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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CDH23-NSD1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CDH23-NSD1
FusionPDB ID: 15062
FusionGDB2.0 ID: 15062
HgeneTgene
Gene symbol

CDH23

NSD1

Gene ID

64072

64324

Gene namecadherin related 23nuclear receptor binding SET domain protein 1
SynonymsCDHR23|PITA5|USH1DARA267|KMT3B|SOTOS|SOTOS1|STO
Cytomap

10q22.1

5q35.3

Type of geneprotein-codingprotein-coding
Descriptioncadherin-23cadherin-like 23cadherin-related family member 23otocadherinhistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificH3-K36-HMTaseH4-K20-HMTaseNR-binding SET domain-containing proteinandrogen receptor coactivator 267 kDa proteinandrogen receptor-associated coregulator 267androgen receptor-as
Modification date2020032020200321
UniProtAcc

Q9H251

.
Ensembl transtripts involved in fusion geneENST idsENST00000224721, ENST00000299366, 
ENST00000398788, ENST00000398809, 
ENST00000398842, ENST00000461841, 
ENST00000475158, 		ENST00000361032, 
ENST00000511258, ENST00000347982, 
ENST00000354179, ENST00000439151, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 7 X 2=9812 X 14 X 7=1176
# samples 717
** MAII scorelog2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1176*10)=-2.79028140869866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CDH23 [Title/Abstract] AND NSD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NSD1(176563031)-CDH23(73434869), # samples:3
CDH23(73501678)-NSD1(176618885), # samples:2
Anticipated loss of major functional domain due to fusion event.CDH23-NSD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH23-NSD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH23-NSD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH23-NSD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNSD1

GO:0045893

positive regulation of transcription, DNA-templated

11509567


check buttonFusion gene breakpoints across CDH23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NSD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0FJ-01ACDH23chr10

73501678

-NSD1chr5

176618885

+
ChimerDB4BRCATCGA-AN-A0FJ-01ACDH23chr10

73501678

+NSD1chr5

176618885

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000224721CDH23chr1073501678+ENST00000354179NSD1chr5176618885+1678048655120284007
ENST00000224721CDH23chr1073501678+ENST00000439151NSD1chr5176618885+1678548655120284007
ENST00000224721CDH23chr1073501678+ENST00000347982NSD1chr5176618885+1233248655120284007

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000224721ENST00000354179CDH23chr1073501678+NSD1chr5176618885+0.0002619530.99973804
ENST00000224721ENST00000439151CDH23chr1073501678+NSD1chr5176618885+0.0002619960.99973804
ENST00000224721ENST00000347982CDH23chr1073501678+NSD1chr5176618885+0.0005037950.9994962

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15062_15062_1_CDH23-NSD1_CDH23_chr10_73501678_ENST00000224721_NSD1_chr5_176618885_ENST00000347982_length(amino acids)=4007AA_BP=1618
MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLR
QPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS
QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK
GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSV
AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAK
VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIA
RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSR
PLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG
STQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP
DLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF
VAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHV
LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDN
GPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRP
LDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK
FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQ
ITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVG
QRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPP
VIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLS
CQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLR
RRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADE
KEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAK
KEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAF
DRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSS
SISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDS
SDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSP
GRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSK
LRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDP
GKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTP
SASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQK
KVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALES
EELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAA
KMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLE
CLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLM
RCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCK
AGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQ
EAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGG
RCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFM
NHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT
QGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGR
LSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSR
PQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTS
VPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERA
ASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRA
SAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSC

--------------------------------------------------------------

>15062_15062_2_CDH23-NSD1_CDH23_chr10_73501678_ENST00000224721_NSD1_chr5_176618885_ENST00000354179_length(amino acids)=4007AA_BP=1618
MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLR
QPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS
QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK
GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSV
AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAK
VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIA
RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSR
PLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG
STQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP
DLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF
VAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHV
LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDN
GPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRP
LDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK
FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQ
ITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVG
QRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPP
VIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLS
CQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLR
RRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADE
KEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAK
KEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAF
DRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSS
SISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDS
SDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSP
GRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSK
LRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDP
GKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTP
SASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQK
KVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALES
EELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAA
KMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLE
CLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLM
RCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCK
AGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQ
EAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGG
RCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFM
NHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT
QGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGR
LSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSR
PQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTS
VPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERA
ASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRA
SAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSC

--------------------------------------------------------------

>15062_15062_3_CDH23-NSD1_CDH23_chr10_73501678_ENST00000224721_NSD1_chr5_176618885_ENST00000439151_length(amino acids)=4007AA_BP=1618
MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLR
QPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATGNTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS
QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK
GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSV
AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAK
VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIA
RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSR
PLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG
STQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP
DLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF
VAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHV
LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDN
GPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRP
LDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK
FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQ
ITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVG
QRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPP
VIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLS
CQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLR
RRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADE
KEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAK
KEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAF
DRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSS
SISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDS
SDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSP
GRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSK
LRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDP
GKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTP
SASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQK
KVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALES
EELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAA
KMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLE
CLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLM
RCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCK
AGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQ
EAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGG
RCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFM
NHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRT
QGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGR
LSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSR
PQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTS
VPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERA
ASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRA
SAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:176563031/chr5:73434869)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDH23

Q9H251

.
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. {ECO:0000269|PubMed:11138009, ECO:0000269|PubMed:16679490}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822242207_242140.02428.0Compositional biasNote=Pro-rich
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792242207_242140.02428.0Compositional biasNote=Pro-rich
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320202207_24210.02594.0Compositional biasNote=Pro-rich
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511232207_2421309.02697.0Compositional biasNote=Pro-rich
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241756_181840.02428.0DomainPWWP 2
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241890_194040.02428.0DomainAWS
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241942_205940.02428.0DomainSET
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822242066_208240.02428.0DomainPost-SET
TgeneNSD1chr10:73501678chr5:176618885ENST00000347982224323_38840.02428.0DomainPWWP 1
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241756_181840.02428.0DomainPWWP 2
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241890_194040.02428.0DomainAWS
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241942_205940.02428.0DomainSET
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792242066_208240.02428.0DomainPost-SET
TgeneNSD1chr10:73501678chr5:176618885ENST00000354179224323_38840.02428.0DomainPWWP 1
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201756_18180.02594.0DomainPWWP 2
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201890_19400.02594.0DomainAWS
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201942_20590.02594.0DomainSET
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320202066_20820.02594.0DomainPost-SET
TgeneNSD1chr10:73501678chr5:176618885ENST00000361032020323_3880.02594.0DomainPWWP 1
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231756_1818309.02697.0DomainPWWP 2
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231890_1940309.02697.0DomainAWS
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231942_2059309.02697.0DomainSET
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511232066_2082309.02697.0DomainPost-SET
TgeneNSD1chr10:73501678chr5:176618885ENST00000439151123323_388309.02697.0DomainPWWP 1
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241952_195440.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241994_199740.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822242020_202140.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822242060_206640.02428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241952_195440.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241994_199740.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792242020_202140.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792242060_206640.02428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201952_19540.02594.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201994_19970.02594.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320202020_20210.02594.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320202060_20660.02594.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231952_1954309.02697.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231994_1997309.02697.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511232020_2021309.02697.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511232060_2066309.02697.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241543_158940.02428.0Zinc fingerPHD-type 1
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241590_164640.02428.0Zinc fingerPHD-type 2
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822241707_175140.02428.0Zinc fingerPHD-type 3
TgeneNSD1chr10:73501678chr5:176618885ENST000003479822242118_216540.02428.0Zinc fingerPHD-type 4%3B atypical
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241543_158940.02428.0Zinc fingerPHD-type 1
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241590_164640.02428.0Zinc fingerPHD-type 2
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792241707_175140.02428.0Zinc fingerPHD-type 3
TgeneNSD1chr10:73501678chr5:176618885ENST000003541792242118_216540.02428.0Zinc fingerPHD-type 4%3B atypical
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201543_15890.02594.0Zinc fingerPHD-type 1
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201590_16460.02594.0Zinc fingerPHD-type 2
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320201707_17510.02594.0Zinc fingerPHD-type 3
TgeneNSD1chr10:73501678chr5:176618885ENST000003610320202118_21650.02594.0Zinc fingerPHD-type 4%3B atypical
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231543_1589309.02697.0Zinc fingerPHD-type 1
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231590_1646309.02697.0Zinc fingerPHD-type 2
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511231707_1751309.02697.0Zinc fingerPHD-type 3
TgeneNSD1chr10:73501678chr5:176618885ENST000004391511232118_2165309.02697.0Zinc fingerPHD-type 4%3B atypical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231103_120801115.0DomainCadherin 11
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231210_131301115.0DomainCadherin 12
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231314_141801115.0DomainCadherin 13
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123133_23601115.0DomainCadherin 2
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231420_152701115.0DomainCadherin 14
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231529_163401115.0DomainCadherin 15
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231635_174401115.0DomainCadherin 16
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231745_185101115.0DomainCadherin 17
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231852_195901115.0DomainCadherin 18
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1231960_206901115.0DomainCadherin 19
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232070_217401115.0DomainCadherin 20
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232175_229301115.0DomainCadherin 21
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232297_240201115.0DomainCadherin 22
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123237_34801115.0DomainCadherin 3
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232403_250901115.0DomainCadherin 23
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232510_261101115.0DomainCadherin 24
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232614_272201115.0DomainCadherin 25
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232729_284601115.0DomainCadherin 26
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1232847_297501115.0DomainCadherin 27
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123349_46001115.0DomainCadherin 4
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+12334_13201115.0DomainCadherin 1
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123461_56101115.0DomainCadherin 5
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123562_67101115.0DomainCadherin 6
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123672_78401115.0DomainCadherin 7
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123779_89001115.0DomainCadherin 8
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123891_99501115.0DomainCadherin 9
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+123996_110201115.0DomainCadherin 10
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141103_12080531.0DomainCadherin 11
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141210_13130531.0DomainCadherin 12
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141314_14180531.0DomainCadherin 13
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114133_2360531.0DomainCadherin 2
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141420_15270531.0DomainCadherin 14
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141529_16340531.0DomainCadherin 15
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141635_17440531.0DomainCadherin 16
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141745_18510531.0DomainCadherin 17
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141852_19590531.0DomainCadherin 18
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1141960_20690531.0DomainCadherin 19
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142070_21740531.0DomainCadherin 20
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142175_22930531.0DomainCadherin 21
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142297_24020531.0DomainCadherin 22
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114237_3480531.0DomainCadherin 3
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142403_25090531.0DomainCadherin 23
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142510_26110531.0DomainCadherin 24
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142614_27220531.0DomainCadherin 25
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142729_28460531.0DomainCadherin 26
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1142847_29750531.0DomainCadherin 27
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114349_4600531.0DomainCadherin 4
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+11434_1320531.0DomainCadherin 1
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114461_5610531.0DomainCadherin 5
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114562_6710531.0DomainCadherin 6
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114672_7840531.0DomainCadherin 7
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114779_8900531.0DomainCadherin 8
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114891_9950531.0DomainCadherin 9
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+114996_11020531.0DomainCadherin 10
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+12324_306401115.0Topological domainExtracellular
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1233086_335401115.0Topological domainCytoplasmic
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+11424_30640531.0Topological domainExtracellular
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1143086_33540531.0Topological domainCytoplasmic
HgeneCDH23chr10:73501678chr5:176618885ENST00000398788+1233065_308501115.0TransmembraneHelical
HgeneCDH23chr10:73501678chr5:176618885ENST00000398809+1143065_30850531.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CDH23
NSD1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CDH23-NSD1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CDH23-NSD1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource