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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CD44-FAM120A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CD44-FAM120A
FusionPDB ID: 14514
FusionGDB2.0 ID: 14514
HgeneTgene
Gene symbol

CD44

FAM120A

Gene ID

960

23196

Gene nameCD44 molecule (Indian blood group)family with sequence similarity 120A
SynonymsCDW44|CSPG8|ECMR-III|HCELL|HUTCH-I|IN|LHR|MC56|MDU2|MDU3|MIC4|Pgp1C9orf10|HBVPTPAP|OSSA
Cytomap

11p13

9q22.31

Type of geneprotein-codingprotein-coding
DescriptionCD44 antigenGP90 lymphocyte homing/adhesion receptorHermes antigenIndian blood group antigencell surface glycoprotein CD44chondroitin sulfate proteoglycan 8epicanextracellular matrix receptor IIIhematopoietic cell E- and L-selectin ligandheparan constitutive coactivator of PPAR-gamma-like protein 1oxidative stess-associated Src activatoroxidative stress-associated Src activator
Modification date2020032920200320
UniProtAcc

P16070

Q5T036

Ensembl transtripts involved in fusion geneENST idsENST00000415148, ENST00000428726, 
ENST00000433354, ENST00000437706, 
ENST00000449691, ENST00000263398, 
ENST00000278386, ENST00000352818, 
ENST00000360158, ENST00000433892, 
ENST00000434472, ENST00000526025, 
ENST00000526669, ENST00000528922, 
ENST00000333936, ENST00000340893, 
ENST00000375389, ENST00000475933, 
ENST00000277165, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score24 X 25 X 12=720017 X 12 X 5=1020
# samples 3618
** MAII scorelog2(36/7200*10)=-4.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1020*10)=-2.50250034052918
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CD44 [Title/Abstract] AND FAM120A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CD44(35227790)-FAM120A(96305504), # samples:1
Anticipated loss of major functional domain due to fusion event.CD44-FAM120A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD44-FAM120A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD44-FAM120A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CD44-FAM120A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD44

GO:0007155

cell adhesion

19703720

HgeneCD44

GO:0016477

cell migration

22726066

HgeneCD44

GO:0030214

hyaluronan catabolic process

17170110

HgeneCD44

GO:0033138

positive regulation of peptidyl-serine phosphorylation

17045821

HgeneCD44

GO:0042110

T cell activation

7528188

HgeneCD44

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

17045821

HgeneCD44

GO:0044344

cellular response to fibroblast growth factor stimulus

19577615

HgeneCD44

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

17045821

HgeneCD44

GO:0070374

positive regulation of ERK1 and ERK2 cascade

17045821

HgeneCD44

GO:1902166

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

17045821


check buttonFusion gene breakpoints across CD44 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM120A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8080-01ACD44chr11

35227790

+FAM120Achr9

96305504

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000449691CD44chr1135227790+ENST00000277165FAM120Achr996305504+4434141952866953
ENST00000415148CD44chr1135227790+ENST00000277165FAM120Achr996305504+4434141952866953
ENST00000437706CD44chr1135227790+ENST00000277165FAM120Achr996305504+4563154852995996
ENST00000433354CD44chr1135227790+ENST00000277165FAM120Achr996305504+4566155152998997
ENST00000428726CD44chr1135227790+ENST00000277165FAM120Achr996305504+45521537152984989

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000449691ENST00000277165CD44chr1135227790+FAM120Achr996305504+0.0008294850.99917054
ENST00000415148ENST00000277165CD44chr1135227790+FAM120Achr996305504+0.0008911310.99910885
ENST00000437706ENST00000277165CD44chr1135227790+FAM120Achr996305504+0.0006919120.9993081
ENST00000433354ENST00000277165CD44chr1135227790+FAM120Achr996305504+0.0006890990.99931085
ENST00000428726ENST00000277165CD44chr1135227790+FAM120Achr996305504+0.0006739710.9993261

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>14514_14514_1_CD44-FAM120A_CD44_chr11_35227790_ENST00000415148_FAM120A_chr9_96305504_ENST00000277165_length(amino acids)=953AA_BP=471
MPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRT
EAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPN
AFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATSTSSN
TISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWN
PEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSW
TDFFNPISHPMGRGHQAGRRMVSPVIIKEWAAYKGKSPQTPELVEALAFREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNP
ANVPTHLMVLCCVLRYMVQWPGARILRRQELDAFLAQALSPKLYEPDQLQELKIENLDPRGIQLSALFMSGVDMALFANDACGQPIPWEH
CCPWMYFDGKLFQSKLLKASREKTPLIDLCDGQADQAAKVEKMRQSVLEGLSFSRQSHTLPFPPPPALPFYPASAYPRHFGPVPPSQGRG
RGFAGVCGFGGPYGETVATGPYRAFRVAAASGHCGAFSGSDSSRTSKSQGGVQPIPSQGGKLEIAGTVVGHWAGSRRGRGGRGPFPLQVV
SVGGPARGRPRGVISTPVIRTFGRGGRYYGRGYKNQAAIQGRPPYAASAEEVAKELKSKSGESKSSAMSSDGSLAENGVMAEEKPAPQMN

--------------------------------------------------------------

>14514_14514_2_CD44-FAM120A_CD44_chr11_35227790_ENST00000428726_FAM120A_chr9_96305504_ENST00000277165_length(amino acids)=989AA_BP=507
MPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCK
AFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPIT
ITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATET
ATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDW
TQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQ
TPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMVSPVIIKEWAAYKGKSPQTPELVEALAFREWTC
PNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPANVPTHLMVLCCVLRYMVQWPGARILRRQELDAFLAQALSPKLYEPDQLQELKI
ENLDPRGIQLSALFMSGVDMALFANDACGQPIPWEHCCPWMYFDGKLFQSKLLKASREKTPLIDLCDGQADQAAKVEKMRQSVLEGLSFS
RQSHTLPFPPPPALPFYPASAYPRHFGPVPPSQGRGRGFAGVCGFGGPYGETVATGPYRAFRVAAASGHCGAFSGSDSSRTSKSQGGVQP
IPSQGGKLEIAGTVVGHWAGSRRGRGGRGPFPLQVVSVGGPARGRPRGVISTPVIRTFGRGGRYYGRGYKNQAAIQGRPPYAASAEEVAK

--------------------------------------------------------------

>14514_14514_3_CD44-FAM120A_CD44_chr11_35227790_ENST00000433354_FAM120A_chr9_96305504_ENST00000277165_length(amino acids)=997AA_BP=515
MPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRT
EAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPN
AFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMST
SATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDH
TKQNQDWTQWNPSHSNPEVLLQTTTRMTADVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGN
RWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMVSPVIIKEWAAYKGKSPQTPELVEA
LAFREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPANVPTHLMVLCCVLRYMVQWPGARILRRQELDAFLAQALSPKLYEP
DQLQELKIENLDPRGIQLSALFMSGVDMALFANDACGQPIPWEHCCPWMYFDGKLFQSKLLKASREKTPLIDLCDGQADQAAKVEKMRQS
VLEGLSFSRQSHTLPFPPPPALPFYPASAYPRHFGPVPPSQGRGRGFAGVCGFGGPYGETVATGPYRAFRVAAASGHCGAFSGSDSSRTS
KSQGGVQPIPSQGGKLEIAGTVVGHWAGSRRGRGGRGPFPLQVVSVGGPARGRPRGVISTPVIRTFGRGGRYYGRGYKNQAAIQGRPPYA
ASAEEVAKELKSKSGESKSSAMSSDGSLAENGVMAEEKPAPQMNGSTGDARAPSHSESALNNDSKTCNTNPHLNALSTDSACRREAALEA

--------------------------------------------------------------

>14514_14514_4_CD44-FAM120A_CD44_chr11_35227790_ENST00000437706_FAM120A_chr9_96305504_ENST00000277165_length(amino acids)=996AA_BP=514
MPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRT
EAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPN
AFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMST
SATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDH
TKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNR
WHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMVSPVIIKEWAAYKGKSPQTPELVEAL
AFREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPANVPTHLMVLCCVLRYMVQWPGARILRRQELDAFLAQALSPKLYEPD
QLQELKIENLDPRGIQLSALFMSGVDMALFANDACGQPIPWEHCCPWMYFDGKLFQSKLLKASREKTPLIDLCDGQADQAAKVEKMRQSV
LEGLSFSRQSHTLPFPPPPALPFYPASAYPRHFGPVPPSQGRGRGFAGVCGFGGPYGETVATGPYRAFRVAAASGHCGAFSGSDSSRTSK
SQGGVQPIPSQGGKLEIAGTVVGHWAGSRRGRGGRGPFPLQVVSVGGPARGRPRGVISTPVIRTFGRGGRYYGRGYKNQAAIQGRPPYAA
SAEEVAKELKSKSGESKSSAMSSDGSLAENGVMAEEKPAPQMNGSTGDARAPSHSESALNNDSKTCNTNPHLNALSTDSACRREAALEAA

--------------------------------------------------------------

>14514_14514_5_CD44-FAM120A_CD44_chr11_35227790_ENST00000449691_FAM120A_chr9_96305504_ENST00000277165_length(amino acids)=953AA_BP=471
MPSGPQPLPGSVRHPRPVLRRPLPRAQGSSSSFRPRPPFAPDTMDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRT
EAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPN
AFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMST
SATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDH
TKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTTASAHTSHPMQGRTTPSPEDSSW
TDFFNPISHPMGRGHQAGRRMVSPVIIKEWAAYKGKSPQTPELVEALAFREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNP
ANVPTHLMVLCCVLRYMVQWPGARILRRQELDAFLAQALSPKLYEPDQLQELKIENLDPRGIQLSALFMSGVDMALFANDACGQPIPWEH
CCPWMYFDGKLFQSKLLKASREKTPLIDLCDGQADQAAKVEKMRQSVLEGLSFSRQSHTLPFPPPPALPFYPASAYPRHFGPVPPSQGRG
RGFAGVCGFGGPYGETVATGPYRAFRVAAASGHCGAFSGSDSSRTSKSQGGVQPIPSQGGKLEIAGTVVGHWAGSRRGRGGRGPFPLQVV
SVGGPARGRPRGVISTPVIRTFGRGGRYYGRGYKNQAAIQGRPPYAASAEEVAKELKSKSGESKSSAMSSDGSLAENGVMAEEKPAPQMN

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:35227790/chr9:96305504)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD44

P16070

FAM120A

Q5T036

FUNCTION: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:7528188}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD44chr11:35227790chr9:96305504ENST00000415148+1017150_158428.3333333333333700.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35227790chr9:96305504ENST00000428726+1118150_158471.3333333333333743.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35227790chr9:96305504ENST00000437706+1117150_158471.3333333333333675.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35227790chr9:96305504ENST00000449691+1017150_158428.3333333333333700.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35227790chr9:96305504ENST00000415148+101732_120428.3333333333333700.0DomainLink
HgeneCD44chr11:35227790chr9:96305504ENST00000428726+111832_120471.3333333333333743.0DomainLink
HgeneCD44chr11:35227790chr9:96305504ENST00000437706+111732_120471.3333333333333675.0DomainLink
HgeneCD44chr11:35227790chr9:96305504ENST00000449691+101732_120428.3333333333333700.0DomainLink
TgeneFAM120Achr11:35227790chr9:96305504ENST00000277165918829_1118636.33333333333341119.0RegionNote=RNA binding
TgeneFAM120Achr11:35227790chr9:96305504ENST000003339361019829_1118664.33333333333341147.0RegionNote=RNA binding
TgeneFAM120Achr11:35227790chr9:96305504ENST00000340893917829_1118636.33333333333341073.0RegionNote=RNA binding
TgeneFAM120Achr11:35227790chr9:96305504ENST0000037538909829_11180629.0RegionNote=RNA binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD44chr11:35227790chr9:96305504ENST00000263398+19150_1580362.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35227790chr9:96305504ENST00000278386+14150_1580140.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35227790chr9:96305504ENST00000352818+18150_1580.0341.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35227790chr9:96305504ENST00000360158+110150_1580397.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35227790chr9:96305504ENST00000433892+112150_1580494.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35227790chr9:96305504ENST00000434472+110150_1580430.0Compositional biasNote=Arg/Lys-rich (basic)
HgeneCD44chr11:35227790chr9:96305504ENST00000263398+1932_1200362.0DomainLink
HgeneCD44chr11:35227790chr9:96305504ENST00000278386+1432_1200140.0DomainLink
HgeneCD44chr11:35227790chr9:96305504ENST00000352818+1832_1200.0341.0DomainLink
HgeneCD44chr11:35227790chr9:96305504ENST00000360158+11032_1200397.0DomainLink
HgeneCD44chr11:35227790chr9:96305504ENST00000433892+11232_1200494.0DomainLink
HgeneCD44chr11:35227790chr9:96305504ENST00000434472+11032_1200430.0DomainLink
HgeneCD44chr11:35227790chr9:96305504ENST00000263398+19224_6490362.0RegionNote=Stem
HgeneCD44chr11:35227790chr9:96305504ENST00000278386+14224_6490140.0RegionNote=Stem
HgeneCD44chr11:35227790chr9:96305504ENST00000352818+18224_6490.0341.0RegionNote=Stem
HgeneCD44chr11:35227790chr9:96305504ENST00000360158+110224_6490397.0RegionNote=Stem
HgeneCD44chr11:35227790chr9:96305504ENST00000415148+1017224_649428.3333333333333700.0RegionNote=Stem
HgeneCD44chr11:35227790chr9:96305504ENST00000428726+1118224_649471.3333333333333743.0RegionNote=Stem
HgeneCD44chr11:35227790chr9:96305504ENST00000433892+112224_6490494.0RegionNote=Stem
HgeneCD44chr11:35227790chr9:96305504ENST00000434472+110224_6490430.0RegionNote=Stem
HgeneCD44chr11:35227790chr9:96305504ENST00000437706+1117224_649471.3333333333333675.0RegionNote=Stem
HgeneCD44chr11:35227790chr9:96305504ENST00000449691+1017224_649428.3333333333333700.0RegionNote=Stem
HgeneCD44chr11:35227790chr9:96305504ENST00000263398+1921_6490362.0Topological domainExtracellular
HgeneCD44chr11:35227790chr9:96305504ENST00000263398+19671_7420362.0Topological domainCytoplasmic
HgeneCD44chr11:35227790chr9:96305504ENST00000278386+1421_6490140.0Topological domainExtracellular
HgeneCD44chr11:35227790chr9:96305504ENST00000278386+14671_7420140.0Topological domainCytoplasmic
HgeneCD44chr11:35227790chr9:96305504ENST00000352818+1821_6490.0341.0Topological domainExtracellular
HgeneCD44chr11:35227790chr9:96305504ENST00000352818+18671_7420.0341.0Topological domainCytoplasmic
HgeneCD44chr11:35227790chr9:96305504ENST00000360158+11021_6490397.0Topological domainExtracellular
HgeneCD44chr11:35227790chr9:96305504ENST00000360158+110671_7420397.0Topological domainCytoplasmic
HgeneCD44chr11:35227790chr9:96305504ENST00000415148+101721_649428.3333333333333700.0Topological domainExtracellular
HgeneCD44chr11:35227790chr9:96305504ENST00000415148+1017671_742428.3333333333333700.0Topological domainCytoplasmic
HgeneCD44chr11:35227790chr9:96305504ENST00000428726+111821_649471.3333333333333743.0Topological domainExtracellular
HgeneCD44chr11:35227790chr9:96305504ENST00000428726+1118671_742471.3333333333333743.0Topological domainCytoplasmic
HgeneCD44chr11:35227790chr9:96305504ENST00000433892+11221_6490494.0Topological domainExtracellular
HgeneCD44chr11:35227790chr9:96305504ENST00000433892+112671_7420494.0Topological domainCytoplasmic
HgeneCD44chr11:35227790chr9:96305504ENST00000434472+11021_6490430.0Topological domainExtracellular
HgeneCD44chr11:35227790chr9:96305504ENST00000434472+110671_7420430.0Topological domainCytoplasmic
HgeneCD44chr11:35227790chr9:96305504ENST00000437706+111721_649471.3333333333333675.0Topological domainExtracellular
HgeneCD44chr11:35227790chr9:96305504ENST00000437706+1117671_742471.3333333333333675.0Topological domainCytoplasmic
HgeneCD44chr11:35227790chr9:96305504ENST00000449691+101721_649428.3333333333333700.0Topological domainExtracellular
HgeneCD44chr11:35227790chr9:96305504ENST00000449691+1017671_742428.3333333333333700.0Topological domainCytoplasmic
HgeneCD44chr11:35227790chr9:96305504ENST00000263398+19650_6700362.0TransmembraneHelical
HgeneCD44chr11:35227790chr9:96305504ENST00000278386+14650_6700140.0TransmembraneHelical
HgeneCD44chr11:35227790chr9:96305504ENST00000352818+18650_6700.0341.0TransmembraneHelical
HgeneCD44chr11:35227790chr9:96305504ENST00000360158+110650_6700397.0TransmembraneHelical
HgeneCD44chr11:35227790chr9:96305504ENST00000415148+1017650_670428.3333333333333700.0TransmembraneHelical
HgeneCD44chr11:35227790chr9:96305504ENST00000428726+1118650_670471.3333333333333743.0TransmembraneHelical
HgeneCD44chr11:35227790chr9:96305504ENST00000433892+112650_6700494.0TransmembraneHelical
HgeneCD44chr11:35227790chr9:96305504ENST00000434472+110650_6700430.0TransmembraneHelical
HgeneCD44chr11:35227790chr9:96305504ENST00000437706+1117650_670471.3333333333333675.0TransmembraneHelical
HgeneCD44chr11:35227790chr9:96305504ENST00000449691+1017650_670428.3333333333333700.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CD44
FAM120A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneFAM120Achr11:35227790chr9:96305504ENST00000277165918339_405636.33333333333341119.0YES1%2C SRC and FYN
TgeneFAM120Achr11:35227790chr9:96305504ENST000003339361019339_405664.33333333333341147.0YES1%2C SRC and FYN
TgeneFAM120Achr11:35227790chr9:96305504ENST00000340893917339_405636.33333333333341073.0YES1%2C SRC and FYN


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Related Drugs to CD44-FAM120A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CD44-FAM120A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource