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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CELF1-MTCH2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CELF1-MTCH2
FusionPDB ID: 15591
FusionGDB2.0 ID: 15591
HgeneTgene
Gene symbol

CELF1

MTCH2

Gene ID

10658

23788

Gene nameCUGBP Elav-like family member 1mitochondrial carrier 2
SynonymsBRUNOL2|CUG-BP|CUGBP|CUGBP1|EDEN-BP|NAB50|NAPOR|hNab50HSPC032|MIMP|SLC25A50
Cytomap

11p11.2

11p11.2

Type of geneprotein-codingprotein-coding
DescriptionCUGBP Elav-like family member 150 kDa nuclear polyadenylated RNA-binding proteinCUG RNA-binding proteinCUG triplet repeat RNA-binding protein 1CUG-BP- and ETR-3-like factor 1EDEN-BP homologRNA-binding protein BRUNOL-2bruno-like 2bruno-like proteinmitochondrial carrier homolog 22310034D24Rikmet-induced mitochondrial proteinsolute carrier family 25, member 50
Modification date2020031320200313
UniProtAcc

Q92879

Q9Y6C9

Ensembl transtripts involved in fusion geneENST idsENST00000310513, ENST00000358597, 
ENST00000361904, ENST00000395290, 
ENST00000395292, ENST00000531165, 
ENST00000532048, ENST00000539455, 
ENST00000542981, ENST00000534074, 
ENST00000302503, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 21 X 14=67626 X 8 X 5=240
# samples 359
** MAII scorelog2(35/6762*10)=-4.27202318906105
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CELF1 [Title/Abstract] AND MTCH2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CELF1(47494639)-MTCH2(47660603), # samples:1
CELF1(47494640)-MTCH2(47660603), # samples:1
CELF1(47586826)-MTCH2(47644328), # samples:1
CELF1(47494639)-MTCH2(47660602), # samples:1
CELF1(47564876)-MTCH2(47642128), # samples:1
Anticipated loss of major functional domain due to fusion event.CELF1-MTCH2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CELF1-MTCH2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CELF1-MTCH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CELF1-MTCH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CELF1-MTCH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CELF1-MTCH2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CELF1-MTCH2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCELF1

GO:0006376

mRNA splice site selection

11158314

HgeneCELF1

GO:0043484

regulation of RNA splicing

16946708


check buttonFusion gene breakpoints across CELF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MTCH2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-EW-A1OW-01ACELF1chr11

47586826

-MTCH2chr11

47644328

-
ChimerDB4LUSCTCGA-43-6771-01ACELF1chr11

47494639

-MTCH2chr11

47660602

-
ChimerDB4LUSCTCGA-43-6771-01ACELF1chr11

47494640

-MTCH2chr11

47660603

-
ChimerDB4LUSCTCGA-43-6771CELF1chr11

47494639

-MTCH2chr11

47660603

-
ChiTaRS5.0N/AEI791118CELF1chr11

47564876

+MTCH2chr11

47642128

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000310513CELF1chr1147494639-ENST00000302503MTCH2chr1147660603-379914571361467443
ENST00000310513CELF1chr1147494640-ENST00000302503MTCH2chr1147660603-379914571361467443
ENST00000310513CELF1chr1147494639-ENST00000302503MTCH2chr1147660602-379914571361467443

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000310513ENST00000302503CELF1chr1147494639-MTCH2chr1147660603-0.0016903960.9983096
ENST00000310513ENST00000302503CELF1chr1147494640-MTCH2chr1147660603-0.0016903960.9983096
ENST00000310513ENST00000302503CELF1chr1147494639-MTCH2chr1147660602-0.0016903960.9983096

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15591_15591_1_CELF1-MTCH2_CELF1_chr11_47494639_ENST00000310513_MTCH2_chr11_47660602_ENST00000302503_length(amino acids)=443AA_BP=
MNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHH
PIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEGCSSP
MVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLAGLNTLGPQYLALLQQTASSGNLNTLSSLHPMGGLNAMQLQNLAALAAAASAA
QNTPSGTNALTTSSSPLSVLTSSGSSPSSSSSNSVNPIASLGALQTLAGATAGLNVGSLAGMAALNGGLGSSGLSNGTGSTMEALTQAYS

--------------------------------------------------------------

>15591_15591_2_CELF1-MTCH2_CELF1_chr11_47494639_ENST00000310513_MTCH2_chr11_47660603_ENST00000302503_length(amino acids)=443AA_BP=
MNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHH
PIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEGCSSP
MVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLAGLNTLGPQYLALLQQTASSGNLNTLSSLHPMGGLNAMQLQNLAALAAAASAA
QNTPSGTNALTTSSSPLSVLTSSGSSPSSSSSNSVNPIASLGALQTLAGATAGLNVGSLAGMAALNGGLGSSGLSNGTGSTMEALTQAYS

--------------------------------------------------------------

>15591_15591_3_CELF1-MTCH2_CELF1_chr11_47494640_ENST00000310513_MTCH2_chr11_47660603_ENST00000302503_length(amino acids)=443AA_BP=
MNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHH
PIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEGCSSP
MVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLAGLNTLGPQYLALLQQTASSGNLNTLSSLHPMGGLNAMQLQNLAALAAAASAA
QNTPSGTNALTTSSSPLSVLTSSGSSPSSSSSNSVNPIASLGALQTLAGATAGLNVGSLAGMAALNGGLGSSGLSNGTGSTMEALTQAYS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:47494639/chr11:47660603)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CELF1

Q92879

MTCH2

Q9Y6C9

FUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233). {ECO:0000250, ECO:0000269|PubMed:10536163, ECO:0000269|PubMed:11124939, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:12799066, ECO:0000269|PubMed:14726956, ECO:0000269|PubMed:16601207, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:28431233}.FUNCTION: The substrate transported is not yet known. Induces mitochondrial depolarization.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCELF1chr11:47494639chr11:47660602ENST00000310513-1214287_308440.3333333333333596.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494639chr11:47660602ENST00000358597-1113287_308444.3333333333333658.3333333333334Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494639chr11:47660602ENST00000361904-1113287_308441.3333333333333475.0Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494639chr11:47660602ENST00000395290-1113287_308443.33333333333332504.3333333333335Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494639chr11:47660602ENST00000395292-1214287_308441.3333333333333579.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494639chr11:47660602ENST00000532048-1416287_308470.3333333333333488.3333333333333Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494639chr11:47660603ENST00000310513-1214287_308440.3333333333333596.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494639chr11:47660603ENST00000358597-1113287_308444.3333333333333658.3333333333334Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494639chr11:47660603ENST00000361904-1113287_308441.3333333333333475.0Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494639chr11:47660603ENST00000395290-1113287_308443.33333333333332504.3333333333335Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494639chr11:47660603ENST00000395292-1214287_308441.3333333333333579.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494639chr11:47660603ENST00000532048-1416287_308470.3333333333333488.3333333333333Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494640chr11:47660603ENST00000310513-1214287_308440.3333333333333596.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494640chr11:47660603ENST00000358597-1113287_308444.3333333333333658.3333333333334Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494640chr11:47660603ENST00000361904-1113287_308441.3333333333333475.0Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494640chr11:47660603ENST00000395290-1113287_308443.33333333333332504.3333333333335Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494640chr11:47660603ENST00000395292-1214287_308441.3333333333333579.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494640chr11:47660603ENST00000532048-1416287_308470.3333333333333488.3333333333333Compositional biasNote=Ser-rich
HgeneCELF1chr11:47494639chr11:47660602ENST00000310513-1214108_188440.3333333333333596.6666666666666DomainRRM 2
HgeneCELF1chr11:47494639chr11:47660602ENST00000310513-121416_99440.3333333333333596.6666666666666DomainRRM 1
HgeneCELF1chr11:47494639chr11:47660602ENST00000358597-1113108_188444.3333333333333658.3333333333334DomainRRM 2
HgeneCELF1chr11:47494639chr11:47660602ENST00000358597-111316_99444.3333333333333658.3333333333334DomainRRM 1
HgeneCELF1chr11:47494639chr11:47660602ENST00000361904-1113108_188441.3333333333333475.0DomainRRM 2
HgeneCELF1chr11:47494639chr11:47660602ENST00000361904-111316_99441.3333333333333475.0DomainRRM 1
HgeneCELF1chr11:47494639chr11:47660602ENST00000395290-1113108_188443.33333333333332504.3333333333335DomainRRM 2
HgeneCELF1chr11:47494639chr11:47660602ENST00000395290-111316_99443.33333333333332504.3333333333335DomainRRM 1
HgeneCELF1chr11:47494639chr11:47660602ENST00000395292-1214108_188441.3333333333333579.6666666666666DomainRRM 2
HgeneCELF1chr11:47494639chr11:47660602ENST00000395292-121416_99441.3333333333333579.6666666666666DomainRRM 1
HgeneCELF1chr11:47494639chr11:47660602ENST00000532048-1416108_188470.3333333333333488.3333333333333DomainRRM 2
HgeneCELF1chr11:47494639chr11:47660602ENST00000532048-141616_99470.3333333333333488.3333333333333DomainRRM 1
HgeneCELF1chr11:47494639chr11:47660603ENST00000310513-1214108_188440.3333333333333596.6666666666666DomainRRM 2
HgeneCELF1chr11:47494639chr11:47660603ENST00000310513-121416_99440.3333333333333596.6666666666666DomainRRM 1
HgeneCELF1chr11:47494639chr11:47660603ENST00000358597-1113108_188444.3333333333333658.3333333333334DomainRRM 2
HgeneCELF1chr11:47494639chr11:47660603ENST00000358597-111316_99444.3333333333333658.3333333333334DomainRRM 1
HgeneCELF1chr11:47494639chr11:47660603ENST00000361904-1113108_188441.3333333333333475.0DomainRRM 2
HgeneCELF1chr11:47494639chr11:47660603ENST00000361904-111316_99441.3333333333333475.0DomainRRM 1
HgeneCELF1chr11:47494639chr11:47660603ENST00000395290-1113108_188443.33333333333332504.3333333333335DomainRRM 2
HgeneCELF1chr11:47494639chr11:47660603ENST00000395290-111316_99443.33333333333332504.3333333333335DomainRRM 1
HgeneCELF1chr11:47494639chr11:47660603ENST00000395292-1214108_188441.3333333333333579.6666666666666DomainRRM 2
HgeneCELF1chr11:47494639chr11:47660603ENST00000395292-121416_99441.3333333333333579.6666666666666DomainRRM 1
HgeneCELF1chr11:47494639chr11:47660603ENST00000532048-1416108_188470.3333333333333488.3333333333333DomainRRM 2
HgeneCELF1chr11:47494639chr11:47660603ENST00000532048-141616_99470.3333333333333488.3333333333333DomainRRM 1
HgeneCELF1chr11:47494640chr11:47660603ENST00000310513-1214108_188440.3333333333333596.6666666666666DomainRRM 2
HgeneCELF1chr11:47494640chr11:47660603ENST00000310513-121416_99440.3333333333333596.6666666666666DomainRRM 1
HgeneCELF1chr11:47494640chr11:47660603ENST00000358597-1113108_188444.3333333333333658.3333333333334DomainRRM 2
HgeneCELF1chr11:47494640chr11:47660603ENST00000358597-111316_99444.3333333333333658.3333333333334DomainRRM 1
HgeneCELF1chr11:47494640chr11:47660603ENST00000361904-1113108_188441.3333333333333475.0DomainRRM 2
HgeneCELF1chr11:47494640chr11:47660603ENST00000361904-111316_99441.3333333333333475.0DomainRRM 1
HgeneCELF1chr11:47494640chr11:47660603ENST00000395290-1113108_188443.33333333333332504.3333333333335DomainRRM 2
HgeneCELF1chr11:47494640chr11:47660603ENST00000395290-111316_99443.33333333333332504.3333333333335DomainRRM 1
HgeneCELF1chr11:47494640chr11:47660603ENST00000395292-1214108_188441.3333333333333579.6666666666666DomainRRM 2
HgeneCELF1chr11:47494640chr11:47660603ENST00000395292-121416_99441.3333333333333579.6666666666666DomainRRM 1
HgeneCELF1chr11:47494640chr11:47660603ENST00000532048-1416108_188470.3333333333333488.3333333333333DomainRRM 2
HgeneCELF1chr11:47494640chr11:47660603ENST00000532048-141616_99470.3333333333333488.3333333333333DomainRRM 1
TgeneMTCH2chr11:47494639chr11:47660602ENST00000302503013118_20629.0304.0RepeatNote=Solcar 2
TgeneMTCH2chr11:47494639chr11:47660603ENST00000302503013118_20629.0304.0RepeatNote=Solcar 2
TgeneMTCH2chr11:47494640chr11:47660603ENST00000302503013118_20629.0304.0RepeatNote=Solcar 2
TgeneMTCH2chr11:47494639chr11:47660602ENST00000302503013175_19529.0304.0TransmembraneHelical
TgeneMTCH2chr11:47494639chr11:47660602ENST00000302503013224_24429.0304.0TransmembraneHelical
TgeneMTCH2chr11:47494639chr11:47660603ENST00000302503013175_19529.0304.0TransmembraneHelical
TgeneMTCH2chr11:47494639chr11:47660603ENST00000302503013224_24429.0304.0TransmembraneHelical
TgeneMTCH2chr11:47494640chr11:47660603ENST00000302503013175_19529.0304.0TransmembraneHelical
TgeneMTCH2chr11:47494640chr11:47660603ENST00000302503013224_24429.0304.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCELF1chr11:47494639chr11:47660602ENST00000310513-1214401_479440.3333333333333596.6666666666666DomainRRM 3
HgeneCELF1chr11:47494639chr11:47660602ENST00000358597-1113401_479444.3333333333333658.3333333333334DomainRRM 3
HgeneCELF1chr11:47494639chr11:47660602ENST00000361904-1113401_479441.3333333333333475.0DomainRRM 3
HgeneCELF1chr11:47494639chr11:47660602ENST00000395290-1113401_479443.33333333333332504.3333333333335DomainRRM 3
HgeneCELF1chr11:47494639chr11:47660602ENST00000395292-1214401_479441.3333333333333579.6666666666666DomainRRM 3
HgeneCELF1chr11:47494639chr11:47660602ENST00000532048-1416401_479470.3333333333333488.3333333333333DomainRRM 3
HgeneCELF1chr11:47494639chr11:47660603ENST00000310513-1214401_479440.3333333333333596.6666666666666DomainRRM 3
HgeneCELF1chr11:47494639chr11:47660603ENST00000358597-1113401_479444.3333333333333658.3333333333334DomainRRM 3
HgeneCELF1chr11:47494639chr11:47660603ENST00000361904-1113401_479441.3333333333333475.0DomainRRM 3
HgeneCELF1chr11:47494639chr11:47660603ENST00000395290-1113401_479443.33333333333332504.3333333333335DomainRRM 3
HgeneCELF1chr11:47494639chr11:47660603ENST00000395292-1214401_479441.3333333333333579.6666666666666DomainRRM 3
HgeneCELF1chr11:47494639chr11:47660603ENST00000532048-1416401_479470.3333333333333488.3333333333333DomainRRM 3
HgeneCELF1chr11:47494640chr11:47660603ENST00000310513-1214401_479440.3333333333333596.6666666666666DomainRRM 3
HgeneCELF1chr11:47494640chr11:47660603ENST00000358597-1113401_479444.3333333333333658.3333333333334DomainRRM 3
HgeneCELF1chr11:47494640chr11:47660603ENST00000361904-1113401_479441.3333333333333475.0DomainRRM 3
HgeneCELF1chr11:47494640chr11:47660603ENST00000395290-1113401_479443.33333333333332504.3333333333335DomainRRM 3
HgeneCELF1chr11:47494640chr11:47660603ENST00000395292-1214401_479441.3333333333333579.6666666666666DomainRRM 3
HgeneCELF1chr11:47494640chr11:47660603ENST00000532048-1416401_479470.3333333333333488.3333333333333DomainRRM 3
TgeneMTCH2chr11:47494639chr11:47660602ENST000003025030132_9829.0304.0RepeatNote=Solcar 1
TgeneMTCH2chr11:47494639chr11:47660603ENST000003025030132_9829.0304.0RepeatNote=Solcar 1
TgeneMTCH2chr11:47494640chr11:47660603ENST000003025030132_9829.0304.0RepeatNote=Solcar 1
TgeneMTCH2chr11:47494639chr11:47660602ENST000003025030138_2829.0304.0TransmembraneHelical
TgeneMTCH2chr11:47494639chr11:47660603ENST000003025030138_2829.0304.0TransmembraneHelical
TgeneMTCH2chr11:47494640chr11:47660603ENST000003025030138_2829.0304.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CELF1
MTCH2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CELF1-MTCH2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CELF1-MTCH2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource