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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CDK6-KMT2A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CDK6-KMT2A
FusionPDB ID: 15293
FusionGDB2.0 ID: 15295
HgeneTgene
Gene symbol

CDK6

KMT2A

Gene ID

1021

4297

Gene namecyclin dependent kinase 6lysine methyltransferase 2A
SynonymsMCPH12|PLSTIREALL-1|CXXC7|HRX|HTRX1|MLL|MLL1|MLL1A|TRX1|WDSTS
Cytomap

7q21.2

11q23.3

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 6cell division protein kinase 6serine/threonine-protein kinase PLSTIREhistone-lysine N-methyltransferase 2ACXXC-type zinc finger protein 7lysine (K)-specific methyltransferase 2Alysine N-methyltransferase 2Amixed lineage leukemia 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)trithorax-like
Modification date2020032920200319
UniProtAcc

Q00534

Q03164

Ensembl transtripts involved in fusion geneENST idsENST00000265734, ENST00000424848, 
ENST00000491250, 		ENST00000354520, 
ENST00000420751, ENST00000389506, 
ENST00000534358, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 9 X 7=75631 X 72 X 3=6696
# samples 1779
** MAII scorelog2(17/756*10)=-2.15285148808337
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(79/6696*10)=-3.08337496948588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CDK6 [Title/Abstract] AND KMT2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CDK6(92404010)-KMT2A(118360505), # samples:1
CDK6(92364333)-KMT2A(118199863), # samples:1
Anticipated loss of major functional domain due to fusion event.CDK6-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDK6-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDK6-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDK6-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDK6-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CDK6-KMT2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CDK6-KMT2A seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
CDK6-KMT2A seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CDK6-KMT2A seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CDK6-KMT2A seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CDK6-KMT2A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CDK6-KMT2A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CDK6-KMT2A seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDK6

GO:0001954

positive regulation of cell-matrix adhesion

10205165

HgeneCDK6

GO:0003323

type B pancreatic cell development

20668294

HgeneCDK6

GO:0006468

protein phosphorylation

8114739

HgeneCDK6

GO:0010468

regulation of gene expression

15254224

HgeneCDK6

GO:0045638

negative regulation of myeloid cell differentiation

17431401

HgeneCDK6

GO:0045656

negative regulation of monocyte differentiation

26542173

HgeneCDK6

GO:0045668

negative regulation of osteoblast differentiation

15254224

HgeneCDK6

GO:0045786

negative regulation of cell cycle

14985467

HgeneCDK6

GO:2000773

negative regulation of cellular senescence

17420273

TgeneKMT2A

GO:0044648

histone H3-K4 dimethylation

25561738

TgeneKMT2A

GO:0045944

positive regulation of transcription by RNA polymerase II

20861184

TgeneKMT2A

GO:0051568

histone H3-K4 methylation

19556245

TgeneKMT2A

GO:0065003

protein-containing complex assembly

15199122

TgeneKMT2A

GO:0080182

histone H3-K4 trimethylation

20861184

TgeneKMT2A

GO:0097692

histone H3-K4 monomethylation

25561738|26324722


check buttonFusion gene breakpoints across CDK6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KMT2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..CDK6chr7

92462404

-KMT2Achr11

118355576

+
ChiTaRS5.0N/AAF492830CDK6chr7

92404010

-KMT2Achr11

118360505

+
ChiTaRS5.0N/AAF492834CDK6chr7

92364333

-KMT2Achr11

118199863

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265734CDK6chr792462404-ENST00000534358KMT2Achr11118355576+1299864545383452630
ENST00000265734CDK6chr792462404-ENST00000389506KMT2Achr11118355576+1008264545383362627
ENST00000424848CDK6chr792404010-ENST00000534358KMT2Achr11118360505+1294585348482922602
ENST00000424848CDK6chr792404010-ENST00000389506KMT2Achr11118360505+1002985348482832599
ENST00000424848CDK6chr792404010-ENST00000354520KMT2Achr11118360505+1080885348482832599

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000424848ENST00000534358CDK6chr792404010-KMT2Achr11118360505+0.0004195230.99958044
ENST00000424848ENST00000389506CDK6chr792404010-KMT2Achr11118360505+0.0007225610.9992774
ENST00000424848ENST00000354520CDK6chr792404010-KMT2Achr11118360505+0.0007949110.99920505

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15293_15293_1_CDK6-KMT2A_CDK6_chr7_92404010_ENST00000424848_KMT2A_chr11_118360505_ENST00000354520_length(amino acids)=2599AA_BP=123
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDR
ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWS
HDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKEL
QISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDI
VKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLM
KKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEV
FEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVD
FEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHD
ENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGD
PLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTV
VTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFS
SKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPG
QVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALK
ESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFG
LTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGV
DDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRV
HTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQ
LPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMT
PDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIV
VNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQ
SSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPS
QLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTT
TPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAA
SPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSV
PGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVT
QNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLS
FAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEE
VQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDS

--------------------------------------------------------------

>15293_15293_2_CDK6-KMT2A_CDK6_chr7_92404010_ENST00000424848_KMT2A_chr11_118360505_ENST00000389506_length(amino acids)=2599AA_BP=123
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDR
ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWS
HDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKEL
QISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDI
VKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLM
KKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEV
FEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVD
FEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHD
ENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGD
PLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTV
VTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFS
SKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPG
QVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALK
ESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFG
LTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGV
DDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRV
HTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQ
LPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMT
PDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIV
VNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQ
SSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPS
QLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTT
TPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAA
SPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSV
PGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVT
QNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLS
FAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEE
VQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDS

--------------------------------------------------------------

>15293_15293_3_CDK6-KMT2A_CDK6_chr7_92404010_ENST00000424848_KMT2A_chr11_118360505_ENST00000534358_length(amino acids)=2602AA_BP=123
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDR
ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWS
HDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALE
KELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFS
DDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQP
PLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWS
AEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRV
FVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTV
EHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVT
VGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQ
RTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSV
SFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFL
EPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKN
ALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNM
FFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQL
DGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESS
RRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVF
SQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEG
HMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEK
LIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPA
ATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINF
TPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQ
TTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGI
TAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSAS
PSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEV
QVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLK
QLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEE
EEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRI

--------------------------------------------------------------

>15293_15293_4_CDK6-KMT2A_CDK6_chr7_92462404_ENST00000265734_KMT2A_chr11_118355576_ENST00000389506_length(amino acids)=2627AA_BP=63
MRGGDRGGRLWEGVQGPRLEERRPFRGVEARAGADRRGGHAALHHPRGGGAEAPGDLRAPQRGQEDCEAENVWEMGGLGILTSVPITPRV
VCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKK
KVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSN
LPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDD
QQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNA
VLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDD
SANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKV
YCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDAR
KRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSP
TQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKV
VDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLA
PQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSS
RDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKEL
QAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPD
GPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSG
GEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDN
CHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSS
ELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTI
TEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTD
SPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTS
QSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNK
KLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQD
TSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTS
QTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALS
SAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQD
TASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQIC
AESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRK
SAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNV
IRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDAS

--------------------------------------------------------------

>15293_15293_5_CDK6-KMT2A_CDK6_chr7_92462404_ENST00000265734_KMT2A_chr11_118355576_ENST00000534358_length(amino acids)=2630AA_BP=63
MRGGDRGGRLWEGVQGPRLEERRPFRGVEARAGADRRGGHAALHHPRGGGAEAPGDLRAPQRGQEDCEAENVWEMGGLGILTSVPITPRV
VCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKK
KVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEI
LSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSK
QDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGML
PNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTY
GDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDD
KKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTT
DARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPS
YSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESS
AKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIP
KLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMG
SSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSA
KELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLM
LPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVI
SSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPK
MDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPES
SSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKR
VTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPN
STDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSL
PTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTR
KNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTI
SQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQL
GTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNK
ALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAE
QQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGF
QICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVH
LRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYA
GNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:92404010/chr11:118360505)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK6

Q00534

KMT2A

Q03164

FUNCTION: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}.FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250|UniProtKB:P55200, ECO:0000269|PubMed:10490642, ECO:0000269|PubMed:12453419, ECO:0000269|PubMed:15960975, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20010842, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:24235145, ECO:0000269|PubMed:26886794, ECO:0000305|PubMed:20677832}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDK6chr7:92404010chr11:118360505ENST00000265734-3819_27123.0327.0Nucleotide bindingATP
HgeneCDK6chr7:92404010chr11:118360505ENST00000424848-3819_27123.0327.0Nucleotide bindingATP
TgeneKMT2Achr7:92404010chr11:118360505ENST000003545209351703_17481455.03932.0DomainBromo%3B divergent
TgeneKMT2Achr7:92404010chr11:118360505ENST000003545209352018_20741455.03932.0DomainFYR N-terminal
TgeneKMT2Achr7:92404010chr11:118360505ENST000003545209353666_37471455.03932.0DomainFYR C-terminal
TgeneKMT2Achr7:92404010chr11:118360505ENST000003545209353829_39451455.03932.0DomainSET
TgeneKMT2Achr7:92404010chr11:118360505ENST000003545209353953_39691455.03932.0DomainPost-SET
TgeneKMT2Achr7:92404010chr11:118360505ENST0000038950610361703_17481493.03970.0DomainBromo%3B divergent
TgeneKMT2Achr7:92404010chr11:118360505ENST0000038950610362018_20741493.03970.0DomainFYR N-terminal
TgeneKMT2Achr7:92404010chr11:118360505ENST0000038950610363666_37471493.03970.0DomainFYR C-terminal
TgeneKMT2Achr7:92404010chr11:118360505ENST0000038950610363829_39451493.03970.0DomainSET
TgeneKMT2Achr7:92404010chr11:118360505ENST0000038950610363953_39691493.03970.0DomainPost-SET
TgeneKMT2Achr7:92404010chr11:118360505ENST0000053435810361703_17481493.03973.0DomainBromo%3B divergent
TgeneKMT2Achr7:92404010chr11:118360505ENST0000053435810362018_20741493.03973.0DomainFYR N-terminal
TgeneKMT2Achr7:92404010chr11:118360505ENST0000053435810363666_37471493.03973.0DomainFYR C-terminal
TgeneKMT2Achr7:92404010chr11:118360505ENST0000053435810363829_39451493.03973.0DomainSET
TgeneKMT2Achr7:92404010chr11:118360505ENST0000053435810363953_39691493.03973.0DomainPost-SET
TgeneKMT2Achr7:92404010chr11:118360505ENST000003545209353906_39071455.03932.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Achr7:92404010chr11:118360505ENST0000038950610363906_39071493.03970.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Achr7:92404010chr11:118360505ENST0000053435810363906_39071493.03973.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Achr7:92404010chr11:118360505ENST000003545209351479_15331455.03932.0Zinc fingerPHD-type 2
TgeneKMT2Achr7:92404010chr11:118360505ENST000003545209351566_16271455.03932.0Zinc fingerPHD-type 3
TgeneKMT2Achr7:92404010chr11:118360505ENST000003545209351870_19101455.03932.0Zinc fingerC2HC pre-PHD-type
TgeneKMT2Achr7:92404010chr11:118360505ENST000003545209351931_19781455.03932.0Zinc fingerPHD-type 4
TgeneKMT2Achr7:92404010chr11:118360505ENST0000038950610361566_16271493.03970.0Zinc fingerPHD-type 3
TgeneKMT2Achr7:92404010chr11:118360505ENST0000038950610361870_19101493.03970.0Zinc fingerC2HC pre-PHD-type
TgeneKMT2Achr7:92404010chr11:118360505ENST0000038950610361931_19781493.03970.0Zinc fingerPHD-type 4
TgeneKMT2Achr7:92404010chr11:118360505ENST0000053435810361566_16271493.03973.0Zinc fingerPHD-type 3
TgeneKMT2Achr7:92404010chr11:118360505ENST0000053435810361870_19101493.03973.0Zinc fingerC2HC pre-PHD-type
TgeneKMT2Achr7:92404010chr11:118360505ENST0000053435810361931_19781493.03973.0Zinc fingerPHD-type 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDK6chr7:92404010chr11:118360505ENST00000265734-3813_300123.0327.0DomainProtein kinase
HgeneCDK6chr7:92404010chr11:118360505ENST00000424848-3813_300123.0327.0DomainProtein kinase
TgeneKMT2Achr7:92404010chr11:118360505ENST00000354520935137_1431455.03932.0Compositional biasNote=Poly-Gly
TgeneKMT2Achr7:92404010chr11:118360505ENST0000035452093517_1021455.03932.0Compositional biasNote=Ala/Gly/Ser-rich
TgeneKMT2Achr7:92404010chr11:118360505ENST00000354520935561_5641455.03932.0Compositional biasNote=Poly-Pro
TgeneKMT2Achr7:92404010chr11:118360505ENST00000354520935568_5711455.03932.0Compositional biasNote=Poly-Pro
TgeneKMT2Achr7:92404010chr11:118360505ENST000003895061036137_1431493.03970.0Compositional biasNote=Poly-Gly
TgeneKMT2Achr7:92404010chr11:118360505ENST00000389506103617_1021493.03970.0Compositional biasNote=Ala/Gly/Ser-rich
TgeneKMT2Achr7:92404010chr11:118360505ENST000003895061036561_5641493.03970.0Compositional biasNote=Poly-Pro
TgeneKMT2Achr7:92404010chr11:118360505ENST000003895061036568_5711493.03970.0Compositional biasNote=Poly-Pro
TgeneKMT2Achr7:92404010chr11:118360505ENST000005343581036137_1431493.03973.0Compositional biasNote=Poly-Gly
TgeneKMT2Achr7:92404010chr11:118360505ENST00000534358103617_1021493.03973.0Compositional biasNote=Ala/Gly/Ser-rich
TgeneKMT2Achr7:92404010chr11:118360505ENST000005343581036561_5641493.03973.0Compositional biasNote=Poly-Pro
TgeneKMT2Achr7:92404010chr11:118360505ENST000005343581036568_5711493.03973.0Compositional biasNote=Poly-Pro
TgeneKMT2Achr7:92404010chr11:118360505ENST00000354520935169_1801455.03932.0DNA bindingNote=A.T hook 1
TgeneKMT2Achr7:92404010chr11:118360505ENST00000354520935217_2271455.03932.0DNA bindingNote=A.T hook 2
TgeneKMT2Achr7:92404010chr11:118360505ENST00000354520935301_3091455.03932.0DNA bindingNote=A.T hook 3
TgeneKMT2Achr7:92404010chr11:118360505ENST000003895061036169_1801493.03970.0DNA bindingNote=A.T hook 1
TgeneKMT2Achr7:92404010chr11:118360505ENST000003895061036217_2271493.03970.0DNA bindingNote=A.T hook 2
TgeneKMT2Achr7:92404010chr11:118360505ENST000003895061036301_3091493.03970.0DNA bindingNote=A.T hook 3
TgeneKMT2Achr7:92404010chr11:118360505ENST000005343581036169_1801493.03973.0DNA bindingNote=A.T hook 1
TgeneKMT2Achr7:92404010chr11:118360505ENST000005343581036217_2271493.03973.0DNA bindingNote=A.T hook 2
TgeneKMT2Achr7:92404010chr11:118360505ENST000005343581036301_3091493.03973.0DNA bindingNote=A.T hook 3
TgeneKMT2Achr7:92404010chr11:118360505ENST00000354520935123_1341455.03932.0MotifIntegrase domain-binding motif 1 (IBM1)
TgeneKMT2Achr7:92404010chr11:118360505ENST00000354520935147_1521455.03932.0MotifIntegrase domain-binding motif 2 (IBM2)
TgeneKMT2Achr7:92404010chr11:118360505ENST000003545209356_251455.03932.0MotifMenin-binding motif (MBM)
TgeneKMT2Achr7:92404010chr11:118360505ENST000003895061036123_1341493.03970.0MotifIntegrase domain-binding motif 1 (IBM1)
TgeneKMT2Achr7:92404010chr11:118360505ENST000003895061036147_1521493.03970.0MotifIntegrase domain-binding motif 2 (IBM2)
TgeneKMT2Achr7:92404010chr11:118360505ENST0000038950610366_251493.03970.0MotifMenin-binding motif (MBM)
TgeneKMT2Achr7:92404010chr11:118360505ENST000005343581036123_1341493.03973.0MotifIntegrase domain-binding motif 1 (IBM1)
TgeneKMT2Achr7:92404010chr11:118360505ENST000005343581036147_1521493.03973.0MotifIntegrase domain-binding motif 2 (IBM2)
TgeneKMT2Achr7:92404010chr11:118360505ENST0000053435810366_251493.03973.0MotifMenin-binding motif (MBM)
TgeneKMT2Achr7:92404010chr11:118360505ENST000003545209351147_11951455.03932.0Zinc fingerCXXC-type
TgeneKMT2Achr7:92404010chr11:118360505ENST000003545209351431_14821455.03932.0Zinc fingerPHD-type 1
TgeneKMT2Achr7:92404010chr11:118360505ENST0000038950610361147_11951493.03970.0Zinc fingerCXXC-type
TgeneKMT2Achr7:92404010chr11:118360505ENST0000038950610361431_14821493.03970.0Zinc fingerPHD-type 1
TgeneKMT2Achr7:92404010chr11:118360505ENST0000038950610361479_15331493.03970.0Zinc fingerPHD-type 2
TgeneKMT2Achr7:92404010chr11:118360505ENST0000053435810361147_11951493.03973.0Zinc fingerCXXC-type
TgeneKMT2Achr7:92404010chr11:118360505ENST0000053435810361431_14821493.03973.0Zinc fingerPHD-type 1
TgeneKMT2Achr7:92404010chr11:118360505ENST0000053435810361479_15331493.03973.0Zinc fingerPHD-type 2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (1164) >>>1164.pdbFusion protein BP residue: 63
CIF file (1164) >>>1164.cif		CDK6chr792462404-KMT2Achr11118355576+
MRGGDRGGRLWEGVQGPRLEERRPFRGVEARAGADRRGGHAALHHPRGGG
AEAPGDLRAPQRGQEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGH
VEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQAT
KQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPG
KGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCD
RWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQI
SLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPP
VLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDG
GQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNA
VLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLH
PPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLY
IGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGAT
VGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFE
VFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCED
KLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDEN
RTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKV
PRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGS
RRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKV
VDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSS
ASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRE
LNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSS
PDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHS
SKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGL
SMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKES
SPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLP
VQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGE
EDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSG
GEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPK
RNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQ
GQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCG
NILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMG
LFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVP
SQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPD
HFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQ
NQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQ
TLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTS
QSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPP
DPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSN
IAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSS
IMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLN
VVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGI
QDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASP
SGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNS
MGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKR
FQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQD
TASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNF
SSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKS
LTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRN
YKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYN
PNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRG
LFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEV
VDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTY
2627
3D view using mol* of 1164 (AA BP:63)
PDB file (1166) >>>1166.pdbFusion protein BP residue: 63
CIF file (1166) >>>1166.cif		CDK6chr792462404-KMT2Achr11118355576+
MRGGDRGGRLWEGVQGPRLEERRPFRGVEARAGADRRGGHAALHHPRGGG
AEAPGDLRAPQRGQEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGH
VEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQAT
KQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPG
KGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCD
RWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKE
LQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGP
DPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAIN
SDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGML
PNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPT
PLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGR
LLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKP
GATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPEN
GFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSD
CEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEH
DENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVI
SKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRS
IGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESS
AKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMK
QSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTT
SRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSA
NSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKE
KHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGD
KGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNAL
KESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQ
NLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRS
YGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVI
SSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQ
IPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRV
KTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSD
DCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREK
DMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSP
TVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHM
TPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTV
PIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLY
VLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSL
PTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQ
PPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSST
PSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRS
KSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSS
VLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQS
LGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITA
ASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDA
PNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPK
TKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAE
QQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEE
SNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDA
WKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKH
CRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPP
EYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIH
GRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDD
SEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEE
2630
3D view using mol* of 1166 (AA BP:63)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CDK6_pLDDT.png
all structure
all structure
KMT2A_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CDK6_KMT2A_1164_pLDDT.png (AA BP:63)
all structure
CDK6_KMT2A_1166_pLDDT.png (AA BP:63)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
CDK6CDKN2C, CDKN2A, CCND1, CDKN2D, PPP2CA, PPM1B, CDK2, CCND2, CCND3, CDKN1B, CDC37, FBXO7, CDKN1A, UHRF2, CDK5R1, ELAVL1, CCNE1, CCNA2, KIF26B, RB1, CDK7, ATXN1, HIST1H1A, PML, HSP90AA1, FOXM1, ZSCAN1, SYNPO2, DEDD2, SRSF12, ZNF101, SNIP1, ZNF335, PRX, EBF4, EIF4ENIF1, RBM23, BCL11A, TCEB3B, PPHLN1, TRA2A, SENP3, NIPBL, CBY1, SSBP2, SIRT1, POGZ, LPIN1, ANKRD12, TPX2, TRAK1, CASC3, CLASRP, PPARGC1A, MSL3, SORBS1, ABI2, N4BP1, VGLL4, TJP2, SRSF11, ZMYM3, ZNF174, SLBP, ZFP36, MZF1, KLF10, TFDP1, ZEB1, SOX5, SOX10, SRSF1, SRSF2, SRSF7, TRA2B, RBL1, RBL2, NUMA1, NFATC3, MYC, MEF2D, MLLT3, ISL1, HSF1, EZH2, FOXO3, ELK1, ATF6B, DDIT3, CDC6, MCM2, MCM10, UCHL1, CDKN2B, WDR33, CDKL3, CDK6, DMBT1, AMY2A, PIGR, CDK4, DAB1, PSMA3, RTFDC1, HSP90AA5P, UBE2W, CCNT2, CCNT1, RCHY1, EIF2AK1, CDKN1C, NTRK1, RUNX1, CTNNB1, AR, VHL, FGFR3, USP17L2, MCF2L2, PAK4, FKBP5, FAM26E, TRIM25, HHV8GK18_gp82, EGLN2, RBPMS, HEXIM1, LARP7, KIAA1429, GBF1, SUMO1, UBE2I, ARNT, BECN1, AKT1, CD44, EPHA2, FGFR4, LATS2, STK11, FZR1, GLIS2, MAP2K3, MAP2K5, NF2, RAF1, RASSF1, ARAF, CBLC, KEAP1, MAP3K5, TEAD2, TERT, TSC1, ERBB2, GLIS1, GRM1, HGF, HIF1A, KAT2A, KDELR2, MAPK14, MET, PDGFRA, TNFRSF1A, TP53, TRIM28, APOBEC1, CCNI, CCNH, OTP, TRIM15, UBE2N, FASN, ACACA, NUPR1, USP51, ATG7, BSPRY, KLC3, CA4, NEU2, METTL21B, PPM1M, FAM96A, EPB41L5, HSP90AB1, PCNA, MAP1LC3B, CALCOCO2,
KMT2APPIE, PPP1R15A, KMT2A, ASH2L, HCFC1, HCFC2, MEN1, RBBP5, WDR5, AVP, INS, OXT, MAP3K5, HDAC1, CTBP1, CBX4, BMI1, CREBBP, SMARCB1, CXXC1, MYB, CTNNB1, SNW1, E2F2, E2F4, E2F6, PSIP1, MLLT4, POLR2A, KAT8, RNF2, TP53, tat, SBF1, MTM1, SET, HIST1H3A, HIST1H4A, KAT6A, ELL, AFF1, AFF4, CDK9, CCNT1, CTR9, LEO1, PAF1, CDC73, WDR61, MLLT3, DOT1L, SKP2, HIST3H3, SVIL, HIST2H3C, SIN3A, MLLT1, RUNX1, CBFB, H3F3A, SIRT7, ASB2, TCEB1, TCEB2, CBX8, TOP1, TAF6, NCL, HECW2, LGR4, CSNK2A2, SENP3, SYMPK, PKN1, PIH1D1, KRAS, TAF1, CHD3, SMARCA2, SMARCC2, SMARCC1, HDAC2, RBBP4, RBBP7, TBP, MBD3, SAP30, RAN, TAF9, TASP1, HIST1H2BG, EWSR1, DYNLT1, KIF11, ING4, Cbx1, Set, ZNF131, ASB7, AR, CSNK2A1, OGT, BRD4, KDM5B, KDM5D, KDM6B, CKS1B, CKS2, CHD4, ESR2, AGR2, EZH2, FBXW7, SOX2, MED17, WDR82, ACTR8, GEMIN5, RUVBL1, MCM2, RTF1, MED15, MED8, MRGBP, MED14, HIST1H2BB, HIST1H2AB, KIAA1429, SP1, MYC, NR2C2, IRF2, PLEKHA4, DPY30, PTEN, NPM1, RPL13, CCT6A, TMCO1, ITGB1, ESR1, MYCN, SUPT5H, CIT, Pik3r2, FASN, LDLR, CDC27, KMT2B, SETD1A, KDM6A, KANSL2, BUB3, SETD1B, KANSL1, RERE, MCRS1, KMT2C, ZZZ3, MBIP, YEATS2, PAXIP1, KANSL3, KMT2D, BOD1L1, CSRP2BP, ZNF608, ATN1, PHF20L1, PHF20, NCOA6, TADA3, APEX1, ASF1A, CBX3, CD3EAP, CENPA, NUP50, POLR1E, TERF2IP, ZNF330, NAA40, PRKRA, SRSF4, KRR1, RPL13A, ABT1, CSNK2B, OASL, SRSF5, SRSF6, RPS9, FGFBP1, RPLP0, RPL36, KAL1, RPL3, PML, ELF1, ELF2, FEV, NHLH1, EN1, KLF12, KLF3, NFIX, NFYC, YY1, BRD3,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CDK6all structure
KMT2Aall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CDK6-KMT2A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CDK6-KMT2A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDK6C0004238Atrial Fibrillation2CTD_human
HgeneCDK6C0025149Medulloblastoma2CTD_human
HgeneCDK6C0205833Medullomyoblastoma2CTD_human
HgeneCDK6C0235480Paroxysmal atrial fibrillation2CTD_human
HgeneCDK6C0278510Childhood Medulloblastoma2CTD_human
HgeneCDK6C0278876Adult Medulloblastoma2CTD_human
HgeneCDK6C0751291Desmoplastic Medulloblastoma2CTD_human
HgeneCDK6C1275668Melanotic medulloblastoma2CTD_human
HgeneCDK6C2585653Persistent atrial fibrillation2CTD_human
HgeneCDK6C3468561familial atrial fibrillation2CTD_human
HgeneCDK6C0002871Anemia1CTD_human
HgeneCDK6C0003873Rheumatoid Arthritis1CTD_human
HgeneCDK6C0004403Autosome Abnormalities1CTD_human
HgeneCDK6C0008625Chromosome Aberrations1CTD_human
HgeneCDK6C0017636Glioblastoma1CTD_human
HgeneCDK6C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneCDK6C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneCDK6C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneCDK6C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneCDK6C0026998Acute Myeloid Leukemia, M11CTD_human
HgeneCDK6C0038454Cerebrovascular accident1CTD_human
HgeneCDK6C0263454Chloracne1CTD_human
HgeneCDK6C0334588Giant Cell Glioblastoma1CTD_human
HgeneCDK6C0345967Malignant mesothelioma1CTD_human
HgeneCDK6C0677866Brain Stem Neoplasms1CTD_human
HgeneCDK6C0751886Brain Stem Neoplasms, Primary1CTD_human
HgeneCDK6C0751887Medullary Neoplasms1CTD_human
HgeneCDK6C0751888Mesencephalic Neoplasms1CTD_human
HgeneCDK6C0751889Pontine Tumors1CTD_human
HgeneCDK6C0751956Acute Cerebrovascular Accidents1CTD_human
HgeneCDK6C1168401Squamous cell carcinoma of the head and neck1CTD_human
HgeneCDK6C1621958Glioblastoma Multiforme1CTD_human
HgeneCDK6C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneCDK6C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneCDK6C3711387Autosomal Recessive Primary Microcephaly1ORPHANET
HgeneCDK6C4015156MICROCEPHALY 12, PRIMARY, AUTOSOMAL RECESSIVE1CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneKMT2AC2826025Mixed phenotype acute leukemia3ORPHANET
TgeneKMT2AC0023418leukemia2CTD_human
TgeneKMT2AC0023452Childhood Acute Lymphoblastic Leukemia2CTD_human
TgeneKMT2AC0023453L2 Acute Lymphoblastic Leukemia2CTD_human
TgeneKMT2AC0023466Leukemia, Monocytic, Chronic2CTD_human
TgeneKMT2AC0023467Leukemia, Myelocytic, Acute2CTD_human
TgeneKMT2AC0023470Myeloid Leukemia2CTD_human
TgeneKMT2AC0026998Acute Myeloid Leukemia, M12CTD_human
TgeneKMT2AC1854630Growth Deficiency and Mental Retardation with Facial Dysmorphism2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneKMT2AC1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
TgeneKMT2AC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human
TgeneKMT2AC0001418Adenocarcinoma1CTD_human
TgeneKMT2AC0004403Autosome Abnormalities1CTD_human
TgeneKMT2AC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneKMT2AC0005695Bladder Neoplasm1CTD_human
TgeneKMT2AC0007138Carcinoma, Transitional Cell1CTD_human
TgeneKMT2AC0008625Chromosome Aberrations1CTD_human
TgeneKMT2AC0023448Lymphoid leukemia1CTD_human
TgeneKMT2AC0023465Acute monocytic leukemia1CTD_human
TgeneKMT2AC0023479Acute myelomonocytic leukemia1CTD_human
TgeneKMT2AC0024623Malignant neoplasm of stomach1CTD_human
TgeneKMT2AC0033578Prostatic Neoplasms1CTD_human
TgeneKMT2AC0036341Schizophrenia1PSYGENET
TgeneKMT2AC0038356Stomach Neoplasms1CTD_human
TgeneKMT2AC0149925Small cell carcinoma of lung1CTD_human
TgeneKMT2AC0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneKMT2AC0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneKMT2AC0205643Carcinoma, Cribriform1CTD_human
TgeneKMT2AC0205644Carcinoma, Granular Cell1CTD_human
TgeneKMT2AC0205645Adenocarcinoma, Tubular1CTD_human
TgeneKMT2AC0270972Cornelia De Lange Syndrome1ORPHANET
TgeneKMT2AC0280141Acute Undifferentiated Leukemia1ORPHANET
TgeneKMT2AC0376358Malignant neoplasm of prostate1CTD_human
TgeneKMT2AC0856823Undifferentiated type acute leukemia1ORPHANET
TgeneKMT2AC1535926Neurodevelopmental Disorders1CTD_human
TgeneKMT2AC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneKMT2AC2239176Liver carcinoma1CTD_human
TgeneKMT2AC2930974Acute erythroleukemia1CTD_human
TgeneKMT2AC2930975Acute erythroleukemia - M6a subtype1CTD_human
TgeneKMT2AC2930976Acute myeloid leukemia FAB-M61CTD_human
TgeneKMT2AC2930977Acute erythroleukemia - M6b subtype1CTD_human