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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CEP170-AKT3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CEP170-AKT3
	FusionPDB ID: 15794
	FusionGDB2.0 ID: 15794
		Hgene	Tgene
	Gene symbol	CEP170	AKT3
	Gene ID	9859	10000
	Gene name	centrosomal protein 170	AKT serine/threonine kinase 3
	Synonyms	FAM68A\|KAB\|KIAA0470	MPPH\|MPPH2\|PKB-GAMMA\|PKBG\|PRKBG\|RAC-PK-gamma\|RAC-gamma\|STK-2
	Cytomap	1q43	1q43-q44
	Type of gene	protein-coding	protein-coding
	Description	centrosomal protein of 170 kDaKARP-1-binding proteinXRCC5 binding proteincentrosomal protein 170kDa	RAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
	Modification date	20200313	20200313
	UniProtAcc	Q9Y4F5	Q9Y243
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000366542, ENST00000366543, ENST00000366544, ENST00000468254, ENST00000481987, ENST00000490813,	ENST00000492957, ENST00000263826, ENST00000336199, ENST00000366539, ENST00000366540,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	12 X 9 X 10=1080	19 X 18 X 8=2736
	# samples	13	19
	** MAII score	log2(13/1080*10)=-3.05444778402238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/2736*10)=-3.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CEP170 [Title/Abstract] AND AKT3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CEP170(243349081)-AKT3(243736350), # samples:3 AKT3(244006427)-CEP170(243336148), # samples:1
Anticipated loss of major functional domain due to fusion event.	CEP170-AKT3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CEP170-AKT3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CEP170-AKT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CEP170-AKT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AKT3-CEP170 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AKT3-CEP170 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AKT3-CEP170 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. AKT3-CEP170 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. AKT3-CEP170 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. AKT3-CEP170 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	AKT3	GO:0043536	positive regulation of blood vessel endothelial cell migration	28254819
Tgene	AKT3	GO:1905564	positive regulation of vascular endothelial cell proliferation	28254819

Fusion gene breakpoints across CEP170 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AKT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-FS-A1ZD-06A	CEP170	chr1	243349081	-	AKT3	chr1	243736350	-
ChimerDB4	SKCM	TCGA-FS-A1ZD-06A	CEP170	chr1	243349561	-	AKT3	chr1	243736350	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000366542	CEP170	chr1	243349081	-	ENST00000336199	AKT3	chr1	243736350	-	2544	1618	52	2319	755
ENST00000366542	CEP170	chr1	243349081	-	ENST00000366540	AKT3	chr1	243736350	-	2344	1618	52	2319	755
ENST00000366542	CEP170	chr1	243349081	-	ENST00000366539	AKT3	chr1	243736350	-	5848	1618	52	2361	769
ENST00000366542	CEP170	chr1	243349081	-	ENST00000263826	AKT3	chr1	243736350	-	4429	1618	52	2361	769
ENST00000366542	CEP170	chr1	243349561	-	ENST00000336199	AKT3	chr1	243736350	-	2250	1324	52	2025	657
ENST00000366542	CEP170	chr1	243349561	-	ENST00000366540	AKT3	chr1	243736350	-	2050	1324	52	2025	657
ENST00000366542	CEP170	chr1	243349561	-	ENST00000366539	AKT3	chr1	243736350	-	5554	1324	52	2067	671
ENST00000366542	CEP170	chr1	243349561	-	ENST00000263826	AKT3	chr1	243736350	-	4135	1324	52	2067	671
ENST00000366543	CEP170	chr1	243349561	-	ENST00000336199	AKT3	chr1	243736350	-	2521	1595	323	2296	657
ENST00000366543	CEP170	chr1	243349561	-	ENST00000366540	AKT3	chr1	243736350	-	2321	1595	323	2296	657
ENST00000366543	CEP170	chr1	243349561	-	ENST00000366539	AKT3	chr1	243736350	-	5825	1595	323	2338	671
ENST00000366543	CEP170	chr1	243349561	-	ENST00000263826	AKT3	chr1	243736350	-	4406	1595	323	2338	671
ENST00000366544	CEP170	chr1	243349561	-	ENST00000336199	AKT3	chr1	243736350	-	2521	1595	323	2296	657
ENST00000366544	CEP170	chr1	243349561	-	ENST00000366540	AKT3	chr1	243736350	-	2321	1595	323	2296	657
ENST00000366544	CEP170	chr1	243349561	-	ENST00000366539	AKT3	chr1	243736350	-	5825	1595	323	2338	671
ENST00000366544	CEP170	chr1	243349561	-	ENST00000263826	AKT3	chr1	243736350	-	4406	1595	323	2338	671

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000366542	ENST00000336199	CEP170	chr1	243349081	-	AKT3	chr1	243736350	-	0.001934246	0.99806577
ENST00000366542	ENST00000366540	CEP170	chr1	243349081	-	AKT3	chr1	243736350	-	0.001972313	0.9980276
ENST00000366542	ENST00000366539	CEP170	chr1	243349081	-	AKT3	chr1	243736350	-	0.000872663	0.9991273
ENST00000366542	ENST00000263826	CEP170	chr1	243349081	-	AKT3	chr1	243736350	-	0.001261099	0.99873894
ENST00000366542	ENST00000336199	CEP170	chr1	243349561	-	AKT3	chr1	243736350	-	0.003175723	0.99682426
ENST00000366542	ENST00000366540	CEP170	chr1	243349561	-	AKT3	chr1	243736350	-	0.003301474	0.99669844
ENST00000366542	ENST00000366539	CEP170	chr1	243349561	-	AKT3	chr1	243736350	-	0.001301687	0.99869823
ENST00000366542	ENST00000263826	CEP170	chr1	243349561	-	AKT3	chr1	243736350	-	0.001952877	0.9980471
ENST00000366543	ENST00000336199	CEP170	chr1	243349561	-	AKT3	chr1	243736350	-	0.003209028	0.99679095
ENST00000366543	ENST00000366540	CEP170	chr1	243349561	-	AKT3	chr1	243736350	-	0.003247565	0.9967525
ENST00000366543	ENST00000366539	CEP170	chr1	243349561	-	AKT3	chr1	243736350	-	0.001282341	0.99871767
ENST00000366543	ENST00000263826	CEP170	chr1	243349561	-	AKT3	chr1	243736350	-	0.001965827	0.9980342
ENST00000366544	ENST00000336199	CEP170	chr1	243349561	-	AKT3	chr1	243736350	-	0.003209028	0.99679095
ENST00000366544	ENST00000366540	CEP170	chr1	243349561	-	AKT3	chr1	243736350	-	0.003247565	0.9967525
ENST00000366544	ENST00000366539	CEP170	chr1	243349561	-	AKT3	chr1	243736350	-	0.001282341	0.99871767
ENST00000366544	ENST00000263826	CEP170	chr1	243349561	-	AKT3	chr1	243736350	-	0.001965827	0.9980342

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15794_15794_1_CEP170-AKT3_CEP170_chr1_243349081_ENST00000366542_AKT3_chr1_243736350_ENST00000263826_length(amino acids)=769AA_BP=522
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS
VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKLFFHLSRERVFSEDRTRF
YGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM
CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSET

--------------------------------------------------------------

>15794_15794_2_CEP170-AKT3_CEP170_chr1_243349081_ENST00000366542_AKT3_chr1_243736350_ENST00000336199_length(amino acids)=755AA_BP=522
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS
VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKLFFHLSRERVFSEDRTRF
YGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM
CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSET

--------------------------------------------------------------

>15794_15794_3_CEP170-AKT3_CEP170_chr1_243349081_ENST00000366542_AKT3_chr1_243736350_ENST00000366539_length(amino acids)=769AA_BP=522
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS
VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKLFFHLSRERVFSEDRTRF
YGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM
CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSET

--------------------------------------------------------------

>15794_15794_4_CEP170-AKT3_CEP170_chr1_243349081_ENST00000366542_AKT3_chr1_243736350_ENST00000366540_length(amino acids)=755AA_BP=522
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS
VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKLFFHLSRERVFSEDRTRF
YGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM
CGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSET

--------------------------------------------------------------

>15794_15794_5_CEP170-AKT3_CEP170_chr1_243349561_ENST00000366542_AKT3_chr1_243736350_ENST00000263826_length(amino acids)=671AA_BP=424
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVLFFHLSRERVFSEDRTRFYGAEIVSA
LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN
QDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEE

--------------------------------------------------------------

>15794_15794_6_CEP170-AKT3_CEP170_chr1_243349561_ENST00000366542_AKT3_chr1_243736350_ENST00000336199_length(amino acids)=657AA_BP=424
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVLFFHLSRERVFSEDRTRFYGAEIVSA
LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN
QDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEE

--------------------------------------------------------------

>15794_15794_7_CEP170-AKT3_CEP170_chr1_243349561_ENST00000366542_AKT3_chr1_243736350_ENST00000366539_length(amino acids)=671AA_BP=424
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVLFFHLSRERVFSEDRTRFYGAEIVSA
LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN
QDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEE

--------------------------------------------------------------

>15794_15794_8_CEP170-AKT3_CEP170_chr1_243349561_ENST00000366542_AKT3_chr1_243736350_ENST00000366540_length(amino acids)=657AA_BP=424
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVLFFHLSRERVFSEDRTRFYGAEIVSA
LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN
QDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEE

--------------------------------------------------------------

>15794_15794_9_CEP170-AKT3_CEP170_chr1_243349561_ENST00000366543_AKT3_chr1_243736350_ENST00000263826_length(amino acids)=671AA_BP=424
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVLFFHLSRERVFSEDRTRFYGAEIVSA
LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN
QDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEE

--------------------------------------------------------------

>15794_15794_10_CEP170-AKT3_CEP170_chr1_243349561_ENST00000366543_AKT3_chr1_243736350_ENST00000336199_length(amino acids)=657AA_BP=424
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVLFFHLSRERVFSEDRTRFYGAEIVSA
LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN
QDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEE

--------------------------------------------------------------

>15794_15794_11_CEP170-AKT3_CEP170_chr1_243349561_ENST00000366543_AKT3_chr1_243736350_ENST00000366539_length(amino acids)=671AA_BP=424
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVLFFHLSRERVFSEDRTRFYGAEIVSA
LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN
QDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEE

--------------------------------------------------------------

>15794_15794_12_CEP170-AKT3_CEP170_chr1_243349561_ENST00000366543_AKT3_chr1_243736350_ENST00000366540_length(amino acids)=657AA_BP=424
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVLFFHLSRERVFSEDRTRFYGAEIVSA
LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN
QDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEE

--------------------------------------------------------------

>15794_15794_13_CEP170-AKT3_CEP170_chr1_243349561_ENST00000366544_AKT3_chr1_243736350_ENST00000263826_length(amino acids)=671AA_BP=424
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVLFFHLSRERVFSEDRTRFYGAEIVSA
LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN
QDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEE

--------------------------------------------------------------

>15794_15794_14_CEP170-AKT3_CEP170_chr1_243349561_ENST00000366544_AKT3_chr1_243736350_ENST00000336199_length(amino acids)=657AA_BP=424
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVLFFHLSRERVFSEDRTRFYGAEIVSA
LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN
QDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEE

--------------------------------------------------------------

>15794_15794_15_CEP170-AKT3_CEP170_chr1_243349561_ENST00000366544_AKT3_chr1_243736350_ENST00000366539_length(amino acids)=671AA_BP=424
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVLFFHLSRERVFSEDRTRFYGAEIVSA
LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN
QDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEE

--------------------------------------------------------------

>15794_15794_16_CEP170-AKT3_CEP170_chr1_243349561_ENST00000366544_AKT3_chr1_243736350_ENST00000366540_length(amino acids)=657AA_BP=424
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVLFFHLSRERVFSEDRTRFYGAEIVSA
LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN
QDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:243349081/chr1:243736350)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CEP170 Q9Y4F5	AKT3 Q9Y243
FUNCTION: Plays a role in microtubule organization. {ECO:0000250\|UniProtKB:Q5SW79}.	FUNCTION: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269\|PubMed:18524868, ECO:0000269\|PubMed:21191416}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CEP170

chr1:243349081

chr1:243736350

ENST00000366542

23_73

522.0

1585.0

Domain

FHA

Hgene

CEP170

chr1:243349561

chr1:243736350

ENST00000366542

23_73

424.0

1585.0

Domain

FHA

Hgene

CEP170

chr1:243349561

chr1:243736350

ENST00000366543

23_73

424.0

1461.0

Domain

FHA

Hgene

CEP170

chr1:243349561

chr1:243736350

ENST00000366544

23_73

424.0

1487.0

Domain

FHA

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000263826

406_479

232.0

480.0

Domain

AGC-kinase C-terminal

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000336199

406_479

232.0

476.0

Domain

AGC-kinase C-terminal

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000366539

406_479

232.0

480.0

Domain

AGC-kinase C-terminal

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000366540

406_479

232.0

466.0

Domain

AGC-kinase C-terminal

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000263826

406_479

232.0

480.0

Domain

AGC-kinase C-terminal

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000336199

406_479

232.0

476.0

Domain

AGC-kinase C-terminal

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000366539

406_479

232.0

480.0

Domain

AGC-kinase C-terminal

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000366540

406_479

232.0

466.0

Domain

AGC-kinase C-terminal

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CEP170

chr1:243349081

chr1:243736350

ENST00000366542

1467_1495

522.0

1585.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP170

chr1:243349081

chr1:243736350

ENST00000366543

1467_1495

1461.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP170

chr1:243349081

chr1:243736350

ENST00000366544

1467_1495

1487.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP170

chr1:243349561

chr1:243736350

ENST00000366542

1467_1495

424.0

1585.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP170

chr1:243349561

chr1:243736350

ENST00000366543

1467_1495

424.0

1461.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP170

chr1:243349561

chr1:243736350

ENST00000366544

1467_1495

424.0

1487.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP170

chr1:243349081

chr1:243736350

ENST00000366543

23_73

1461.0

Domain

FHA

Hgene

CEP170

chr1:243349081

chr1:243736350

ENST00000366544

23_73

1487.0

Domain

FHA

Hgene

CEP170

chr1:243349081

chr1:243736350

ENST00000366542

1113_1584

522.0

1585.0

Region

Note=Targeting to centrosomes

Hgene

CEP170

chr1:243349081

chr1:243736350

ENST00000366542

853_1584

522.0

1585.0

Region

Note=Targeting to microtubules

Hgene

CEP170

chr1:243349081

chr1:243736350

ENST00000366543

1113_1584

1461.0

Region

Note=Targeting to centrosomes

Hgene

CEP170

chr1:243349081

chr1:243736350

ENST00000366543

853_1584

1461.0

Region

Note=Targeting to microtubules

Hgene

CEP170

chr1:243349081

chr1:243736350

ENST00000366544

1113_1584

1487.0

Region

Note=Targeting to centrosomes

Hgene

CEP170

chr1:243349081

chr1:243736350

ENST00000366544

853_1584

1487.0

Region

Note=Targeting to microtubules

Hgene

CEP170

chr1:243349561

chr1:243736350

ENST00000366542

1113_1584

424.0

1585.0

Region

Note=Targeting to centrosomes

Hgene

CEP170

chr1:243349561

chr1:243736350

ENST00000366542

853_1584

424.0

1585.0

Region

Note=Targeting to microtubules

Hgene

CEP170

chr1:243349561

chr1:243736350

ENST00000366543

1113_1584

424.0

1461.0

Region

Note=Targeting to centrosomes

Hgene

CEP170

chr1:243349561

chr1:243736350

ENST00000366543

853_1584

424.0

1461.0

Region

Note=Targeting to microtubules

Hgene

CEP170

chr1:243349561

chr1:243736350

ENST00000366544

1113_1584

424.0

1487.0

Region

Note=Targeting to centrosomes

Hgene

CEP170

chr1:243349561

chr1:243736350

ENST00000366544

853_1584

424.0

1487.0

Region

Note=Targeting to microtubules

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000263826

148_405

232.0

480.0

Domain

Protein kinase

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000263826

5_107

232.0

480.0

Domain

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000336199

148_405

232.0

476.0

Domain

Protein kinase

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000336199

5_107

232.0

476.0

Domain

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000366539

148_405

232.0

480.0

Domain

Protein kinase

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000366539

5_107

232.0

480.0

Domain

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000366540

148_405

232.0

466.0

Domain

Protein kinase

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000366540

5_107

232.0

466.0

Domain

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000263826

148_405

232.0

480.0

Domain

Protein kinase

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000263826

5_107

232.0

480.0

Domain

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000336199

148_405

232.0

476.0

Domain

Protein kinase

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000336199

5_107

232.0

476.0

Domain

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000366539

148_405

232.0

480.0

Domain

Protein kinase

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000366539

5_107

232.0

480.0

Domain

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000366540

148_405

232.0

466.0

Domain

Protein kinase

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000366540

5_107

232.0

466.0

Domain

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000263826

154_162

232.0

480.0

Nucleotide binding

ATP

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000336199

154_162

232.0

476.0

Nucleotide binding

ATP

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000366539

154_162

232.0

480.0

Nucleotide binding

ATP

Tgene

AKT3

chr1:243349081

chr1:243736350

ENST00000366540

154_162

232.0

466.0

Nucleotide binding

ATP

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000263826

154_162

232.0

480.0

Nucleotide binding

ATP

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000336199

154_162

232.0

476.0

Nucleotide binding

ATP

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000366539

154_162

232.0

480.0

Nucleotide binding

ATP

Tgene

AKT3

chr1:243349561

chr1:243736350

ENST00000366540

154_162

232.0

466.0

Nucleotide binding

ATP

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CEP170
AKT3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CEP170	chr1:243349081	chr1:243736350	ENST00000366542	-	10	20	1015_1460	522.0	1585.0	CCDC61
Hgene	CEP170	chr1:243349081	chr1:243736350	ENST00000366543	-	1	19	1015_1460	0	1461.0	CCDC61
Hgene	CEP170	chr1:243349081	chr1:243736350	ENST00000366544	-	1	19	1015_1460	0	1487.0	CCDC61
Hgene	CEP170	chr1:243349561	chr1:243736350	ENST00000366542	-	9	20	1015_1460	424.0	1585.0	CCDC61
Hgene	CEP170	chr1:243349561	chr1:243736350	ENST00000366543	-	9	19	1015_1460	424.0	1461.0	CCDC61
Hgene	CEP170	chr1:243349561	chr1:243736350	ENST00000366544	-	9	19	1015_1460	424.0	1487.0	CCDC61

Top

Related Drugs to CEP170-AKT3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CEP170-AKT3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source