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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CDC42BPA-KCNK1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CDC42BPA-KCNK1
FusionPDB ID: 14838
FusionGDB2.0 ID: 14838
HgeneTgene
Gene symbol

CDC42BPA

KCNK1

Gene ID

8476

3775

Gene nameCDC42 binding protein kinase alphapotassium two pore domain channel subfamily K member 1
SynonymsMRCK|MRCKA|PK428DPK|HOHO|K2P1|K2p1.1|KCNO1|TWIK-1|TWIK1
Cytomap

1q42.13

1q42.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase MRCK alphaCDC42 binding protein kinase alpha (DMPK-like)CDC42 binding protein kinase betamyotonic dystrophy kinase-related CDC42-binding protein kinase alphamyotonic dystrophy protein kinase-like alphaser-thr protein kpotassium channel subfamily K member 1inward rectifying potassium channel protein TWIK-1potassium channel K2P1potassium channel KCNO1potassium channel, two pore domain subfamily K, member 1potassium inwardly-rectifying channel, subfamily K, member 1
Modification date2020031320200320
UniProtAcc

Q5VT25

Q96T54

Ensembl transtripts involved in fusion geneENST idsENST00000334218, ENST00000366764, 
ENST00000366765, ENST00000366766, 
ENST00000366767, ENST00000366769, 
ENST00000535525, ENST00000488131, 
ENST00000366620, ENST00000472190, 
ENST00000366621, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 12 X 9=15126 X 3 X 5=90
# samples 156
** MAII scorelog2(15/1512*10)=-3.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CDC42BPA [Title/Abstract] AND KCNK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CDC42BPA(227259909)-KCNK1(233802341), # samples:1
Anticipated loss of major functional domain due to fusion event.CDC42BPA-KCNK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42BPA-KCNK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42BPA-KCNK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42BPA-KCNK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC42BPA

GO:0006468

protein phosphorylation

9092543

HgeneCDC42BPA

GO:0031532

actin cytoskeleton reorganization

9418861

TgeneKCNK1

GO:0035725

sodium ion transmembrane transport

21653227

TgeneKCNK1

GO:0071805

potassium ion transmembrane transport

21653227|22282804


check buttonFusion gene breakpoints across CDC42BPA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KCNK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-5799-01ACDC42BPAchr1

227259909

-KCNK1chr1

233802341

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366767CDC42BPAchr1227259909-ENST00000366621KCNK1chr1233802341+42222584032391079
ENST00000366769CDC42BPAchr1227259909-ENST00000366621KCNK1chr1233802341+57574119129247741160
ENST00000366764CDC42BPAchr1227259909-ENST00000366621KCNK1chr1233802341+5408377094344251160
ENST00000334218CDC42BPAchr1227259909-ENST00000366621KCNK1chr1233802341+5408377094344251160
ENST00000366766CDC42BPAchr1227259909-ENST00000366621KCNK1chr1233802341+5408377094344251160
ENST00000535525CDC42BPAchr1227259909-ENST00000366621KCNK1chr1233802341+449228542735091160
ENST00000366765CDC42BPAchr1227259909-ENST00000366621KCNK1chr1233802341+4997335953240141160

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366767ENST00000366621CDC42BPAchr1227259909-KCNK1chr1233802341+0.0002345840.99976546
ENST00000366769ENST00000366621CDC42BPAchr1227259909-KCNK1chr1233802341+0.0013146930.9986853
ENST00000366764ENST00000366621CDC42BPAchr1227259909-KCNK1chr1233802341+0.0008973170.9991027
ENST00000334218ENST00000366621CDC42BPAchr1227259909-KCNK1chr1233802341+0.0008973170.9991027
ENST00000366766ENST00000366621CDC42BPAchr1227259909-KCNK1chr1233802341+0.0008973170.9991027
ENST00000535525ENST00000366621CDC42BPAchr1227259909-KCNK1chr1233802341+0.0005081890.9994918
ENST00000366765ENST00000366621CDC42BPAchr1227259909-KCNK1chr1233802341+0.0005641890.99943584

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>14838_14838_1_CDC42BPA-KCNK1_CDC42BPA_chr1_227259909_ENST00000334218_KCNK1_chr1_233802341_ENST00000366621_length(amino acids)=1160AA_BP=942
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGE
VAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF
YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGV
CMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP
EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKR
LEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL
QQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTERAKKE
LEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK
ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADK
KESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL
NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHVTRRPVL
YFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLG

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>14838_14838_2_CDC42BPA-KCNK1_CDC42BPA_chr1_227259909_ENST00000366764_KCNK1_chr1_233802341_ENST00000366621_length(amino acids)=1160AA_BP=942
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGE
VAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF
YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGV
CMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP
EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKR
LEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL
QQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTERAKKE
LEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK
ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADK
KESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL
NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHVTRRPVL
YFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLG

--------------------------------------------------------------

>14838_14838_3_CDC42BPA-KCNK1_CDC42BPA_chr1_227259909_ENST00000366765_KCNK1_chr1_233802341_ENST00000366621_length(amino acids)=1160AA_BP=942
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGE
VAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF
YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGV
CMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP
EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKR
LEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL
QQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTERAKKE
LEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK
ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADK
KESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL
NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHVTRRPVL
YFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLG

--------------------------------------------------------------

>14838_14838_4_CDC42BPA-KCNK1_CDC42BPA_chr1_227259909_ENST00000366766_KCNK1_chr1_233802341_ENST00000366621_length(amino acids)=1160AA_BP=942
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGE
VAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF
YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGV
CMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP
EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKR
LEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL
QQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTERAKKE
LEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK
ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADK
KESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL
NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHVTRRPVL
YFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLG

--------------------------------------------------------------

>14838_14838_5_CDC42BPA-KCNK1_CDC42BPA_chr1_227259909_ENST00000366767_KCNK1_chr1_233802341_ENST00000366621_length(amino acids)=1079AA_BP=861
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGE
VAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF
YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGV
CMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP
EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKR
LEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL
QQEREDLNKLEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIH
ANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLE
EEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIR
AKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRIT
VHVTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKI

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>14838_14838_6_CDC42BPA-KCNK1_CDC42BPA_chr1_227259909_ENST00000366769_KCNK1_chr1_233802341_ENST00000366621_length(amino acids)=1160AA_BP=942
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGE
VAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF
YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGV
CMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP
EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKR
LEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL
QQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTERAKKE
LEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK
ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADK
KESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL
NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHVTRRPVL
YFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLG

--------------------------------------------------------------

>14838_14838_7_CDC42BPA-KCNK1_CDC42BPA_chr1_227259909_ENST00000535525_KCNK1_chr1_233802341_ENST00000366621_length(amino acids)=1160AA_BP=942
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGE
VAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF
YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGV
CMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP
EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKR
LEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL
QQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTERAKKE
LEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK
ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADK
KESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL
NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHVTRRPVL
YFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLG

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:227259909/chr1:233802341)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDC42BPA

Q5VT25

KCNK1

Q96T54

FUNCTION: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). {ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:11340065, ECO:0000269|PubMed:11399775, ECO:0000269|PubMed:15723050, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:20188707, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:29162624, ECO:0000269|PubMed:9092543, ECO:0000269|PubMed:9418861}.FUNCTION: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000334218-2037437_820942.33333333333341782.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000334218-2037880_943942.33333333333341782.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366764-2035437_820942.33333333333341692.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366764-2035880_943942.33333333333341692.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366765-2037437_820942.33333333333341733.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366765-2037880_943942.33333333333341733.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366766-2037437_820942.33333333333341755.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366766-2037880_943942.33333333333341755.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366767-1935437_820861.33333333333341639.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366769-2036437_820942.33333333333341720.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366769-2036880_943942.33333333333341720.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000334218-2037344_414942.33333333333341782.0DomainAGC-kinase C-terminal
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000334218-203777_343942.33333333333341782.0DomainProtein kinase
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366764-2035344_414942.33333333333341692.0DomainAGC-kinase C-terminal
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366764-203577_343942.33333333333341692.0DomainProtein kinase
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366765-2037344_414942.33333333333341733.0DomainAGC-kinase C-terminal
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366765-203777_343942.33333333333341733.0DomainProtein kinase
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366766-2037344_414942.33333333333341755.0DomainAGC-kinase C-terminal
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366766-203777_343942.33333333333341755.0DomainProtein kinase
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366767-1935344_414861.33333333333341639.0DomainAGC-kinase C-terminal
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366767-193577_343861.33333333333341639.0DomainProtein kinase
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366769-2036344_414942.33333333333341720.0DomainAGC-kinase C-terminal
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366769-203677_343942.33333333333341720.0DomainProtein kinase
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000334218-203783_91942.33333333333341782.0Nucleotide bindingATP
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366764-203583_91942.33333333333341692.0Nucleotide bindingATP
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366765-203783_91942.33333333333341733.0Nucleotide bindingATP
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366766-203783_91942.33333333333341755.0Nucleotide bindingATP
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366767-193583_91861.33333333333341639.0Nucleotide bindingATP
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366769-203683_91942.33333333333341720.0Nucleotide bindingATP
TgeneKCNK1chr1:227259909chr1:233802341ENST0000036662103212_224118.33333333333333337.0IntramembraneHelical%3B Name%3DPore helix 2
TgeneKCNK1chr1:227259909chr1:233802341ENST0000036662103225_231118.33333333333333337.0IntramembraneOntology_term=ECO:0000269
TgeneKCNK1chr1:227259909chr1:233802341ENST0000036662103117_122118.33333333333333337.0RegionSelectivity filter 1
TgeneKCNK1chr1:227259909chr1:233802341ENST0000036662103225_230118.33333333333333337.0RegionSelectivity filter 2
TgeneKCNK1chr1:227259909chr1:233802341ENST0000036662103293_299118.33333333333333337.0RegionImportant for intracellular retention in recycling endosomes
TgeneKCNK1chr1:227259909chr1:233802341ENST0000036662103123_132118.33333333333333337.0Topological domainExtracellular
TgeneKCNK1chr1:227259909chr1:233802341ENST0000036662103157_181118.33333333333333337.0Topological domainCytoplasmic
TgeneKCNK1chr1:227259909chr1:233802341ENST0000036662103203_211118.33333333333333337.0Topological domainExtracellular
TgeneKCNK1chr1:227259909chr1:233802341ENST0000036662103232_243118.33333333333333337.0Topological domainExtracellular
TgeneKCNK1chr1:227259909chr1:233802341ENST0000036662103268_336118.33333333333333337.0Topological domainCytoplasmic
TgeneKCNK1chr1:227259909chr1:233802341ENST0000036662103133_156118.33333333333333337.0TransmembraneHelical
TgeneKCNK1chr1:227259909chr1:233802341ENST0000036662103182_202118.33333333333333337.0TransmembraneHelical
TgeneKCNK1chr1:227259909chr1:233802341ENST0000036662103244_267118.33333333333333337.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366767-1935880_943861.33333333333341639.0Coiled coilOntology_term=ECO:0000255
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000334218-20371082_1201942.33333333333341782.0DomainPH
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000334218-20371227_1499942.33333333333341782.0DomainCNH
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000334218-20371571_1584942.33333333333341782.0DomainCRIB
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366764-20351082_1201942.33333333333341692.0DomainPH
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366764-20351227_1499942.33333333333341692.0DomainCNH
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366764-20351571_1584942.33333333333341692.0DomainCRIB
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366765-20371082_1201942.33333333333341733.0DomainPH
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366765-20371227_1499942.33333333333341733.0DomainCNH
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366765-20371571_1584942.33333333333341733.0DomainCRIB
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366766-20371082_1201942.33333333333341755.0DomainPH
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366766-20371227_1499942.33333333333341755.0DomainCNH
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366766-20371571_1584942.33333333333341755.0DomainCRIB
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366767-19351082_1201861.33333333333341639.0DomainPH
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366767-19351227_1499861.33333333333341639.0DomainCNH
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366767-19351571_1584861.33333333333341639.0DomainCRIB
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366769-20361082_1201942.33333333333341720.0DomainPH
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366769-20361227_1499942.33333333333341720.0DomainCNH
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366769-20361571_1584942.33333333333341720.0DomainCRIB
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000334218-20371012_1062942.33333333333341782.0Zinc fingerPhorbol-ester/DAG-type
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366764-20351012_1062942.33333333333341692.0Zinc fingerPhorbol-ester/DAG-type
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366765-20371012_1062942.33333333333341733.0Zinc fingerPhorbol-ester/DAG-type
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366766-20371012_1062942.33333333333341755.0Zinc fingerPhorbol-ester/DAG-type
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366767-19351012_1062861.33333333333341639.0Zinc fingerPhorbol-ester/DAG-type
HgeneCDC42BPAchr1:227259909chr1:233802341ENST00000366769-20361012_1062942.33333333333341720.0Zinc fingerPhorbol-ester/DAG-type
TgeneKCNK1chr1:227259909chr1:233802341ENST0000036662103104_116118.33333333333333337.0IntramembraneHelical%3B Name%3DPore helix 1
TgeneKCNK1chr1:227259909chr1:233802341ENST00000366621031_20118.33333333333333337.0Topological domainCytoplasmic
TgeneKCNK1chr1:227259909chr1:233802341ENST000003666210342_103118.33333333333333337.0Topological domainExtracellular
TgeneKCNK1chr1:227259909chr1:233802341ENST000003666210321_41118.33333333333333337.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CDC42BPA
KCNK1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CDC42BPA-KCNK1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CDC42BPA-KCNK1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource