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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CD44-ABTB2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CD44-ABTB2
FusionPDB ID: 14502
FusionGDB2.0 ID: 14502
HgeneTgene
Gene symbol

CD44

ABTB2

Gene ID

960

25841

Gene nameCD44 molecule (Indian blood group)ankyrin repeat and BTB domain containing 2
SynonymsCDW44|CSPG8|ECMR-III|HCELL|HUTCH-I|IN|LHR|MC56|MDU2|MDU3|MIC4|Pgp1ABTB2A|BTBD22
Cytomap

11p13

11p13

Type of geneprotein-codingprotein-coding
DescriptionCD44 antigenGP90 lymphocyte homing/adhesion receptorHermes antigenIndian blood group antigencell surface glycoprotein CD44chondroitin sulfate proteoglycan 8epicanextracellular matrix receptor IIIhematopoietic cell E- and L-selectin ligandheparan ankyrin repeat and BTB/POZ domain-containing protein 2ankyrin repeat and BTB (POZ) domain containing 2
Modification date2020032920200313
UniProtAcc

P16070

Q8N961

Ensembl transtripts involved in fusion geneENST idsENST00000263398, ENST00000278386, 
ENST00000352818, ENST00000360158, 
ENST00000415148, ENST00000428726, 
ENST00000433354, ENST00000433892, 
ENST00000434472, ENST00000437706, 
ENST00000449691, ENST00000526025, 
ENST00000526669, ENST00000528922, 
ENST00000530814, ENST00000298992, 
ENST00000435224, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score24 X 25 X 12=72007 X 5 X 5=175
# samples 367
** MAII scorelog2(36/7200*10)=-4.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CD44 [Title/Abstract] AND ABTB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CD44(35160917)-ABTB2(34226237), # samples:1
Anticipated loss of major functional domain due to fusion event.CD44-ABTB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD44-ABTB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD44-ABTB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CD44-ABTB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD44

GO:0007155

cell adhesion

19703720

HgeneCD44

GO:0016477

cell migration

22726066

HgeneCD44

GO:0030214

hyaluronan catabolic process

17170110

HgeneCD44

GO:0033138

positive regulation of peptidyl-serine phosphorylation

17045821

HgeneCD44

GO:0042110

T cell activation

7528188

HgeneCD44

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

17045821

HgeneCD44

GO:0044344

cellular response to fibroblast growth factor stimulus

19577615

HgeneCD44

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

17045821

HgeneCD44

GO:0070374

positive regulation of ERK1 and ERK2 cascade

17045821

HgeneCD44

GO:1902166

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

17045821


check buttonFusion gene breakpoints across CD44 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABTB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A44T-01ACD44chr11

35160917

+ABTB2chr11

34226237

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263398CD44chr1135160917+ENST00000298992ABTB2chr1134226237-40955012782695805
ENST00000263398CD44chr1135160917+ENST00000435224ABTB2chr1134226237-40955012782695805
ENST00000526025CD44chr1135160917+ENST00000298992ABTB2chr1134226237-40834892662683805
ENST00000526025CD44chr1135160917+ENST00000435224ABTB2chr1134226237-40834892662683805
ENST00000449691CD44chr1135160917+ENST00000298992ABTB2chr1134226237-379520152395796
ENST00000449691CD44chr1135160917+ENST00000435224ABTB2chr1134226237-379520152395796
ENST00000360158CD44chr1135160917+ENST00000298992ABTB2chr1134226237-379520152395796
ENST00000360158CD44chr1135160917+ENST00000435224ABTB2chr1134226237-379520152395796
ENST00000415148CD44chr1135160917+ENST00000298992ABTB2chr1134226237-379520152395796
ENST00000415148CD44chr1135160917+ENST00000435224ABTB2chr1134226237-379520152395796
ENST00000437706CD44chr1135160917+ENST00000298992ABTB2chr1134226237-379520152395796
ENST00000437706CD44chr1135160917+ENST00000435224ABTB2chr1134226237-379520152395796
ENST00000433354CD44chr1135160917+ENST00000298992ABTB2chr1134226237-379520152395796
ENST00000433354CD44chr1135160917+ENST00000435224ABTB2chr1134226237-379520152395796
ENST00000428726CD44chr1135160917+ENST00000298992ABTB2chr1134226237-3784190152384789
ENST00000428726CD44chr1135160917+ENST00000435224ABTB2chr1134226237-3784190152384789
ENST00000526669CD44chr1135160917+ENST00000298992ABTB2chr1134226237-3783189142383789
ENST00000526669CD44chr1135160917+ENST00000435224ABTB2chr1134226237-3783189142383789
ENST00000433892CD44chr1135160917+ENST00000298992ABTB2chr1134226237-377718382377789
ENST00000433892CD44chr1135160917+ENST00000435224ABTB2chr1134226237-377718382377789
ENST00000278386CD44chr1135160917+ENST00000298992ABTB2chr1134226237-367985182279753
ENST00000278386CD44chr1135160917+ENST00000435224ABTB2chr1134226237-367985182279753
ENST00000434472CD44chr1135160917+ENST00000298992ABTB2chr1134226237-367278112272753
ENST00000434472CD44chr1135160917+ENST00000435224ABTB2chr1134226237-367278112272753
ENST00000352818CD44chr1135160917+ENST00000298992ABTB2chr1134226237-36616702261753
ENST00000352818CD44chr1135160917+ENST00000435224ABTB2chr1134226237-36616702261753

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263398ENST00000298992CD44chr1135160917+ABTB2chr1134226237-0.0089702920.99102974
ENST00000263398ENST00000435224CD44chr1135160917+ABTB2chr1134226237-0.0089702920.99102974
ENST00000526025ENST00000298992CD44chr1135160917+ABTB2chr1134226237-0.0087911540.9912088
ENST00000526025ENST00000435224CD44chr1135160917+ABTB2chr1134226237-0.0087911540.9912088
ENST00000449691ENST00000298992CD44chr1135160917+ABTB2chr1134226237-0.0086896110.99131036
ENST00000449691ENST00000435224CD44chr1135160917+ABTB2chr1134226237-0.0086896110.99131036
ENST00000360158ENST00000298992CD44chr1135160917+ABTB2chr1134226237-0.0086896110.99131036
ENST00000360158ENST00000435224CD44chr1135160917+ABTB2chr1134226237-0.0086896110.99131036
ENST00000415148ENST00000298992CD44chr1135160917+ABTB2chr1134226237-0.0086896110.99131036
ENST00000415148ENST00000435224CD44chr1135160917+ABTB2chr1134226237-0.0086896110.99131036
ENST00000437706ENST00000298992CD44chr1135160917+ABTB2chr1134226237-0.0086896110.99131036
ENST00000437706ENST00000435224CD44chr1135160917+ABTB2chr1134226237-0.0086896110.99131036
ENST00000433354ENST00000298992CD44chr1135160917+ABTB2chr1134226237-0.0086896110.99131036
ENST00000433354ENST00000435224CD44chr1135160917+ABTB2chr1134226237-0.0086896110.99131036
ENST00000428726ENST00000298992CD44chr1135160917+ABTB2chr1134226237-0.0086164850.99138343
ENST00000428726ENST00000435224CD44chr1135160917+ABTB2chr1134226237-0.0086164850.99138343
ENST00000526669ENST00000298992CD44chr1135160917+ABTB2chr1134226237-0.0085749590.99142504
ENST00000526669ENST00000435224CD44chr1135160917+ABTB2chr1134226237-0.0085749590.99142504
ENST00000433892ENST00000298992CD44chr1135160917+ABTB2chr1134226237-0.0084741620.9915258
ENST00000433892ENST00000435224CD44chr1135160917+ABTB2chr1134226237-0.0084741620.9915258
ENST00000278386ENST00000298992CD44chr1135160917+ABTB2chr1134226237-0.0090261390.9909739
ENST00000278386ENST00000435224CD44chr1135160917+ABTB2chr1134226237-0.0090261390.9909739
ENST00000434472ENST00000298992CD44chr1135160917+ABTB2chr1134226237-0.0090081070.99099195
ENST00000434472ENST00000435224CD44chr1135160917+ABTB2chr1134226237-0.0090081070.99099195
ENST00000352818ENST00000298992CD44chr1135160917+ABTB2chr1134226237-0.0091014370.99089855
ENST00000352818ENST00000435224CD44chr1135160917+ABTB2chr1134226237-0.0091014370.99089855

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>14502_14502_1_CD44-ABTB2_CD44_chr11_35160917_ENST00000263398_ABTB2_chr11_34226237_ENST00000298992_length(amino acids)=805AA_BP=73
MQPTSEAASLPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGS
LGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESME
NPNLDPPRMTLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDL
GFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGH
ISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLL
TQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSR
YSVVQSLLRDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFL
VEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCE

--------------------------------------------------------------

>14502_14502_2_CD44-ABTB2_CD44_chr11_35160917_ENST00000263398_ABTB2_chr11_34226237_ENST00000435224_length(amino acids)=805AA_BP=73
MQPTSEAASLPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGS
LGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESME
NPNLDPPRMTLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDL
GFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGH
ISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLL
TQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSR
YSVVQSLLRDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFL
VEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCE

--------------------------------------------------------------

>14502_14502_3_CD44-ABTB2_CD44_chr11_35160917_ENST00000278386_ABTB2_chr11_34226237_ENST00000298992_length(amino acids)=753AA_BP=21
MDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCP
GASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAAR
LLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLI
DAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD
PLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMY
YSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFT
HCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMM
QYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQLI

--------------------------------------------------------------

>14502_14502_4_CD44-ABTB2_CD44_chr11_35160917_ENST00000278386_ABTB2_chr11_34226237_ENST00000435224_length(amino acids)=753AA_BP=21
MDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCP
GASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAAR
LLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLI
DAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD
PLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMY
YSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFT
HCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMM
QYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQLI

--------------------------------------------------------------

>14502_14502_5_CD44-ABTB2_CD44_chr11_35160917_ENST00000352818_ABTB2_chr11_34226237_ENST00000298992_length(amino acids)=753AA_BP=21
MDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCP
GASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAAR
LLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLI
DAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD
PLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMY
YSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFT
HCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMM
QYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQLI

--------------------------------------------------------------

>14502_14502_6_CD44-ABTB2_CD44_chr11_35160917_ENST00000352818_ABTB2_chr11_34226237_ENST00000435224_length(amino acids)=753AA_BP=21
MDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCP
GASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAAR
LLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLI
DAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD
PLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMY
YSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFT
HCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMM
QYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQLI

--------------------------------------------------------------

>14502_14502_7_CD44-ABTB2_CD44_chr11_35160917_ENST00000360158_ABTB2_chr11_34226237_ENST00000298992_length(amino acids)=796AA_BP=64
MPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADA
YAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRM
TLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGR
TDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLD
AGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKAD
VLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLR
DFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAH
KVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSM

--------------------------------------------------------------

>14502_14502_8_CD44-ABTB2_CD44_chr11_35160917_ENST00000360158_ABTB2_chr11_34226237_ENST00000435224_length(amino acids)=796AA_BP=64
MPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADA
YAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRM
TLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGR
TDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLD
AGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKAD
VLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLR
DFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAH
KVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSM

--------------------------------------------------------------

>14502_14502_9_CD44-ABTB2_CD44_chr11_35160917_ENST00000415148_ABTB2_chr11_34226237_ENST00000298992_length(amino acids)=796AA_BP=64
MPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADA
YAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRM
TLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGR
TDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLD
AGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKAD
VLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLR
DFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAH
KVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSM

--------------------------------------------------------------

>14502_14502_10_CD44-ABTB2_CD44_chr11_35160917_ENST00000415148_ABTB2_chr11_34226237_ENST00000435224_length(amino acids)=796AA_BP=64
MPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADA
YAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRM
TLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGR
TDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLD
AGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKAD
VLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLR
DFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAH
KVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSM

--------------------------------------------------------------

>14502_14502_11_CD44-ABTB2_CD44_chr11_35160917_ENST00000428726_ABTB2_chr11_34226237_ENST00000298992_length(amino acids)=789AA_BP=57
MPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADAYAQLELR
TLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERP
FMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQA
IEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEG
SAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEI
LAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIRE
EEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTA
SNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTY

--------------------------------------------------------------

>14502_14502_12_CD44-ABTB2_CD44_chr11_35160917_ENST00000428726_ABTB2_chr11_34226237_ENST00000435224_length(amino acids)=789AA_BP=57
MPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADAYAQLELR
TLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERP
FMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQA
IEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEG
SAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEI
LAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIRE
EEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTA
SNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTY

--------------------------------------------------------------

>14502_14502_13_CD44-ABTB2_CD44_chr11_35160917_ENST00000433354_ABTB2_chr11_34226237_ENST00000298992_length(amino acids)=796AA_BP=64
MPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADA
YAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRM
TLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGR
TDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLD
AGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKAD
VLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLR
DFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAH
KVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSM

--------------------------------------------------------------

>14502_14502_14_CD44-ABTB2_CD44_chr11_35160917_ENST00000433354_ABTB2_chr11_34226237_ENST00000435224_length(amino acids)=796AA_BP=64
MPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADA
YAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRM
TLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGR
TDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLD
AGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKAD
VLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLR
DFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAH
KVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSM

--------------------------------------------------------------

>14502_14502_15_CD44-ABTB2_CD44_chr11_35160917_ENST00000433892_ABTB2_chr11_34226237_ENST00000298992_length(amino acids)=789AA_BP=57
MPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADAYAQLELR
TLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERP
FMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQA
IEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEG
SAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEI
LAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIRE
EEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTA
SNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTY

--------------------------------------------------------------

>14502_14502_16_CD44-ABTB2_CD44_chr11_35160917_ENST00000433892_ABTB2_chr11_34226237_ENST00000435224_length(amino acids)=789AA_BP=57
MPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADAYAQLELR
TLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERP
FMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQA
IEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEG
SAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEI
LAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIRE
EEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTA
SNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTY

--------------------------------------------------------------

>14502_14502_17_CD44-ABTB2_CD44_chr11_35160917_ENST00000434472_ABTB2_chr11_34226237_ENST00000298992_length(amino acids)=753AA_BP=21
MDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCP
GASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAAR
LLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLI
DAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD
PLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMY
YSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFT
HCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMM
QYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQLI

--------------------------------------------------------------

>14502_14502_18_CD44-ABTB2_CD44_chr11_35160917_ENST00000434472_ABTB2_chr11_34226237_ENST00000435224_length(amino acids)=753AA_BP=21
MDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCP
GASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAAR
LLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLI
DAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGAD
PLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMY
YSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFT
HCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMM
QYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPELALFCEGFFLKHMKALLEQDAFRQLI

--------------------------------------------------------------

>14502_14502_19_CD44-ABTB2_CD44_chr11_35160917_ENST00000437706_ABTB2_chr11_34226237_ENST00000298992_length(amino acids)=796AA_BP=64
MPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADA
YAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRM
TLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGR
TDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLD
AGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKAD
VLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLR
DFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAH
KVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSM

--------------------------------------------------------------

>14502_14502_20_CD44-ABTB2_CD44_chr11_35160917_ENST00000437706_ABTB2_chr11_34226237_ENST00000435224_length(amino acids)=796AA_BP=64
MPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADA
YAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRM
TLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGR
TDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLD
AGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKAD
VLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLR
DFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAH
KVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSM

--------------------------------------------------------------

>14502_14502_21_CD44-ABTB2_CD44_chr11_35160917_ENST00000449691_ABTB2_chr11_34226237_ENST00000298992_length(amino acids)=796AA_BP=64
MPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADA
YAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRM
TLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGR
TDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLD
AGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKAD
VLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLR
DFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAH
KVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSM

--------------------------------------------------------------

>14502_14502_22_CD44-ABTB2_CD44_chr11_35160917_ENST00000449691_ABTB2_chr11_34226237_ENST00000435224_length(amino acids)=796AA_BP=64
MPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADA
YAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRM
TLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGR
TDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLD
AGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKAD
VLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLR
DFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAH
KVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSM

--------------------------------------------------------------

>14502_14502_23_CD44-ABTB2_CD44_chr11_35160917_ENST00000526025_ABTB2_chr11_34226237_ENST00000298992_length(amino acids)=805AA_BP=73
MQPTSEAASLPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGS
LGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESME
NPNLDPPRMTLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDL
GFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGH
ISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLL
TQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSR
YSVVQSLLRDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFL
VEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCE

--------------------------------------------------------------

>14502_14502_24_CD44-ABTB2_CD44_chr11_35160917_ENST00000526025_ABTB2_chr11_34226237_ENST00000435224_length(amino acids)=805AA_BP=73
MQPTSEAASLPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGS
LGHDERADAYAQLELRTLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESME
NPNLDPPRMTLNNERPFMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDL
GFRMLNCGRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGH
ISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLL
TQPQQAKADVLSLEEILAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSR
YSVVQSLLRDFSSIREEEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFL
VEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCE

--------------------------------------------------------------

>14502_14502_25_CD44-ABTB2_CD44_chr11_35160917_ENST00000526669_ABTB2_chr11_34226237_ENST00000298992_length(amino acids)=789AA_BP=57
MPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADAYAQLELR
TLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERP
FMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQA
IEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEG
SAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEI
LAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIRE
EEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTA
SNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTY

--------------------------------------------------------------

>14502_14502_26_CD44-ABTB2_CD44_chr11_35160917_ENST00000526669_ABTB2_chr11_34226237_ENST00000435224_length(amino acids)=789AA_BP=57
MPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIGVLSLPAYFSPYNGGSLGHDERADAYAQLELR
TLEQSLLATCVGSISELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESMENPNLDPPRMTLNNERP
FMLLPPLMEWMRVAITYAEHRRSLTVDSGDIRQAARLLLPGLDCEPRQLKPEHCFSSFRRLDARAATEKFNQDLGFRMLNCGRTDLINQA
IEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSPRHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEG
SAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMGSSLHEDMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLSLEEI
LAEGVEESDASSQGSGSEGPVRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIESLRTSFSQSRYSVVQSLLRDFSSIRE
EEYNEELVTEGLQLMFDILKTSKNDSVIQQLATIFTHCYGSSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTA
SNRFKTLMTNKSEQDGDSSKTIEISDMKYHIFQMMMQYLYYGGTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTY

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:35160917/chr11:34226237)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD44

P16070

ABTB2

Q8N961

FUNCTION: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}.FUNCTION: May be involved in the initiation of hepatocyte growth. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABTB2chr11:35160917chr11:34226237ENST00000298992017845_914108.33333333333333840.0DomainBTB
TgeneABTB2chr11:35160917chr11:34226237ENST00000435224017845_914294.33333333333331026.0DomainBTB
TgeneABTB2chr11:35160917chr11:34226237ENST00000298992017521_550108.33333333333333840.0RepeatNote=ANK 1
TgeneABTB2chr11:35160917chr11:34226237ENST00000298992017567_596108.33333333333333840.0RepeatNote=ANK 2
TgeneABTB2chr11:35160917chr11:34226237ENST00000298992017606_635108.33333333333333840.0RepeatNote=ANK 3
TgeneABTB2chr11:35160917chr11:34226237ENST00000298992017649_678108.33333333333333840.0RepeatNote=ANK 4
TgeneABTB2chr11:35160917chr11:34226237ENST00000435224017521_550294.33333333333331026.0RepeatNote=ANK 1
TgeneABTB2chr11:35160917chr11:34226237ENST00000435224017567_596294.33333333333331026.0RepeatNote=ANK 2
TgeneABTB2chr11:35160917chr11:34226237ENST00000435224017606_635294.33333333333331026.0RepeatNote=ANK 3
TgeneABTB2chr11:35160917chr11:34226237ENST00000435224017649_678294.33333333333331026.0RepeatNote=ANK 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD44chr11:35160917chr11:34226237ENST00000263398+19150_15822.333333333333332362.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35160917chr11:34226237ENST00000278386+14150_15822.333333333333332140.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35160917chr11:34226237ENST00000352818+18150_15822.333333333333332341.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35160917chr11:34226237ENST00000360158+110150_15822.333333333333332397.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35160917chr11:34226237ENST00000415148+117150_15822.333333333333332700.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35160917chr11:34226237ENST00000428726+118150_15822.333333333333332743.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35160917chr11:34226237ENST00000433892+112150_15822.333333333333332494.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35160917chr11:34226237ENST00000434472+110150_15822.333333333333332430.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35160917chr11:34226237ENST00000437706+117150_15822.333333333333332675.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35160917chr11:34226237ENST00000449691+117150_15822.333333333333332700.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35160917chr11:34226237ENST00000263398+1932_12022.333333333333332362.0DomainLink
HgeneCD44chr11:35160917chr11:34226237ENST00000278386+1432_12022.333333333333332140.0DomainLink
HgeneCD44chr11:35160917chr11:34226237ENST00000352818+1832_12022.333333333333332341.0DomainLink
HgeneCD44chr11:35160917chr11:34226237ENST00000360158+11032_12022.333333333333332397.0DomainLink
HgeneCD44chr11:35160917chr11:34226237ENST00000415148+11732_12022.333333333333332700.0DomainLink
HgeneCD44chr11:35160917chr11:34226237ENST00000428726+11832_12022.333333333333332743.0DomainLink
HgeneCD44chr11:35160917chr11:34226237ENST00000433892+11232_12022.333333333333332494.0DomainLink
HgeneCD44chr11:35160917chr11:34226237ENST00000434472+11032_12022.333333333333332430.0DomainLink
HgeneCD44chr11:35160917chr11:34226237ENST00000437706+11732_12022.333333333333332675.0DomainLink
HgeneCD44chr11:35160917chr11:34226237ENST00000449691+11732_12022.333333333333332700.0DomainLink
HgeneCD44chr11:35160917chr11:34226237ENST00000263398+19224_64922.333333333333332362.0RegionNote=Stem
HgeneCD44chr11:35160917chr11:34226237ENST00000278386+14224_64922.333333333333332140.0RegionNote=Stem
HgeneCD44chr11:35160917chr11:34226237ENST00000352818+18224_64922.333333333333332341.0RegionNote=Stem
HgeneCD44chr11:35160917chr11:34226237ENST00000360158+110224_64922.333333333333332397.0RegionNote=Stem
HgeneCD44chr11:35160917chr11:34226237ENST00000415148+117224_64922.333333333333332700.0RegionNote=Stem
HgeneCD44chr11:35160917chr11:34226237ENST00000428726+118224_64922.333333333333332743.0RegionNote=Stem
HgeneCD44chr11:35160917chr11:34226237ENST00000433892+112224_64922.333333333333332494.0RegionNote=Stem
HgeneCD44chr11:35160917chr11:34226237ENST00000434472+110224_64922.333333333333332430.0RegionNote=Stem
HgeneCD44chr11:35160917chr11:34226237ENST00000437706+117224_64922.333333333333332675.0RegionNote=Stem
HgeneCD44chr11:35160917chr11:34226237ENST00000449691+117224_64922.333333333333332700.0RegionNote=Stem
HgeneCD44chr11:35160917chr11:34226237ENST00000263398+1921_64922.333333333333332362.0Topological domainExtracellular
HgeneCD44chr11:35160917chr11:34226237ENST00000263398+19671_74222.333333333333332362.0Topological domainCytoplasmic
HgeneCD44chr11:35160917chr11:34226237ENST00000278386+1421_64922.333333333333332140.0Topological domainExtracellular
HgeneCD44chr11:35160917chr11:34226237ENST00000278386+14671_74222.333333333333332140.0Topological domainCytoplasmic
HgeneCD44chr11:35160917chr11:34226237ENST00000352818+1821_64922.333333333333332341.0Topological domainExtracellular
HgeneCD44chr11:35160917chr11:34226237ENST00000352818+18671_74222.333333333333332341.0Topological domainCytoplasmic
HgeneCD44chr11:35160917chr11:34226237ENST00000360158+11021_64922.333333333333332397.0Topological domainExtracellular
HgeneCD44chr11:35160917chr11:34226237ENST00000360158+110671_74222.333333333333332397.0Topological domainCytoplasmic
HgeneCD44chr11:35160917chr11:34226237ENST00000415148+11721_64922.333333333333332700.0Topological domainExtracellular
HgeneCD44chr11:35160917chr11:34226237ENST00000415148+117671_74222.333333333333332700.0Topological domainCytoplasmic
HgeneCD44chr11:35160917chr11:34226237ENST00000428726+11821_64922.333333333333332743.0Topological domainExtracellular
HgeneCD44chr11:35160917chr11:34226237ENST00000428726+118671_74222.333333333333332743.0Topological domainCytoplasmic
HgeneCD44chr11:35160917chr11:34226237ENST00000433892+11221_64922.333333333333332494.0Topological domainExtracellular
HgeneCD44chr11:35160917chr11:34226237ENST00000433892+112671_74222.333333333333332494.0Topological domainCytoplasmic
HgeneCD44chr11:35160917chr11:34226237ENST00000434472+11021_64922.333333333333332430.0Topological domainExtracellular
HgeneCD44chr11:35160917chr11:34226237ENST00000434472+110671_74222.333333333333332430.0Topological domainCytoplasmic
HgeneCD44chr11:35160917chr11:34226237ENST00000437706+11721_64922.333333333333332675.0Topological domainExtracellular
HgeneCD44chr11:35160917chr11:34226237ENST00000437706+117671_74222.333333333333332675.0Topological domainCytoplasmic
HgeneCD44chr11:35160917chr11:34226237ENST00000449691+11721_64922.333333333333332700.0Topological domainExtracellular
HgeneCD44chr11:35160917chr11:34226237ENST00000449691+117671_74222.333333333333332700.0Topological domainCytoplasmic
HgeneCD44chr11:35160917chr11:34226237ENST00000263398+19650_67022.333333333333332362.0TransmembraneHelical
HgeneCD44chr11:35160917chr11:34226237ENST00000278386+14650_67022.333333333333332140.0TransmembraneHelical
HgeneCD44chr11:35160917chr11:34226237ENST00000352818+18650_67022.333333333333332341.0TransmembraneHelical
HgeneCD44chr11:35160917chr11:34226237ENST00000360158+110650_67022.333333333333332397.0TransmembraneHelical
HgeneCD44chr11:35160917chr11:34226237ENST00000415148+117650_67022.333333333333332700.0TransmembraneHelical
HgeneCD44chr11:35160917chr11:34226237ENST00000428726+118650_67022.333333333333332743.0TransmembraneHelical
HgeneCD44chr11:35160917chr11:34226237ENST00000433892+112650_67022.333333333333332494.0TransmembraneHelical
HgeneCD44chr11:35160917chr11:34226237ENST00000434472+110650_67022.333333333333332430.0TransmembraneHelical
HgeneCD44chr11:35160917chr11:34226237ENST00000437706+117650_67022.333333333333332675.0TransmembraneHelical
HgeneCD44chr11:35160917chr11:34226237ENST00000449691+117650_67022.333333333333332700.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CD44
ABTB2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CD44-ABTB2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CD44-ABTB2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource