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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CAPZA2-MET

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CAPZA2-MET
FusionPDB ID: 12985
FusionGDB2.0 ID: 12985
HgeneTgene
Gene symbol

CAPZA2

MET

Gene ID

830

8731

Gene namecapping actin protein of muscle Z-line subunit alpha 2RNA guanine-7 methyltransferase
SynonymsCAPPA2|CAPZCMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMet
Cytomap

7q31.2

18p11.21

Type of geneprotein-codingprotein-coding
DescriptionF-actin-capping protein subunit alpha-2F-actin capping protein alpha-2 subunitcapZ alpha-2capping actin protein of muscle Z-line alpha subunit 2capping protein (actin filament) muscle Z-line, alpha 2epididymis secretory sperm binding proteinmRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase
Modification date2020031320200329
UniProtAcc

P47755

Q9H1A3

Ensembl transtripts involved in fusion geneENST idsENST00000466023, ENST00000361183, 
ENST00000458284, ENST00000490693, 
ENST00000318493, ENST00000397752, 
ENST00000436117, ENST00000495962, 
ENST00000539704, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 6 X 9=91814 X 18 X 10=2520
# samples 2027
** MAII scorelog2(20/918*10)=-2.19849415363908
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2520*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CAPZA2 [Title/Abstract] AND MET [Title/Abstract] AND fusion [Title/Abstract]

Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer (pmid: 28512244)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CAPZA2(116550365)-MET(116409699), # samples:2
CAPZA2(116528244)-MET(116395409), # samples:2
CAPZA2(116528244)-MET(116414935), # samples:2
MET(116399544)-CAPZA2(116528181), # samples:2
Anticipated loss of major functional domain due to fusion event.CAPZA2-MET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPZA2-MET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPZA2-MET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPZA2-MET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MET-CAPZA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MET-CAPZA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPZA2-MET seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CAPZA2-MET seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CAPZA2-MET seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CAPZA2-MET seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMET

GO:0006370

7-methylguanosine mRNA capping

27422871


check buttonFusion gene breakpoints across CAPZA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A1AN-01ACAPZA2chr7

116550365

-METchr7

116409699

+
ChimerDB4BRCATCGA-AR-A1AN-01ACAPZA2chr7

116550365

+METchr7

116409699

+
ChimerDB4KIRPTCGA-G7-6793-01ACAPZA2chr7

116528244

-METchr7

116395409

+
ChimerDB4KIRPTCGA-G7-6793CAPZA2chr7

116528244

+METchr7

116395409

+
ChimerDB4LUADTCGA-78-7220-01ACAPZA2chr7

116528244

-METchr7

116414935

+
ChimerDB4LUADTCGA-78-7220-01ACAPZA2chr7

116528244

+METchr7

116414935

+
ChimerDB4STADTCGA-HU-8238-01ACAPZA2chr7

116502704

+METchr7

116435709

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361183CAPZA2chr7116550365+ENST00000397752METchr7116409699+45767241002313737
ENST00000361183CAPZA2chr7116550365+ENST00000318493METchr7116409699+25327241002313737
ENST00000361183CAPZA2chr7116528244+ENST00000397752METchr7116414935+36492421001386428
ENST00000361183CAPZA2chr7116528244+ENST00000318493METchr7116414935+16052421001386428
ENST00000458284CAPZA2chr7116528244+ENST00000397752METchr7116414935+3563156141300428
ENST00000458284CAPZA2chr7116528244+ENST00000318493METchr7116414935+1519156141300428
ENST00000490693CAPZA2chr7116528244+ENST00000397752METchr7116414935+3522115121259415
ENST00000490693CAPZA2chr7116528244+ENST00000318493METchr7116414935+1478115121259415

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361183ENST00000397752CAPZA2chr7116550365+METchr7116409699+0.0004711910.9995289
ENST00000361183ENST00000318493CAPZA2chr7116550365+METchr7116409699+0.0012178890.9987821
ENST00000361183ENST00000397752CAPZA2chr7116528244+METchr7116414935+0.0003189090.9996811
ENST00000361183ENST00000318493CAPZA2chr7116528244+METchr7116414935+0.0006527510.99934727
ENST00000458284ENST00000397752CAPZA2chr7116528244+METchr7116414935+0.0003160450.999684
ENST00000458284ENST00000318493CAPZA2chr7116528244+METchr7116414935+0.0005756890.99942434
ENST00000490693ENST00000397752CAPZA2chr7116528244+METchr7116414935+0.0003022740.9996978
ENST00000490693ENST00000318493CAPZA2chr7116528244+METchr7116414935+0.0005895970.9994104

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>12985_12985_1_CAPZA2-MET_CAPZA2_chr7_116528244_ENST00000361183_MET_chr7_116414935_ENST00000318493_length(amino acids)=428AA_BP=47
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVH
IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL
LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDK
EYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP

--------------------------------------------------------------

>12985_12985_2_CAPZA2-MET_CAPZA2_chr7_116528244_ENST00000361183_MET_chr7_116414935_ENST00000397752_length(amino acids)=428AA_BP=47
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVH
IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL
LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDK
EYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP

--------------------------------------------------------------

>12985_12985_3_CAPZA2-MET_CAPZA2_chr7_116528244_ENST00000458284_MET_chr7_116414935_ENST00000318493_length(amino acids)=428AA_BP=47
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVH
IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL
LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDK
EYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP

--------------------------------------------------------------

>12985_12985_4_CAPZA2-MET_CAPZA2_chr7_116528244_ENST00000458284_MET_chr7_116414935_ENST00000397752_length(amino acids)=428AA_BP=47
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVH
IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL
LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDK
EYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP

--------------------------------------------------------------

>12985_12985_5_CAPZA2-MET_CAPZA2_chr7_116528244_ENST00000490693_MET_chr7_116414935_ENST00000318493_length(amino acids)=415AA_BP=34
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQA
VQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLV
VLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL
PVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVS

--------------------------------------------------------------

>12985_12985_6_CAPZA2-MET_CAPZA2_chr7_116528244_ENST00000490693_MET_chr7_116414935_ENST00000397752_length(amino acids)=415AA_BP=34
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQA
VQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLV
VLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL
PVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVS

--------------------------------------------------------------

>12985_12985_7_CAPZA2-MET_CAPZA2_chr7_116550365_ENST00000361183_MET_chr7_116409699_ENST00000318493_length(amino acids)=737AA_BP=207
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLIT
EHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKN
FWNGRWRSEWKFTITPSTTQVVGILKIQGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKV
IVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFP
NSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGK
KIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMK
YLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPP
YPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSED

--------------------------------------------------------------

>12985_12985_8_CAPZA2-MET_CAPZA2_chr7_116550365_ENST00000361183_MET_chr7_116409699_ENST00000397752_length(amino acids)=737AA_BP=207
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLIT
EHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKN
FWNGRWRSEWKFTITPSTTQVVGILKIQGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKV
IVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFP
NSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGK
KIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMK
YLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPP
YPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSED

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:116550365/chr7:116409699)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPZA2

P47755

MET

Q9H1A3

FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMETchr7:116502704chr7:116435709ENST00000436117091078_13450.0765.0DomainProtein kinase
TgeneMETchr7:116502704chr7:116435709ENST000004361170927_5150.0765.0DomainSema
TgeneMETchr7:116502704chr7:116435709ENST0000043611709563_6550.0765.0DomainNote=IPT/TIG 1
TgeneMETchr7:116502704chr7:116435709ENST0000043611709657_7390.0765.0DomainNote=IPT/TIG 2
TgeneMETchr7:116502704chr7:116435709ENST0000043611709742_8360.0765.0DomainNote=IPT/TIG 3
TgeneMETchr7:116528244chr7:116414935ENST0000031849313211078_13451027.33333333333331409.0DomainProtein kinase
TgeneMETchr7:116528244chr7:116414935ENST0000039775213211078_13451009.33333333333341391.0DomainProtein kinase
TgeneMETchr7:116528244chr7:116414935ENST00000436117091078_13450.0765.0DomainProtein kinase
TgeneMETchr7:116528244chr7:116414935ENST000004361170927_5150.0765.0DomainSema
TgeneMETchr7:116528244chr7:116414935ENST0000043611709563_6550.0765.0DomainNote=IPT/TIG 1
TgeneMETchr7:116528244chr7:116414935ENST0000043611709657_7390.0765.0DomainNote=IPT/TIG 2
TgeneMETchr7:116528244chr7:116414935ENST0000043611709742_8360.0765.0DomainNote=IPT/TIG 3
TgeneMETchr7:116550365chr7:116409699ENST0000031849310211078_1345879.01409.0DomainProtein kinase
TgeneMETchr7:116550365chr7:116409699ENST0000039775210211078_1345861.01391.0DomainProtein kinase
TgeneMETchr7:116550365chr7:116409699ENST00000436117091078_13450.0765.0DomainProtein kinase
TgeneMETchr7:116550365chr7:116409699ENST000004361170927_5150.0765.0DomainSema
TgeneMETchr7:116550365chr7:116409699ENST0000043611709563_6550.0765.0DomainNote=IPT/TIG 1
TgeneMETchr7:116550365chr7:116409699ENST0000043611709657_7390.0765.0DomainNote=IPT/TIG 2
TgeneMETchr7:116550365chr7:116409699ENST0000043611709742_8360.0765.0DomainNote=IPT/TIG 3
TgeneMETchr7:116502704chr7:116435709ENST00000436117091084_10920.0765.0Nucleotide bindingATP
TgeneMETchr7:116528244chr7:116414935ENST0000031849313211084_10921027.33333333333331409.0Nucleotide bindingATP
TgeneMETchr7:116528244chr7:116414935ENST0000039775213211084_10921009.33333333333341391.0Nucleotide bindingATP
TgeneMETchr7:116528244chr7:116414935ENST00000436117091084_10920.0765.0Nucleotide bindingATP
TgeneMETchr7:116550365chr7:116409699ENST0000031849310211084_1092879.01409.0Nucleotide bindingATP
TgeneMETchr7:116550365chr7:116409699ENST0000039775210211084_1092861.01391.0Nucleotide bindingATP
TgeneMETchr7:116550365chr7:116409699ENST00000436117091084_10920.0765.0Nucleotide bindingATP
TgeneMETchr7:116502704chr7:116435709ENST000004361170925_9320.0765.0Topological domainExtracellular
TgeneMETchr7:116502704chr7:116435709ENST0000043611709956_13900.0765.0Topological domainCytoplasmic
TgeneMETchr7:116528244chr7:116414935ENST000004361170925_9320.0765.0Topological domainExtracellular
TgeneMETchr7:116528244chr7:116414935ENST0000043611709956_13900.0765.0Topological domainCytoplasmic
TgeneMETchr7:116550365chr7:116409699ENST000003184931021956_1390879.01409.0Topological domainCytoplasmic
TgeneMETchr7:116550365chr7:116409699ENST000003977521021956_1390861.01391.0Topological domainCytoplasmic
TgeneMETchr7:116550365chr7:116409699ENST000004361170925_9320.0765.0Topological domainExtracellular
TgeneMETchr7:116550365chr7:116409699ENST0000043611709956_13900.0765.0Topological domainCytoplasmic
TgeneMETchr7:116502704chr7:116435709ENST0000043611709933_9550.0765.0TransmembraneHelical
TgeneMETchr7:116528244chr7:116414935ENST0000043611709933_9550.0765.0TransmembraneHelical
TgeneMETchr7:116550365chr7:116409699ENST000003184931021933_955879.01409.0TransmembraneHelical
TgeneMETchr7:116550365chr7:116409699ENST000003977521021933_955861.01391.0TransmembraneHelical
TgeneMETchr7:116550365chr7:116409699ENST0000043611709933_9550.0765.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMETchr7:116502704chr7:116435709ENST0000031849318211078_13451284.01409.0DomainProtein kinase
TgeneMETchr7:116502704chr7:116435709ENST00000318493182127_5151284.01409.0DomainSema
TgeneMETchr7:116502704chr7:116435709ENST000003184931821563_6551284.01409.0DomainNote=IPT/TIG 1
TgeneMETchr7:116502704chr7:116435709ENST000003184931821657_7391284.01409.0DomainNote=IPT/TIG 2
TgeneMETchr7:116502704chr7:116435709ENST000003184931821742_8361284.01409.0DomainNote=IPT/TIG 3
TgeneMETchr7:116502704chr7:116435709ENST0000039775218211078_13451266.01391.0DomainProtein kinase
TgeneMETchr7:116502704chr7:116435709ENST00000397752182127_5151266.01391.0DomainSema
TgeneMETchr7:116502704chr7:116435709ENST000003977521821563_6551266.01391.0DomainNote=IPT/TIG 1
TgeneMETchr7:116502704chr7:116435709ENST000003977521821657_7391266.01391.0DomainNote=IPT/TIG 2
TgeneMETchr7:116502704chr7:116435709ENST000003977521821742_8361266.01391.0DomainNote=IPT/TIG 3
TgeneMETchr7:116528244chr7:116414935ENST00000318493132127_5151027.33333333333331409.0DomainSema
TgeneMETchr7:116528244chr7:116414935ENST000003184931321563_6551027.33333333333331409.0DomainNote=IPT/TIG 1
TgeneMETchr7:116528244chr7:116414935ENST000003184931321657_7391027.33333333333331409.0DomainNote=IPT/TIG 2
TgeneMETchr7:116528244chr7:116414935ENST000003184931321742_8361027.33333333333331409.0DomainNote=IPT/TIG 3
TgeneMETchr7:116528244chr7:116414935ENST00000397752132127_5151009.33333333333341391.0DomainSema
TgeneMETchr7:116528244chr7:116414935ENST000003977521321563_6551009.33333333333341391.0DomainNote=IPT/TIG 1
TgeneMETchr7:116528244chr7:116414935ENST000003977521321657_7391009.33333333333341391.0DomainNote=IPT/TIG 2
TgeneMETchr7:116528244chr7:116414935ENST000003977521321742_8361009.33333333333341391.0DomainNote=IPT/TIG 3
TgeneMETchr7:116550365chr7:116409699ENST00000318493102127_515879.01409.0DomainSema
TgeneMETchr7:116550365chr7:116409699ENST000003184931021563_655879.01409.0DomainNote=IPT/TIG 1
TgeneMETchr7:116550365chr7:116409699ENST000003184931021657_739879.01409.0DomainNote=IPT/TIG 2
TgeneMETchr7:116550365chr7:116409699ENST000003184931021742_836879.01409.0DomainNote=IPT/TIG 3
TgeneMETchr7:116550365chr7:116409699ENST00000397752102127_515861.01391.0DomainSema
TgeneMETchr7:116550365chr7:116409699ENST000003977521021563_655861.01391.0DomainNote=IPT/TIG 1
TgeneMETchr7:116550365chr7:116409699ENST000003977521021657_739861.01391.0DomainNote=IPT/TIG 2
TgeneMETchr7:116550365chr7:116409699ENST000003977521021742_836861.01391.0DomainNote=IPT/TIG 3
TgeneMETchr7:116502704chr7:116435709ENST0000031849318211084_10921284.01409.0Nucleotide bindingATP
TgeneMETchr7:116502704chr7:116435709ENST0000039775218211084_10921266.01391.0Nucleotide bindingATP
TgeneMETchr7:116502704chr7:116435709ENST00000318493182125_9321284.01409.0Topological domainExtracellular
TgeneMETchr7:116502704chr7:116435709ENST000003184931821956_13901284.01409.0Topological domainCytoplasmic
TgeneMETchr7:116502704chr7:116435709ENST00000397752182125_9321266.01391.0Topological domainExtracellular
TgeneMETchr7:116502704chr7:116435709ENST000003977521821956_13901266.01391.0Topological domainCytoplasmic
TgeneMETchr7:116528244chr7:116414935ENST00000318493132125_9321027.33333333333331409.0Topological domainExtracellular
TgeneMETchr7:116528244chr7:116414935ENST000003184931321956_13901027.33333333333331409.0Topological domainCytoplasmic
TgeneMETchr7:116528244chr7:116414935ENST00000397752132125_9321009.33333333333341391.0Topological domainExtracellular
TgeneMETchr7:116528244chr7:116414935ENST000003977521321956_13901009.33333333333341391.0Topological domainCytoplasmic
TgeneMETchr7:116550365chr7:116409699ENST00000318493102125_932879.01409.0Topological domainExtracellular
TgeneMETchr7:116550365chr7:116409699ENST00000397752102125_932861.01391.0Topological domainExtracellular
TgeneMETchr7:116502704chr7:116435709ENST000003184931821933_9551284.01409.0TransmembraneHelical
TgeneMETchr7:116502704chr7:116435709ENST000003977521821933_9551266.01391.0TransmembraneHelical
TgeneMETchr7:116528244chr7:116414935ENST000003184931321933_9551027.33333333333331409.0TransmembraneHelical
TgeneMETchr7:116528244chr7:116414935ENST000003977521321933_9551009.33333333333341391.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CAPZA2
MET


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMETchr7:116502704chr7:116435709ENST0000031849318211212_13901284.01409.0RANBP9
TgeneMETchr7:116502704chr7:116435709ENST0000039775218211212_13901266.01391.0RANBP9


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Related Drugs to CAPZA2-MET


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CAPZA2-MET


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource