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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CAMSAP2-ANKRD36

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CAMSAP2-ANKRD36
	FusionPDB ID: 12738
	FusionGDB2.0 ID: 12738
		Hgene	Tgene
	Gene symbol	CAMSAP2	ANKRD36
	Gene ID	23271	375248
	Gene name	calmodulin regulated spectrin associated protein family member 2	ankyrin repeat domain 36
	Synonyms	CAMSAP1L1	UNQ2430
	Cytomap	1q32.1	2q11.2
	Type of gene	protein-coding	protein-coding
	Description	calmodulin-regulated spectrin-associated protein 2calmodulin-regulated spectrin-associated protein 1-like protein 1	ankyrin repeat domain-containing protein 36Aankyrin repeat domain-containing protein 36ankyrin-related
	Modification date	20200313	20200313
	UniProtAcc	Q08AD1	Q5JPF3
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000236925, ENST00000358823, ENST00000413307,	ENST00000357042, ENST00000420699, ENST00000461153,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 9 X 5=450	4 X 5 X 4=80
	# samples	10	5
	** MAII score	log2(10/450*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CAMSAP2 [Title/Abstract] AND ANKRD36 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CAMSAP2(200827036)-ANKRD36(97879277), # samples:2
Anticipated loss of major functional domain due to fusion event.	CAMSAP2-ANKRD36 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CAMSAP2-ANKRD36 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CAMSAP2-ANKRD36 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CAMSAP2	GO:0000226	microtubule cytoskeleton organization	24486153\|24706919\|24908486\|27666745
Hgene	CAMSAP2	GO:0031113	regulation of microtubule polymerization	24486153\|24706919
Hgene	CAMSAP2	GO:0050773	regulation of dendrite development	24908486
Hgene	CAMSAP2	GO:0061564	axon development	24908486
Hgene	CAMSAP2	GO:1903358	regulation of Golgi organization	27666745

Fusion gene breakpoints across CAMSAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANKRD36 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BU567802	CAMSAP2	chr1	200827036	+	ANKRD36	chr2	97879277	+
ChiTaRS5.0	N/A	BU567810	CAMSAP2	chr1	200827036	+	ANKRD36	chr2	97879277	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000413307

CAMSAP2

chr1

200827036

ENST00000461153

ANKRD36

chr2

97879277

6703

4343

4146

1365

ENST00000413307

CAMSAP2

chr1

200827036

ENST00000420699

ANKRD36

chr2

97879277

6870

4343

4146

1365

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000413307	ENST00000461153	CAMSAP2	chr1	200827036	+	ANKRD36	chr2	97879277	+	0.000251164	0.9997489
ENST00000413307	ENST00000420699	CAMSAP2	chr1	200827036	+	ANKRD36	chr2	97879277	+	0.000249443	0.99975055

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>12738_12738_1_CAMSAP2-ANKRD36_CAMSAP2_chr1_200827036_ENST00000413307_ANKRD36_chr2_97879277_ENST00000420699_length(amino acids)=1365AA_BP=
MGDAADPREMRKTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFGTENVPEELQEPFYTDQYDQEHIKPPVVNLLLSAELYCRAGSLILK
SDAAKPLLGHDAVIQALAQKGLYVTDQEKLVTERDLHKKPIQMSAHLAMIDTLMMAYTVEMVSIEKVIACAQQYSAFFQATDLPYDIEDA
VMYWINKVNEHLKDIMEQEQKLKEHHTVEAPGGQKARYRKEQTLLKQLPCIPLVENLLKDGTDGCALAALIHFYCPDVVRLEDICLKETM
SLADSLYNLQLIQEFCQEYLNQCCHFTLEDMLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPRVVRPQGAEPVKDMPSIPVLNAAKRNV
LDSSSDFPSRYSRPQAHSSASGGIRRSSSMSYVDGFIGTWPKEKRSSVHGVSFDISFDKEDSVQRSTPNRGITRSISNEGLTLNNSHVSK
HIRKNLSFKPINGEEEAESIEEELNIDSHSDLKSCVPLNTNELNSNENIHYKLPNGALQNRILLDEFGNQIETPSIEEALQIIHDTEKSP
HTPQPDQIANGFFLHSQEMSILNSNIKLNQSSPDNVTDTKGALSPITDNTEVDTGIHVPSEDIPETMDEDSSLRDYTVSLDSDMDDASKF
LQDYDIRTGNTREALSPCPSTVSTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSSQKTTPEGSELNIPHVVAWAQIPEETGL
PQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQKT
DGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQS
WVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRR
FSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEP
PPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRK
QQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGPPVS
SLSLASLNTGDNESVHSGKRTPRSESVEGFLSPSRCGSRNGEKDWENASTTSSVASGTEYTGPKLYKEPSAKSNKHIIQNALAHCCLAGK

--------------------------------------------------------------

>12738_12738_2_CAMSAP2-ANKRD36_CAMSAP2_chr1_200827036_ENST00000413307_ANKRD36_chr2_97879277_ENST00000461153_length(amino acids)=1365AA_BP=
MGDAADPREMRKTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFGTENVPEELQEPFYTDQYDQEHIKPPVVNLLLSAELYCRAGSLILK
SDAAKPLLGHDAVIQALAQKGLYVTDQEKLVTERDLHKKPIQMSAHLAMIDTLMMAYTVEMVSIEKVIACAQQYSAFFQATDLPYDIEDA
VMYWINKVNEHLKDIMEQEQKLKEHHTVEAPGGQKARYRKEQTLLKQLPCIPLVENLLKDGTDGCALAALIHFYCPDVVRLEDICLKETM
SLADSLYNLQLIQEFCQEYLNQCCHFTLEDMLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPRVVRPQGAEPVKDMPSIPVLNAAKRNV
LDSSSDFPSRYSRPQAHSSASGGIRRSSSMSYVDGFIGTWPKEKRSSVHGVSFDISFDKEDSVQRSTPNRGITRSISNEGLTLNNSHVSK
HIRKNLSFKPINGEEEAESIEEELNIDSHSDLKSCVPLNTNELNSNENIHYKLPNGALQNRILLDEFGNQIETPSIEEALQIIHDTEKSP
HTPQPDQIANGFFLHSQEMSILNSNIKLNQSSPDNVTDTKGALSPITDNTEVDTGIHVPSEDIPETMDEDSSLRDYTVSLDSDMDDASKF
LQDYDIRTGNTREALSPCPSTVSTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSSQKTTPEGSELNIPHVVAWAQIPEETGL
PQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQKT
DGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQS
WVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRR
FSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEP
PPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRK
QQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGPPVS
SLSLASLNTGDNESVHSGKRTPRSESVEGFLSPSRCGSRNGEKDWENASTTSSVASGTEYTGPKLYKEPSAKSNKHIIQNALAHCCLAGK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:200827036/chr2:97879277)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CAMSAP2 Q08AD1	ANKRD36 Q5JPF3
FUNCTION: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269\|PubMed:23169647, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:24706919, ECO:0000269\|PubMed:24908486, ECO:0000269\|PubMed:27666745, ECO:0000269\|PubMed:28726242}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000420699

1383_1466

1166.0

1859.3333333333333

Coiled coil

Ontology_term=ECO:0000255

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000420699

1504_1531

1166.0

1859.3333333333333

Coiled coil

Ontology_term=ECO:0000255

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000420699

1573_1614

1166.0

1859.3333333333333

Coiled coil

Ontology_term=ECO:0000255

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000420699

1727_1814

1166.0

1859.3333333333333

Coiled coil

Ontology_term=ECO:0000255

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000461153

1383_1466

1166.0

1942.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000461153

1504_1531

1166.0

1942.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000461153

1573_1614

1166.0

1942.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000461153

1727_1814

1166.0

1942.0

Coiled coil

Ontology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000236925

1166_1238

1490.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000236925

756_793

1490.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000236925

887_926

1490.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000358823

1166_1238

1479.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000358823

756_793

1479.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000358823

887_926

1479.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000413307

1166_1238

1463.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000413307

756_793

1463.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000413307

887_926

1463.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000236925

1349_1483

1490.0

Domain

CKK

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000236925

222_335

1490.0

Domain

Calponin-homology (CH)

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000358823

1349_1483

1479.0

Domain

CKK

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000358823

222_335

1479.0

Domain

Calponin-homology (CH)

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000413307

1349_1483

1463.0

Domain

CKK

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000413307

222_335

1463.0

Domain

Calponin-homology (CH)

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000236925

922_1034

1490.0

Region

MBD region

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000358823

922_1034

1479.0

Region

MBD region

Hgene

CAMSAP2

chr1:200827036

chr2:97879277

ENST00000413307

922_1034

1463.0

Region

MBD region

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000420699

130_159

1166.0

1859.3333333333333

Repeat

ANK 4

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000420699

163_192

1166.0

1859.3333333333333

Repeat

ANK 5

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000420699

196_225

1166.0

1859.3333333333333

Repeat

ANK 6

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000420699

31_60

1166.0

1859.3333333333333

Repeat

ANK 1

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000420699

64_93

1166.0

1859.3333333333333

Repeat

ANK 2

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000420699

97_126

1166.0

1859.3333333333333

Repeat

ANK 3

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000461153

130_159

1166.0

1942.0

Repeat

ANK 4

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000461153

163_192

1166.0

1942.0

Repeat

ANK 5

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000461153

196_225

1166.0

1942.0

Repeat

ANK 6

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000461153

31_60

1166.0

1942.0

Repeat

ANK 1

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000461153

64_93

1166.0

1942.0

Repeat

ANK 2

Tgene

ANKRD36

chr1:200827036

chr2:97879277

ENST00000461153

97_126

1166.0

1942.0

Repeat

ANK 3

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>2022_CAMSAP2_200827036_ANKRD36_97879277_ranked_0.pdb	CAMSAP2	200827036	200827036	ENST00000420699	ANKRD36	chr2	97879277	+	MGDAADPREMRKTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFGTENVPEELQEPFYTDQYDQEHIKPPVVNLLLSAELYCRAGSLILK SDAAKPLLGHDAVIQALAQKGLYVTDQEKLVTERDLHKKPIQMSAHLAMIDTLMMAYTVEMVSIEKVIACAQQYSAFFQATDLPYDIEDA VMYWINKVNEHLKDIMEQEQKLKEHHTVEAPGGQKARYRKEQTLLKQLPCIPLVENLLKDGTDGCALAALIHFYCPDVVRLEDICLKETM SLADSLYNLQLIQEFCQEYLNQCCHFTLEDMLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPRVVRPQGAEPVKDMPSIPVLNAAKRNV LDSSSDFPSRYSRPQAHSSASGGIRRSSSMSYVDGFIGTWPKEKRSSVHGVSFDISFDKEDSVQRSTPNRGITRSISNEGLTLNNSHVSK HIRKNLSFKPINGEEEAESIEEELNIDSHSDLKSCVPLNTNELNSNENIHYKLPNGALQNRILLDEFGNQIETPSIEEALQIIHDTEKSP HTPQPDQIANGFFLHSQEMSILNSNIKLNQSSPDNVTDTKGALSPITDNTEVDTGIHVPSEDIPETMDEDSSLRDYTVSLDSDMDDASKF LQDYDIRTGNTREALSPCPSTVSTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSSQKTTPEGSELNIPHVVAWAQIPEETGL PQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQKT DGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQS WVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRR FSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEP PPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRK QQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGPPVS SLSLASLNTGDNESVHSGKRTPRSESVEGFLSPSRCGSRNGEKDWENASTTSSVASGTEYTGPKLYKEPSAKSNKHIIQNALAHCCLAGK	1365

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CAMSAP2_pLDDT.png

ANKRD36_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CAMSAP2
ANKRD36

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to CAMSAP2-ANKRD36

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CAMSAP2-ANKRD36

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source