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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CAMSAP2-CARS

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CAMSAP2-CARS
	FusionPDB ID: 12741
	FusionGDB2.0 ID: 12741
		Hgene	Tgene
	Gene symbol	CAMSAP2	CARS
	Gene ID	23271	833
	Gene name	calmodulin regulated spectrin associated protein family member 2	cysteinyl-tRNA synthetase 1
	Synonyms	CAMSAP1L1	CARS\|CYSRS\|MGC:11246
	Cytomap	1q32.1	11p15.4
	Type of gene	protein-coding	protein-coding
	Description	calmodulin-regulated spectrin-associated protein 2calmodulin-regulated spectrin-associated protein 1-like protein 1	cysteine--tRNA ligase, cytoplasmiccysteine tRNA ligase 1, cytoplasmiccysteine translase
	Modification date	20200313	20200313
	UniProtAcc	Q08AD1	Q9HA77
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000236925, ENST00000358823, ENST00000413307,	ENST00000397114, ENST00000401769, ENST00000470221, ENST00000278224, ENST00000380525, ENST00000397111,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 9 X 5=450	11 X 12 X 6=792
	# samples	10	12
	** MAII score	log2(10/450*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/792*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CAMSAP2 [Title/Abstract] AND CARS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CAMSAP2(200824017)-CARS(3022478), # samples:2
Anticipated loss of major functional domain due to fusion event.	CAMSAP2-CARS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CAMSAP2-CARS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CAMSAP2-CARS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CAMSAP2-CARS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CAMSAP2-CARS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CAMSAP2-CARS seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. CAMSAP2-CARS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CAMSAP2	GO:0000226	microtubule cytoskeleton organization	24486153\|24706919\|24908486\|27666745
Hgene	CAMSAP2	GO:0031113	regulation of microtubule polymerization	24486153\|24706919
Hgene	CAMSAP2	GO:0050773	regulation of dendrite development	24908486
Hgene	CAMSAP2	GO:0061564	axon development	24908486
Hgene	CAMSAP2	GO:1903358	regulation of Golgi organization	27666745
Tgene	CARS	GO:0006423	cysteinyl-tRNA aminoacylation	10908348\|17303165

Fusion gene breakpoints across CAMSAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CARS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-43-8115-01A	CAMSAP2	chr1	200824017	+	CARS	chr11	3022478	-
ChimerDB4	LUSC	TCGA-43-8115	CAMSAP2	chr1	200824017	+	CARS	chr11	3022478	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000358823	CAMSAP2	chr1	200824017	+	ENST00000397111	CARS	chr11	3022478	-	4493	4166	270	4226	1318
ENST00000413307	CAMSAP2	chr1	200824017	+	ENST00000397111	CARS	chr11	3022478	-	4224	3897	49	3957	1302
ENST00000236925	CAMSAP2	chr1	200824017	+	ENST00000397111	CARS	chr11	3022478	-	4305	3978	49	4038	1329

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000358823	ENST00000397111	CAMSAP2	chr1	200824017	+	CARS	chr11	3022478	-	0.000292707	0.9997073
ENST00000413307	ENST00000397111	CAMSAP2	chr1	200824017	+	CARS	chr11	3022478	-	0.000291475	0.9997085
ENST00000236925	ENST00000397111	CAMSAP2	chr1	200824017	+	CARS	chr11	3022478	-	0.000200892	0.9997991

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>12741_12741_1_CAMSAP2-CARS_CAMSAP2_chr1_200824017_ENST00000236925_CARS_chr11_3022478_ENST00000397111_length(amino acids)=1329AA_BP=1309
MGDAADPREMRKTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFGTENVPEELQEPFYTDQYDQEHIKPPVVNLLLSAELYCRAGSLILK
SDAAKPLLGHDAVIQALAQKGLYVTDQEKLVTERDLHKKPIQMSAHLAMIDTLMMAYTVEMVSIEKVIACAQQYSAFFQATDLPYDIEDA
VMYWINKVNEHLKDIMEQEQKLKEHHTVEAPGGQKSPSKWFWKLVPARYRKEQTLLKQLPCIPLVENLLKDGTDGCALAALIHFYCPDVV
RLEDICLKETMSLADSLYNLQLIQEFCQEYLNQCCHFTLEDMLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPRVVRPQGAEPVKDMPS
IPVLNAAKRNVLDSSSDFPSSGEGATFTQSHHHLPSRYSRPQAHSSASGGIRRSSSMSYVDGFIGTWPKEKRSSVHGVSFDISFDKEDSV
QRSTPNRGITRSISNEGLTLNNSHVSKHIRKNLSFKPINGEEEAESIEEELNIDSHSDLKSCVPLNTNELNSNENIHYKLPNGALQNRIL
LDEFGNQIETPSIEEALQIIHDTEKSPHTPQPDQIANGFFLHSQEMSILNSNIKLNQSSPDNVTDTKGALSPITDNTEVDTGIHVPSEDI
PETMDEDSSLRDYTVSLDSDMDDASKFLQDYDIRTGNTREALSPCPSTVSTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSS
QKTTPEGSELNIPHVVAWAQIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGIS
PLREEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNS
SLHFLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPR
PNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTV
SEVLSLPVTETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQK
AENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVK

--------------------------------------------------------------

>12741_12741_2_CAMSAP2-CARS_CAMSAP2_chr1_200824017_ENST00000358823_CARS_chr11_3022478_ENST00000397111_length(amino acids)=1318AA_BP=1298
MGDAADPREMRKTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFGTENVPEELQEPFYTDQYDQEHIKPPVVNLLLSAELYCRAGSLILK
SDAAKPLLGHDAVIQALAQKGLYVTDQEKLVTERDLHKKPIQMSAHLAMIDTLMMAYTVEMVSIEKVIACAQQYSAFFQATDLPYDIEDA
VMYWINKVNEHLKDIMEQEQKLKEHHTVEAPGGQKARYRKEQTLLKQLPCIPLVENLLKDGTDGCALAALIHFYCPDVVRLEDICLKETM
SLADSLYNLQLIQEFCQEYLNQCCHFTLEDMLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPRVVRPQGAEPVKDMPSIPVLNAAKRNV
LDSSSDFPSSGEGATFTQSHHHLPSRYSRPQAHSSASGGIRRSSSMSYVDGFIGTWPKEKRSSVHGVSFDISFDKEDSVQRSTPNRGITR
SISNEGLTLNNSHVSKHIRKNLSFKPINGEEEAESIEEELNIDSHSDLKSCVPLNTNELNSNENIHYKLPNGALQNRILLDEFGNQIETP
SIEEALQIIHDTEKSPHTPQPDQIANGFFLHSQEMSILNSNIKLNQSSPDNVTDTKGALSPITDNTEVDTGIHVPSEDIPETMDEDSSLR
DYTVSLDSDMDDASKFLQDYDIRTGNTREALSPCPSTVSTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSSQKTTPEGSELN
IPHVVAWAQIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAED
EKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQR
LSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNR
TLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTET
VCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAA
LLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHR

--------------------------------------------------------------

>12741_12741_3_CAMSAP2-CARS_CAMSAP2_chr1_200824017_ENST00000413307_CARS_chr11_3022478_ENST00000397111_length(amino acids)=1302AA_BP=1282
MGDAADPREMRKTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFGTENVPEELQEPFYTDQYDQEHIKPPVVNLLLSAELYCRAGSLILK
SDAAKPLLGHDAVIQALAQKGLYVTDQEKLVTERDLHKKPIQMSAHLAMIDTLMMAYTVEMVSIEKVIACAQQYSAFFQATDLPYDIEDA
VMYWINKVNEHLKDIMEQEQKLKEHHTVEAPGGQKARYRKEQTLLKQLPCIPLVENLLKDGTDGCALAALIHFYCPDVVRLEDICLKETM
SLADSLYNLQLIQEFCQEYLNQCCHFTLEDMLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPRVVRPQGAEPVKDMPSIPVLNAAKRNV
LDSSSDFPSRYSRPQAHSSASGGIRRSSSMSYVDGFIGTWPKEKRSSVHGVSFDISFDKEDSVQRSTPNRGITRSISNEGLTLNNSHVSK
HIRKNLSFKPINGEEEAESIEEELNIDSHSDLKSCVPLNTNELNSNENIHYKLPNGALQNRILLDEFGNQIETPSIEEALQIIHDTEKSP
HTPQPDQIANGFFLHSQEMSILNSNIKLNQSSPDNVTDTKGALSPITDNTEVDTGIHVPSEDIPETMDEDSSLRDYTVSLDSDMDDASKF
LQDYDIRTGNTREALSPCPSTVSTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSSQKTTPEGSELNIPHVVAWAQIPEETGL
PQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGISPLREEAAGAEDEKVYTDRAKEKESQKT
DGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNSSLHFLQQEMQRLSLQQEMLMQMREQQS
WVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPRPNELKITPLNRTLTPPRSVDSLPRLRR
FSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTVSEVLSLPVTETVCLTPNEDQLNQPTEP
PPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQKAENDMAMKRAALLEKRLRREKETQLRK
QQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVKQKKQRPKSIHRDHIESPKTPIKGPPVS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:200824017/chr11:3022478)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CAMSAP2 Q08AD1	CARS Q9HA77
FUNCTION: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). {ECO:0000269\|PubMed:23169647, ECO:0000269\|PubMed:24486153, ECO:0000269\|PubMed:24706919, ECO:0000269\|PubMed:24908486, ECO:0000269\|PubMed:27666745, ECO:0000269\|PubMed:28726242}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000236925

1166_1238

1309.6666666666667

1490.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000236925

756_793

1309.6666666666667

1490.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000236925

887_926

1309.6666666666667

1490.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000358823

1166_1238

1298.6666666666667

1479.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000358823

756_793

1298.6666666666667

1479.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000358823

887_926

1298.6666666666667

1479.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000413307

1166_1238

1282.6666666666667

1463.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000413307

756_793

1282.6666666666667

1463.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000413307

887_926

1282.6666666666667

1463.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000236925

222_335

1309.6666666666667

1490.0

Domain

Calponin-homology (CH)

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000358823

222_335

1298.6666666666667

1479.0

Domain

Calponin-homology (CH)

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000413307

222_335

1282.6666666666667

1463.0

Domain

Calponin-homology (CH)

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000236925

922_1034

1309.6666666666667

1490.0

Region

MBD region

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000358823

922_1034

1298.6666666666667

1479.0

Region

MBD region

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000413307

922_1034

1282.6666666666667

1463.0

Region

MBD region

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000236925

1349_1483

1309.6666666666667

1490.0

Domain

CKK

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000358823

1349_1483

1298.6666666666667

1479.0

Domain

CKK

Hgene

CAMSAP2

chr1:200824017

chr11:3022478

ENST00000413307

1349_1483

1282.6666666666667

1463.0

Domain

CKK

Tgene

CARS

chr1:200824017

chr11:3022478

ENST00000278224

406_410

706.6666666666666

727.0

Motif

Note='KMSKS' region

Tgene

CARS

chr1:200824017

chr11:3022478

ENST00000278224

57_67

706.6666666666666

727.0

Motif

Note='HIGH' region

Tgene

CARS

chr1:200824017

chr11:3022478

ENST00000380525

406_410

787.0

832.0

Motif

Note='KMSKS' region

Tgene

CARS

chr1:200824017

chr11:3022478

ENST00000380525

57_67

787.0

832.0

Motif

Note='HIGH' region

Tgene

CARS

chr1:200824017

chr11:3022478

ENST00000397111

406_410

704.0

749.0

Motif

Note='KMSKS' region

Tgene

CARS

chr1:200824017

chr11:3022478

ENST00000397111

57_67

704.0

749.0

Motif

Note='HIGH' region

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>2007_CAMSAP2_200824017_CARS_3022478_ranked_0.pdb	CAMSAP2	200824017	200824017	ENST00000397111	CARS	chr11	3022478	-	MGDAADPREMRKTFIVPAIKPFDHYDFSRAKIACNLAWLVAKAFGTENVPEELQEPFYTDQYDQEHIKPPVVNLLLSAELYCRAGSLILK SDAAKPLLGHDAVIQALAQKGLYVTDQEKLVTERDLHKKPIQMSAHLAMIDTLMMAYTVEMVSIEKVIACAQQYSAFFQATDLPYDIEDA VMYWINKVNEHLKDIMEQEQKLKEHHTVEAPGGQKSPSKWFWKLVPARYRKEQTLLKQLPCIPLVENLLKDGTDGCALAALIHFYCPDVV RLEDICLKETMSLADSLYNLQLIQEFCQEYLNQCCHFTLEDMLYAASSIKSNYLVFMAELFWWFEVVKPSFVQPRVVRPQGAEPVKDMPS IPVLNAAKRNVLDSSSDFPSSGEGATFTQSHHHLPSRYSRPQAHSSASGGIRRSSSMSYVDGFIGTWPKEKRSSVHGVSFDISFDKEDSV QRSTPNRGITRSISNEGLTLNNSHVSKHIRKNLSFKPINGEEEAESIEEELNIDSHSDLKSCVPLNTNELNSNENIHYKLPNGALQNRIL LDEFGNQIETPSIEEALQIIHDTEKSPHTPQPDQIANGFFLHSQEMSILNSNIKLNQSSPDNVTDTKGALSPITDNTEVDTGIHVPSEDI PETMDEDSSLRDYTVSLDSDMDDASKFLQDYDIRTGNTREALSPCPSTVSTKSQPGSSASSSSGVKMTSFAEQKFRKLNHTDGKSSGSSS QKTTPEGSELNIPHVVAWAQIPEETGLPQGRDTTQLLASEMVHLRMKLEEKRRAIEAQKKKMEAAFTKQRQKMGRTAFLTVVKKKGDGIS PLREEAAGAEDEKVYTDRAKEKESQKTDGQRSKSLADIKESMENPQAKWLKSPTTPIDPEKQWNLASPSEETLNEGEILEYTKSIEKLNS SLHFLQQEMQRLSLQQEMLMQMREQQSWVISPPQPSPQKQIRDFKPSKQAGLSSAIAPFSSDSPRPTHPSPQSSNRKSASFSVKSQRTPR PNELKITPLNRTLTPPRSVDSLPRLRRFSPSQVPIQTRSFVCFGDDGEPQLKESKPKEEVKKEELESKGTLEQRGHNPEEKEIKPFESTV SEVLSLPVTETVCLTPNEDQLNQPTEPPPKPVFPPTAPKNVNLIEVSLSDLKPPEKADVPVEKYDGESDKEQFDDDQKVCCGFFFKDDQK AENDMAMKRAALLEKRLRREKETQLRKQQLEAEMEHKKEETRRKTEEERQKKEDERARREFIRQEYMRRKQLKLMEDMDTVIKPRPQVVK	1329

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CAMSAP2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

CARS

EEF1G, PACSIN1, PACSIN2, PACSIN3, PSTPIP1, APP, APEH, CAND1, DNM1L, FAF1, GARS, GART, GFPT1, HIRIP3, HIST1H4A, IDE, JMJD6, KARS, LUC7L2, PAWR, PPAT, PPM1G, SEC23A, SHMT1, TROVE2, TTC1, XPO7, HSPA4, SEC24D, THUMPD3, SUMO2, CBS, HNRNPA1, PICALM, SBDS, SFPQ, LARS, MCFD2, PROSC, NTRK1, Eef1a1, TRAF6, EEF1D, EEF1A1, EEF1A2, ABTB1, MLLT6, LITAF, BATF3, TRIM25, BTF3, CARS, CTNNBL1, GTF2E1, PSMD1, PSMD12, RPL13, SNAPC1, UBA2, XRN2, EFTUD2, AAR2, PIH1D1, DPF2, ATG16L1, STAU1, WWP2, PLEKHA4, TRIM55, TRIM63, LRRC59, ATG7, ERP27, SUV420H1, NBR1, DVL2,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CAMSAP2
CARS

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CAMSAP2-CARS

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CAMSAP2-CARS

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source