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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CD74-NRG1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CD74-NRG1
	FusionPDB ID: 14642
	FusionGDB2.0 ID: 14642
		Hgene	Tgene
	Gene symbol	CD74	NRG1
	Gene ID	972	3084
	Gene name	CD74 molecule	neuregulin 1
	Synonyms	DHLAG\|HLADG\|II\|Ia-GAMMA\|p33	ARIA\|GGF\|GGF2\|HGL\|HRG\|HRG1\|HRGA\|MST131\|MSTP131\|NDF\|NRG1-IT2\|SMDF
	Cytomap	5q33.1	8p12
	Type of gene	protein-coding	protein-coding
	Description	HLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated	pro-neuregulin-1, membrane-bound isoformacetylcholine receptor-inducing activityglial growth factor 2heregulin, alpha (45kD, ERBB2 p185-activator)neu differentiation factorpro-NRG1sensory and motor neuron derived factor
	Modification date	20200313	20200320
	UniProtAcc	P04233	Q02297
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000377795, ENST00000009530, ENST00000353334, ENST00000524315,	ENST00000287842, ENST00000287845, ENST00000338921, ENST00000341377, ENST00000356819, ENST00000405005, ENST00000519301, ENST00000520407, ENST00000520502, ENST00000521670, ENST00000523079, ENST00000539990, ENST00000523681,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	43 X 51 X 20=43860	25 X 17 X 14=5950
	# samples	59	27
	** MAII score	log2(59/43860*10)=-6.21604704731175 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(27/5950*10)=-4.46185835603184 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CD74 [Title/Abstract] AND NRG1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.	CD74-NRG1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. CD74-NRG1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CD74-NRG1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CD74	GO:0001516	prostaglandin biosynthetic process	12782713
Hgene	CD74	GO:0001934	positive regulation of protein phosphorylation	24942581
Hgene	CD74	GO:0002792	negative regulation of peptide secretion	19849849
Hgene	CD74	GO:0033674	positive regulation of kinase activity	24942581
Hgene	CD74	GO:0043066	negative regulation of apoptotic process	12782713
Hgene	CD74	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	24942581
Hgene	CD74	GO:0043410	positive regulation of MAPK cascade	24942581
Hgene	CD74	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	17045821
Hgene	CD74	GO:0045657	positive regulation of monocyte differentiation	24942581
Hgene	CD74	GO:0045893	positive regulation of transcription, DNA-templated	24942581
Hgene	CD74	GO:0046598	positive regulation of viral entry into host cell	24942581
Hgene	CD74	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	17045821
Hgene	CD74	GO:0070374	positive regulation of ERK1 and ERK2 cascade	17045821\|24942581
Tgene	NRG1	GO:0003222	ventricular trabecula myocardium morphogenesis	17336907
Tgene	NRG1	GO:0031334	positive regulation of protein complex assembly	10559227
Tgene	NRG1	GO:0038127	ERBB signaling pathway	11389077
Tgene	NRG1	GO:0038129	ERBB3 signaling pathway	27353365
Tgene	NRG1	GO:0045892	negative regulation of transcription, DNA-templated	15073182
Tgene	NRG1	GO:0051048	negative regulation of secretion	10559227
Tgene	NRG1	GO:0060379	cardiac muscle cell myoblast differentiation	17336907
Tgene	NRG1	GO:0060956	endocardial cell differentiation	17336907

Fusion gene breakpoints across CD74 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NRG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	CD74	chr5	149782125	-	NRG1	chr8	32585466	+
ChimerKB3	.	.	CD74	chr5	149784242	-	NRG1	chr8	32585466	+
ChimerKB3	.	.	CD74	chr5	149784242	-	NRG1	chr8	32600192	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000353334	CD74	chr5	149782125	-	ENST00000519301	NRG1	chr8	32585466	+	2307	868	180	2303	707
ENST00000353334	CD74	chr5	149782125	-	ENST00000520407	NRG1	chr8	32585466	+	1548	868	180	1091	303
ENST00000353334	CD74	chr5	149782125	-	ENST00000523079	NRG1	chr8	32585466	+	2208	868	180	1628	482
ENST00000353334	CD74	chr5	149782125	-	ENST00000338921	NRG1	chr8	32585466	+	2941	868	180	2312	710
ENST00000353334	CD74	chr5	149782125	-	ENST00000356819	NRG1	chr8	32585466	+	2932	868	180	2303	707
ENST00000353334	CD74	chr5	149782125	-	ENST00000287845	NRG1	chr8	32585466	+	2932	868	180	2303	707
ENST00000353334	CD74	chr5	149782125	-	ENST00000341377	NRG1	chr8	32585466	+	2976	868	1109	2347	412
ENST00000353334	CD74	chr5	149782125	-	ENST00000287842	NRG1	chr8	32585466	+	2389	868	180	2279	699
ENST00000353334	CD74	chr5	149782125	-	ENST00000521670	NRG1	chr8	32585466	+	2027	868	180	1754	524
ENST00000353334	CD74	chr5	149782125	-	ENST00000405005	NRG1	chr8	32585466	+	2358	868	180	2288	702
ENST00000353334	CD74	chr5	149782125	-	ENST00000520502	NRG1	chr8	32585466	+	1531	868	180	1091	303
ENST00000353334	CD74	chr5	149782125	-	ENST00000539990	NRG1	chr8	32585466	+	2386	868	180	2279	699
ENST00000009530	CD74	chr5	149782125	-	ENST00000519301	NRG1	chr8	32585466	+	2321	882	2	2317	771
ENST00000009530	CD74	chr5	149782125	-	ENST00000520407	NRG1	chr8	32585466	+	1562	882	2	1105	367
ENST00000009530	CD74	chr5	149782125	-	ENST00000523079	NRG1	chr8	32585466	+	2222	882	2	1642	546
ENST00000009530	CD74	chr5	149782125	-	ENST00000338921	NRG1	chr8	32585466	+	2955	882	2	2326	774
ENST00000009530	CD74	chr5	149782125	-	ENST00000356819	NRG1	chr8	32585466	+	2946	882	2	2317	771
ENST00000009530	CD74	chr5	149782125	-	ENST00000287845	NRG1	chr8	32585466	+	2946	882	2	2317	771
ENST00000009530	CD74	chr5	149782125	-	ENST00000341377	NRG1	chr8	32585466	+	2990	882	1123	2361	412
ENST00000009530	CD74	chr5	149782125	-	ENST00000287842	NRG1	chr8	32585466	+	2403	882	2	2293	763
ENST00000009530	CD74	chr5	149782125	-	ENST00000521670	NRG1	chr8	32585466	+	2041	882	2	1768	588
ENST00000009530	CD74	chr5	149782125	-	ENST00000405005	NRG1	chr8	32585466	+	2372	882	2	2302	766
ENST00000009530	CD74	chr5	149782125	-	ENST00000520502	NRG1	chr8	32585466	+	1545	882	2	1105	367
ENST00000009530	CD74	chr5	149782125	-	ENST00000539990	NRG1	chr8	32585466	+	2400	882	2	2293	763
ENST00000353334	CD74	chr5	149784242	-	ENST00000519301	NRG1	chr8	32585466	+	2244	805	180	2240	686
ENST00000353334	CD74	chr5	149784242	-	ENST00000520407	NRG1	chr8	32585466	+	1485	805	180	1028	282
ENST00000353334	CD74	chr5	149784242	-	ENST00000523079	NRG1	chr8	32585466	+	2145	805	180	1565	461
ENST00000353334	CD74	chr5	149784242	-	ENST00000338921	NRG1	chr8	32585466	+	2878	805	180	2249	689
ENST00000353334	CD74	chr5	149784242	-	ENST00000356819	NRG1	chr8	32585466	+	2869	805	180	2240	686
ENST00000353334	CD74	chr5	149784242	-	ENST00000287845	NRG1	chr8	32585466	+	2869	805	180	2240	686
ENST00000353334	CD74	chr5	149784242	-	ENST00000341377	NRG1	chr8	32585466	+	2913	805	1046	2284	412
ENST00000353334	CD74	chr5	149784242	-	ENST00000287842	NRG1	chr8	32585466	+	2326	805	180	2216	678
ENST00000353334	CD74	chr5	149784242	-	ENST00000521670	NRG1	chr8	32585466	+	1964	805	180	1691	503
ENST00000353334	CD74	chr5	149784242	-	ENST00000405005	NRG1	chr8	32585466	+	2295	805	180	2225	681
ENST00000353334	CD74	chr5	149784242	-	ENST00000520502	NRG1	chr8	32585466	+	1468	805	180	1028	282
ENST00000353334	CD74	chr5	149784242	-	ENST00000539990	NRG1	chr8	32585466	+	2323	805	180	2216	678
ENST00000009530	CD74	chr5	149784242	-	ENST00000519301	NRG1	chr8	32585466	+	2066	627	2	2062	686
ENST00000009530	CD74	chr5	149784242	-	ENST00000520407	NRG1	chr8	32585466	+	1307	627	2	850	282
ENST00000009530	CD74	chr5	149784242	-	ENST00000523079	NRG1	chr8	32585466	+	1967	627	2	1387	461
ENST00000009530	CD74	chr5	149784242	-	ENST00000338921	NRG1	chr8	32585466	+	2700	627	2	2071	689
ENST00000009530	CD74	chr5	149784242	-	ENST00000356819	NRG1	chr8	32585466	+	2691	627	2	2062	686
ENST00000009530	CD74	chr5	149784242	-	ENST00000287845	NRG1	chr8	32585466	+	2691	627	2	2062	686
ENST00000009530	CD74	chr5	149784242	-	ENST00000341377	NRG1	chr8	32585466	+	2735	627	868	2106	412
ENST00000009530	CD74	chr5	149784242	-	ENST00000287842	NRG1	chr8	32585466	+	2148	627	2	2038	678
ENST00000009530	CD74	chr5	149784242	-	ENST00000521670	NRG1	chr8	32585466	+	1786	627	2	1513	503
ENST00000009530	CD74	chr5	149784242	-	ENST00000405005	NRG1	chr8	32585466	+	2117	627	2	2047	681
ENST00000009530	CD74	chr5	149784242	-	ENST00000520502	NRG1	chr8	32585466	+	1290	627	2	850	282
ENST00000009530	CD74	chr5	149784242	-	ENST00000539990	NRG1	chr8	32585466	+	2145	627	2	2038	678

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>14642_14642_1_CD74-NRG1_CD74_chr5_149782125_ENST00000009530_NRG1_chr8_32585466_ENST00000287842_length(amino acids)=763AA_BP=293
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHN
CSESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEE
LYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVERE
AETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRD
SPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAH
DSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAA

--------------------------------------------------------------

>14642_14642_2_CD74-NRG1_CD74_chr5_149782125_ENST00000009530_NRG1_chr8_32585466_ENST00000287845_length(amino acids)=771AA_BP=293
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHN
CSESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLG
IEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVIS
SEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHAR
ETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFS
SFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFL

--------------------------------------------------------------

>14642_14642_3_CD74-NRG1_CD74_chr5_149782125_ENST00000009530_NRG1_chr8_32585466_ENST00000338921_length(amino acids)=774AA_BP=293
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHN
CSESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEK
HSGEPFPEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN
VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR
HARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQ
QFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDT

--------------------------------------------------------------

>14642_14642_4_CD74-NRG1_CD74_chr5_149782125_ENST00000009530_NRG1_chr8_32585466_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>14642_14642_5_CD74-NRG1_CD74_chr5_149782125_ENST00000009530_NRG1_chr8_32585466_ENST00000356819_length(amino acids)=771AA_BP=293
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHN
CSESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLG
IEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVIS
SEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHAR
ETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFS
SFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFL

--------------------------------------------------------------

>14642_14642_6_CD74-NRG1_CD74_chr5_149782125_ENST00000009530_NRG1_chr8_32585466_ENST00000405005_length(amino acids)=766AA_BP=293
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHN
CSESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEK
AEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIV
EREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDS
YRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHN
PAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNP

--------------------------------------------------------------

>14642_14642_7_CD74-NRG1_CD74_chr5_149782125_ENST00000009530_NRG1_chr8_32585466_ENST00000519301_length(amino acids)=771AA_BP=293
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHN
CSESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLG
IEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVIS
SEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHAR
ETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFS
SFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFL

--------------------------------------------------------------

>14642_14642_8_CD74-NRG1_CD74_chr5_149782125_ENST00000009530_NRG1_chr8_32585466_ENST00000520407_length(amino acids)=367AA_BP=293
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHN
CSESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTST

--------------------------------------------------------------

>14642_14642_9_CD74-NRG1_CD74_chr5_149782125_ENST00000009530_NRG1_chr8_32585466_ENST00000520502_length(amino acids)=367AA_BP=293
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHN
CSESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTST

--------------------------------------------------------------

>14642_14642_10_CD74-NRG1_CD74_chr5_149782125_ENST00000009530_NRG1_chr8_32585466_ENST00000521670_length(amino acids)=588AA_BP=293
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHN
CSESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEK
AEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIV
EREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDS

--------------------------------------------------------------

>14642_14642_11_CD74-NRG1_CD74_chr5_149782125_ENST00000009530_NRG1_chr8_32585466_ENST00000523079_length(amino acids)=546AA_BP=293
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHN
CSESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEE
LYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVERE
AETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRD

--------------------------------------------------------------

>14642_14642_12_CD74-NRG1_CD74_chr5_149782125_ENST00000009530_NRG1_chr8_32585466_ENST00000539990_length(amino acids)=763AA_BP=293
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHN
CSESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEE
LYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVERE
AETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRD
SPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAH
DSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAA

--------------------------------------------------------------

>14642_14642_13_CD74-NRG1_CD74_chr5_149782125_ENST00000353334_NRG1_chr8_32585466_ENST00000287842_length(amino acids)=699AA_BP=229
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRY
LCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNP
PPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGR
LNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLV
TPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSS

--------------------------------------------------------------

>14642_14642_14_CD74-NRG1_CD74_chr5_149782125_ENST00000353334_NRG1_chr8_32585466_ENST00000287845_length(amino acids)=707AA_BP=229
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRY
LCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIA
NGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSS
PTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFME
EERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVD

--------------------------------------------------------------

>14642_14642_15_CD74-NRG1_CD74_chr5_149782125_ENST00000353334_NRG1_chr8_32585466_ENST00000338921_length(amino acids)=710AA_BP=229
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRY
LCKCQPGFTGARCTENVPMKVQNQEKHSGEPFPEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMM
NIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSR
HSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSP
FMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRL

--------------------------------------------------------------

>14642_14642_16_CD74-NRG1_CD74_chr5_149782125_ENST00000353334_NRG1_chr8_32585466_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>14642_14642_17_CD74-NRG1_CD74_chr5_149782125_ENST00000353334_NRG1_chr8_32585466_ENST00000356819_length(amino acids)=707AA_BP=229
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRY
LCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIA
NGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSS
PTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFME
EERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVD

--------------------------------------------------------------

>14642_14642_18_CD74-NRG1_CD74_chr5_149782125_ENST00000353334_NRG1_chr8_32585466_ENST00000405005_length(amino acids)=702AA_BP=229
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRY
LCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHH
PNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPL
LLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS

--------------------------------------------------------------

>14642_14642_19_CD74-NRG1_CD74_chr5_149782125_ENST00000353334_NRG1_chr8_32585466_ENST00000519301_length(amino acids)=707AA_BP=229
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRY
LCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIA
NGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSS
PTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFME
EERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVD

--------------------------------------------------------------

>14642_14642_20_CD74-NRG1_CD74_chr5_149782125_ENST00000353334_NRG1_chr8_32585466_ENST00000520407_length(amino acids)=303AA_BP=229
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRY

--------------------------------------------------------------

>14642_14642_21_CD74-NRG1_CD74_chr5_149782125_ENST00000353334_NRG1_chr8_32585466_ENST00000520502_length(amino acids)=303AA_BP=229
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRY

--------------------------------------------------------------

>14642_14642_22_CD74-NRG1_CD74_chr5_149782125_ENST00000353334_NRG1_chr8_32585466_ENST00000521670_length(amino acids)=524AA_BP=229
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRY
LCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHH
PNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP

--------------------------------------------------------------

>14642_14642_23_CD74-NRG1_CD74_chr5_149782125_ENST00000353334_NRG1_chr8_32585466_ENST00000523079_length(amino acids)=482AA_BP=229
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRY
LCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNP
PPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGR

--------------------------------------------------------------

>14642_14642_24_CD74-NRG1_CD74_chr5_149782125_ENST00000353334_NRG1_chr8_32585466_ENST00000539990_length(amino acids)=699AA_BP=229
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRY
LCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNP
PPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGR
LNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLV
TPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSS

--------------------------------------------------------------

>14642_14642_25_CD74-NRG1_CD74_chr5_149784242_ENST00000009530_NRG1_chr8_32585466_ENST00000287842_length(amino acids)=678AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF
YKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEH
IVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETP
DSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFH
HNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQ

--------------------------------------------------------------

>14642_14642_26_CD74-NRG1_CD74_chr5_149784242_ENST00000009530_NRG1_chr8_32585466_ENST00000287845_length(amino acids)=686AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF
YKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVS
KNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSF
LRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHH
PQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGE

--------------------------------------------------------------

>14642_14642_27_CD74-NRG1_CD74_chr5_149784242_ENST00000009530_NRG1_chr8_32585466_ENST00000338921_length(amino acids)=689AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKV
QNQEKHSGEPFPEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQ
YVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC
NSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKF
DHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDER

--------------------------------------------------------------

>14642_14642_28_CD74-NRG1_CD74_chr5_149784242_ENST00000009530_NRG1_chr8_32585466_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>14642_14642_29_CD74-NRG1_CD74_chr5_149784242_ENST00000009530_NRG1_chr8_32585466_ENST00000356819_length(amino acids)=686AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF
YKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVS
KNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSF
LRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHH
PQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGE

--------------------------------------------------------------

>14642_14642_30_CD74-NRG1_CD74_chr5_149784242_ENST00000009530_NRG1_chr8_32585466_ENST00000405005_length(amino acids)=681AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKV
QNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVIS
SEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHAR
ETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFS
SFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFL

--------------------------------------------------------------

>14642_14642_31_CD74-NRG1_CD74_chr5_149784242_ENST00000009530_NRG1_chr8_32585466_ENST00000519301_length(amino acids)=686AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF
YKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVS
KNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSF
LRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHH
PQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGE

--------------------------------------------------------------

>14642_14642_32_CD74-NRG1_CD74_chr5_149784242_ENST00000009530_NRG1_chr8_32585466_ENST00000520407_length(amino acids)=282AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF

--------------------------------------------------------------

>14642_14642_33_CD74-NRG1_CD74_chr5_149784242_ENST00000009530_NRG1_chr8_32585466_ENST00000520502_length(amino acids)=282AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF

--------------------------------------------------------------

>14642_14642_34_CD74-NRG1_CD74_chr5_149784242_ENST00000009530_NRG1_chr8_32585466_ENST00000521670_length(amino acids)=503AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKV
QNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVIS
SEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHAR

--------------------------------------------------------------

>14642_14642_35_CD74-NRG1_CD74_chr5_149784242_ENST00000009530_NRG1_chr8_32585466_ENST00000523079_length(amino acids)=461AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF
YKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEH
IVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETP

--------------------------------------------------------------

>14642_14642_36_CD74-NRG1_CD74_chr5_149784242_ENST00000009530_NRG1_chr8_32585466_ENST00000539990_length(amino acids)=678AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF
YKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEH
IVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETP
DSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFH
HNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQ

--------------------------------------------------------------

>14642_14642_37_CD74-NRG1_CD74_chr5_149784242_ENST00000353334_NRG1_chr8_32585466_ENST00000287842_length(amino acids)=678AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF
YKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEH
IVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETP
DSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFH
HNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQ

--------------------------------------------------------------

>14642_14642_38_CD74-NRG1_CD74_chr5_149784242_ENST00000353334_NRG1_chr8_32585466_ENST00000287845_length(amino acids)=686AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF
YKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVS
KNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSF
LRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHH
PQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGE

--------------------------------------------------------------

>14642_14642_39_CD74-NRG1_CD74_chr5_149784242_ENST00000353334_NRG1_chr8_32585466_ENST00000338921_length(amino acids)=689AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKV
QNQEKHSGEPFPEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQ
YVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC
NSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKF
DHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDER

--------------------------------------------------------------

>14642_14642_40_CD74-NRG1_CD74_chr5_149784242_ENST00000353334_NRG1_chr8_32585466_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>14642_14642_41_CD74-NRG1_CD74_chr5_149784242_ENST00000353334_NRG1_chr8_32585466_ENST00000356819_length(amino acids)=686AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF
YKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVS
KNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSF
LRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHH
PQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGE

--------------------------------------------------------------

>14642_14642_42_CD74-NRG1_CD74_chr5_149784242_ENST00000353334_NRG1_chr8_32585466_ENST00000405005_length(amino acids)=681AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKV
QNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVIS
SEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHAR
ETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFS
SFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFL

--------------------------------------------------------------

>14642_14642_43_CD74-NRG1_CD74_chr5_149784242_ENST00000353334_NRG1_chr8_32585466_ENST00000519301_length(amino acids)=686AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF
YKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVS
KNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSF
LRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHH
PQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGE

--------------------------------------------------------------

>14642_14642_44_CD74-NRG1_CD74_chr5_149784242_ENST00000353334_NRG1_chr8_32585466_ENST00000520407_length(amino acids)=282AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF

--------------------------------------------------------------

>14642_14642_45_CD74-NRG1_CD74_chr5_149784242_ENST00000353334_NRG1_chr8_32585466_ENST00000520502_length(amino acids)=282AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF

--------------------------------------------------------------

>14642_14642_46_CD74-NRG1_CD74_chr5_149784242_ENST00000353334_NRG1_chr8_32585466_ENST00000521670_length(amino acids)=503AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKV
QNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVIS
SEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHAR

--------------------------------------------------------------

>14642_14642_47_CD74-NRG1_CD74_chr5_149784242_ENST00000353334_NRG1_chr8_32585466_ENST00000523079_length(amino acids)=461AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF
YKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEH
IVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETP

--------------------------------------------------------------

>14642_14642_48_CD74-NRG1_CD74_chr5_149784242_ENST00000353334_NRG1_chr8_32585466_ENST00000539990_length(amino acids)=678AA_BP=208
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQL
ENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASF
YKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEH
IVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETP
DSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFH
HNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQ

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:/chr8:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CD74 P04233	NRG1 Q02297
FUNCTION: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000269\|PubMed:1448172}.; FUNCTION: [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215). {ECO:0000250\|UniProtKB:P04441, ECO:0000269\|PubMed:32855215}.	FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250\|UniProtKB:P43322, ECO:0000269\|PubMed:10867024, ECO:0000269\|PubMed:1348215, ECO:0000269\|PubMed:20682778, ECO:0000269\|PubMed:7902537}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (52) >>>52.pdbFusion protein BP residue: 208 CIF file (52) >>>52.cif	CD74	chr5	149784242	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYL	282
3D view using mol* of 52 (AA BP:208)


PDB file (64) >>>64.pdbFusion protein BP residue: 229 CIF file (64) >>>64.cif	CD74	chr5	149782125	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKT FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLS	303
3D view using mol* of 64 (AA BP:229)


PDB file (121) >>>121.pdbFusion protein BP residue: 293 CIF file (121) >>>121.cif	CD74	chr5	149782125	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYC WCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPATSTSTT GTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNY	367
3D view using mol* of 121 (AA BP:293)


PDB file (175) >>>175.pdbFusion protein BP residue: CIF file (175) >>>175.cif	CD74	chr5	149782125	-	NRG1	chr8	32585466	+	MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRL RQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVEN SRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAM TTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPL LLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETT QEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETE DERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL	412
3D view using mol* of 175 (AA BP:)


PDB file (233) >>>233.pdbFusion protein BP residue: 208 CIF file (233) >>>233.cif	CD74	chr5	149784242	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYL CKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVV AYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQY VSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTES ILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETP	461
3D view using mol* of 233 (AA BP:208)


PDB file (269) >>>269.pdbFusion protein BP residue: 229 CIF file (269) >>>269.cif	CD74	chr5	149782125	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKT FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQK RVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMN IANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGR	482
3D view using mol* of 269 (AA BP:229)


PDB file (308) >>>308.pdbFusion protein BP residue: 208 CIF file (308) >>>308.cif	CD74	chr5	149784242	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYL CKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIM CVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLV NQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGH TESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHAR ETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLG	503
3D view using mol* of 308 (AA BP:208)


PDB file (350) >>>350.pdbFusion protein BP residue: 229 CIF file (350) >>>350.cif	CD74	chr5	149782125	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKT FCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEEL YQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNN MMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERHNLIAELRRNKAHRS	524
3D view using mol* of 350 (AA BP:229)


PDB file (384) >>>384.pdbFusion protein BP residue: 293 CIF file (384) >>>384.cif	CD74	chr5	149782125	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYC WCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPATSTSTT GTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNY VMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDR LRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVERE AETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVE	546
3D view using mol* of 384 (AA BP:293)


PDB file (451) >>>451.pdbFusion protein BP residue: 293 CIF file (451) >>>451.cif	CD74	chr5	149782125	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYC WCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPATSTSTT GTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTEN VPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKL HDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIV EREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMS SVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERH	588
3D view using mol* of 451 (AA BP:293)


PDB file (548) >>>548.pdbFusion protein BP residue: 208 CIF file (548) >>>548.cif	CD74	chr5	149784242	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYL CKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVV AYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQY VSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTES ILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETP DSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVS MPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSL PASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEV DSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRT	678
3D view using mol* of 548 (AA BP:208)


PDB file (549) >>>549.pdbFusion protein BP residue: 208 CIF file (549) >>>549.cif	CD74	chr5	149784242	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYL CKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIM CVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLV NQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGH TESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHAR ETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSM TVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDS NSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANR LEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLAD	681
3D view using mol* of 549 (AA BP:208)


PDB file (559) >>>559.pdbFusion protein BP residue: 208 CIF file (559) >>>559.cif	CD74	chr5	149784242	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYL CKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALL VVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPE NVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHS WSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSF LRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSP PVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHN PAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNG HIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPA	686
3D view using mol* of 559 (AA BP:208)


PDB file (563) >>>563.pdbFusion protein BP residue: 208 CIF file (563) >>>563.cif	CD74	chr5	149784242	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYL CKCQPGFTGARCTENVPMKVQNQEKHSGEPFPEAEELYQKRVLTITGICI ALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNP PPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTP SHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC NSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSE MSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSF HHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTK PNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEA	689
3D view using mol* of 563 (AA BP:208)


PDB file (568) >>>568.pdbFusion protein BP residue: 229 CIF file (568) >>>568.cif	CD74	chr5	149782125	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKT FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQK RVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMN IANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGR LNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHT PSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKF DHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKL ANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGI	699
3D view using mol* of 568 (AA BP:229)


PDB file (575) >>>575.pdbFusion protein BP residue: 229 CIF file (575) >>>575.cif	CD74	chr5	149782125	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKT FCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEEL YQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNN MMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVD FHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLRE KKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPV KKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF LGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPI	702
3D view using mol* of 575 (AA BP:229)


PDB file (580) >>>580.pdbFusion protein BP residue: 229 CIF file (580) >>>580.cif	CD74	chr5	149782125	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKT FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFM EAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLR SERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFS TSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSS PTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPAR MSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTP PRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEP AQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVG EDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIA	707
3D view using mol* of 580 (AA BP:229)


PDB file (584) >>>584.pdbFusion protein BP residue: 229 CIF file (584) >>>584.cif	CD74	chr5	149782125	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKESLELEDPSSGLGVTKQDLGPATSTSTTGTSHLVKCAEKEKT FCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHSGE PFPEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQ SLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAET SFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSR HSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTT PARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLL VTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQE YEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDE RVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSS	710
3D view using mol* of 584 (AA BP:229)


PDB file (624) >>>624.pdbFusion protein BP residue: 293 CIF file (624) >>>624.cif	CD74	chr5	149782125	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYC WCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPATSTSTT GTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNY VMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDR LRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVERE AETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVE NSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSA MTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERP LLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYET TQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESET EDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQAR	763
3D view using mol* of 624 (AA BP:293)


PDB file (626) >>>626.pdbFusion protein BP residue: 293 CIF file (626) >>>626.cif	CD74	chr5	149782125	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYC WCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPATSTSTT GTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTEN VPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKL HDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIV EREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMS SVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERY VSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEE ERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEE YETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSE SETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEI	766
3D view using mol* of 626 (AA BP:293)


PDB file (629) >>>629.pdbFusion protein BP residue: 293 CIF file (629) >>>629.cif	CD74	chr5	149782125	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYC WCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPATSTSTT GTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNY VMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKK QRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVIS SEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHS VIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSP HSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVS PFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRI VEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQ SSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFS	771
3D view using mol* of 629 (AA BP:293)


PDB file (631) >>>631.pdbFusion protein BP residue: 293 CIF file (631) >>>631.cif	CD74	chr5	149782125	-	NRG1	chr8	32585466	+	MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALY TGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKP PKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNAD PLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQ KPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYC WCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPATSTSTT GTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTEN VPMKVQNQEKHSGEPFPEAEELYQKRVLTITGICIALLVVGIMCVVAYCK TKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKN VISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSE SHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYR DSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSM AVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASP LRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNT SSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAG	774
3D view using mol* of 631 (AA BP:293)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CD74_pLDDT.png

NRG1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CD74_NRG1_52_PAE.png (AA BP:208)

CD74_NRG1_52_pLDDT.png (AA BP:208)

CD74_NRG1_52_pLDDT_and_active_sites.png (AA BP:208)

CD74_NRG1_52_violinplot.png (AA BP:208)

CD74_NRG1_64_PAE.png (AA BP:229)

CD74_NRG1_64_pLDDT.png (AA BP:229)

CD74_NRG1_64_pLDDT_and_active_sites.png (AA BP:229)

CD74_NRG1_64_violinplot.png (AA BP:229)

CD74_NRG1_121_PAE.png (AA BP:293)

CD74_NRG1_121_pLDDT.png (AA BP:293)

CD74_NRG1_121_pLDDT_and_active_sites.png (AA BP:293)

CD74_NRG1_121_violinplot.png (AA BP:293)

CD74_NRG1_175_PAE.png (AA BP:)

CD74_NRG1_175_pLDDT.png (AA BP:)

CD74_NRG1_175_pLDDT_and_active_sites.png (AA BP:)

CD74_NRG1_175_violinplot.png (AA BP:)

CD74_NRG1_233_PAE.png (AA BP:208)

CD74_NRG1_233_pLDDT.png (AA BP:208)

CD74_NRG1_233_pLDDT_and_active_sites.png (AA BP:208)

CD74_NRG1_233_violinplot.png (AA BP:208)

CD74_NRG1_269_pLDDT.png (AA BP:229)

CD74_NRG1_269_pLDDT_and_active_sites.png (AA BP:229)

CD74_NRG1_269_violinplot.png (AA BP:229)

CD74_NRG1_308_pLDDT.png (AA BP:208)

CD74_NRG1_308_pLDDT_and_active_sites.png (AA BP:208)

CD74_NRG1_308_violinplot.png (AA BP:208)

CD74_NRG1_350_pLDDT.png (AA BP:229)

CD74_NRG1_350_pLDDT_and_active_sites.png (AA BP:229)

CD74_NRG1_350_violinplot.png (AA BP:229)

CD74_NRG1_384_pLDDT.png (AA BP:293)

CD74_NRG1_384_pLDDT_and_active_sites.png (AA BP:293)

CD74_NRG1_384_violinplot.png (AA BP:293)

CD74_NRG1_451_pLDDT.png (AA BP:293)

CD74_NRG1_451_pLDDT_and_active_sites.png (AA BP:293)

CD74_NRG1_451_violinplot.png (AA BP:293)

CD74_NRG1_548_pLDDT.png (AA BP:208)

CD74_NRG1_548_pLDDT_and_active_sites.png (AA BP:208)

CD74_NRG1_548_violinplot.png (AA BP:208)

CD74_NRG1_549_pLDDT.png (AA BP:208)

CD74_NRG1_549_pLDDT_and_active_sites.png (AA BP:208)

CD74_NRG1_549_violinplot.png (AA BP:208)

CD74_NRG1_559_pLDDT.png (AA BP:208)

CD74_NRG1_559_pLDDT_and_active_sites.png (AA BP:208)

CD74_NRG1_563_pLDDT.png (AA BP:208)

CD74_NRG1_563_pLDDT_and_active_sites.png (AA BP:208)

CD74_NRG1_563_violinplot.png (AA BP:208)

CD74_NRG1_568_pLDDT.png (AA BP:229)

CD74_NRG1_568_pLDDT_and_active_sites.png (AA BP:229)

CD74_NRG1_568_violinplot.png (AA BP:229)

CD74_NRG1_575_pLDDT.png (AA BP:229)

CD74_NRG1_575_pLDDT_and_active_sites.png (AA BP:229)

CD74_NRG1_575_violinplot.png (AA BP:229)

CD74_NRG1_580_pLDDT.png (AA BP:229)

CD74_NRG1_580_pLDDT_and_active_sites.png (AA BP:229)

CD74_NRG1_580_violinplot.png (AA BP:229)

CD74_NRG1_584_pLDDT.png (AA BP:229)

CD74_NRG1_584_pLDDT_and_active_sites.png (AA BP:229)

CD74_NRG1_584_violinplot.png (AA BP:229)

CD74_NRG1_624_pLDDT.png (AA BP:293)

CD74_NRG1_624_pLDDT_and_active_sites.png (AA BP:293)

CD74_NRG1_624_violinplot.png (AA BP:293)

CD74_NRG1_626_pLDDT.png (AA BP:293)

CD74_NRG1_626_pLDDT_and_active_sites.png (AA BP:293)

CD74_NRG1_626_violinplot.png (AA BP:293)

CD74_NRG1_629_pLDDT.png (AA BP:293)

CD74_NRG1_629_pLDDT_and_active_sites.png (AA BP:293)

CD74_NRG1_629_violinplot.png (AA BP:293)

CD74_NRG1_631_pLDDT.png (AA BP:293)

CD74_NRG1_631_pLDDT_and_active_sites.png (AA BP:293)

CD74_NRG1_631_violinplot.png (AA BP:293)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

CD74_NRG1_52.png

CD74_NRG1_64.png

CD74_NRG1_121.png

CD74_NRG1_175.png

CD74_NRG1_233.png

CD74_NRG1_269.png

CD74_NRG1_308.png

CD74_NRG1_350.png

CD74_NRG1_384.png

CD74_NRG1_451.png

CD74_NRG1_549.png

CD74_NRG1_559.png

CD74_NRG1_563.png

CD74_NRG1_568.png

CD74_NRG1_575.png

CD74_NRG1_580.png

CD74_NRG1_584.png

CD74_NRG1_624.png

CD74_NRG1_626.png

CD74_NRG1_629.png

CD74_NRG1_631.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
52	0.555	29	0.503	63.455	0.724	0.512	0.733	0.128	0.952	0.135	1.096	Chain A: 222,223,228,231,234,235,236,237
64	0.833	69	0.835	282.632	0.743	0.61	0.782	0.271	0.958	0.282	1.454	Chain A: 94,95,97,98,99,100,102,255,257,271,272,27 3,274,275,276,277,280,281
121	0.69	40	0.68	70.315	0.6	0.556	0.786	0.368	0.761	0.484	1.928	Chain A: 254,260,261,262,263,274,275,277,278
175	1.022735	658	1.026981	1574.027	0.50038	0.731992	0.948644	0.57119	1.080412	0.528678	0.891494	Chain A: 1,2,3,4,5,6,7,8,9,10,11,12,107,108,109,11 0,111,112,113,114,115,117,119,127,129,132,151,154, 159,160,162,173,175,176,177,178,179,180,181,182,18 4,185,186,221,222,223,224,226,227,229,239,240,241, 243,244,245,246,247,248,249,250,251,252,253,254,25 5,256,257,258,259,260,261,262,263,264,265,266,267, 270,271,273,276,277,278,279,283,284,287,300,302,30 3,305,306,308,311,312
233	1.018	125	1.089	351.575	0.637	0.626	0.755	0.648	0.695	0.932	1.334	Chain A: 71,74,75,77,78,81,82,84,85,88,89,92,256,2 65,266,267,270,271,274,277,278,281,282
269	1.091	119	1.212	289.149	0.61	0.627	0.867	2.043	0.32	6.391	0.699	Chain A: 42,43,45,46,49,50,52,53,56,57,60,312,313, 316,317,319,320,321,323,324,325,327,328,329,331
308	0.915	65	0.991	201.341	0.717	0.592	0.734	1.298	0.374	3.468	0.541	Chain A: 57,60,61,64,67,68,71,72,75,276,277,279,28 0,283,284,287,288,291,292,295
350	0.931	80	0.978	332.024	0.707	0.617	0.789	0.745	0.714	1.044	1.196	Chain A: 71,74,75,78,81,82,84,85,86,88,89,90,91,92 ,288,290,291,293,294,297,298,300,301
384	0.852	77	0.824	210.259	0.694	0.611	0.817	0.306	1.129	0.272	0.466	Chain A: 83,86,87,88,89,90,91,92,93,94,96,198,199, 201,202,204,205,206,207,209,340,341
451	0.784	41	0.77	119.707	0.539	0.683	1.037	0.906	0.741	1.222	0.293	Chain A: 44,45,46,49,390,391,394,395,398
548	1.09	111	1.205	313.159	0.613	0.637	0.878	2.136	0.36	5.926	0.427	Chain A: 46,49,50,52,53,56,57,60,61,64,288,291,292 ,295,296,298,299,302,303,304,306,307,310
549	0.991	58	1.088	117.992	0.58	0.677	0.939	3.116	0.104	29.858	12.515	Chain A: 49,50,52,53,56,57,60,291,294,295,298,301, 302,305,306
563	1.092324	122	1.214693	336.483	0.605178	0.625694	0.838988	2.235645	0.308969	7.235825	0.576871	Chain A: 45,46,49,50,52,53,56,57,60,61,64,67,295,2 98,299,302,303,306,307,309,310,313,314,317,318,321
568	1.071	156	1.178	425.32	0.603	0.627	0.841	1.764	0.423	4.169	0.468	Chain A: 46,49,50,52,53,56,57,60,61,63,64,67,70,71 ,298,301,302,305,306,309,312,313,316,317,319,320,3 23,324,327,328,331
575	1.07	145	1.174	304.927	0.57	0.631	0.873	1.916	0.443	4.324	0.675	Chain A: 7,8,9,10,11,46,49,50,52,53,56,57,60,315,3 16,319,320,322,323,326,327,330,331,334,335
580	1.061	143	1.178	335.111	0.645	0.596	0.774	1.781	0.368	4.842	0.591	Chain A: 46,49,50,52,53,56,57,60,61,63,64,67,310,3 13,314,317,320,321,324,325,327,328,331,332,335,336 ,339
584	1.106	122	1.232	329.966	0.597	0.636	0.833	2.2	0.276	7.967	0.68	Chain A: 45,46,49,50,52,53,56,57,60,61,63,64,320,3 23,324,327,328,330,331,334,335,338,339,342
624	0.708	35	0.728	83.006	0.748	0.55	0.696	1.152	0.486	2.374	1.208	Chain A: 128,130,131,134,140,141,143,144,145,147
626	0.687	22	0.69	106.673	0.784	0.622	0.771	1.159	0.379	3.058	0.491	Chain A: 143,155,156,157,158,162,165,166,169,181
629	0.685	26	0.676	76.832	0.671	0.62	0.858	1.153	0.54	2.136	1.4	Chain A: 191,194,195,198,358,359,362,363
631	0.878395	59	0.933615	234.612	0.717703	0.604311	0.757114	1.325526	0.463188	2.861743	0.478688	Chain A: 42,43,44,45,46,48,49,50,52,53,56,392,395, 398,399,400,402,403,406

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB	ZINC ID	DrugBank ID	Drug name	Docking score	Glide gscore
52	ZINC000003927870	DB01073	Fludarabine	-6.22965	-6.32165
52	ZINC000000388081	DB05381	Histamine	-5.60082	-6.05582
52	ZINC000003830813	DB01077	Etidronic acid	-5.69071	-5.93681
52	ZINC000000001795	DB00627	Niacin	-5.92129	-5.93089
52	ZINC000001531009	DB00884	Risedronic acid	-5.60444	-5.79294
52	ZINC000000001706	DB13882	Methyl nicotinate	-5.75745	-5.75745
52	ZINC000006467621	DB11115	Ensulizole	-5.18023	-5.74683
52	ZINC000000000882	DB00173	Adenine	-5.71092	-5.73162
52	ZINC000003831475	DB14089	Dimercaptosuccinic acid	-5.729	-5.729
52	ZINC000003803652	DB00399	Zoledronic acid	-5.09	-5.6342
52	ZINC000008015016	DB14078	Medronic acid	-5.29749	-5.61109
52	ZINC000003875368	DB00698	Nitrofurantoin	-4.31958	-5.60068
52	ZINC000013585233	DB00360	Sapropterin	-5.57229	-5.59199
52	ZINC000001035331	DB00811	Ribavirin	-5.56876	-5.56876
52	ZINC000038212689	DB00544	Fluorouracil	-5.3501	-5.5501
52	ZINC000003872277	DB01119	Diazoxide	-5.52148	-5.52928
52	ZINC000008101109	DB00529	Foscarnet	-5.48238	-5.48878
52	ZINC000002015035	DB06262	Droxidopa	-5.4699	-5.4699
52	ZINC000004640636	DB00550	Propylthiouracil	-5.40905	-5.44765
52	ZINC000003831477	DB14089	Dimercaptosuccinic acid	-5.40519	-5.40519

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID	DrugBank ID	Drug name	Drug type	SMILES	Drug group
ZINC000003927870	DB01073	Fludarabine	Small molecule	NC1=NC(F)=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O	Approved
ZINC000000388081	DB05381	Histamine	Small molecule	NCCC1=CNC=N1	Approved\|Investigational
ZINC000003830813	DB01077	Etidronic acid	Small molecule	CC(O)(P(O)(O)=O)P(O)(O)=O	Approved
ZINC000000001795	DB00627	Niacin	Small molecule	OC(=O)C1=CN=CC=C1	Approved\|Investigational\|Nutraceutical
ZINC000001531009	DB00884	Risedronic acid	Small molecule	OC(CC1=CN=CC=C1)(P(O)(O)=O)P(O)(O)=O	Approved\|Investigational
ZINC000000001706	DB13882	Methyl nicotinate	Small molecule	COC(=O)C1=CN=CC=C1	Approved
ZINC000006467621	DB11115	Ensulizole	Small molecule	OS(=O)(=O)C1=CC2=C(C=C1)N=C(N2)C1=CC=CC=C1	Approved
ZINC000000000882	DB00173	Adenine	Small molecule	NC1=C2NC=NC2=NC=N1	Approved\|Nutraceutical
ZINC000003803652	DB00399	Zoledronic acid	Small molecule	OC(CN1C=CN=C1)(P(O)(O)=O)P(O)(O)=O	Approved
ZINC000008015016	DB14078	Medronic acid	Small molecule	OP(O)(=O)CP(O)(O)=O	Approved\|Investigational
ZINC000001035331	DB00811	Ribavirin	Small molecule	NC(=O)C1=NN(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	Approved
ZINC000038212689	DB00544	Fluorouracil	Small molecule	FC1=CNC(=O)NC1=O	Approved
ZINC000003872277	DB01119	Diazoxide	Small molecule	CC1=NS(=O)(=O)C2=C(N1)C=CC(Cl)=C2	Approved
ZINC000008101109	DB00529	Foscarnet	Small molecule	OC(=O)P(O)(O)=O	Approved
ZINC000002015035	DB06262	Droxidopa	Small molecule	N[C@@H]([C@H](O)C1=CC(O)=C(O)C=C1)C(O)=O	Approved\|Investigational
ZINC000004640636	DB00550	Propylthiouracil	Small molecule	CCCC1=CC(=O)NC(=S)N1	Approved\|Investigational
ZINC000003831477	DB14089	Dimercaptosuccinic acid	Small molecule	OC(=O)C(S)C(S)C(O)=O	Approved\|Experimental

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID	mol_MW	dipole	SASA	FOSA	FISA	PISA	WPSA	volume	donorHB	accptHB	IP	Human Oral Absorption	Percent Human Oral Absorption	Rule Of Five	Rule Of Three
ZINC000003927870	365.214	10.011	558.493	73.58	358.734	76.063	50.116	953.163	6	14.1	8.598	1	0	2	1
ZINC000003927870	365.214	6.236	564.927	82.608	356.666	68.682	56.971	956.451	6	14.1	8.73	1	0	2	1
ZINC000000388081	111.146	4.788	315.231	92.229	118.535	104.468	0	466.776	3	2.5	9.295	2	65.253	0	0
ZINC000000388081	111.146	5.535	313.532	90.818	116.688	106.026	0	465.559	3	3	9.188	2	64.917	0	0
ZINC000000388081	111.146	4.794	316.569	91.628	116.549	108.393	0	470.468	3	2.5	9.292	2	65.823	0	0
ZINC000003830813	206.029	8.234	343.926	58.866	278.645	0	6.414	541.497	1	6.75	9.379	1	20.728	0	1
ZINC000003830813	206.029	8.446	343.742	59.548	277.922	0	6.271	541.502	1	6.75	9.388	1	20.88	0	1
ZINC000003830813	206.029	7.127	340.461	65.078	269.49	0	5.893	540.584	1	6.75	9.311	1	22.658	0	1
ZINC000000001795	123.111	4.24	302.099	0	134.143	167.956	0	449.108	1	3.5	10.657	2	68.969	0	0
ZINC000000001795	123.111	4.501	300.772	0	131.945	168.826	0	447.811	1	3.5	10.574	2	69.375	0	0
ZINC000001531009	283.114	8.624	429.179	20.113	269.828	134.694	4.543	742.511	1	8.25	9.463	1	26.76	0	1
ZINC000001531009	283.114	9.607	427.754	22.11	268.873	132.458	4.312	739.953	1	8.25	9.593	1	26.859	0	1
ZINC000001531009	283.114	7.642	425.511	19.856	269.894	133.142	2.619	746.321	1	8.25	9.496	1	26.881	0	1
ZINC000000001706	137.138	4.434	351.185	98.444	86.892	165.848	0	531.212	0	3.5	10.407	3	87.307	0	0
ZINC000006467621	274.294	9.514	495.179	0	165.642	327.077	2.46	816.857	2	5.5	9.09	3	70.241	0	0
ZINC000006467621	274.294	5.937	496.167	0	165.586	328.124	2.456	817.805	2	5.5	9.121	3	70.288	0	0
ZINC000006467621	274.294	9.57	496.894	0	166.022	328.377	2.495	819.646	2	5.5	8.954	3	70.264	0	0
ZINC000000000882	135.128	2.734	303.153	0	170.481	132.672	0	451.892	3	4	8.538	3	68.38	0	0
ZINC000000000882	135.128	9.438	304.278	0	171.466	132.812	0	454.287	3	4	8.639	3	68.214	0	0
ZINC000003831475	182.209	3.697	335.088	26	184.497	0	124.591	518.524	2	3	10.006	2	54.049	0	1
ZINC000003803652	272.091	6.149	414.004	25.436	272.399	109.477	6.692	698.612	1	8.75	9.817	1	23.489	0	1
ZINC000003803652	272.091	10.346	412.626	22.493	273.968	109.284	6.881	697.133	1	8.75	8.891	1	23.124	0	1
ZINC000003803652	272.091	2.82	416.545	22.709	279.09	108.406	6.34	697.546	1	8.75	9.904	1	21.992	0	1
ZINC000003803652	272.091	11.882	412.711	24.614	274.426	108.467	5.205	696.74	1	8.75	9.026	1	22.968	0	1
ZINC000003803652	272.091	12.418	410.051	22.071	274.507	110.827	2.646	702.503	1	8.75	8.712	1	23.166	0	1
ZINC000003803652	272.091	12.445	414.593	23.463	272.373	114.555	4.201	705.321	1	8.75	8.718	1	23.722	0	1
ZINC000008015016	176.002	3.602	323.868	34.991	281.713	0	7.164	486.492	0	6	9.674	1	16.795	0	1
ZINC000008015016	176.002	13.068	326.073	33.644	285.397	0	7.032	489.653	0	6	9.876	1	16.139	0	1
ZINC000003875368	238.159	4.578	425.423	58.928	250.52	115.975	0	683.161	1	5	9.961	2	53.722	0	0
ZINC000003875368	238.159	4.877	423.946	59.354	248.434	116.158	0	680.796	1	5	9.943	2	54.077	0	0
ZINC000013585233	241.249	7.548	455.149	158.349	273.982	22.819	0	749.387	7	8.9	7.637	2	28.323	1	0
ZINC000013585233	241.249	11.056	455.167	158.05	274.486	22.631	0	750.263	7	8.9	7.777	2	28.249	1	0
ZINC000001035331	244.207	7.612	427.913	90.998	287.486	49.429	0	713.931	5	12.3	9.744	2	34.344	0	1
ZINC000038212689	130.078	5.522	259.136	0	161.594	52.299	45.242	383.043	2	3.5	9.983	2	65.855	0	0
ZINC000038212689	130.078	5.054	262.519	0	162.511	54.553	45.455	386.145	2	3.5	9.862	2	65.704	0	0
ZINC000003872277	230.668	10.522	415.073	94.247	119.686	128.269	72.87	661.918	0	4.5	9.329	3	82.986	0	0
ZINC000003872277	230.668	11.183	413.943	93.631	118.113	129.281	72.918	659.366	1	5.5	9.406	3	83.218	0	0
ZINC000008101109	126.005	6.9	264.917	0	260.554	0	4.362	372.032	3	7	9.757	1	17.558	0	1
ZINC000008101109	126.005	11.927	257.279	0	253.345	0	3.934	359.323	3	7	9.932	1	18.931	0	1
ZINC000002015035	213.19	5.76	408.685	26.39	279.826	102.469	0	664.786	5	5.2	8.908	1	0	1	1
ZINC000004640636	170.229	6.707	408.008	178.11	116.084	32.743	81.071	619.311	2	3	9.191	3	82.875	0	0
ZINC000004640636	170.229	7.083	390.596	167.972	99.585	42.266	80.773	608.72	2	3	8.797	3	90.531	0	0
ZINC000003831477	182.209	7.58	330.563	25.281	178.679	0	126.603	516.577	2	3	10.071	2	55.288	0	1

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID	Smile	Surface Accessibility	Toxicity
ZINC000003927870	Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@@H]1O	0.050585445	0.380605086
ZINC000000388081	NCCc1cnc[nH]1	0.212944784	0.352067312
ZINC000003830813	CC(O)(P(=O)(O)O)P(=O)(O)O	0.095573527	0.535505529
ZINC000000001795	O=C(O)c1cccnc1	0.556974396	0.499160568
ZINC000001531009	O=P(O)(O)C(O)(Cc1cccnc1)P(=O)(O)O	0.151740248	0.484505913
ZINC000000001706	COC(=O)c1cccnc1	0.562051569	0.439867718
ZINC000006467621	O=S(=O)(O)c1ccc2[nH]c(-c3ccccc3)nc2c1	0.38504104	0.405031793
ZINC000000000882	Nc1ncnc2[nH]cnc12	0.174637229	0.465480638
ZINC000003831475	O=C(O)[C@H](S)[C@H](S)C(=O)O	0.046119564	0.585775635
ZINC000003803652	O=P(O)(O)C(O)(Cn1ccnc1)P(=O)(O)O	0.100052268	0.353941778
ZINC000008015016	O=P(O)(O)CP(=O)(O)O	0.097212655	0.606313084
ZINC000003875368	O=C1CN(/N=C/c2ccc([N+](=O)[O-])o2)C(=O)N1	0.144023256	0.52186584
ZINC000013585233	C[C@H](O)[C@H](O)[C@H]1CNc2nc(N)[nH]c(=O)c2N1	0.031410569	0.318425003
ZINC000001035331	NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)n1	0.05676866	0.366258102
ZINC000038212689	O=c1[nH]cc(F)c(=O)[nH]1	0.190312538	0.481453644
ZINC000003872277	CC1=NS(=O)(=O)c2cc(Cl)ccc2N1	0.17675056	0.347952196
ZINC000008101109	O=C(O)P(=O)(O)O	0.151109156	0.530839371
ZINC000002015035	N[C@@H](C(=O)O)[C@@H](O)c1ccc(O)c(O)c1	0.133345121	0.276427601
ZINC000004640636	CCCc1cc(=O)[nH]c(=S)[nH]1	0.185646757	0.507723366
ZINC000003831477	O=C(O)[C@H](S)[C@@H](S)C(=O)O	0.046119564	0.585775635

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

CD74

MIF, CD74, APP, HADHA, LAMTOR5, MAP3K1, TM4SF20, COPG1, COPG2, HLA-DPB1, HLA-DQA1, nef, CD44, AKAP8, ANKRD28, AP3D1, ARCN1, ASCC1, ASCC3, ASNS, CANX, CHAF1B, COPA, COPB1, COPB2, COPE, DDX60, DGKE, DNAJB11, DNAJB12, EIF1, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, EIF4A1, EIF4G1, EIF4G2, FKBP8, GANAB, GEMIN4, GRAMD1A, GTF2I, GTF3C1, HADHB, HMOX2, HUWE1, IPO13, IQGAP2, KPNB1, KRT1, LTN1, MAP1B, MTOR, NCAPD2, NCAPD3, NCAPH, OSBPL8, PCNA, PDAP1, PDCD4, PGRMC1, PGRMC2, PHB, POLR2E, POLR3A, POLR3B, PPP6R1, PPP6R3, PRRC2A, PRRC2B, PRRC2C, PSMC2, PSMD3, PSMD6, RCN1, RHOT2, RWDD1, SGPL1, SNRPE, SRP9, TBRG4, TJP2, TPP2, TUBA1A, TUBA1C, UBE3C, UBR4, UBR5, VDAC1, VWA8, YWHAB, YWHAE, YWHAQ, YWHAZ, IFITM3, FDFT1, POMGNT1, BET1, TMEM97, UPK2, TEX11, SERP1, SLC35B1, SEC22A, PLP1, TMEM254, C14orf1, TMEM243, TMEM60, FXYD6, CMTM7, CLDN19, LPAR3, CLEC7A, EDDM3B, C14orf180, PTCH1, TMEM120B, RTP2, PPAPDC1A, PGA4, SMIM1, CUL7, CCR1, ROPN1L, HLA-DRB3, HLA-DRB1, HLA-DRA,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CD74
NRG1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CD74-NRG1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Drug	Source	PMID
CD74	NRG1	Afatinib	PubMed	29169524

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Related Diseases to CD74-NRG1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
CD74	NRG1	Lung Cancer	PubMed	29169524
CD74	NRG1	Lung Adenocarcinoma	MyCancerGenome
CD74	NRG1	Breast Invasive Ductal Carcinoma	MyCancerGenome
CD74	NRG1	Invasive Breast Carcinoma	MyCancerGenome
CD74	NRG1	Adenocarcinoma Of Unknown Primary	MyCancerGenome
CD74	NRG1	Bladder Urothelial Carcinoma	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CD74	C0006142	Malignant neoplasm of breast	1	CTD_human
Hgene	CD74	C0007131	Non-Small Cell Lung Carcinoma	1	CTD_human
Hgene	CD74	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Hgene	CD74	C0162557	Liver Failure, Acute	1	CTD_human
Hgene	CD74	C0678222	Breast Carcinoma	1	CTD_human
Hgene	CD74	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	CD74	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	CD74	C4704874	Mammary Carcinoma, Human	1	CTD_human
Tgene	NRG1	C0036341	Schizophrenia	7	CTD_human
Tgene	NRG1	C0005586	Bipolar Disorder	5	PSYGENET
Tgene	NRG1	C0024809	Marijuana Abuse	3	PSYGENET
Tgene	NRG1	C0011570	Mental Depression	2	PSYGENET
Tgene	NRG1	C0011581	Depressive disorder	2	PSYGENET
Tgene	NRG1	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	NRG1	C0006870	Cannabis Dependence	1	PSYGENET
Tgene	NRG1	C0007621	Neoplastic Cell Transformation	1	CTD_human
Tgene	NRG1	C0011616	Contact Dermatitis	1	CTD_human
Tgene	NRG1	C0018801	Heart failure	1	CTD_human
Tgene	NRG1	C0018802	Congestive heart failure	1	CTD_human
Tgene	NRG1	C0019569	Hirschsprung Disease	1	CTD_human
Tgene	NRG1	C0023212	Left-Sided Heart Failure	1	CTD_human
Tgene	NRG1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	NRG1	C0024121	Lung Neoplasms	1	CTD_human
Tgene	NRG1	C0026650	Movement Disorders	1	CTD_human
Tgene	NRG1	C0027626	Neoplasm Invasiveness	1	CTD_human
Tgene	NRG1	C0030193	Pain	1	CTD_human
Tgene	NRG1	C0032460	Polycystic Ovary Syndrome	1	CTD_human
Tgene	NRG1	C0038358	Gastric ulcer	1	CTD_human
Tgene	NRG1	C0085758	Aganglionosis, Colonic	1	CTD_human
Tgene	NRG1	C0087031	Juvenile-Onset Still Disease	1	CTD_human
Tgene	NRG1	C0162351	Contact hypersensitivity	1	CTD_human
Tgene	NRG1	C0234230	Pain, Burning	1	CTD_human
Tgene	NRG1	C0234238	Ache	1	CTD_human
Tgene	NRG1	C0234254	Radiating pain	1	CTD_human
Tgene	NRG1	C0235527	Heart Failure, Right-Sided	1	CTD_human
Tgene	NRG1	C0236733	Amphetamine-Related Disorders	1	CTD_human
Tgene	NRG1	C0236804	Amphetamine Addiction	1	CTD_human
Tgene	NRG1	C0236807	Amphetamine Abuse	1	CTD_human
Tgene	NRG1	C0242379	Malignant neoplasm of lung	1	CTD_human
Tgene	NRG1	C0266487	Etat Marbre	1	CTD_human
Tgene	NRG1	C0458257	Pain, Splitting	1	CTD_human
Tgene	NRG1	C0458259	Pain, Crushing	1	CTD_human
Tgene	NRG1	C0678222	Breast Carcinoma	1	CTD_human
Tgene	NRG1	C0751407	Pain, Migratory	1	CTD_human
Tgene	NRG1	C0751408	Suffering, Physical	1	CTD_human
Tgene	NRG1	C0876994	Cardiotoxicity	1	CTD_human
Tgene	NRG1	C1136382	Sclerocystic Ovaries	1	CTD_human
Tgene	NRG1	C1257840	Aganglionosis, Rectosigmoid Colon	1	CTD_human
Tgene	NRG1	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	NRG1	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	NRG1	C1959583	Myocardial Failure	1	CTD_human
Tgene	NRG1	C1961112	Heart Decompensation	1	CTD_human
Tgene	NRG1	C3495559	Juvenile arthritis	1	CTD_human
Tgene	NRG1	C3661523	Congenital Intestinal Aganglionosis	1	CTD_human
Tgene	NRG1	C3714758	Juvenile psoriatic arthritis	1	CTD_human
Tgene	NRG1	C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Tgene	NRG1	C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human
Tgene	NRG1	C4704874	Mammary Carcinoma, Human	1	CTD_human