UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:CASK-ABCB4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CASK-ABCB4
FusionPDB ID: 13186
FusionGDB2.0 ID: 13186
HgeneTgene
Gene symbol

CASK

ABCB4

Gene ID

8573

5244

Gene namecalcium/calmodulin dependent serine protein kinaseATP binding cassette subfamily B member 4
SynonymsCAGH39|CAMGUK|CMG|FGS4|LIN2|MICPCH|MRXSNA|TNRC8|hCASKABC21|GBD1|ICP3|MDR2|MDR2/3|MDR3|PFIC-3|PGY3
Cytomap

Xp11.4

7q21.12

Type of geneprotein-codingprotein-coding
Descriptionperipheral plasma membrane protein CASKcalcium/calmodulin-dependent serin protein kinasecalcium/calmodulin-dependent serine protein kinase (MAGUK family)calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinaseprotein linphosphatidylcholine translocator ABCB4ATP-binding cassette sub-family B member 4ATP-binding cassette, sub-family B (MDR/TAP), member 4P-glycoprotein 3P-glycoprotein-3/multiple drug resistance-3multidrug resistance protein 3multiple drug resistance 3
Modification date2020032720200315
UniProtAcc

Q8WXE0

P21439

Ensembl transtripts involved in fusion geneENST idsENST00000318588, ENST00000361962, 
ENST00000378154, ENST00000378158, 
ENST00000378163, ENST00000378166, 
ENST00000421587, ENST00000442742, 
ENST00000472704, 		ENST00000265723, 
ENST00000358400, ENST00000359206, 
ENST00000453593, ENST00000545634, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 12 X 5=7804 X 5 X 4=80
# samples 144
** MAII scorelog2(14/780*10)=-2.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CASK [Title/Abstract] AND ABCB4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CASK(41782183)-ABCB4(87104787), # samples:1
CASK(41782183)-ABCB4(87092224), # samples:1
Anticipated loss of major functional domain due to fusion event.CASK-ABCB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CASK-ABCB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CASK-ABCB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CASK-ABCB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCASK

GO:0010839

negative regulation of keratinocyte proliferation

18664494

TgeneABCB4

GO:0032376

positive regulation of cholesterol transport

17523162

TgeneABCB4

GO:0045332

phospholipid translocation

8898203

TgeneABCB4

GO:0055088

lipid homeostasis

17523162

TgeneABCB4

GO:0061092

positive regulation of phospholipid translocation

17523162

TgeneABCB4

GO:0099040

ceramide translocation

8898203

TgeneABCB4

GO:1903413

cellular response to bile acid

17523162

TgeneABCB4

GO:2001140

positive regulation of phospholipid transport

8898203


check buttonFusion gene breakpoints across CASK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCB4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-5799-01ACASKchrX

41782183

-ABCB4chr7

87092224

-
ChimerDB4STADTCGA-CD-5799-01ACASKchrX

41782183

-ABCB4chr7

87104787

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000421587CASKchrX41782183-ENST00000359206ABCB4chr787092224-38398311037871225
ENST00000421587CASKchrX41782183-ENST00000358400ABCB4chr787092224-36988311036461178
ENST00000421587CASKchrX41782183-ENST00000265723ABCB4chr787092224-38568311038081232
ENST00000421587CASKchrX41782183-ENST00000545634ABCB4chr787092224-37888311037871226
ENST00000421587CASKchrX41782183-ENST00000453593ABCB4chr787092224-36478311036461179
ENST00000318588CASKchrX41782183-ENST00000359206ABCB4chr787092224-38611052138091262
ENST00000318588CASKchrX41782183-ENST00000358400ABCB4chr787092224-37201052136681215
ENST00000318588CASKchrX41782183-ENST00000265723ABCB4chr787092224-38781052138301269
ENST00000318588CASKchrX41782183-ENST00000545634ABCB4chr787092224-38101052138091262
ENST00000318588CASKchrX41782183-ENST00000453593ABCB4chr787092224-36691052136681215
ENST00000361962CASKchrX41782183-ENST00000359206ABCB4chr787092224-38611052138091262
ENST00000361962CASKchrX41782183-ENST00000358400ABCB4chr787092224-37201052136681215
ENST00000361962CASKchrX41782183-ENST00000265723ABCB4chr787092224-38781052138301269
ENST00000361962CASKchrX41782183-ENST00000545634ABCB4chr787092224-38101052138091262
ENST00000361962CASKchrX41782183-ENST00000453593ABCB4chr787092224-36691052136681215
ENST00000378163CASKchrX41782183-ENST00000359206ABCB4chr787092224-429053429742381313
ENST00000378163CASKchrX41782183-ENST00000358400ABCB4chr787092224-414953429740971266
ENST00000378163CASKchrX41782183-ENST00000265723ABCB4chr787092224-430753429742591320
ENST00000378163CASKchrX41782183-ENST00000545634ABCB4chr787092224-423953429742381313
ENST00000378163CASKchrX41782183-ENST00000453593ABCB4chr787092224-409853429740971266
ENST00000378158CASKchrX41782183-ENST00000359206ABCB4chr787092224-416641017341141313
ENST00000378158CASKchrX41782183-ENST00000358400ABCB4chr787092224-402541017339731266
ENST00000378158CASKchrX41782183-ENST00000265723ABCB4chr787092224-418341017341351320
ENST00000378158CASKchrX41782183-ENST00000545634ABCB4chr787092224-411541017341141314
ENST00000378158CASKchrX41782183-ENST00000453593ABCB4chr787092224-397441017339731267
ENST00000378166CASKchrX41782183-ENST00000359206ABCB4chr787092224-384286237901262
ENST00000378166CASKchrX41782183-ENST00000358400ABCB4chr787092224-370186236491215
ENST00000378166CASKchrX41782183-ENST00000265723ABCB4chr787092224-385986238111269
ENST00000378166CASKchrX41782183-ENST00000545634ABCB4chr787092224-379186237901263
ENST00000378166CASKchrX41782183-ENST00000453593ABCB4chr787092224-365086236491216
ENST00000442742CASKchrX41782183-ENST00000359206ABCB4chr787092224-38347810537821225
ENST00000442742CASKchrX41782183-ENST00000358400ABCB4chr787092224-36937810536411178
ENST00000442742CASKchrX41782183-ENST00000265723ABCB4chr787092224-38517810538031232
ENST00000442742CASKchrX41782183-ENST00000545634ABCB4chr787092224-37837810537821225
ENST00000442742CASKchrX41782183-ENST00000453593ABCB4chr787092224-36427810536411178
ENST00000378154CASKchrX41782183-ENST00000359206ABCB4chr787092224-429053429742381313
ENST00000378154CASKchrX41782183-ENST00000358400ABCB4chr787092224-414953429740971266
ENST00000378154CASKchrX41782183-ENST00000265723ABCB4chr787092224-430753429742591320
ENST00000378154CASKchrX41782183-ENST00000545634ABCB4chr787092224-423953429742381313
ENST00000378154CASKchrX41782183-ENST00000453593ABCB4chr787092224-409853429740971266

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000421587ENST00000359206CASKchrX41782183-ABCB4chr787092224-0.0030792560.9969208
ENST00000421587ENST00000358400CASKchrX41782183-ABCB4chr787092224-0.0018449190.99815506
ENST00000421587ENST00000265723CASKchrX41782183-ABCB4chr787092224-0.003167660.9968323
ENST00000421587ENST00000545634CASKchrX41782183-ABCB4chr787092224-0.0034044090.99659556
ENST00000421587ENST00000453593CASKchrX41782183-ABCB4chr787092224-0.0020856820.99791425
ENST00000318588ENST00000359206CASKchrX41782183-ABCB4chr787092224-0.0031086520.9968913
ENST00000318588ENST00000358400CASKchrX41782183-ABCB4chr787092224-0.001865320.9981346
ENST00000318588ENST00000265723CASKchrX41782183-ABCB4chr787092224-0.0032013270.99679863
ENST00000318588ENST00000545634CASKchrX41782183-ABCB4chr787092224-0.0034347350.9965653
ENST00000318588ENST00000453593CASKchrX41782183-ABCB4chr787092224-0.0021053050.9978947
ENST00000361962ENST00000359206CASKchrX41782183-ABCB4chr787092224-0.0031086520.9968913
ENST00000361962ENST00000358400CASKchrX41782183-ABCB4chr787092224-0.001865320.9981346
ENST00000361962ENST00000265723CASKchrX41782183-ABCB4chr787092224-0.0032013270.99679863
ENST00000361962ENST00000545634CASKchrX41782183-ABCB4chr787092224-0.0034347350.9965653
ENST00000361962ENST00000453593CASKchrX41782183-ABCB4chr787092224-0.0021053050.9978947
ENST00000378163ENST00000359206CASKchrX41782183-ABCB4chr787092224-0.0048370790.99516284
ENST00000378163ENST00000358400CASKchrX41782183-ABCB4chr787092224-0.0030923250.99690765
ENST00000378163ENST00000265723CASKchrX41782183-ABCB4chr787092224-0.0048823980.99511766
ENST00000378163ENST00000545634CASKchrX41782183-ABCB4chr787092224-0.0051903780.9948096
ENST00000378163ENST00000453593CASKchrX41782183-ABCB4chr787092224-0.0034355270.99656445
ENST00000378158ENST00000359206CASKchrX41782183-ABCB4chr787092224-0.004156680.99584335
ENST00000378158ENST00000358400CASKchrX41782183-ABCB4chr787092224-0.0025475710.99745244
ENST00000378158ENST00000265723CASKchrX41782183-ABCB4chr787092224-0.0041881340.99581194
ENST00000378158ENST00000545634CASKchrX41782183-ABCB4chr787092224-0.004525220.99547476
ENST00000378158ENST00000453593CASKchrX41782183-ABCB4chr787092224-0.0028269730.99717295
ENST00000378166ENST00000359206CASKchrX41782183-ABCB4chr787092224-0.0030668290.9969331
ENST00000378166ENST00000358400CASKchrX41782183-ABCB4chr787092224-0.0018356820.99816436
ENST00000378166ENST00000265723CASKchrX41782183-ABCB4chr787092224-0.0031534410.9968465
ENST00000378166ENST00000545634CASKchrX41782183-ABCB4chr787092224-0.0033922640.9966078
ENST00000378166ENST00000453593CASKchrX41782183-ABCB4chr787092224-0.0020748470.99792516
ENST00000442742ENST00000359206CASKchrX41782183-ABCB4chr787092224-0.0030353750.99696463
ENST00000442742ENST00000358400CASKchrX41782183-ABCB4chr787092224-0.0018116520.9981883
ENST00000442742ENST00000265723CASKchrX41782183-ABCB4chr787092224-0.003119070.9968809
ENST00000442742ENST00000545634CASKchrX41782183-ABCB4chr787092224-0.0033508070.9966492
ENST00000442742ENST00000453593CASKchrX41782183-ABCB4chr787092224-0.0020487670.9979512
ENST00000378154ENST00000359206CASKchrX41782183-ABCB4chr787092224-0.0048370790.99516284
ENST00000378154ENST00000358400CASKchrX41782183-ABCB4chr787092224-0.0030923250.99690765
ENST00000378154ENST00000265723CASKchrX41782183-ABCB4chr787092224-0.0048823980.99511766
ENST00000378154ENST00000545634CASKchrX41782183-ABCB4chr787092224-0.0051903780.9948096
ENST00000378154ENST00000453593CASKchrX41782183-ABCB4chr787092224-0.0034355270.99656445

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>13186_13186_1_CASK-ABCB4_CASK_chrX_41782183_ENST00000318588_ABCB4_chr7_87092224_ENST00000265723_length(amino acids)=1269AA_BP=374
MRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGK
ILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ
AVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK
EIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKI
DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY
LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD
EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDE
KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA
IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGA
TGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFES
MYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL
FMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDF
GFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQK
QRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV

--------------------------------------------------------------

>13186_13186_2_CASK-ABCB4_CASK_chrX_41782183_ENST00000318588_ABCB4_chr7_87092224_ENST00000358400_length(amino acids)=1215AA_BP=374
MRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGK
ILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ
AVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK
EIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKI
DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY
LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD
EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDE
KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA
IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGA
TGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFES
MYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQG
LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEI
VSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS

--------------------------------------------------------------

>13186_13186_3_CASK-ABCB4_CASK_chrX_41782183_ENST00000318588_ABCB4_chr7_87092224_ENST00000359206_length(amino acids)=1262AA_BP=374
MRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGK
ILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ
AVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK
EIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKI
DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY
LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD
EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDE
KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA
IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGA
TGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFES
MYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL
FMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG
QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR
ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ

--------------------------------------------------------------

>13186_13186_4_CASK-ABCB4_CASK_chrX_41782183_ENST00000318588_ABCB4_chr7_87092224_ENST00000453593_length(amino acids)=1215AA_BP=374
MRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGK
ILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ
AVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK
EIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKI
DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY
LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD
EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDE
KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA
IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGA
TGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFES
MYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQG
LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEI
VSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS

--------------------------------------------------------------

>13186_13186_5_CASK-ABCB4_CASK_chrX_41782183_ENST00000318588_ABCB4_chr7_87092224_ENST00000545634_length(amino acids)=1262AA_BP=374
MRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGK
ILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ
AVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK
EIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKI
DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY
LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD
EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDE
KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA
IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGA
TGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFES
MYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL
FMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG
QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR
ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ

--------------------------------------------------------------

>13186_13186_6_CASK-ABCB4_CASK_chrX_41782183_ENST00000361962_ABCB4_chr7_87092224_ENST00000265723_length(amino acids)=1269AA_BP=374
MRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGK
ILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ
AVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK
EIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKI
DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY
LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD
EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDE
KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA
IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGA
TGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFES
MYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL
FMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDF
GFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQK
QRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV

--------------------------------------------------------------

>13186_13186_7_CASK-ABCB4_CASK_chrX_41782183_ENST00000361962_ABCB4_chr7_87092224_ENST00000358400_length(amino acids)=1215AA_BP=374
MRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGK
ILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ
AVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK
EIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKI
DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY
LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD
EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDE
KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA
IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGA
TGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFES
MYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQG
LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEI
VSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS

--------------------------------------------------------------

>13186_13186_8_CASK-ABCB4_CASK_chrX_41782183_ENST00000361962_ABCB4_chr7_87092224_ENST00000359206_length(amino acids)=1262AA_BP=374
MRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGK
ILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ
AVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK
EIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKI
DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY
LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD
EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDE
KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA
IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGA
TGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFES
MYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL
FMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG
QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR
ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ

--------------------------------------------------------------

>13186_13186_9_CASK-ABCB4_CASK_chrX_41782183_ENST00000361962_ABCB4_chr7_87092224_ENST00000453593_length(amino acids)=1215AA_BP=374
MRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGK
ILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ
AVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK
EIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKI
DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY
LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD
EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDE
KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA
IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGA
TGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFES
MYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQG
LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEI
VSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS

--------------------------------------------------------------

>13186_13186_10_CASK-ABCB4_CASK_chrX_41782183_ENST00000361962_ABCB4_chr7_87092224_ENST00000545634_length(amino acids)=1262AA_BP=374
MRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGK
ILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ
AVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK
EIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKI
DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY
LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD
EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDE
KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA
IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGA
TGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFES
MYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL
FMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG
QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR
ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ

--------------------------------------------------------------

>13186_13186_11_CASK-ABCB4_CASK_chrX_41782183_ENST00000378154_ABCB4_chr7_87092224_ENST00000265723_length(amino acids)=1320AA_BP=425
MQRKAPQSLGLAAPLERPRHRGLAGPEGRRRSRGWALSSWAPPPPFSKPSTLRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLF
MSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQI
RKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAK
ILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISK
EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLN
LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAV
KEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRN
ADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD
GLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF
GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPI
IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCF
RFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTR
ANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAEN
IAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDK

--------------------------------------------------------------

>13186_13186_12_CASK-ABCB4_CASK_chrX_41782183_ENST00000378154_ABCB4_chr7_87092224_ENST00000358400_length(amino acids)=1266AA_BP=425
MQRKAPQSLGLAAPLERPRHRGLAGPEGRRRSRGWALSSWAPPPPFSKPSTLRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLF
MSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQI
RKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAK
ILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISK
EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLN
LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAV
KEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRN
ADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD
GLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF
GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPI
IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLS
AAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTV
LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRI
AIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ

--------------------------------------------------------------

>13186_13186_13_CASK-ABCB4_CASK_chrX_41782183_ENST00000378154_ABCB4_chr7_87092224_ENST00000359206_length(amino acids)=1313AA_BP=425
MQRKAPQSLGLAAPLERPRHRGLAGPEGRRRSRGWALSSWAPPPPFSKPSTLRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLF
MSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQI
RKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAK
ILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISK
EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLN
LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAV
KEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRN
ADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD
GLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF
GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPI
IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCF
RFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTR
ANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNS
RVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTC

--------------------------------------------------------------

>13186_13186_14_CASK-ABCB4_CASK_chrX_41782183_ENST00000378154_ABCB4_chr7_87092224_ENST00000453593_length(amino acids)=1266AA_BP=425
MQRKAPQSLGLAAPLERPRHRGLAGPEGRRRSRGWALSSWAPPPPFSKPSTLRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLF
MSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQI
RKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAK
ILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISK
EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLN
LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAV
KEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRN
ADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD
GLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF
GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPI
IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLS
AAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTV
LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRI
AIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ

--------------------------------------------------------------

>13186_13186_15_CASK-ABCB4_CASK_chrX_41782183_ENST00000378154_ABCB4_chr7_87092224_ENST00000545634_length(amino acids)=1313AA_BP=425
MQRKAPQSLGLAAPLERPRHRGLAGPEGRRRSRGWALSSWAPPPPFSKPSTLRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLF
MSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQI
RKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAK
ILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISK
EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLN
LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAV
KEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRN
ADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD
GLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF
GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPI
IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCF
RFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTR
ANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNS
RVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTC

--------------------------------------------------------------

>13186_13186_16_CASK-ABCB4_CASK_chrX_41782183_ENST00000378158_ABCB4_chr7_87092224_ENST00000265723_length(amino acids)=1320AA_BP=425
MQRKAPQSLGLAAPLERPRHRGLAGPEGRRRSRGWALSSWAPPPPFSKPSTLRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLF
MSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQI
RKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAK
ILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISK
EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLN
LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAV
KEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRN
ADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD
GLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF
GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPI
IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCF
RFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTR
ANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAEN
IAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDK

--------------------------------------------------------------

>13186_13186_17_CASK-ABCB4_CASK_chrX_41782183_ENST00000378158_ABCB4_chr7_87092224_ENST00000358400_length(amino acids)=1266AA_BP=425
MQRKAPQSLGLAAPLERPRHRGLAGPEGRRRSRGWALSSWAPPPPFSKPSTLRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLF
MSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQI
RKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAK
ILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISK
EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLN
LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAV
KEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRN
ADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD
GLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF
GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPI
IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLS
AAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTV
LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRI
AIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ

--------------------------------------------------------------

>13186_13186_18_CASK-ABCB4_CASK_chrX_41782183_ENST00000378158_ABCB4_chr7_87092224_ENST00000359206_length(amino acids)=1313AA_BP=425
MQRKAPQSLGLAAPLERPRHRGLAGPEGRRRSRGWALSSWAPPPPFSKPSTLRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLF
MSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQI
RKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAK
ILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISK
EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLN
LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAV
KEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRN
ADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD
GLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF
GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPI
IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCF
RFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTR
ANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNS
RVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTC

--------------------------------------------------------------

>13186_13186_19_CASK-ABCB4_CASK_chrX_41782183_ENST00000378158_ABCB4_chr7_87092224_ENST00000453593_length(amino acids)=1267AA_BP=425
MQRKAPQSLGLAAPLERPRHRGLAGPEGRRRSRGWALSSWAPPPPFSKPSTLRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLF
MSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQI
RKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAK
ILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISK
EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLN
LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAV
KEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRN
ADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD
GLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF
GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPI
IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLS
AAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTV
LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRI
AIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ

--------------------------------------------------------------

>13186_13186_20_CASK-ABCB4_CASK_chrX_41782183_ENST00000378158_ABCB4_chr7_87092224_ENST00000545634_length(amino acids)=1314AA_BP=425
MQRKAPQSLGLAAPLERPRHRGLAGPEGRRRSRGWALSSWAPPPPFSKPSTLRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLF
MSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQI
RKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAK
ILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISK
EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLN
LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAV
KEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRN
ADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD
GLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF
GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPI
IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCF
RFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTR
ANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNS
RVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTC

--------------------------------------------------------------

>13186_13186_21_CASK-ABCB4_CASK_chrX_41782183_ENST00000378163_ABCB4_chr7_87092224_ENST00000265723_length(amino acids)=1320AA_BP=425
MQRKAPQSLGLAAPLERPRHRGLAGPEGRRRSRGWALSSWAPPPPFSKPSTLRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLF
MSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQI
RKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAK
ILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISK
EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLN
LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAV
KEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRN
ADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD
GLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF
GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPI
IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCF
RFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTR
ANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAEN
IAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDK

--------------------------------------------------------------

>13186_13186_22_CASK-ABCB4_CASK_chrX_41782183_ENST00000378163_ABCB4_chr7_87092224_ENST00000358400_length(amino acids)=1266AA_BP=425
MQRKAPQSLGLAAPLERPRHRGLAGPEGRRRSRGWALSSWAPPPPFSKPSTLRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLF
MSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQI
RKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAK
ILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISK
EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLN
LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAV
KEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRN
ADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD
GLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF
GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPI
IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLS
AAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTV
LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRI
AIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ

--------------------------------------------------------------

>13186_13186_23_CASK-ABCB4_CASK_chrX_41782183_ENST00000378163_ABCB4_chr7_87092224_ENST00000359206_length(amino acids)=1313AA_BP=425
MQRKAPQSLGLAAPLERPRHRGLAGPEGRRRSRGWALSSWAPPPPFSKPSTLRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLF
MSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQI
RKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAK
ILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISK
EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLN
LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAV
KEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRN
ADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD
GLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF
GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPI
IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCF
RFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTR
ANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNS
RVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTC

--------------------------------------------------------------

>13186_13186_24_CASK-ABCB4_CASK_chrX_41782183_ENST00000378163_ABCB4_chr7_87092224_ENST00000453593_length(amino acids)=1266AA_BP=425
MQRKAPQSLGLAAPLERPRHRGLAGPEGRRRSRGWALSSWAPPPPFSKPSTLRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLF
MSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQI
RKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAK
ILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISK
EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLN
LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAV
KEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRN
ADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD
GLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF
GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPI
IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLS
AAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTV
LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRI
AIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ

--------------------------------------------------------------

>13186_13186_25_CASK-ABCB4_CASK_chrX_41782183_ENST00000378163_ABCB4_chr7_87092224_ENST00000545634_length(amino acids)=1313AA_BP=425
MQRKAPQSLGLAAPLERPRHRGLAGPEGRRRSRGWALSSWAPPPPFSKPSTLRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLF
MSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQI
RKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAK
ILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISK
EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLN
LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAV
KEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRN
ADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETD
GLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTF
GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPI
IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCF
RFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTR
ANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNS
RVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTC

--------------------------------------------------------------

>13186_13186_26_CASK-ABCB4_CASK_chrX_41782183_ENST00000378166_ABCB4_chr7_87092224_ENST00000265723_length(amino acids)=1269AA_BP=374
LRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGK
ILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ
AVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK
EIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKI
DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY
LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD
EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDE
KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA
IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGA
TGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFES
MYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL
FMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDF
GFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQK
QRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV

--------------------------------------------------------------

>13186_13186_27_CASK-ABCB4_CASK_chrX_41782183_ENST00000378166_ABCB4_chr7_87092224_ENST00000358400_length(amino acids)=1215AA_BP=374
LRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGK
ILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ
AVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK
EIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKI
DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY
LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD
EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDE
KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA
IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGA
TGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFES
MYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQG
LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEI
VSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS

--------------------------------------------------------------

>13186_13186_28_CASK-ABCB4_CASK_chrX_41782183_ENST00000378166_ABCB4_chr7_87092224_ENST00000359206_length(amino acids)=1262AA_BP=374
LRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGK
ILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ
AVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK
EIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKI
DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY
LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD
EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDE
KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA
IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGA
TGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFES
MYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL
FMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG
QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR
ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ

--------------------------------------------------------------

>13186_13186_29_CASK-ABCB4_CASK_chrX_41782183_ENST00000378166_ABCB4_chr7_87092224_ENST00000453593_length(amino acids)=1216AA_BP=374
LRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGK
ILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ
AVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK
EIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKI
DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY
LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD
EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDE
KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA
IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGA
TGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFES
MYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQG
LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEI
VSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS

--------------------------------------------------------------

>13186_13186_30_CASK-ABCB4_CASK_chrX_41782183_ENST00000378166_ABCB4_chr7_87092224_ENST00000545634_length(amino acids)=1263AA_BP=374
LRPLSPPDHGRRRRAVRGCVRAVRGDRKFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGK
ILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ
AVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK
EIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKI
DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY
LREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD
EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDE
KAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIA
IFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGA
TGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFES
MYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL
FMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG
QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR
ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ

--------------------------------------------------------------

>13186_13186_31_CASK-ABCB4_CASK_chrX_41782183_ENST00000421587_ABCB4_chr7_87092224_ENST00000265723_length(amino acids)=1232AA_BP=337
MFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGR
QIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVW
AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVI
SKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKG
LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKK
AVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTV
RNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE
TDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGF
TFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVV
PIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAG
CFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYP
TRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA
ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEAL

--------------------------------------------------------------

>13186_13186_32_CASK-ABCB4_CASK_chrX_41782183_ENST00000421587_ABCB4_chr7_87092224_ENST00000358400_length(amino acids)=1178AA_BP=337
MFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGR
QIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVW
AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVI
SKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKG
LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKK
AVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTV
RNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE
TDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGF
TFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVV
PIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAK
LSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG
TVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQ
RIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS

--------------------------------------------------------------

>13186_13186_33_CASK-ABCB4_CASK_chrX_41782183_ENST00000421587_ABCB4_chr7_87092224_ENST00000359206_length(amino acids)=1225AA_BP=337
MFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGR
QIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVW
AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVI
SKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKG
LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKK
AVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTV
RNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE
TDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGF
TFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVV
PIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAG
CFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYP
TRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGD
NSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGR

--------------------------------------------------------------

>13186_13186_34_CASK-ABCB4_CASK_chrX_41782183_ENST00000421587_ABCB4_chr7_87092224_ENST00000453593_length(amino acids)=1179AA_BP=337
MFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGR
QIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVW
AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVI
SKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKG
LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKK
AVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTV
RNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE
TDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGF
TFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVV
PIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAK
LSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG
TVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQ
RIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS

--------------------------------------------------------------

>13186_13186_35_CASK-ABCB4_CASK_chrX_41782183_ENST00000421587_ABCB4_chr7_87092224_ENST00000545634_length(amino acids)=1226AA_BP=337
MFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGR
QIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVW
AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVI
SKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKG
LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKK
AVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTV
RNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE
TDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGF
TFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVV
PIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAG
CFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYP
TRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGD
NSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGR

--------------------------------------------------------------

>13186_13186_36_CASK-ABCB4_CASK_chrX_41782183_ENST00000442742_ABCB4_chr7_87092224_ENST00000265723_length(amino acids)=1232AA_BP=337
MFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGR
QIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVW
AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVI
SKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKG
LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKK
AVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTV
RNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE
TDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGF
TFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVV
PIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAG
CFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYP
TRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA
ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEAL

--------------------------------------------------------------

>13186_13186_37_CASK-ABCB4_CASK_chrX_41782183_ENST00000442742_ABCB4_chr7_87092224_ENST00000358400_length(amino acids)=1178AA_BP=337
MFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGR
QIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVW
AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVI
SKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKG
LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKK
AVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTV
RNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE
TDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGF
TFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVV
PIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAK
LSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG
TVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQ
RIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS

--------------------------------------------------------------

>13186_13186_38_CASK-ABCB4_CASK_chrX_41782183_ENST00000442742_ABCB4_chr7_87092224_ENST00000359206_length(amino acids)=1225AA_BP=337
MFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGR
QIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVW
AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVI
SKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKG
LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKK
AVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTV
RNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE
TDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGF
TFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVV
PIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAG
CFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYP
TRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGD
NSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGR

--------------------------------------------------------------

>13186_13186_39_CASK-ABCB4_CASK_chrX_41782183_ENST00000442742_ABCB4_chr7_87092224_ENST00000453593_length(amino acids)=1178AA_BP=337
MFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGR
QIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVW
AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVI
SKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKG
LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKK
AVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTV
RNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE
TDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGF
TFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVV
PIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAK
LSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG
TVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQ
RIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS

--------------------------------------------------------------

>13186_13186_40_CASK-ABCB4_CASK_chrX_41782183_ENST00000442742_ABCB4_chr7_87092224_ENST00000545634_length(amino acids)=1225AA_BP=337
MFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGR
QIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVW
AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVI
SKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKG
LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKK
AVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTV
RNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE
TDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGF
TFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVV
PIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAG
CFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYP
TRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGD
NSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGR

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:41782183/chr7:87104787)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CASK

Q8WXE0

ABCB4

P21439

FUNCTION: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571, PubMed:28012258). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity). {ECO:0000250|UniProtKB:P21440, ECO:0000269|PubMed:17523162, ECO:0000269|PubMed:21820390, ECO:0000269|PubMed:23468132, ECO:0000269|PubMed:24045840, ECO:0000269|PubMed:24594635, ECO:0000269|PubMed:24723470, ECO:0000269|PubMed:24806754, ECO:0000269|PubMed:28012258, ECO:0000269|PubMed:7957936, ECO:0000269|PubMed:8898203, ECO:0000269|PubMed:9366571}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCB4chrX:41782183chr7:87092224ENST000002657232281034_127945.01287.0DomainABC transporter 2
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228394_63045.01287.0DomainABC transporter 1
TgeneABCB4chrX:41782183chr7:87092224ENST0000026572322857_35945.01287.0DomainABC transmembrane type-1 1
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228711_99945.01287.0DomainABC transmembrane type-1 2
TgeneABCB4chrX:41782183chr7:87092224ENST000003584002271034_127945.01233.0DomainABC transporter 2
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227394_63045.01233.0DomainABC transporter 1
TgeneABCB4chrX:41782183chr7:87092224ENST0000035840022757_35945.01233.0DomainABC transmembrane type-1 1
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227711_99945.01233.0DomainABC transmembrane type-1 2
TgeneABCB4chrX:41782183chr7:87092224ENST000003592062281034_127945.01280.0DomainABC transporter 2
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228394_63045.01280.0DomainABC transporter 1
TgeneABCB4chrX:41782183chr7:87092224ENST0000035920622857_35945.01280.0DomainABC transmembrane type-1 1
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228711_99945.01280.0DomainABC transmembrane type-1 2
TgeneABCB4chrX:41782183chr7:87092224ENST000004535931261034_127945.01233.0DomainABC transporter 2
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126394_63045.01233.0DomainABC transporter 1
TgeneABCB4chrX:41782183chr7:87092224ENST0000045359312657_35945.01233.0DomainABC transmembrane type-1 1
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126711_99945.01233.0DomainABC transmembrane type-1 2
TgeneABCB4chrX:41782183chr7:87092224ENST000005456341271034_127945.01280.0DomainABC transporter 2
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127394_63045.01280.0DomainABC transporter 1
TgeneABCB4chrX:41782183chr7:87092224ENST0000054563412757_35945.01280.0DomainABC transmembrane type-1 1
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127711_99945.01280.0DomainABC transmembrane type-1 2
TgeneABCB4chrX:41782183chr7:87092224ENST000002657232281069_107645.01287.0Nucleotide bindingATP 2
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228429_43645.01287.0Nucleotide bindingATP 1
TgeneABCB4chrX:41782183chr7:87092224ENST000003584002271069_107645.01233.0Nucleotide bindingATP 2
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227429_43645.01233.0Nucleotide bindingATP 1
TgeneABCB4chrX:41782183chr7:87092224ENST000003592062281069_107645.01280.0Nucleotide bindingATP 2
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228429_43645.01280.0Nucleotide bindingATP 1
TgeneABCB4chrX:41782183chr7:87092224ENST000004535931261069_107645.01233.0Nucleotide bindingATP 2
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126429_43645.01233.0Nucleotide bindingATP 1
TgeneABCB4chrX:41782183chr7:87092224ENST000005456341271069_107645.01280.0Nucleotide bindingATP 2
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127429_43645.01280.0Nucleotide bindingATP 1
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228140_18845.01287.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228211_21745.01287.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228239_29645.01287.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228319_33245.01287.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228355_71145.01287.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228733_75545.01287.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST0000026572322874_11845.01287.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228777_83145.01287.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228853_85345.01287.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228874_93345.01287.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228957_97245.01287.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228995_128645.01287.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227140_18845.01233.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227211_21745.01233.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227239_29645.01233.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227319_33245.01233.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227355_71145.01233.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227733_75545.01233.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST0000035840022774_11845.01233.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227777_83145.01233.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227853_85345.01233.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227874_93345.01233.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227957_97245.01233.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227995_128645.01233.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228140_18845.01280.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228211_21745.01280.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228239_29645.01280.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228319_33245.01280.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228355_71145.01280.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228733_75545.01280.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST0000035920622874_11845.01280.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228777_83145.01280.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228853_85345.01280.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228874_93345.01280.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228957_97245.01280.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228995_128645.01280.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126140_18845.01233.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126211_21745.01233.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126239_29645.01233.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126319_33245.01233.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126355_71145.01233.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126733_75545.01233.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST0000045359312674_11845.01233.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126777_83145.01233.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126853_85345.01233.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126874_93345.01233.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126957_97245.01233.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126995_128645.01233.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127140_18845.01280.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127211_21745.01280.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127239_29645.01280.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127319_33245.01280.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127355_71145.01280.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127733_75545.01280.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST0000054563412774_11845.01280.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127777_83145.01280.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127853_85345.01280.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127874_93345.01280.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127957_97245.01280.0Topological domainExtracellular
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127995_128645.01280.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228119_13945.01287.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228189_21045.01287.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228218_23845.01287.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228297_31845.01287.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228333_35445.01287.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST0000026572322851_7345.01287.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228712_73245.01287.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228756_77645.01287.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228832_85245.01287.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228854_87345.01287.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228934_95645.01287.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000265723228973_99445.01287.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227119_13945.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227189_21045.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227218_23845.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227297_31845.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227333_35445.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST0000035840022751_7345.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227712_73245.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227756_77645.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227832_85245.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227854_87345.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227934_95645.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000358400227973_99445.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228119_13945.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228189_21045.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228218_23845.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228297_31845.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228333_35445.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST0000035920622851_7345.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228712_73245.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228756_77645.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228832_85245.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228854_87345.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228934_95645.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000359206228973_99445.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126119_13945.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126189_21045.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126218_23845.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126297_31845.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126333_35445.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST0000045359312651_7345.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126712_73245.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126756_77645.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126832_85245.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126854_87345.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126934_95645.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000453593126973_99445.01233.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127119_13945.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127189_21045.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127218_23845.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127297_31845.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127333_35445.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST0000054563412751_7345.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127712_73245.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127756_77645.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127832_85245.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127854_87345.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127934_95645.01280.0TransmembraneHelical
TgeneABCB4chrX:41782183chr7:87092224ENST00000545634127973_99445.01280.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASKchrX:41782183chr7:87092224ENST00000378158-12612_27619.666666666666668910.0DomainProtein kinase
HgeneCASKchrX:41782183chr7:87092224ENST00000378158-126343_39819.666666666666668910.0DomainL27 1
HgeneCASKchrX:41782183chr7:87092224ENST00000378158-126402_45519.666666666666668910.0DomainL27 2
HgeneCASKchrX:41782183chr7:87092224ENST00000378158-126489_56419.666666666666668910.0DomainPDZ
HgeneCASKchrX:41782183chr7:87092224ENST00000378158-126612_68219.666666666666668910.0DomainSH3
HgeneCASKchrX:41782183chr7:87092224ENST00000378158-126739_91119.666666666666668910.0DomainGuanylate kinase-like
HgeneCASKchrX:41782183chr7:87092224ENST00000378163-12712_27619.666666666666668927.0DomainProtein kinase
HgeneCASKchrX:41782183chr7:87092224ENST00000378163-127343_39819.666666666666668927.0DomainL27 1
HgeneCASKchrX:41782183chr7:87092224ENST00000378163-127402_45519.666666666666668927.0DomainL27 2
HgeneCASKchrX:41782183chr7:87092224ENST00000378163-127489_56419.666666666666668927.0DomainPDZ
HgeneCASKchrX:41782183chr7:87092224ENST00000378163-127612_68219.666666666666668927.0DomainSH3
HgeneCASKchrX:41782183chr7:87092224ENST00000378163-127739_91119.666666666666668927.0DomainGuanylate kinase-like
HgeneCASKchrX:41782183chr7:87092224ENST00000378166-12712_27619.666666666666668922.0DomainProtein kinase
HgeneCASKchrX:41782183chr7:87092224ENST00000378166-127343_39819.666666666666668922.0DomainL27 1
HgeneCASKchrX:41782183chr7:87092224ENST00000378166-127402_45519.666666666666668922.0DomainL27 2
HgeneCASKchrX:41782183chr7:87092224ENST00000378166-127489_56419.666666666666668922.0DomainPDZ
HgeneCASKchrX:41782183chr7:87092224ENST00000378166-127612_68219.666666666666668922.0DomainSH3
HgeneCASKchrX:41782183chr7:87092224ENST00000378166-127739_91119.666666666666668922.0DomainGuanylate kinase-like
HgeneCASKchrX:41782183chr7:87092224ENST00000421587-12512_27619.666666666666668898.0DomainProtein kinase
HgeneCASKchrX:41782183chr7:87092224ENST00000421587-125343_39819.666666666666668898.0DomainL27 1
HgeneCASKchrX:41782183chr7:87092224ENST00000421587-125402_45519.666666666666668898.0DomainL27 2
HgeneCASKchrX:41782183chr7:87092224ENST00000421587-125489_56419.666666666666668898.0DomainPDZ
HgeneCASKchrX:41782183chr7:87092224ENST00000421587-125612_68219.666666666666668898.0DomainSH3
HgeneCASKchrX:41782183chr7:87092224ENST00000421587-125739_91119.666666666666668898.0DomainGuanylate kinase-like
HgeneCASKchrX:41782183chr7:87092224ENST00000442742-12612_27619.666666666666668899.0DomainProtein kinase
HgeneCASKchrX:41782183chr7:87092224ENST00000442742-126343_39819.666666666666668899.0DomainL27 1
HgeneCASKchrX:41782183chr7:87092224ENST00000442742-126402_45519.666666666666668899.0DomainL27 2
HgeneCASKchrX:41782183chr7:87092224ENST00000442742-126489_56419.666666666666668899.0DomainPDZ
HgeneCASKchrX:41782183chr7:87092224ENST00000442742-126612_68219.666666666666668899.0DomainSH3
HgeneCASKchrX:41782183chr7:87092224ENST00000442742-126739_91119.666666666666668899.0DomainGuanylate kinase-like
HgeneCASKchrX:41782183chr7:87092224ENST00000378158-12618_2619.666666666666668910.0Nucleotide bindingATP
HgeneCASKchrX:41782183chr7:87092224ENST00000378163-12718_2619.666666666666668927.0Nucleotide bindingATP
HgeneCASKchrX:41782183chr7:87092224ENST00000378166-12718_2619.666666666666668922.0Nucleotide bindingATP
HgeneCASKchrX:41782183chr7:87092224ENST00000421587-12518_2619.666666666666668898.0Nucleotide bindingATP
HgeneCASKchrX:41782183chr7:87092224ENST00000442742-12618_2619.666666666666668899.0Nucleotide bindingATP
HgeneCASKchrX:41782183chr7:87092224ENST00000378158-126305_31519.666666666666668910.0RegionNote=Calmodulin-binding
HgeneCASKchrX:41782183chr7:87092224ENST00000378163-127305_31519.666666666666668927.0RegionNote=Calmodulin-binding
HgeneCASKchrX:41782183chr7:87092224ENST00000378166-127305_31519.666666666666668922.0RegionNote=Calmodulin-binding
HgeneCASKchrX:41782183chr7:87092224ENST00000421587-125305_31519.666666666666668898.0RegionNote=Calmodulin-binding
HgeneCASKchrX:41782183chr7:87092224ENST00000442742-126305_31519.666666666666668899.0RegionNote=Calmodulin-binding
TgeneABCB4chrX:41782183chr7:87092224ENST000002657232281_5045.01287.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST000003584002271_5045.01233.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST000003592062281_5045.01280.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST000004535931261_5045.01233.0Topological domainCytoplasmic
TgeneABCB4chrX:41782183chr7:87092224ENST000005456341271_5045.01280.0Topological domainCytoplasmic


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CASK
ABCB4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to CASK-ABCB4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to CASK-ABCB4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource