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Fusion Protein:CCDC57-CSNK1D |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: CCDC57-CSNK1D | FusionPDB ID: 13838 | FusionGDB2.0 ID: 13838 | Hgene | Tgene | Gene symbol | CCDC57 | CSNK1D | Gene ID | 284001 | 1453 |
| Gene name | coiled-coil domain containing 57 | casein kinase 1 delta | |
| Synonyms | - | ASPS|CKI-delta|CKId|CKIdelta|FASPS2|HCKID | |
| Cytomap | 17q25.3 | 17q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | coiled-coil domain-containing protein 57 | casein kinase I isoform deltacasein kinase Itau-protein kinase CSNK1D | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q2TAC2 | P48730 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000389641, ENST00000392346, ENST00000392347, ENST00000327026, ENST00000392343, | ENST00000578904, ENST00000314028, ENST00000392334, ENST00000398519, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 14 X 12 X 12=2016 | 20 X 19 X 9=3420 |
| # samples | 18 | 22 | |
| ** MAII score | log2(18/2016*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(22/3420*10)=-3.9584208962486 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: CCDC57 [Title/Abstract] AND CSNK1D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CCDC57(80109436)-CSNK1D(80209403), # samples:2 CSNK1D(80209254)-CCDC57(80059742), # samples:1 CSNK1D(80209255)-CCDC57(80059742), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | CCDC57-CSNK1D seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CCDC57-CSNK1D seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CCDC57-CSNK1D seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CCDC57-CSNK1D seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CSNK1D-CCDC57 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CSNK1D-CCDC57 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CCDC57-CSNK1D seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. CCDC57-CSNK1D seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CCDC57-CSNK1D seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. CSNK1D-CCDC57 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CSNK1D-CCDC57 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CSNK1D-CCDC57 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CSNK1D | GO:0006468 | protein phosphorylation | 16618118 |
| Tgene | CSNK1D | GO:0018105 | peptidyl-serine phosphorylation | 25500533 |
| Tgene | CSNK1D | GO:0051225 | spindle assembly | 10826492 |
| Fusion gene breakpoints across CCDC57 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CSNK1D (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LIHC | TCGA-BC-A10T-01A | CCDC57 | chr17 | 80085568 | - | CSNK1D | chr17 | 80223672 | - |
| ChimerDB4 | LUSC | TCGA-21-A5DI-01A | CCDC57 | chr17 | 80085568 | - | CSNK1D | chr17 | 80211120 | - |
| ChimerDB4 | UCEC | TCGA-B5-A5OD-01A | CCDC57 | chr17 | 80109436 | - | CSNK1D | chr17 | 80209403 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000392346 | CCDC57 | chr17 | 80085568 | - | ENST00000398519 | CSNK1D | chr17 | 80223672 | - | 2641 | 1184 | 517 | 2391 | 624 |
| ENST00000392346 | CCDC57 | chr17 | 80085568 | - | ENST00000314028 | CSNK1D | chr17 | 80223672 | - | 4470 | 1184 | 517 | 2355 | 612 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000392346 | ENST00000398519 | CCDC57 | chr17 | 80085568 | - | CSNK1D | chr17 | 80223672 | - | 0.027745519 | 0.9722545 |
| ENST00000392346 | ENST00000314028 | CCDC57 | chr17 | 80085568 | - | CSNK1D | chr17 | 80223672 | - | 0.007760548 | 0.9922395 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >13838_13838_1_CCDC57-CSNK1D_CCDC57_chr17_80085568_ENST00000392346_CSNK1D_chr17_80223672_ENST00000314028_length(amino acids)=612AA_BP=222 MLQGLTKRGPMEAEDQGELFLHLRSVARAPQTLSMHRLQRKLKEAARKIISLRLEKEQLIEMGNRLRAELGRPERWLLHHALPPAPEARK PGEEPRRPLDRSPPLGQVQPHFTSQDAKSAEDEAPSRHLGKHQPRSAQVGSRLDALQGPKTQHSIHTVTCKSPRQKEDRSPKPPQAPQHP EEHGRQSHSSSSFASGTLQDMWRLLDLGSSPSGVTSQGDSTPGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGA EGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQ HIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLN FCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPP -------------------------------------------------------------- >13838_13838_2_CCDC57-CSNK1D_CCDC57_chr17_80085568_ENST00000392346_CSNK1D_chr17_80223672_ENST00000398519_length(amino acids)=624AA_BP=222 MLQGLTKRGPMEAEDQGELFLHLRSVARAPQTLSMHRLQRKLKEAARKIISLRLEKEQLIEMGNRLRAELGRPERWLLHHALPPAPEARK PGEEPRRPLDRSPPLGQVQPHFTSQDAKSAEDEAPSRHLGKHQPRSAQVGSRLDALQGPKTQHSIHTVTCKSPRQKEDRSPKPPQAPQHP EEHGRQSHSSSSFASGTLQDMWRLLDLGSSPSGVTSQGDSTPGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGA EGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQ HIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLN FCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPP -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:80109436/chr17:80209403) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCDC57 | CSNK1D |
| FUNCTION: Pleiotropic regulator of centriole duplication, mitosis, and ciliogenesis. Critical interface between centrosome and microtubule-mediated cellular processes. Centriole duplication protein required for recruitment of CEP63, CEP152, and PLK4 to the centrosome. Independent of its centrosomal targeting, localizes to and interacts with microtubules and regulates microtubule nucleation, stability, and mitotic progression. {ECO:0000269|PubMed:32402286}. | FUNCTION: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:19339517, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000389641 | - | 17 | 18 | 214_422 | 855.3333333333334 | 917.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000389641 | - | 17 | 18 | 456_483 | 855.3333333333334 | 917.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000389641 | - | 17 | 18 | 521_548 | 855.3333333333334 | 917.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000389641 | - | 17 | 18 | 92_173 | 855.3333333333334 | 917.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000392347 | - | 16 | 17 | 214_422 | 855.3333333333334 | 917.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000392347 | - | 16 | 17 | 456_483 | 855.3333333333334 | 917.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000392347 | - | 16 | 17 | 521_548 | 855.3333333333334 | 917.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000392347 | - | 16 | 17 | 92_173 | 855.3333333333334 | 917.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000389641 | - | 17 | 18 | 1_502 | 855.3333333333334 | 917.0 | Region | Centrosomal targeting domain |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000392347 | - | 16 | 17 | 1_502 | 855.3333333333334 | 917.0 | Region | Centrosomal targeting domain |
| Tgene | CSNK1D | chr17:80085568 | chr17:80223672 | ENST00000314028 | 0 | 9 | 278_364 | 25.333333333333332 | 416.0 | Region | Note=Centrosomal localization signal (CLS) | |
| Tgene | CSNK1D | chr17:80085568 | chr17:80223672 | ENST00000314028 | 0 | 9 | 317_342 | 25.333333333333332 | 416.0 | Region | Autoinhibitory | |
| Tgene | CSNK1D | chr17:80085568 | chr17:80223672 | ENST00000392334 | 0 | 10 | 278_364 | 25.333333333333332 | 420.3333333333333 | Region | Note=Centrosomal localization signal (CLS) | |
| Tgene | CSNK1D | chr17:80085568 | chr17:80223672 | ENST00000392334 | 0 | 10 | 317_342 | 25.333333333333332 | 420.3333333333333 | Region | Autoinhibitory |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000392343 | - | 1 | 15 | 214_422 | 0 | 752.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000392343 | - | 1 | 15 | 456_483 | 0 | 752.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000392343 | - | 1 | 15 | 521_548 | 0 | 752.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000392343 | - | 1 | 15 | 92_173 | 0 | 752.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000389641 | - | 17 | 18 | 606_915 | 855.3333333333334 | 917.0 | Region | Microtubule binding domain |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000392343 | - | 1 | 15 | 1_502 | 0 | 752.0 | Region | Centrosomal targeting domain |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000392343 | - | 1 | 15 | 606_915 | 0 | 752.0 | Region | Microtubule binding domain |
| Hgene | CCDC57 | chr17:80085568 | chr17:80223672 | ENST00000392347 | - | 16 | 17 | 606_915 | 855.3333333333334 | 917.0 | Region | Microtubule binding domain |
| Tgene | CSNK1D | chr17:80085568 | chr17:80223672 | ENST00000314028 | 0 | 9 | 9_277 | 25.333333333333332 | 416.0 | Domain | Protein kinase | |
| Tgene | CSNK1D | chr17:80085568 | chr17:80223672 | ENST00000392334 | 0 | 10 | 9_277 | 25.333333333333332 | 420.3333333333333 | Domain | Protein kinase | |
| Tgene | CSNK1D | chr17:80085568 | chr17:80223672 | ENST00000314028 | 0 | 9 | 15_23 | 25.333333333333332 | 416.0 | Nucleotide binding | ATP | |
| Tgene | CSNK1D | chr17:80085568 | chr17:80223672 | ENST00000392334 | 0 | 10 | 15_23 | 25.333333333333332 | 420.3333333333333 | Nucleotide binding | ATP |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| CCDC57 | |
| CSNK1D |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to CCDC57-CSNK1D |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to CCDC57-CSNK1D |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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