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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CCDC104-NDRG1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CCDC104-NDRG1
	FusionPDB ID: 13566
	FusionGDB2.0 ID: 13566
		Hgene	Tgene
	Gene symbol	CCDC104	NDRG1
	Gene ID	112942	10397
	Gene name	cilia and flagella associated protein 36	N-myc downstream regulated 1
	Synonyms	BARTL1\|CCDC104	CAP43\|CMT4D\|DRG-1\|DRG1\|GC4\|HMSNL\|NDR1\|NMSL\|PROXY1\|RIT42\|RTP\|TARG1\|TDD5
	Cytomap	2p16.1	8q24.22
	Type of gene	protein-coding	protein-coding
	Description	cilia- and flagella-associated protein 36coiled-coil domain containing 104coiled-coil domain-containing protein 104	protein NDRG1N-myc downstream-regulated gene 1 proteindifferentiation-related gene 1 proteinnickel-specific induction protein Cap43protein regulated by oxygen-1reducing agents and tunicamycin-responsive protein
	Modification date	20200313	20200328
	UniProtAcc	.	Q92597
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000339012, ENST00000349456, ENST00000403007, ENST00000406691, ENST00000407816, ENST00000490934,	ENST00000522476, ENST00000414097, ENST00000518066, ENST00000518176, ENST00000521414, ENST00000537882, ENST00000323851, ENST00000354944,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 3 X 3=27	24 X 17 X 10=4080
	# samples	4	26
	** MAII score	log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(26/4080*10)=-3.9719856238304 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CCDC104 [Title/Abstract] AND NDRG1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CCDC104(55750958)-NDRG1(134276895), # samples:1
Anticipated loss of major functional domain due to fusion event.	CCDC104-NDRG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CCDC104-NDRG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CCDC104 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NDRG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-DO-A1JZ-11A	CCDC104	chr2	55750958	+	NDRG1	chr8	134276895	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000339012	CCDC104	chr2	55750958	+	ENST00000323851	NDRG1	chr8	134276895	-	3348	555	180	1640	486
ENST00000339012	CCDC104	chr2	55750958	+	ENST00000354944	NDRG1	chr8	134276895	-	3137	555	180	1430	416
ENST00000406691	CCDC104	chr2	55750958	+	ENST00000323851	NDRG1	chr8	134276895	-	3231	438	138	1523	461
ENST00000406691	CCDC104	chr2	55750958	+	ENST00000354944	NDRG1	chr8	134276895	-	3020	438	138	1313	391
ENST00000349456	CCDC104	chr2	55750958	+	ENST00000323851	NDRG1	chr8	134276895	-	3223	430	130	1515	461
ENST00000349456	CCDC104	chr2	55750958	+	ENST00000354944	NDRG1	chr8	134276895	-	3012	430	130	1305	391
ENST00000407816	CCDC104	chr2	55750958	+	ENST00000323851	NDRG1	chr8	134276895	-	3187	394	94	1479	461
ENST00000407816	CCDC104	chr2	55750958	+	ENST00000354944	NDRG1	chr8	134276895	-	2976	394	94	1269	391
ENST00000403007	CCDC104	chr2	55750958	+	ENST00000323851	NDRG1	chr8	134276895	-	3146	353	53	1438	461
ENST00000403007	CCDC104	chr2	55750958	+	ENST00000354944	NDRG1	chr8	134276895	-	2935	353	53	1228	391

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000339012	ENST00000323851	CCDC104	chr2	55750958	+	NDRG1	chr8	134276895	-	0.004019482	0.9959805
ENST00000339012	ENST00000354944	CCDC104	chr2	55750958	+	NDRG1	chr8	134276895	-	0.004329093	0.9956709
ENST00000406691	ENST00000323851	CCDC104	chr2	55750958	+	NDRG1	chr8	134276895	-	0.004946064	0.9950539
ENST00000406691	ENST00000354944	CCDC104	chr2	55750958	+	NDRG1	chr8	134276895	-	0.007260216	0.99273974
ENST00000349456	ENST00000323851	CCDC104	chr2	55750958	+	NDRG1	chr8	134276895	-	0.004896717	0.99510324
ENST00000349456	ENST00000354944	CCDC104	chr2	55750958	+	NDRG1	chr8	134276895	-	0.007156894	0.99284315
ENST00000407816	ENST00000323851	CCDC104	chr2	55750958	+	NDRG1	chr8	134276895	-	0.00499837	0.9950016
ENST00000407816	ENST00000354944	CCDC104	chr2	55750958	+	NDRG1	chr8	134276895	-	0.00721328	0.9927867
ENST00000403007	ENST00000323851	CCDC104	chr2	55750958	+	NDRG1	chr8	134276895	-	0.004715209	0.99528486
ENST00000403007	ENST00000354944	CCDC104	chr2	55750958	+	NDRG1	chr8	134276895	-	0.006953044	0.99304694

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>13566_13566_1_CCDC104-NDRG1_CCDC104_chr2_55750958_ENST00000339012_NDRG1_chr8_134276895_ENST00000323851_length(amino acids)=486AA_BP=124
MPLWGGMAAEEEDEVEWVVESIAGFLRGPDWSIPILDFVEQKCEVNCKGGHVITPGSPEPVILVACVPLVFDDEEESKLTYTEIHQEYKE
LVEKLLEGYLKEIGINEDQFQEACTSPLAKTHTSQEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQH
FAVCHVDAPGQQDGAASFPAGYMYPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAAS
KISGWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDA
VVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSE

--------------------------------------------------------------

>13566_13566_2_CCDC104-NDRG1_CCDC104_chr2_55750958_ENST00000339012_NDRG1_chr8_134276895_ENST00000354944_length(amino acids)=416AA_BP=124
MPLWGGMAAEEEDEVEWVVESIAGFLRGPDWSIPILDFVEQKCEVNCKGGHVITPGSPEPVILVACVPLVFDDEEESKLTYTEIHQEYKE
LVEKLLEGYLKEIGINEDQFQEACTSPLAKTHTSQEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCAYILTRFALNNPEMVE
GLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHT
VTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLD

--------------------------------------------------------------

>13566_13566_3_CCDC104-NDRG1_CCDC104_chr2_55750958_ENST00000349456_NDRG1_chr8_134276895_ENST00000323851_length(amino acids)=461AA_BP=99
MPLWGGMAAEEEDEVEWVVESIAGFLRGPDWSIPILDFVEQKCEVFDDEEESKLTYTEIHQEYKELVEKLLEGYLKEIGINEDQFQEACT
SPLAKTHTSQEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYP
SMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQS
NVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLP
QISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGN

--------------------------------------------------------------

>13566_13566_4_CCDC104-NDRG1_CCDC104_chr2_55750958_ENST00000349456_NDRG1_chr8_134276895_ENST00000354944_length(amino acids)=391AA_BP=99
MPLWGGMAAEEEDEVEWVVESIAGFLRGPDWSIPILDFVEQKCEVFDDEEESKLTYTEIHQEYKELVEKLLEGYLKEIGINEDQFQEACT
SPLAKTHTSQEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGW
TQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECN
SKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSR

--------------------------------------------------------------

>13566_13566_5_CCDC104-NDRG1_CCDC104_chr2_55750958_ENST00000403007_NDRG1_chr8_134276895_ENST00000323851_length(amino acids)=461AA_BP=99
MPLWGGMAAEEEDEVEWVVESIAGFLRGPDWSIPILDFVEQKCEVFDDEEESKLTYTEIHQEYKELVEKLLEGYLKEIGINEDQFQEACT
SPLAKTHTSQEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYP
SMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQS
NVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLP
QISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGN

--------------------------------------------------------------

>13566_13566_6_CCDC104-NDRG1_CCDC104_chr2_55750958_ENST00000403007_NDRG1_chr8_134276895_ENST00000354944_length(amino acids)=391AA_BP=99
MPLWGGMAAEEEDEVEWVVESIAGFLRGPDWSIPILDFVEQKCEVFDDEEESKLTYTEIHQEYKELVEKLLEGYLKEIGINEDQFQEACT
SPLAKTHTSQEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGW
TQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECN
SKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSR

--------------------------------------------------------------

>13566_13566_7_CCDC104-NDRG1_CCDC104_chr2_55750958_ENST00000406691_NDRG1_chr8_134276895_ENST00000323851_length(amino acids)=461AA_BP=99
MPLWGGMAAEEEDEVEWVVESIAGFLRGPDWSIPILDFVEQKCEVFDDEEESKLTYTEIHQEYKELVEKLLEGYLKEIGINEDQFQEACT
SPLAKTHTSQEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYP
SMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQS
NVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLP
QISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGN

--------------------------------------------------------------

>13566_13566_8_CCDC104-NDRG1_CCDC104_chr2_55750958_ENST00000406691_NDRG1_chr8_134276895_ENST00000354944_length(amino acids)=391AA_BP=99
MPLWGGMAAEEEDEVEWVVESIAGFLRGPDWSIPILDFVEQKCEVFDDEEESKLTYTEIHQEYKELVEKLLEGYLKEIGINEDQFQEACT
SPLAKTHTSQEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGW
TQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECN
SKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSR

--------------------------------------------------------------

>13566_13566_9_CCDC104-NDRG1_CCDC104_chr2_55750958_ENST00000407816_NDRG1_chr8_134276895_ENST00000323851_length(amino acids)=461AA_BP=99
MPLWGGMAAEEEDEVEWVVESIAGFLRGPDWSIPILDFVEQKCEVFDDEEESKLTYTEIHQEYKELVEKLLEGYLKEIGINEDQFQEACT
SPLAKTHTSQEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYP
SMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQS
NVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLP
QISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGN

--------------------------------------------------------------

>13566_13566_10_CCDC104-NDRG1_CCDC104_chr2_55750958_ENST00000407816_NDRG1_chr8_134276895_ENST00000354944_length(amino acids)=391AA_BP=99
MPLWGGMAAEEEDEVEWVVESIAGFLRGPDWSIPILDFVEQKCEVFDDEEESKLTYTEIHQEYKELVEKLLEGYLKEIGINEDQFQEACT
SPLAKTHTSQEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGW
TQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECN
SKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSR

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:55750958/chr8:134276895)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NDRG1 Q92597
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. {ECO:0000269\|PubMed:15247272, ECO:0000269\|PubMed:15377670, ECO:0000269\|PubMed:17786215, ECO:0000269\|PubMed:9766676}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000323851

339_368

33.0

395.0

Region

Note=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000414097

339_368

33.0

395.0

Region

Note=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000522476

339_368

329.0

Region

Note=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000537882

339_368

314.0

Region

Note=3 X 10 AA tandem repeats of G-T-R-S-R-S-H-T-S-E

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000323851

339_348

33.0

395.0

Repeat

Note=1

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000323851

349_358

33.0

395.0

Repeat

Note=2

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000323851

359_368

33.0

395.0

Repeat

Note=3

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000414097

339_348

33.0

395.0

Repeat

Note=1

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000414097

349_358

33.0

395.0

Repeat

Note=2

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000414097

359_368

33.0

395.0

Repeat

Note=3

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000522476

339_348

329.0

Repeat

Note=1

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000522476

349_358

329.0

Repeat

Note=2

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000522476

359_368

329.0

Repeat

Note=3

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000537882

339_348

314.0

Repeat

Note=1

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000537882

349_358

314.0

Repeat

Note=2

Tgene

NDRG1

chr2:55750958

chr8:134276895

ENST00000537882

359_368

314.0

Repeat

Note=3

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CCDC104

chr2:55750958

chr8:134276895

ENST00000339012

150_187

119.0

368.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CCDC104

chr2:55750958

chr8:134276895

ENST00000349456

150_187

94.0

343.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

NDRG1

ARL4D, PHYHIP, S100B, HSP90AA1, HSPA5, VCP, CANX, PSMC3, PSMC2, PSMD2, XRCC6, RUVBL2, ILF3, SEC23A, COPB2, CLTC, AP2M1, AP1M2, MME, CTNNB1, ACTG1, KIF5B, PPP2R2A, TLE3, HSD17B4, CNDP2, DARS, DLST, ACSL3, FASN, MAOA, LDHA, PKM, RPN2, TARS, SHMT2, SLC25A6, ATP1A1, EEF2, EEF1G, EIF2S3, EIF3E, PABPC1, RPS3, RPS6, RPL24, RPL3, RPS16, RPS8, RPS20, RPS9, RPL4, RPS26, NCL, HNRNPF, HNRNPU, HNRNPH1, DDX1, DDX5, UPF1, EWSR1, CDH1, ANXA5, CLNS1A, IGBP1, SPAG9, MLH1, ACOT7, DDX39B, GSR, DPP3, EIF4H, FTO, KYNU, MVD, NAMPT, PEPD, PGD, BCL2L11, HSPA4, CUL2, TAF9, SGK1, SUZ12, EED, NDRG2, DHX15, G6PD, GART, HIP1R, CCDC22, CLIC4, NAA50, RTCB, SH2D4A, THUMPD1, TIMM13, TSG101, USP14, XPO1, NIF3L1, NTMT1, TARDBP, UFM1, TMEM17, ERBB3, FXYD1, PDE4DIP, S1PR2, FAM60A, CDK15, TRIM25, HNRNPL, MYC, SKP2, RABAC1, GSK3B, NR4A1, YAP1, RTN1, Apoa1, Apoa2, Rabac1, Arl6ip1, APOA1, APOA2, RAB4A, ZBTB38, EZR, TGOLN2, LAMP1, PPM1F, HRAS, NRAS, KRAS, RFFL, DYNC1I2, CUL4A, CTBP2, ORF3a, PRKCB, RAB5A, SH2D3C, M, Rnf183, HULC, ARF6, C11orf52, CAV1, LAMTOR1, LYN, MARCKS, OCLN, RAB11A, RAB2A, RAB35, RAB9A, RHOB, STX4, STX6, STX7, ZFPL1, HTRA4, NAA40, ST6GALNAC6, OR2A4, HOXC5, RPL35A, FXYD3, SRRT, PPP2R2B, NAA11, YWHAH, GOT1, STX17, WIF1, GOLGA2, ATP1B1, COL10A1, CERS3, OPTN, SSBP2, ATP1B3, C2orf73, NTNG1, FGF12, OSGEP, CCR1, TIMMDC1, CEP19, MBNL1, CRCP, PINK1, NRSN1, CCDC53, SSUH2, DNAJB6,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CCDC104
NDRG1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to CCDC104-NDRG1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CCDC104-NDRG1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	NDRG1	C0027627	Neoplasm Metastasis	2	CTD_human
Tgene	NDRG1	C1832334	CHARCOT-MARIE-TOOTH DISEASE, TYPE 4D	2	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	NDRG1	C0004114	Astrocytoma	1	CTD_human
Tgene	NDRG1	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	NDRG1	C0007131	Non-Small Cell Lung Carcinoma	1	CTD_human
Tgene	NDRG1	C0007134	Renal Cell Carcinoma	1	CTD_human
Tgene	NDRG1	C0017636	Glioblastoma	1	CTD_human
Tgene	NDRG1	C0022665	Kidney Neoplasm	1	CTD_human
Tgene	NDRG1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	NDRG1	C0023903	Liver neoplasms	1	CTD_human
Tgene	NDRG1	C0025202	melanoma	1	CTD_human
Tgene	NDRG1	C0026640	Mouth Neoplasms	1	CTD_human
Tgene	NDRG1	C0029295	Oropharyngeal Neoplasms	1	CTD_human
Tgene	NDRG1	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	NDRG1	C0149925	Small cell carcinoma of lung	1	CTD_human
Tgene	NDRG1	C0153381	Malignant neoplasm of mouth	1	CTD_human
Tgene	NDRG1	C0205768	Subependymal Giant Cell Astrocytoma	1	CTD_human
Tgene	NDRG1	C0206658	Smooth Muscle Tumor	1	CTD_human
Tgene	NDRG1	C0206734	Hemangioblastoma	1	CTD_human
Tgene	NDRG1	C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	CTD_human
Tgene	NDRG1	C0280783	Juvenile Pilocytic Astrocytoma	1	CTD_human
Tgene	NDRG1	C0280785	Diffuse Astrocytoma	1	CTD_human
Tgene	NDRG1	C0334579	Anaplastic astrocytoma	1	CTD_human
Tgene	NDRG1	C0334580	Protoplasmic astrocytoma	1	CTD_human
Tgene	NDRG1	C0334581	Gemistocytic astrocytoma	1	CTD_human
Tgene	NDRG1	C0334582	Fibrillary Astrocytoma	1	CTD_human
Tgene	NDRG1	C0334583	Pilocytic Astrocytoma	1	CTD_human
Tgene	NDRG1	C0334588	Giant Cell Glioblastoma	1	CTD_human
Tgene	NDRG1	C0338070	Childhood Cerebral Astrocytoma	1	CTD_human
Tgene	NDRG1	C0345904	Malignant neoplasm of liver	1	CTD_human
Tgene	NDRG1	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene	NDRG1	C0547065	Mixed oligoastrocytoma	1	CTD_human
Tgene	NDRG1	C0678222	Breast Carcinoma	1	CTD_human
Tgene	NDRG1	C0740457	Malignant neoplasm of kidney	1	CTD_human
Tgene	NDRG1	C0750935	Cerebral Astrocytoma	1	CTD_human
Tgene	NDRG1	C0750936	Intracranial Astrocytoma	1	CTD_human
Tgene	NDRG1	C0751692	Multiple Hemangioblastomas	1	CTD_human
Tgene	NDRG1	C0887833	Carcinoma, Pancreatic Ductal	1	CTD_human
Tgene	NDRG1	C1168401	Squamous cell carcinoma of the head and neck	1	CTD_human
Tgene	NDRG1	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	NDRG1	C1266042	Chromophobe Renal Cell Carcinoma	1	CTD_human
Tgene	NDRG1	C1266043	Sarcomatoid Renal Cell Carcinoma	1	CTD_human
Tgene	NDRG1	C1266044	Collecting Duct Carcinoma of the Kidney	1	CTD_human
Tgene	NDRG1	C1306837	Papillary Renal Cell Carcinoma	1	CTD_human
Tgene	NDRG1	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	NDRG1	C1621958	Glioblastoma Multiforme	1	CTD_human
Tgene	NDRG1	C1704230	Grade I Astrocytoma	1	CTD_human
Tgene	NDRG1	C2349952	Oropharyngeal Carcinoma	1	CTD_human
Tgene	NDRG1	C4704874	Mammary Carcinoma, Human	1	CTD_human