3_CALU_chr7_128407709_ENST00000249364_LAP3_chr4_17600079_ENST00000606142_length(amino acids)=441AA_BP=281
MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESKERLGKIVSKIDGDKDGFVTV
DELKDWIKFAQKRWIYEDVERQWKGHDLNEDGLVSWEEYKNATYGYVLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFL
HPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEA
RHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHY

--------------------------------------------------------------

>12626_12626_3_CALU-LAP3_CALU_chr7_128407709_ENST00000449187_LAP3_chr4_17600079_ENST00000226299_length(amino acids)=441AA_BP=281
MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESKERLGMIVDKIDADKDGFVTE
GELKSWIKHAQKKYIYDNVENQWQEFDMNQDGLISWDEYRNVTYGTYLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFL
HPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEA
RHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHY

--------------------------------------------------------------

>12626_12626_4_CALU-LAP3_CALU_chr7_128407709_ENST00000449187_LAP3_chr4_17600079_ENST00000606142_length(amino acids)=441AA_BP=281
MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESKERLGMIVDKIDADKDGFVTE
GELKSWIKHAQKKYIYDNVENQWQEFDMNQDGLISWDEYRNVTYGTYLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFL
HPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEA
RHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHY

--------------------------------------------------------------

>12626_12626_5_CALU-LAP3_CALU_chr7_128407709_ENST00000479257_LAP3_chr4_17600079_ENST00000226299_length(amino acids)=472AA_BP=312
MVSFERKQKVDILTISFLSAYNQMKETDLIIMDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAK
TFDQLTPEESKERLGKIVSKIDGDKDGFVTVDELKDWIKFAQKRWIYEDVERQWKGHDLNEDGLVSWEEYKNATYGYVLDDPDPDDGFNY
KQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVE
FRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGV
FTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRK

--------------------------------------------------------------

>12626_12626_6_CALU-LAP3_CALU_chr7_128407709_ENST00000479257_LAP3_chr4_17600079_ENST00000606142_length(amino acids)=472AA_BP=312
MVSFERKQKVDILTISFLSAYNQMKETDLIIMDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAK
TFDQLTPEESKERLGKIVSKIDGDKDGFVTVDELKDWIKFAQKRWIYEDVERQWKGHDLNEDGLVSWEEYKNATYGYVLDDPDPDDGFNY
KQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVE
FRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGV
FTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRK

--------------------------------------------------------------

>12626_12626_7_CALU-LAP3_CALU_chr7_128407709_ENST00000538546_LAP3_chr4_17600079_ENST00000226299_length(amino acids)=290AA_BP=130
MMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFR
DKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFT
NSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGM

--------------------------------------------------------------

>12626_12626_8_CALU-LAP3_CALU_chr7_128407709_ENST00000538546_LAP3_chr4_17600079_ENST00000606142_length(amino acids)=290AA_BP=130
MMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFR
DKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFT
NSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGM

--------------------------------------------------------------

>12626_12626_9_CALU-LAP3_CALU_chr7_128407709_ENST00000542996_LAP3_chr4_17600079_ENST00000226299_length(amino acids)=472AA_BP=312
MVSFERKQKVDILTISFLSAYNQMKETDLIIMDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAK
TFDQLTPEESKERLGMIVDKIDADKDGFVTEGELKSWIKHAQKKYIYDNVENQWQEFDMNQDGLISWDEYRNVTYGTYLDDPDPDDGFNY
KQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVE
FRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGV
FTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRK

--------------------------------------------------------------

>12626_12626_10_CALU-LAP3_CALU_chr7_128407709_ENST00000542996_LAP3_chr4_17600079_ENST00000606142_length(amino acids)=472AA_BP=312
MVSFERKQKVDILTISFLSAYNQMKETDLIIMDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAK
TFDQLTPEESKERLGMIVDKIDADKDGFVTEGELKSWIKHAQKKYIYDNVENQWQEFDMNQDGLISWDEYRNVTYGTYLDDPDPDDGFNY
KQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVE
FRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGV
FTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:128407709/chr4:17600079)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CALU

O43852

LAP3

P28838

FUNCTION: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). {ECO:0000250}.FUNCTION: Cytolosic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. {ECO:0000250|UniProtKB:P00727}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67117_128281.0316.0Calcium binding2
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67164_175281.0316.0Calcium binding3%3B possibly ancestral
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67201_212281.0316.0Calcium binding4
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67242_253281.0316.0Calcium binding5
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+6781_92281.0316.0Calcium binding1
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67117_128281.0316.0Calcium binding2
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67164_175281.0316.0Calcium binding3%3B possibly ancestral
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67201_212281.0316.0Calcium binding4
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67242_253281.0316.0Calcium binding5
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+6781_92281.0316.0Calcium binding1
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78117_128289.0324.0Calcium binding2
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78164_175289.0324.0Calcium binding3%3B possibly ancestral
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78201_212289.0324.0Calcium binding4
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78242_253289.0324.0Calcium binding5
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78278_289289.0324.0Calcium binding6
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+7881_92289.0324.0Calcium binding1
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89117_128353.6666666666667634.6666666666666Calcium binding2
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89164_175353.6666666666667634.6666666666666Calcium binding3%3B possibly ancestral
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89201_212353.6666666666667634.6666666666666Calcium binding4
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89242_253353.6666666666667634.6666666666666Calcium binding5
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89278_289353.6666666666667634.6666666666666Calcium binding6
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+8981_92353.6666666666667634.6666666666666Calcium binding1
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45117_128130.0165.0Calcium binding2
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+4581_92130.0165.0Calcium binding1
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78117_128289.0324.0Calcium binding2
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78164_175289.0324.0Calcium binding3%3B possibly ancestral
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78201_212289.0324.0Calcium binding4
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78242_253289.0324.0Calcium binding5
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78278_289289.0324.0Calcium binding6
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+7881_92289.0324.0Calcium binding1
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67104_139281.0316.0DomainEF-hand 2
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67151_186281.0316.0DomainEF-hand 3
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67188_223281.0316.0DomainEF-hand 4
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67229_264281.0316.0DomainEF-hand 5
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+6768_103281.0316.0DomainEF-hand 1
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67104_139281.0316.0DomainEF-hand 2
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67151_186281.0316.0DomainEF-hand 3
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67188_223281.0316.0DomainEF-hand 4
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67229_264281.0316.0DomainEF-hand 5
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+6768_103281.0316.0DomainEF-hand 1
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78104_139289.0324.0DomainEF-hand 2
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78151_186289.0324.0DomainEF-hand 3
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78188_223289.0324.0DomainEF-hand 4
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78229_264289.0324.0DomainEF-hand 5
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+7868_103289.0324.0DomainEF-hand 1
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89104_139353.6666666666667634.6666666666666DomainEF-hand 2
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89151_186353.6666666666667634.6666666666666DomainEF-hand 3
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89188_223353.6666666666667634.6666666666666DomainEF-hand 4
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89229_264353.6666666666667634.6666666666666DomainEF-hand 5
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89265_300353.6666666666667634.6666666666666DomainEF-hand 6
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+8968_103353.6666666666667634.6666666666666DomainEF-hand 1
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+4568_103130.0165.0DomainEF-hand 1
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78104_139289.0324.0DomainEF-hand 2
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78151_186289.0324.0DomainEF-hand 3
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78188_223289.0324.0DomainEF-hand 4
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78229_264289.0324.0DomainEF-hand 5
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+7868_103289.0324.0DomainEF-hand 1
HgeneCALUchr7:128407709chr4:17600079ENST00000535623+89312_315353.6666666666667634.6666666666666MotifPrevents secretion from ER

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67278_289281.0316.0Calcium binding6
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67278_289281.0316.0Calcium binding6
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16117_1280225.0Calcium binding2
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16164_1750225.0Calcium binding3%3B possibly ancestral
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16201_2120225.0Calcium binding4
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16242_2530225.0Calcium binding5
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16278_2890225.0Calcium binding6
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+1681_920225.0Calcium binding1
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45164_175130.0165.0Calcium binding3%3B possibly ancestral
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45201_212130.0165.0Calcium binding4
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45242_253130.0165.0Calcium binding5
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45278_289130.0165.0Calcium binding6
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67265_300281.0316.0DomainEF-hand 6
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67265_300281.0316.0DomainEF-hand 6
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78265_300289.0324.0DomainEF-hand 6
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16104_1390225.0DomainEF-hand 2
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16151_1860225.0DomainEF-hand 3
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16188_2230225.0DomainEF-hand 4
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16229_2640225.0DomainEF-hand 5
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16265_3000225.0DomainEF-hand 6
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+1668_1030225.0DomainEF-hand 1
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45104_139130.0165.0DomainEF-hand 2
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45151_186130.0165.0DomainEF-hand 3
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45188_223130.0165.0DomainEF-hand 4
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45229_264130.0165.0DomainEF-hand 5
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45265_300130.0165.0DomainEF-hand 6
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78265_300289.0324.0DomainEF-hand 6
HgeneCALUchr7:128407709chr4:17600079ENST00000249364+67312_315281.0316.0MotifPrevents secretion from ER
HgeneCALUchr7:128407709chr4:17600079ENST00000449187+67312_315281.0316.0MotifPrevents secretion from ER
HgeneCALUchr7:128407709chr4:17600079ENST00000479257+78312_315289.0324.0MotifPrevents secretion from ER
HgeneCALUchr7:128407709chr4:17600079ENST00000535011+16312_3150225.0MotifPrevents secretion from ER
HgeneCALUchr7:128407709chr4:17600079ENST00000538546+45312_315130.0165.0MotifPrevents secretion from ER
HgeneCALUchr7:128407709chr4:17600079ENST00000542996+78312_315289.0324.0MotifPrevents secretion from ER


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CALU
LAP3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CALU-LAP3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CALU-LAP3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource