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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CDK12-TAF15

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CDK12-TAF15
FusionPDB ID: 15151
FusionGDB2.0 ID: 15151
HgeneTgene
Gene symbol

CDK12

TAF15

Gene ID

51755

8148

Gene namecyclin dependent kinase 12TATA-box binding protein associated factor 15
SynonymsCRK7|CRKR|CRKRSNpl3|RBP56|TAF2N|TAFII68
Cytomap

17q12

17q12

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12TATA-binding protein-associated factor 2NRBP56/CSMF fusionTAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)TATA box-bin
Modification date2020031320200313
UniProtAcc

Q9NYV4

.
Ensembl transtripts involved in fusion geneENST idsENST00000430627, ENST00000447079, 
ENST00000559545, 		ENST00000311979, 
ENST00000588240, ENST00000592237, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score29 X 13 X 13=490116 X 11 X 11=1936
# samples 3116
** MAII scorelog2(31/4901*10)=-3.98273602613552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1936*10)=-3.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CDK12 [Title/Abstract] AND TAF15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CDK12(37682569)-TAF15(34169371), # samples:3
Anticipated loss of major functional domain due to fusion event.CDK12-TAF15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDK12-TAF15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDK12-TAF15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDK12-TAF15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDK12

GO:0046777

protein autophosphorylation

11683387

TgeneTAF15

GO:0048255

mRNA stabilization

27378374


check buttonFusion gene breakpoints across CDK12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TAF15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-UY-A9PD-01ACDK12chr17

37682569

-TAF15chr17

34169371

+
ChimerDB4BLCATCGA-UY-A9PD-01ACDK12chr17

37682569

+TAF15chr17

34169371

+
ChimerDB4BLCATCGA-UY-A9PDCDK12chr17

37682569

+TAF15chr17

34169370

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000430627CDK12chr1737682569+ENST00000588240TAF15chr1734169371+5234407118549361583
ENST00000430627CDK12chr1737682569+ENST00000592237TAF15chr1734169371+4913407118547801531
ENST00000430627CDK12chr1737682569+ENST00000311979TAF15chr1734169371+5226407118549361583
ENST00000447079CDK12chr1737682569+ENST00000588240TAF15chr1734169371+495637933346581541
ENST00000447079CDK12chr1737682569+ENST00000592237TAF15chr1734169371+463537933345021489
ENST00000447079CDK12chr1737682569+ENST00000311979TAF15chr1734169371+494837933346581541
ENST00000430627CDK12chr1737682569+ENST00000588240TAF15chr1734169370+5234407118549361583
ENST00000430627CDK12chr1737682569+ENST00000592237TAF15chr1734169370+4913407118547801531
ENST00000430627CDK12chr1737682569+ENST00000311979TAF15chr1734169370+5226407118549361583
ENST00000447079CDK12chr1737682569+ENST00000588240TAF15chr1734169370+495637933346581541
ENST00000447079CDK12chr1737682569+ENST00000592237TAF15chr1734169370+463537933345021489
ENST00000447079CDK12chr1737682569+ENST00000311979TAF15chr1734169370+494837933346581541

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000430627ENST00000588240CDK12chr1737682569+TAF15chr1734169371+0.0022061710.9977938
ENST00000430627ENST00000592237CDK12chr1737682569+TAF15chr1734169371+0.0021402780.9978598
ENST00000430627ENST00000311979CDK12chr1737682569+TAF15chr1734169371+0.0022301060.99776995
ENST00000447079ENST00000588240CDK12chr1737682569+TAF15chr1734169371+0.0017828870.99821705
ENST00000447079ENST00000592237CDK12chr1737682569+TAF15chr1734169371+0.001744830.9982552
ENST00000447079ENST00000311979CDK12chr1737682569+TAF15chr1734169371+0.0018042880.9981957
ENST00000430627ENST00000588240CDK12chr1737682569+TAF15chr1734169370+0.0022061710.9977938
ENST00000430627ENST00000592237CDK12chr1737682569+TAF15chr1734169370+0.0021402780.9978598
ENST00000430627ENST00000311979CDK12chr1737682569+TAF15chr1734169370+0.0022301060.99776995
ENST00000447079ENST00000588240CDK12chr1737682569+TAF15chr1734169370+0.0017828870.99821705
ENST00000447079ENST00000592237CDK12chr1737682569+TAF15chr1734169370+0.001744830.9982552
ENST00000447079ENST00000311979CDK12chr1737682569+TAF15chr1734169370+0.0018042880.9981957

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15151_15151_1_CDK12-TAF15_CDK12_chr17_37682569_ENST00000430627_TAF15_chr17_34169370_ENST00000311979_length(amino acids)=1583AA_BP=1477
MPSPPPSRGALVGVELGLGGWVGVAFWSAGELFSLLQVRGKGMPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSK
HSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSS
KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS
DSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGS
YSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAA
AAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQ
GTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPST
HSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGG
DLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFP
ITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHR
DIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELI
SRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQD
CHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTD
LSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLM
KTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWV
CPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGD
RSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGS

--------------------------------------------------------------

>15151_15151_2_CDK12-TAF15_CDK12_chr17_37682569_ENST00000430627_TAF15_chr17_34169370_ENST00000588240_length(amino acids)=1583AA_BP=1477
MPSPPPSRGALVGVELGLGGWVGVAFWSAGELFSLLQVRGKGMPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSK
HSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSS
KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS
DSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGS
YSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAA
AAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQ
GTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPST
HSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGG
DLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFP
ITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHR
DIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELI
SRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQD
CHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTD
LSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLM
KTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWV
CPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGD
RSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGS

--------------------------------------------------------------

>15151_15151_3_CDK12-TAF15_CDK12_chr17_37682569_ENST00000430627_TAF15_chr17_34169370_ENST00000592237_length(amino acids)=1531AA_BP=1319
MPSPPPSRGALVGVELGLGGWVGVAFWSAGELFSLLQVRGKGMPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSK
HSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSS
KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS
DSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGS
YSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAA
AAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQ
GTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPST
HSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGG
DLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFP
ITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHR
DIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELI
SRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQD
CHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTD
LSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLM
KTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWV
CPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRTGGAMEETVVVAVATVETEVEAMEETG
VVAAMEETEVGATEETEVAMEAKWEEETTTEMISATDHTDDCFECSFVSDMIHSEIARVLPAAFLVASSWVVKLSDIWIFIWVGGLGQFF

--------------------------------------------------------------

>15151_15151_4_CDK12-TAF15_CDK12_chr17_37682569_ENST00000430627_TAF15_chr17_34169371_ENST00000311979_length(amino acids)=1583AA_BP=1477
MPSPPPSRGALVGVELGLGGWVGVAFWSAGELFSLLQVRGKGMPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSK
HSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSS
KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS
DSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGS
YSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAA
AAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQ
GTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPST
HSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGG
DLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFP
ITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHR
DIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELI
SRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQD
CHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTD
LSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLM
KTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWV
CPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGD
RSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGS

--------------------------------------------------------------

>15151_15151_5_CDK12-TAF15_CDK12_chr17_37682569_ENST00000430627_TAF15_chr17_34169371_ENST00000588240_length(amino acids)=1583AA_BP=1477
MPSPPPSRGALVGVELGLGGWVGVAFWSAGELFSLLQVRGKGMPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSK
HSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSS
KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS
DSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGS
YSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAA
AAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQ
GTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPST
HSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGG
DLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFP
ITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHR
DIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELI
SRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQD
CHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTD
LSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLM
KTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWV
CPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGD
RSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGS

--------------------------------------------------------------

>15151_15151_6_CDK12-TAF15_CDK12_chr17_37682569_ENST00000430627_TAF15_chr17_34169371_ENST00000592237_length(amino acids)=1531AA_BP=1319
MPSPPPSRGALVGVELGLGGWVGVAFWSAGELFSLLQVRGKGMPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSK
HSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSS
KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS
DSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGS
YSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAA
AAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQ
GTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPST
HSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGG
DLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFP
ITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHR
DIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELI
SRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQD
CHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTD
LSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLM
KTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWV
CPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRTGGAMEETVVVAVATVETEVEAMEETG
VVAAMEETEVGATEETEVAMEAKWEEETTTEMISATDHTDDCFECSFVSDMIHSEIARVLPAAFLVASSWVVKLSDIWIFIWVGGLGQFF

--------------------------------------------------------------

>15151_15151_7_CDK12-TAF15_CDK12_chr17_37682569_ENST00000447079_TAF15_chr17_34169370_ENST00000311979_length(amino acids)=1541AA_BP=1435
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK
LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS
RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS
VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL
PLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFY
LVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIP
SAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDS
ETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAGKEFHGN
IIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGG
ERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRG
GGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMGGRN

--------------------------------------------------------------

>15151_15151_8_CDK12-TAF15_CDK12_chr17_37682569_ENST00000447079_TAF15_chr17_34169370_ENST00000588240_length(amino acids)=1541AA_BP=1435
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK
LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS
RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS
VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL
PLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFY
LVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIP
SAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDS
ETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAGKEFHGN
IIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGG
ERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRG
GGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMGGRN

--------------------------------------------------------------

>15151_15151_9_CDK12-TAF15_CDK12_chr17_37682569_ENST00000447079_TAF15_chr17_34169370_ENST00000592237_length(amino acids)=1489AA_BP=1277
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK
LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS
RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS
VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL
PLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFY
LVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIP
SAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDS
ETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAGKEFHGN
IIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGG
ERGYRGRGGRGGDRGGYGGDRTGGAMEETVVVAVATVETEVEAMEETGVVAAMEETEVGATEETEVAMEAKWEEETTTEMISATDHTDDC

--------------------------------------------------------------

>15151_15151_10_CDK12-TAF15_CDK12_chr17_37682569_ENST00000447079_TAF15_chr17_34169371_ENST00000311979_length(amino acids)=1541AA_BP=1435
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK
LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS
RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS
VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL
PLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFY
LVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIP
SAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDS
ETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAGKEFHGN
IIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGG
ERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRG
GGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMGGRN

--------------------------------------------------------------

>15151_15151_11_CDK12-TAF15_CDK12_chr17_37682569_ENST00000447079_TAF15_chr17_34169371_ENST00000588240_length(amino acids)=1541AA_BP=1435
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK
LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS
RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS
VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL
PLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFY
LVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIP
SAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDS
ETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAGKEFHGN
IIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGG
ERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRG
GGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMGGRN

--------------------------------------------------------------

>15151_15151_12_CDK12-TAF15_CDK12_chr17_37682569_ENST00000447079_TAF15_chr17_34169371_ENST00000592237_length(amino acids)=1489AA_BP=1277
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK
LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS
RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS
VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL
PLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG
KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFY
LVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW
YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIP
SAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK
NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDS
ETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAGKEFHGN
IIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGG
ERGYRGRGGRGGDRGGYGGDRTGGAMEETVVVAVATVETEVEAMEETGVVAAMEETEVGATEETEVAMEAKWEEETTTEMISATDHTDDC

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37682569/chr17:34169371)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK12

Q9NYV4

.
FUNCTION: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDK12chr17:37682569chr17:34169370ENST00000430627+1314407_4131253.33333333333331482.0Compositional biasNote=Poly-Ala
HgeneCDK12chr17:37682569chr17:34169370ENST00000430627+1314535_5401253.33333333333331482.0Compositional biasNote=Poly-Pro
HgeneCDK12chr17:37682569chr17:34169370ENST00000447079+1314407_4131253.33333333333331491.0Compositional biasNote=Poly-Ala
HgeneCDK12chr17:37682569chr17:34169370ENST00000447079+1314535_5401253.33333333333331491.0Compositional biasNote=Poly-Pro
HgeneCDK12chr17:37682569chr17:34169371ENST00000430627+1314407_4131253.33333333333331482.0Compositional biasNote=Poly-Ala
HgeneCDK12chr17:37682569chr17:34169371ENST00000430627+1314535_5401253.33333333333331482.0Compositional biasNote=Poly-Pro
HgeneCDK12chr17:37682569chr17:34169371ENST00000447079+1314407_4131253.33333333333331491.0Compositional biasNote=Poly-Ala
HgeneCDK12chr17:37682569chr17:34169371ENST00000447079+1314535_5401253.33333333333331491.0Compositional biasNote=Poly-Pro
HgeneCDK12chr17:37682569chr17:34169370ENST00000430627+1314727_10201253.33333333333331482.0DomainProtein kinase
HgeneCDK12chr17:37682569chr17:34169370ENST00000447079+1314727_10201253.33333333333331491.0DomainProtein kinase
HgeneCDK12chr17:37682569chr17:34169371ENST00000430627+1314727_10201253.33333333333331482.0DomainProtein kinase
HgeneCDK12chr17:37682569chr17:34169371ENST00000447079+1314727_10201253.33333333333331491.0DomainProtein kinase
HgeneCDK12chr17:37682569chr17:34169370ENST00000430627+1314733_7411253.33333333333331482.0Nucleotide bindingNote=ATP
HgeneCDK12chr17:37682569chr17:34169370ENST00000430627+1314814_8191253.33333333333331482.0Nucleotide bindingNote=ATP
HgeneCDK12chr17:37682569chr17:34169370ENST00000447079+1314733_7411253.33333333333331491.0Nucleotide bindingNote=ATP
HgeneCDK12chr17:37682569chr17:34169370ENST00000447079+1314814_8191253.33333333333331491.0Nucleotide bindingNote=ATP
HgeneCDK12chr17:37682569chr17:34169371ENST00000430627+1314733_7411253.33333333333331482.0Nucleotide bindingNote=ATP
HgeneCDK12chr17:37682569chr17:34169371ENST00000430627+1314814_8191253.33333333333331482.0Nucleotide bindingNote=ATP
HgeneCDK12chr17:37682569chr17:34169371ENST00000447079+1314733_7411253.33333333333331491.0Nucleotide bindingNote=ATP
HgeneCDK12chr17:37682569chr17:34169371ENST00000447079+1314814_8191253.33333333333331491.0Nucleotide bindingNote=ATP
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016320_590301.3333333333333590.0Compositional biasNote=Arg/Gly-rich
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016320_590304.3333333333333593.0Compositional biasNote=Arg/Gly-rich
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016320_590301.3333333333333590.0Compositional biasNote=Arg/Gly-rich
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016320_590304.3333333333333593.0Compositional biasNote=Arg/Gly-rich
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016407_575301.3333333333333590.0RegionNote=21 X approximate tandem repeats of D-R-[S%2CG](0%2C3)-G-G-Y-G-G
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016407_575304.3333333333333593.0RegionNote=21 X approximate tandem repeats of D-R-[S%2CG](0%2C3)-G-G-Y-G-G
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016407_575301.3333333333333590.0RegionNote=21 X approximate tandem repeats of D-R-[S%2CG](0%2C3)-G-G-Y-G-G
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016407_575304.3333333333333593.0RegionNote=21 X approximate tandem repeats of D-R-[S%2CG](0%2C3)-G-G-Y-G-G
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016407_413301.3333333333333590.0RepeatNote=1
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016414_420301.3333333333333590.0RepeatNote=2
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016421_429301.3333333333333590.0RepeatNote=3
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016430_439301.3333333333333590.0RepeatNote=4
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016440_448301.3333333333333590.0RepeatNote=5
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016449_457301.3333333333333590.0RepeatNote=6
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016458_465301.3333333333333590.0RepeatNote=7
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016466_473301.3333333333333590.0RepeatNote=8
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016474_481301.3333333333333590.0RepeatNote=9
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016482_488301.3333333333333590.0RepeatNote=10
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016489_496301.3333333333333590.0RepeatNote=11
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016497_503301.3333333333333590.0RepeatNote=12
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016504_510301.3333333333333590.0RepeatNote=13
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016511_517301.3333333333333590.0RepeatNote=14
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016518_524301.3333333333333590.0RepeatNote=15
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016525_533301.3333333333333590.0RepeatNote=16
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016534_543301.3333333333333590.0RepeatNote=17
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016544_551301.3333333333333590.0RepeatNote=18
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016552_560301.3333333333333590.0RepeatNote=19
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016561_568301.3333333333333590.0RepeatNote=20
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016569_575301.3333333333333590.0RepeatNote=21
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016407_413304.3333333333333593.0RepeatNote=1
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016414_420304.3333333333333593.0RepeatNote=2
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016421_429304.3333333333333593.0RepeatNote=3
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016430_439304.3333333333333593.0RepeatNote=4
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016440_448304.3333333333333593.0RepeatNote=5
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016449_457304.3333333333333593.0RepeatNote=6
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016458_465304.3333333333333593.0RepeatNote=7
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016466_473304.3333333333333593.0RepeatNote=8
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016474_481304.3333333333333593.0RepeatNote=9
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016482_488304.3333333333333593.0RepeatNote=10
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016489_496304.3333333333333593.0RepeatNote=11
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016497_503304.3333333333333593.0RepeatNote=12
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016504_510304.3333333333333593.0RepeatNote=13
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016511_517304.3333333333333593.0RepeatNote=14
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016518_524304.3333333333333593.0RepeatNote=15
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016525_533304.3333333333333593.0RepeatNote=16
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016534_543304.3333333333333593.0RepeatNote=17
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016544_551304.3333333333333593.0RepeatNote=18
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016552_560304.3333333333333593.0RepeatNote=19
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016561_568304.3333333333333593.0RepeatNote=20
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016569_575304.3333333333333593.0RepeatNote=21
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016407_413301.3333333333333590.0RepeatNote=1
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016414_420301.3333333333333590.0RepeatNote=2
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016421_429301.3333333333333590.0RepeatNote=3
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016430_439301.3333333333333590.0RepeatNote=4
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016440_448301.3333333333333590.0RepeatNote=5
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016449_457301.3333333333333590.0RepeatNote=6
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016458_465301.3333333333333590.0RepeatNote=7
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016466_473301.3333333333333590.0RepeatNote=8
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016474_481301.3333333333333590.0RepeatNote=9
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016482_488301.3333333333333590.0RepeatNote=10
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016489_496301.3333333333333590.0RepeatNote=11
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016497_503301.3333333333333590.0RepeatNote=12
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016504_510301.3333333333333590.0RepeatNote=13
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016511_517301.3333333333333590.0RepeatNote=14
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016518_524301.3333333333333590.0RepeatNote=15
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016525_533301.3333333333333590.0RepeatNote=16
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016534_543301.3333333333333590.0RepeatNote=17
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016544_551301.3333333333333590.0RepeatNote=18
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016552_560301.3333333333333590.0RepeatNote=19
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016561_568301.3333333333333590.0RepeatNote=20
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016569_575301.3333333333333590.0RepeatNote=21
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016407_413304.3333333333333593.0RepeatNote=1
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016414_420304.3333333333333593.0RepeatNote=2
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016421_429304.3333333333333593.0RepeatNote=3
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016430_439304.3333333333333593.0RepeatNote=4
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016440_448304.3333333333333593.0RepeatNote=5
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016449_457304.3333333333333593.0RepeatNote=6
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016458_465304.3333333333333593.0RepeatNote=7
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016466_473304.3333333333333593.0RepeatNote=8
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016474_481304.3333333333333593.0RepeatNote=9
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016482_488304.3333333333333593.0RepeatNote=10
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016489_496304.3333333333333593.0RepeatNote=11
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016497_503304.3333333333333593.0RepeatNote=12
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016504_510304.3333333333333593.0RepeatNote=13
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016511_517304.3333333333333593.0RepeatNote=14
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016518_524304.3333333333333593.0RepeatNote=15
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016525_533304.3333333333333593.0RepeatNote=16
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016534_543304.3333333333333593.0RepeatNote=17
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016544_551304.3333333333333593.0RepeatNote=18
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016552_560304.3333333333333593.0RepeatNote=19
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016561_568304.3333333333333593.0RepeatNote=20
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016569_575304.3333333333333593.0RepeatNote=21
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016354_385301.3333333333333590.0Zinc fingerRanBP2-type
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016354_385304.3333333333333593.0Zinc fingerRanBP2-type
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016354_385301.3333333333333590.0Zinc fingerRanBP2-type
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016354_385304.3333333333333593.0Zinc fingerRanBP2-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDK12chr17:37682569chr17:34169370ENST00000430627+13141266_12801253.33333333333331482.0Compositional biasNote=Poly-Pro
HgeneCDK12chr17:37682569chr17:34169370ENST00000447079+13141266_12801253.33333333333331491.0Compositional biasNote=Poly-Pro
HgeneCDK12chr17:37682569chr17:34169371ENST00000430627+13141266_12801253.33333333333331482.0Compositional biasNote=Poly-Pro
HgeneCDK12chr17:37682569chr17:34169371ENST00000447079+13141266_12801253.33333333333331491.0Compositional biasNote=Poly-Pro
TgeneTAF15chr17:37682569chr17:34169370ENST0000031197910161_208301.3333333333333590.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
TgeneTAF15chr17:37682569chr17:34169370ENST0000058824010161_208304.3333333333333593.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
TgeneTAF15chr17:37682569chr17:34169371ENST0000031197910161_208301.3333333333333590.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
TgeneTAF15chr17:37682569chr17:34169371ENST0000058824010161_208304.3333333333333593.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
TgeneTAF15chr17:37682569chr17:34169370ENST000003119791016234_320301.3333333333333590.0DomainRRM
TgeneTAF15chr17:37682569chr17:34169370ENST000005882401016234_320304.3333333333333593.0DomainRRM
TgeneTAF15chr17:37682569chr17:34169371ENST000003119791016234_320301.3333333333333590.0DomainRRM
TgeneTAF15chr17:37682569chr17:34169371ENST000005882401016234_320304.3333333333333593.0DomainRRM


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CDK12
TAF15


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CDK12-TAF15


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to CDK12-TAF15


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource