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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CD58-RAD51B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CD58-RAD51B
	FusionPDB ID: 14564
	FusionGDB2.0 ID: 14564
		Hgene	Tgene
	Gene symbol	CD58	RAD51B
	Gene ID	965	5890
	Gene name	CD58 molecule	RAD51 paralog B
	Synonyms	LFA-3\|LFA3\|ag3	R51H2\|RAD51L1\|REC2
	Cytomap	1p13.1	14q24.1
	Type of gene	protein-coding	protein-coding
	Description	lymphocyte function-associated antigen 3CD58 antigen, (lymphocyte function-associated antigen 3)surface glycoprotein LFA-3	DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
	Modification date	20200313	20200313
	UniProtAcc	P19256	O15315
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000369487, ENST00000369489, ENST00000457047,	ENST00000469165, ENST00000390683, ENST00000471583, ENST00000487270, ENST00000487861, ENST00000488612,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 5 X 5=150	41 X 23 X 12=11316
	# samples	6	56
	** MAII score	log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(56/11316*10)=-4.33679344445129 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CD58 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CD58(117113525)-RAD51B(68758601), # samples:2
Anticipated loss of major functional domain due to fusion event.	CD58-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CD58-RAD51B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CD58	GO:0034113	heterotypic cell-cell adhesion	15345303
Hgene	CD58	GO:0071346	cellular response to interferon-gamma	19109405
Hgene	CD58	GO:0071356	cellular response to tumor necrosis factor	19109405

Fusion gene breakpoints across CD58 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAD51B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-B6-A400-01A	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000369489	CD58	chr1	117113525	-	ENST00000487861	RAD51B	chr14	68758601	+	977	137	11	658	215
ENST00000369489	CD58	chr1	117113525	-	ENST00000471583	RAD51B	chr14	68758601	+	869	137	11	433	140
ENST00000369489	CD58	chr1	117113525	-	ENST00000487270	RAD51B	chr14	68758601	+	1929	137	11	535	174
ENST00000369489	CD58	chr1	117113525	-	ENST00000488612	RAD51B	chr14	68758601	+	904	137	11	481	156
ENST00000369489	CD58	chr1	117113525	-	ENST00000390683	RAD51B	chr14	68758601	+	482	137	11	481	157
ENST00000457047	CD58	chr1	117113525	-	ENST00000487861	RAD51B	chr14	68758601	+	964	124	10	645	211
ENST00000457047	CD58	chr1	117113525	-	ENST00000471583	RAD51B	chr14	68758601	+	856	124	10	420	136
ENST00000457047	CD58	chr1	117113525	-	ENST00000487270	RAD51B	chr14	68758601	+	1916	124	10	522	170
ENST00000457047	CD58	chr1	117113525	-	ENST00000488612	RAD51B	chr14	68758601	+	891	124	10	468	152
ENST00000457047	CD58	chr1	117113525	-	ENST00000390683	RAD51B	chr14	68758601	+	469	124	10	468	153
ENST00000369487	CD58	chr1	117113525	-	ENST00000487861	RAD51B	chr14	68758601	+	977	137	11	658	215
ENST00000369487	CD58	chr1	117113525	-	ENST00000471583	RAD51B	chr14	68758601	+	869	137	11	433	140
ENST00000369487	CD58	chr1	117113525	-	ENST00000487270	RAD51B	chr14	68758601	+	1929	137	11	535	174
ENST00000369487	CD58	chr1	117113525	-	ENST00000488612	RAD51B	chr14	68758601	+	904	137	11	481	156
ENST00000369487	CD58	chr1	117113525	-	ENST00000390683	RAD51B	chr14	68758601	+	482	137	11	481	157

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369489	ENST00000487861	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+	0.6146928	0.38530725
ENST00000369489	ENST00000471583	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+	0.6094765	0.39052346
ENST00000369489	ENST00000487270	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+	0.7021324	0.29786763
ENST00000369489	ENST00000488612	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+	0.16921565	0.8307843
ENST00000369489	ENST00000390683	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+	0.44185874	0.55814123
ENST00000457047	ENST00000487861	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+	0.6466475	0.35335252
ENST00000457047	ENST00000471583	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+	0.60095745	0.39904255
ENST00000457047	ENST00000487270	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+	0.7246118	0.27538815
ENST00000457047	ENST00000488612	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+	0.12305903	0.876941
ENST00000457047	ENST00000390683	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+	0.46309587	0.53690416
ENST00000369487	ENST00000487861	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+	0.6146928	0.38530725
ENST00000369487	ENST00000471583	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+	0.6094765	0.39052346
ENST00000369487	ENST00000487270	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+	0.7021324	0.29786763
ENST00000369487	ENST00000488612	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+	0.16921565	0.8307843
ENST00000369487	ENST00000390683	CD58	chr1	117113525	-	RAD51B	chr14	68758601	+	0.44185874	0.55814123

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>14564_14564_1_CD58-RAD51B_CD58_chr1_117113525_ENST00000369487_RAD51B_chr14_68758601_ENST00000390683_length(amino acids)=157AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW

--------------------------------------------------------------

>14564_14564_2_CD58-RAD51B_CD58_chr1_117113525_ENST00000369487_RAD51B_chr14_68758601_ENST00000471583_length(amino acids)=140AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW

--------------------------------------------------------------

>14564_14564_3_CD58-RAD51B_CD58_chr1_117113525_ENST00000369487_RAD51B_chr14_68758601_ENST00000487270_length(amino acids)=174AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW

--------------------------------------------------------------

>14564_14564_4_CD58-RAD51B_CD58_chr1_117113525_ENST00000369487_RAD51B_chr14_68758601_ENST00000487861_length(amino acids)=215AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW
SHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLLPSV

--------------------------------------------------------------

>14564_14564_5_CD58-RAD51B_CD58_chr1_117113525_ENST00000369487_RAD51B_chr14_68758601_ENST00000488612_length(amino acids)=156AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW

--------------------------------------------------------------

>14564_14564_6_CD58-RAD51B_CD58_chr1_117113525_ENST00000369489_RAD51B_chr14_68758601_ENST00000390683_length(amino acids)=157AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW

--------------------------------------------------------------

>14564_14564_7_CD58-RAD51B_CD58_chr1_117113525_ENST00000369489_RAD51B_chr14_68758601_ENST00000471583_length(amino acids)=140AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW

--------------------------------------------------------------

>14564_14564_8_CD58-RAD51B_CD58_chr1_117113525_ENST00000369489_RAD51B_chr14_68758601_ENST00000487270_length(amino acids)=174AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW

--------------------------------------------------------------

>14564_14564_9_CD58-RAD51B_CD58_chr1_117113525_ENST00000369489_RAD51B_chr14_68758601_ENST00000487861_length(amino acids)=215AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW
SHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLLPSV

--------------------------------------------------------------

>14564_14564_10_CD58-RAD51B_CD58_chr1_117113525_ENST00000369489_RAD51B_chr14_68758601_ENST00000488612_length(amino acids)=156AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW

--------------------------------------------------------------

>14564_14564_11_CD58-RAD51B_CD58_chr1_117113525_ENST00000457047_RAD51B_chr14_68758601_ENST00000390683_length(amino acids)=153AA_BP=38
MLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSV

--------------------------------------------------------------

>14564_14564_12_CD58-RAD51B_CD58_chr1_117113525_ENST00000457047_RAD51B_chr14_68758601_ENST00000471583_length(amino acids)=136AA_BP=38
MLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSV

--------------------------------------------------------------

>14564_14564_13_CD58-RAD51B_CD58_chr1_117113525_ENST00000457047_RAD51B_chr14_68758601_ENST00000487270_length(amino acids)=170AA_BP=38
MLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSV

--------------------------------------------------------------

>14564_14564_14_CD58-RAD51B_CD58_chr1_117113525_ENST00000457047_RAD51B_chr14_68758601_ENST00000487861_length(amino acids)=211AA_BP=38
MLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSV
NTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLLPSVSMCP

--------------------------------------------------------------

>14564_14564_15_CD58-RAD51B_CD58_chr1_117113525_ENST00000457047_RAD51B_chr14_68758601_ENST00000488612_length(amino acids)=152AA_BP=38
MLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSV

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:117113525/chr14:68758601)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CD58 P19256	RAD51B O15315
FUNCTION: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.	FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269\|PubMed:11751635, ECO:0000269\|PubMed:11751636, ECO:0000269\|PubMed:11842113, ECO:0000269\|PubMed:12441335, ECO:0000269\|PubMed:23108668, ECO:0000269\|PubMed:23149936}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CD58

chr1:117113525

chr14:68758601

ENST00000369489

30_121

23.333333333333332

251.0

Domain

Note=Ig-like

Hgene

CD58

chr1:117113525

chr14:68758601

ENST00000457047

30_121

23.333333333333332

249.0

Domain

Note=Ig-like

Hgene

CD58

chr1:117113525

chr14:68758601

ENST00000369489

239_250

23.333333333333332

251.0

Topological domain

Cytoplasmic

Hgene

CD58

chr1:117113525

chr14:68758601

ENST00000369489

29_215

23.333333333333332

251.0

Topological domain

Extracellular

Hgene

CD58

chr1:117113525

chr14:68758601

ENST00000457047

239_250

23.333333333333332

249.0

Topological domain

Cytoplasmic

Hgene

CD58

chr1:117113525

chr14:68758601

ENST00000457047

29_215

23.333333333333332

249.0

Topological domain

Extracellular

Hgene

CD58

chr1:117113525

chr14:68758601

ENST00000369489

216_238

23.333333333333332

251.0

Transmembrane

Helical

Hgene

CD58

chr1:117113525

chr14:68758601

ENST00000457047

216_238

23.333333333333332

249.0

Transmembrane

Helical

Tgene

RAD51B

chr1:117113525

chr14:68758601

ENST00000390683

108_115

252.0

367.0

Nucleotide binding

ATP

Tgene

RAD51B

chr1:117113525

chr14:68758601

ENST00000471583

108_115

252.0

351.0

Nucleotide binding

ATP

Tgene

RAD51B

chr1:117113525

chr14:68758601

ENST00000487270

108_115

252.0

385.0

Nucleotide binding

ATP

Tgene

RAD51B

chr1:117113525

chr14:68758601

ENST00000488612

108_115

252.0

495.6666666666667

Nucleotide binding

ATP

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
RAD51B	RAD51, RAD51C, RAD51D, XRCC2, SWSAP1, FAM9B, DKKL1, ARL4C, MUC20, ADAMTS4, HELQ, HNRNPL, SPDL1, BRCA1, TPT1, ABL1, MEOX2, RPAIN, ANAPC5, BAGE2, C15orf39, PRPF6, C5orf34, N4BP2L2, BANP, ANKHD1-EIF4EBP3, KLRC2, DSCC1, SATB2, ZNHIT6, PMS1, NUF2, APAF1, PRKACB, MAPRE2, CD300LB, PRKACG, TBC1D2B, MTR,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CD58
RAD51B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	RAD51B	chr1:117113525	chr14:68758601	ENST00000390683		5	10	1_75	252.0	367.0	RAD51C
Tgene	RAD51B	chr1:117113525	chr14:68758601	ENST00000471583		6	11	1_75	252.0	351.0	RAD51C
Tgene	RAD51B	chr1:117113525	chr14:68758601	ENST00000487270		6	11	1_75	252.0	385.0	RAD51C
Tgene	RAD51B	chr1:117113525	chr14:68758601	ENST00000488612		6	12	1_75	252.0	495.6666666666667	RAD51C

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Related Drugs to CD58-RAD51B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CD58-RAD51B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	RAD51B	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	RAD51B	C0013146	Drug abuse	1	CTD_human
Tgene	RAD51B	C0013170	Drug habituation	1	CTD_human
Tgene	RAD51B	C0013222	Drug Use Disorders	1	CTD_human
Tgene	RAD51B	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Tgene	RAD51B	C0038580	Substance Dependence	1	CTD_human
Tgene	RAD51B	C0038586	Substance Use Disorders	1	CTD_human
Tgene	RAD51B	C0236969	Substance-Related Disorders	1	CTD_human
Tgene	RAD51B	C0238033	Carcinoma of Male Breast	1	CTD_human
Tgene	RAD51B	C0242788	Breast Neoplasms, Male	1	CTD_human
Tgene	RAD51B	C0678222	Breast Carcinoma	1	CTD_human
Tgene	RAD51B	C0740858	Substance abuse problem	1	CTD_human
Tgene	RAD51B	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	RAD51B	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	RAD51B	C1510472	Drug Dependence	1	CTD_human
Tgene	RAD51B	C4316881	Prescription Drug Abuse	1	CTD_human
Tgene	RAD51B	C4704874	Mammary Carcinoma, Human	1	CTD_human