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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CIC-ZFP57

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CIC-ZFP57
FusionPDB ID: 16804
FusionGDB2.0 ID: 16804
HgeneTgene
Gene symbol

CIC

ZFP57

Gene ID

23152

346171

Gene namecapicua transcriptional repressorZFP57 zinc finger protein
SynonymsMRD45C6orf40|TNDM1|ZNF698|bA145L22|bA145L22.2
Cytomap

19q13.2

6p22.1

Type of geneprotein-codingprotein-coding
Descriptionprotein capicua homologzinc finger protein 57 homologzfp-57zinc finger protein 698
Modification date2020031320200327
UniProtAcc

Q96RK0

.
Ensembl transtripts involved in fusion geneENST idsENST00000160740, ENST00000572681, 
ENST00000575354, ENST00000575839, 
ENST00000376881, ENST00000376883, 
ENST00000383628, ENST00000416974, 
ENST00000432222, ENST00000435906, 
ENST00000437216, ENST00000446005, 
ENST00000448114, ENST00000488757, 
ENST00000547542, ENST00000547911, 
ENST00000548001, ENST00000548337, 
ENST00000548574, ENST00000548769, 
ENST00000549167, ENST00000549312, 
ENST00000549501, ENST00000552809, 
ENST00000552898, ENST00000552987, 
ENST00000553137, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 12 X 6=9362 X 3 X 2=12
# samples 122
** MAII scorelog2(12/936*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CIC [Title/Abstract] AND ZFP57 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CIC(42791392)-ZFP57(29641535), # samples:2
Anticipated loss of major functional domain due to fusion event.CIC-ZFP57 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CIC-ZFP57 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CIC-ZFP57 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CIC-ZFP57 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CIC-ZFP57 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CIC-ZFP57 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CIC-ZFP57 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
CIC-ZFP57 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CIC-ZFP57 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CIC-ZFP57 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CIC-ZFP57 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CIC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZFP57 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1F0-01ACICchr19

42791392

-ZFP57chr6

29641535

-
ChimerDB4BRCATCGA-BH-A1F0-01ACICchr19

42791392

+ZFP57chr6

29641535

-
ChimerDB4BRCATCGA-BH-A1F0-01ACICchr19

42791392

+ZFP57chr6_cox_hap2

1160337

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000572681CICchr1942791392+ENST00000376881ZFP57chr629641535-461432476832951075
ENST00000572681CICchr1942791392+ENST00000376883ZFP57chr629641535-452332476832951075
ENST00000160740CICchr1942791392+ENST00000376881ZFP57chr629641535-250411378302395521
ENST00000160740CICchr1942791392+ENST00000376883ZFP57chr629641535-241311378302395521
ENST00000575354CICchr1942791392+ENST00000376881ZFP57chr629641535-18594921851750521
ENST00000575354CICchr1942791392+ENST00000376883ZFP57chr629641535-17684921851750521

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000572681ENST00000376881CICchr1942791392+ZFP57chr629641535-0.0037374360.9962625
ENST00000572681ENST00000376883CICchr1942791392+ZFP57chr629641535-0.0041275810.99587244
ENST00000160740ENST00000376881CICchr1942791392+ZFP57chr629641535-0.128885140.87111485
ENST00000160740ENST00000376883CICchr1942791392+ZFP57chr629641535-0.137219520.8627805
ENST00000575354ENST00000376881CICchr1942791392+ZFP57chr629641535-0.144912330.85508764
ENST00000575354ENST00000376883CICchr1942791392+ZFP57chr629641535-0.160950630.8390494

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>16804_16804_1_CIC-ZFP57_CIC_chr19_42791392_ENST00000160740_ZFP57_chr6_29641535_ENST00000376881_length(amino acids)=521AA_BP=103
MTPPCSRARPSNLPATQWPPTRAKNLLSRQLLLMNGHQVGQGVLTLSGPLEPHALRAQDPDPHTLWGWWNLVRVRLPPRRRRPPAPQESP
GWTVRQRVTMMMQGKKKELREQHPSLRDEGTSDDKVFLACRGAGQCPLSAPAGTMDRTRVLQASQAGPPFFCYTCGKCFSRRSYLYSHQF
VHNPKLTNSCSQCGKLFRSPKSLSYHRRMHLGERPFCCTLCDKTYCDASGLSRHRRVHLGYRPHSCSVCGKSFRDQSELKRHQKIHQNQE
PVDGNQECTLRIPGTQAEFQTPIARSQRSIQGLLDVNHAPVARSQEPIFRTEGPMAQNQASVLKNQAPVTRTQAPITGTLCQDARSNSHP
VKPSRLNVFCCPHCSLTFSKKSYLSRHQKAHLTEPPNYCFHCSKSFSSFSRLVRHQQTHWKQKSYLCPICDLSFGEKEGLMDHWRGYKGK

--------------------------------------------------------------

>16804_16804_2_CIC-ZFP57_CIC_chr19_42791392_ENST00000160740_ZFP57_chr6_29641535_ENST00000376883_length(amino acids)=521AA_BP=103
MTPPCSRARPSNLPATQWPPTRAKNLLSRQLLLMNGHQVGQGVLTLSGPLEPHALRAQDPDPHTLWGWWNLVRVRLPPRRRRPPAPQESP
GWTVRQRVTMMMQGKKKELREQHPSLRDEGTSDDKVFLACRGAGQCPLSAPAGTMDRTRVLQASQAGPPFFCYTCGKCFSRRSYLYSHQF
VHNPKLTNSCSQCGKLFRSPKSLSYHRRMHLGERPFCCTLCDKTYCDASGLSRHRRVHLGYRPHSCSVCGKSFRDQSELKRHQKIHQNQE
PVDGNQECTLRIPGTQAEFQTPIARSQRSIQGLLDVNHAPVARSQEPIFRTEGPMAQNQASVLKNQAPVTRTQAPITGTLCQDARSNSHP
VKPSRLNVFCCPHCSLTFSKKSYLSRHQKAHLTEPPNYCFHCSKSFSSFSRLVRHQQTHWKQKSYLCPICDLSFGEKEGLMDHWRGYKGK

--------------------------------------------------------------

>16804_16804_3_CIC-ZFP57_CIC_chr19_42791392_ENST00000572681_ZFP57_chr6_29641535_ENST00000376881_length(amino acids)=1075AA_BP=1060
MKPMKKACTGLSGPGSGSKSPPATRAKALRRRGAGEGDKPEEEDDEAQQPQPQSGPEEAEEGEEEEAERGPGAEGPPLELHPGDPAPGPA
EDPKGDGEAGRWEPSLSRKTATFKSRAPKKKYVEEHGAGSSGVAGAPEERVRTPEEASGLGVPPRPPTSTRSSSTDTASEHSADLEDEPA
EACGPGPWPPGSTSGSYDLRQLRSQRVLARRGDGLFLPAVVRQVRRSQDLGVQFPGDRALTFYEGVPGAGVDVVLDATPPPGALVVGTAV
CTCVEPGVAAYREGVVVEVATKPAAYKVRLSPGPSSQPGLPGSLPQPPQPLHREPEEAVWVARSSLRLLRPPWEPETMLRKPPTGPEEEQ
AEPGATLPPCPAALDPKQPEDAEVSKISFGGNLGTHCEEGEEKHPPALGTPALLPLPPPQLLSPPPKSPAFVGPGRPGEQPSPCQEGSQG
GSRSSSVASLEKGTAPAARARTPLTAAQQKYKKGDVVCTPSGIRKKFNGKQWRRLCSRDGCMKESQRRGYCSRHLSMRTKEMEGLADSGP
GGAGRPAAVAAREGSTEFDWGDETSRDSEASSVAARGDSRPRLVAPADLSRFEFDECEAAVMLVSLGSSRSGTPSFSPVSTQSPFSPAPS
PSPSPLFGFRPANFSPINASPVIQRTAVRSRHLSASTPKAGVLTPPDLGPHPPPPAPRERHSSGILPTFQTNLTFTVPISPGRRKTELLP
HPGALGAPGAGGGGAAPDFPKSDSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQPSPLLLLPPPAGLTSDPGPSVRRVPAVQRDSP
VIVRNPDVPLPSKFPGEVGTAGEVRAGGPGRGCRETPVPPGVASGKPGLPPPLPAPVPITVPPAAPTAVAQPMPAFGLASSPFQPVAFHP
SPAALLPVLVPSSYTSHPAPKKEVIMGRPGTVWTNVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQQPASHPVASNQSKEPAESAAVA

--------------------------------------------------------------

>16804_16804_4_CIC-ZFP57_CIC_chr19_42791392_ENST00000572681_ZFP57_chr6_29641535_ENST00000376883_length(amino acids)=1075AA_BP=1060
MKPMKKACTGLSGPGSGSKSPPATRAKALRRRGAGEGDKPEEEDDEAQQPQPQSGPEEAEEGEEEEAERGPGAEGPPLELHPGDPAPGPA
EDPKGDGEAGRWEPSLSRKTATFKSRAPKKKYVEEHGAGSSGVAGAPEERVRTPEEASGLGVPPRPPTSTRSSSTDTASEHSADLEDEPA
EACGPGPWPPGSTSGSYDLRQLRSQRVLARRGDGLFLPAVVRQVRRSQDLGVQFPGDRALTFYEGVPGAGVDVVLDATPPPGALVVGTAV
CTCVEPGVAAYREGVVVEVATKPAAYKVRLSPGPSSQPGLPGSLPQPPQPLHREPEEAVWVARSSLRLLRPPWEPETMLRKPPTGPEEEQ
AEPGATLPPCPAALDPKQPEDAEVSKISFGGNLGTHCEEGEEKHPPALGTPALLPLPPPQLLSPPPKSPAFVGPGRPGEQPSPCQEGSQG
GSRSSSVASLEKGTAPAARARTPLTAAQQKYKKGDVVCTPSGIRKKFNGKQWRRLCSRDGCMKESQRRGYCSRHLSMRTKEMEGLADSGP
GGAGRPAAVAAREGSTEFDWGDETSRDSEASSVAARGDSRPRLVAPADLSRFEFDECEAAVMLVSLGSSRSGTPSFSPVSTQSPFSPAPS
PSPSPLFGFRPANFSPINASPVIQRTAVRSRHLSASTPKAGVLTPPDLGPHPPPPAPRERHSSGILPTFQTNLTFTVPISPGRRKTELLP
HPGALGAPGAGGGGAAPDFPKSDSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQPSPLLLLPPPAGLTSDPGPSVRRVPAVQRDSP
VIVRNPDVPLPSKFPGEVGTAGEVRAGGPGRGCRETPVPPGVASGKPGLPPPLPAPVPITVPPAAPTAVAQPMPAFGLASSPFQPVAFHP
SPAALLPVLVPSSYTSHPAPKKEVIMGRPGTVWTNVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQQPASHPVASNQSKEPAESAAVA

--------------------------------------------------------------

>16804_16804_5_CIC-ZFP57_CIC_chr19_42791392_ENST00000575354_ZFP57_chr6_29641535_ENST00000376881_length(amino acids)=521AA_BP=103
MTPPCSRARPSNLPATQWPPTRAKNLLSRQLLLMNGHQVGQGVLTLSGPLEPHALRAQDPDPHTLWGWWNLVRVRLPPRRRRPPAPQESP
GWTVRQRVTMMMQGKKKELREQHPSLRDEGTSDDKVFLACRGAGQCPLSAPAGTMDRTRVLQASQAGPPFFCYTCGKCFSRRSYLYSHQF
VHNPKLTNSCSQCGKLFRSPKSLSYHRRMHLGERPFCCTLCDKTYCDASGLSRHRRVHLGYRPHSCSVCGKSFRDQSELKRHQKIHQNQE
PVDGNQECTLRIPGTQAEFQTPIARSQRSIQGLLDVNHAPVARSQEPIFRTEGPMAQNQASVLKNQAPVTRTQAPITGTLCQDARSNSHP
VKPSRLNVFCCPHCSLTFSKKSYLSRHQKAHLTEPPNYCFHCSKSFSSFSRLVRHQQTHWKQKSYLCPICDLSFGEKEGLMDHWRGYKGK

--------------------------------------------------------------

>16804_16804_6_CIC-ZFP57_CIC_chr19_42791392_ENST00000575354_ZFP57_chr6_29641535_ENST00000376883_length(amino acids)=521AA_BP=103
MTPPCSRARPSNLPATQWPPTRAKNLLSRQLLLMNGHQVGQGVLTLSGPLEPHALRAQDPDPHTLWGWWNLVRVRLPPRRRRPPAPQESP
GWTVRQRVTMMMQGKKKELREQHPSLRDEGTSDDKVFLACRGAGQCPLSAPAGTMDRTRVLQASQAGPPFFCYTCGKCFSRRSYLYSHQF
VHNPKLTNSCSQCGKLFRSPKSLSYHRRMHLGERPFCCTLCDKTYCDASGLSRHRRVHLGYRPHSCSVCGKSFRDQSELKRHQKIHQNQE
PVDGNQECTLRIPGTQAEFQTPIARSQRSIQGLLDVNHAPVARSQEPIFRTEGPMAQNQASVLKNQAPVTRTQAPITGTLCQDARSNSHP
VKPSRLNVFCCPHCSLTFSKKSYLSRHQKAHLTEPPNYCFHCSKSFSSFSRLVRHQQTHWKQKSYLCPICDLSFGEKEGLMDHWRGYKGK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:42791392/chr6:29641535)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CIC

Q96RK0

.
FUNCTION: Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. {ECO:0000250|UniProtKB:Q924A2}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCICchr19:42791392chr6:29641535ENST00000575354+32042_138150.666666666666661609.0Compositional biasNote=Pro-rich
TgeneZFP57chr19:42791392chr6:29641535ENST000003836280616_880517.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000004169740616_880517.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000004359060616_880517.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000004372160616_880517.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000004460050616_880517.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000004481140616_880517.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000005475420516_880.0517.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000005480010516_880.0517.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000005483370416_880537.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000005485740416_880537.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000005487690416_880537.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000005491670416_880537.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000005493120516_880.0517.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000005495010516_880.0517.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000005528090416_880537.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000005528980516_880.0517.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000005529870516_880.0517.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000005531370416_880537.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST0000037688135119_14197.33333333333333517.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000037688135147_16997.33333333333333517.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000037688135175_19797.33333333333333517.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000037688135300_32297.33333333333333517.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000037688135328_35097.33333333333333517.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000037688135356_37897.33333333333333517.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST0000037688346119_14197.33333333333333517.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000037688346147_16997.33333333333333517.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000037688346175_19797.33333333333333517.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000037688346300_32297.33333333333333517.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000037688346328_35097.33333333333333517.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000037688346356_37897.33333333333333517.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST0000038362806119_1410517.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000038362806147_1690517.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000038362806175_1970517.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000038362806300_3220517.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000038362806328_3500517.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000038362806356_3780517.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000003836280691_1130517.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000041697406119_1410517.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000041697406147_1690517.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000041697406175_1970517.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000041697406300_3220517.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000041697406328_3500517.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000041697406356_3780517.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000004169740691_1130517.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000043590606119_1410517.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000043590606147_1690517.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000043590606175_1970517.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000043590606300_3220517.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000043590606328_3500517.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000043590606356_3780517.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000004359060691_1130517.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000043721606119_1410517.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000043721606147_1690517.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000043721606175_1970517.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000043721606300_3220517.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000043721606328_3500517.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000043721606356_3780517.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000004372160691_1130517.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000044600506119_1410517.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000044600506147_1690517.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000044600506175_1970517.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000044600506300_3220517.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000044600506328_3500517.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000044600506356_3780517.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000004460050691_1130517.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000044811406119_1410517.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000044811406147_1690517.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000044811406175_1970517.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000044811406300_3220517.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000044811406328_3500517.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000044811406356_3780517.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000004481140691_1130517.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000048875724119_141117.33333333333333537.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000048875724147_169117.33333333333333537.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000048875724175_197117.33333333333333537.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000048875724300_322117.33333333333333537.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000048875724328_350117.33333333333333537.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000048875724356_378117.33333333333333537.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST0000054754205119_1410.0517.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000054754205147_1690.0517.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000054754205175_1970.0517.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000054754205300_3220.0517.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000054754205328_3500.0517.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000054754205356_3780.0517.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000005475420591_1130.0517.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000054800105119_1410.0517.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000054800105147_1690.0517.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000054800105175_1970.0517.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000054800105300_3220.0517.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000054800105328_3500.0517.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000054800105356_3780.0517.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000005480010591_1130.0517.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000054833704119_1410537.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000054833704147_1690537.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000054833704175_1970537.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000054833704300_3220537.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000054833704328_3500537.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000054833704356_3780537.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000005483370491_1130537.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000054857404119_1410537.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000054857404147_1690537.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000054857404175_1970537.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000054857404300_3220537.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000054857404328_3500537.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000054857404356_3780537.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000005485740491_1130537.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000054876904119_1410537.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000054876904147_1690537.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000054876904175_1970537.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000054876904300_3220537.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000054876904328_3500537.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000054876904356_3780537.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000005487690491_1130537.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000054916704119_1410537.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000054916704147_1690537.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000054916704175_1970537.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000054916704300_3220537.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000054916704328_3500537.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000054916704356_3780537.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000005491670491_1130537.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000054931205119_1410.0517.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000054931205147_1690.0517.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000054931205175_1970.0517.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000054931205300_3220.0517.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000054931205328_3500.0517.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000054931205356_3780.0517.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000005493120591_1130.0517.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000054950105119_1410.0517.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000054950105147_1690.0517.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000054950105175_1970.0517.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000054950105300_3220.0517.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000054950105328_3500.0517.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000054950105356_3780.0517.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000005495010591_1130.0517.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000055280904119_1410537.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000055280904147_1690537.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000055280904175_1970537.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000055280904300_3220537.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000055280904328_3500537.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000055280904356_3780537.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000005528090491_1130537.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000055289805119_1410.0517.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000055289805147_1690.0517.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000055289805175_1970.0517.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000055289805300_3220.0517.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000055289805328_3500.0517.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000055289805356_3780.0517.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000005528980591_1130.0517.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000055298705119_1410.0517.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000055298705147_1690.0517.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000055298705175_1970.0517.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000055298705300_3220.0517.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000055298705328_3500.0517.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000055298705356_3780.0517.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000005529870591_1130.0517.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST0000055313704119_1410537.0Zinc fingerC2H2-type 2
TgeneZFP57chr19:42791392chr6:29641535ENST0000055313704147_1690537.0Zinc fingerC2H2-type 3
TgeneZFP57chr19:42791392chr6:29641535ENST0000055313704175_1970537.0Zinc fingerC2H2-type 4
TgeneZFP57chr19:42791392chr6:29641535ENST0000055313704300_3220537.0Zinc fingerC2H2-type 5
TgeneZFP57chr19:42791392chr6:29641535ENST0000055313704328_3500537.0Zinc fingerC2H2-type 6
TgeneZFP57chr19:42791392chr6:29641535ENST0000055313704356_3780537.0Zinc fingerC2H2-type 7%3B degenerate
TgeneZFP57chr19:42791392chr6:29641535ENST000005531370491_1130537.0Zinc fingerC2H2-type 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCICchr19:42791392chr6:29641535ENST00000575354+3201524_1601150.666666666666661609.0Compositional biasNote=Pro-rich
HgeneCICchr19:42791392chr6:29641535ENST00000575354+320508_1303150.666666666666661609.0Compositional biasNote=Pro-rich
HgeneCICchr19:42791392chr6:29641535ENST00000575354+320200_268150.666666666666661609.0DNA bindingHMG box
TgeneZFP57chr19:42791392chr6:29641535ENST000003768813516_8897.33333333333333517.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000003768834616_8897.33333333333333517.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000004887572416_88117.33333333333333537.0DomainKRAB
TgeneZFP57chr19:42791392chr6:29641535ENST000003768813591_11397.33333333333333517.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST000003768834691_11397.33333333333333517.0Zinc fingerC2H2-type 1
TgeneZFP57chr19:42791392chr6:29641535ENST000004887572491_113117.33333333333333537.0Zinc fingerC2H2-type 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
CICNFYC, CSNK2B, PLK1, GABPB1, GTPBP3, TRIM22, ZNRD1, ATXN1, SETD2, SEC62, CENPJ, PICK1, PYCR2, NTRK1, EWSR1, Ppp2ca, Cep78, FOXK2, EYA2, ZBTB18, ESR2, SOX2, GOLGA2, KIAA1429, ACTC1, ACLY, HIST1H4A, RAD50, ESR1, SUPT5H, EGFR, FOXK1, SIN3A, HSPA8, PRKDC, HSPA9, HSPA1A, HSPA1B, HSPA5, SATB2, ARID4B, MGA, PRMT5, SAP130, SIN3B, BRMS1L, SUDS3, HSPA2, HDAC1, DCAF7, RBBP7, YWHAQ, SATB1, ARID4A, YWHAE, ATXN1L, HDAC2, DYRK1A, RCC2, NFATC1, NFATC2, DYRK1B, HNRNPK, WDR77, SLC25A5, FAM60A, LMNB1, CUX1, EEF1A1, HNRNPU, SF3B3, VIM, HNRNPH1, CHD4, HNRNPF, SAP30, SF3B1, IRS4, SLC25A6, MTA1, YWHAZ, RIOK1, RPSA, RBBP4, ING2, MYBBP1A, PRDX1, RAE1, XRCC6, RUVBL1, PRPF31, HSPH1, PPP2R1A, E2F7, NFIA, RUVBL2, PBX1, DDX17, RIF1, YWHAG, RBMX, NFIX, SNRNP200, USP7, SF3B2, ZNF687, MYO5B, ORC2, NFIB, TMPO, SUN2, FOXC1, NKX2-4, NFIC, ING1, GTF2I, PBX2, CBX3, ZNF646, YWHAB, IRF2BP1, JAK1, RPS3, EEF2, SAP30L, XRCC5, MATR3, KPNB1, CLNS1A, EFTUD2, RBM10, NKX2-5, PTBP1, RPS8, USP11, HUWE1, HOXA10, ZMYND8, RBM17, BRMS1, ZBTB39, HOXA13, KHDRBS1, DHX15, HOXC13, CHD7, E2F6, TRIM28, HOXD13, HIST1H2BK, EIF3I, U2SURP, EIF4B, EPPK1, TFCP2, ZNF629, STK38, MTA2, RAD54L2, SIX1, NFATC3, RPS5, TP53, TFAP4, NPM1, ANXA2, YWHAH, FBL, UBC, FARP1, SFPQ, RPS11, KDM1A, RFC1, TARDBP, WDR5, CDK1, LMNB2, THRAP3, SF3A1, U2AF2, ZDBF2, KPNA3, EBF3, RB1, LIN9, DNAJA1, SMC1A, L3MBTL2, PAXIP1, TMEM201, PCBP2, MAZ, TFDP1, PFKFB3, MBD3, NONO, HNRNPC, KPNA4, IKZF5, RPS2, KPNA2, ADNP, CCNB1, NFAT5, MBD1, PIAS2, ZBTB33, RPS4X, RNF2, HNRNPM, CSTF1, ATF1, LIN54, PFKP, SLC25A3, BCLAF1, RUNX3, EPB41L3, PRDX4, GTF3C5, GTF3C3, GTF3C1, UBP1, RBM39, HNRNPH2, POLR2A, PAX6, SMARCC1, PGAM5, DNAJA2, RPS20, ALB, DDX5, STK38L, SMARCA4, CAPZB, HNRNPL, GATAD2A, PRDX2, USF1, DHX37, RBPJ, DPM1, PITX2, JUN, INTS3, ZNF24, LRWD1, TIMM50, ZNF384, DDX39A, NR2F2, RPS6, PPP1CC, OTUD4, RING1, HSPA4L, ZBTB24, IK, SNRPD3, RFC4, CBX5, TPX2, GNB2L1, TAOK2, PCBP1, HOXA5, RPS16, FLG2, RPS23, LDB1, CEBPA, SLC25A11, EMD, SMARCA5, CHERP, CAD, DDX3X, EIF4A1, KRT73, NFATC4, SPIN1, ZNF740, RANBP2, RPS15A, LSM14A, TCERG1, EYA4, HOXA11, CHD8, PITX1, LLGL1, AURKB, LMNA, DCD, SRP14, TRPS1, SMCHD1, SF3A3, RPS14, ESRRA, PHF3, TAF4, HMBOX1, RFC5, MLXIPL, SNW1, TRIM21, BAG2, RPS9, ACTL6A, XRN2, ZFP64, ARNT, DSP, RTCB, RPS3A, ZNF362, FARSA, HOXD11, AURKA, RPS24, CEBPB, CHAF1B, SUMO2, PBX3, ASUN, TMEM33, USF2, NUP205, SLC25A1, TUFM, RCOR1, RPS7, POLE, ZFHX4, LIG3, YTHDF2, GATAD2B, RBFOX3, PRPF8, MCM3, SPTBN1, PPP2R2A, EIF3B, ZBTB44, ZIC5, HLTF, RPN1, CSNK2A1, CREB1, MPG, ZBTB21, ATP1A1, CHTOP, RPL4, OTX1, TGIF2, MSL2, EEF1G, TAF1, EHMT1, HIC2, ORC3, GTF3C2, ZNF326, STUB1, DCLK1, WIZ, RALY, RPL23, PRPF19, EIF3E, ZBTB10, H3F3C, NR2F1, SF3B6, BUB3, SCRIB, PPP1CA, SLC25A10, ORC5, TP53BP1, CDC5L, ACTN1, EIF3H, ZMYM2, SEC24C, GAR1, HOXB9, TEAD1, RFC3, PPP3CC, MTA3, HIST4H4, HIST2H4B, HIST1H4I, HIST1H4D, HIST1H4F, HIST1H4K, HIST1H4J, HIST1H4C, HIST1H4H, HIST1H4B, HIST1H4E, HIST1H4L, HIST2H4A, SRSF6, SNRPB, CTPS1, POLR3A, COPS3, THOC3, SMAD4, ADD1, SMAD3, GTF3C4, PELO, RAD21, RPS18, HSP90AB1, PDLIM5, GATA6, PRPF6, BEND3, ZNF865, EIF3G, PRDX6, NDFIP1, LRRC41, SMC3, INTS5, CEBPD, LIMA1, SALL1, RUNX2, CCDC88C, PPP6C, SNTB2, ACIN1, CTBP1, HOXC9, ZFHX3, ZBTB9, CREB5, NPM3, DDX50, C5orf24, SUPT16H, BCL11B, SLC3A2, POLR2B, SKI, NOM1, SF3A2, DDX21, TRMT2A, PDCD11, CPVL, PTS, RPL27, NUP85, SMU1, RPS15, TRIP6, PDK3, CMAS, CCAR1, INTS1, SON, THOC2, ZNF189, JUP, MAPK3, RPS19, KPNA1, NR2E1, SRRT, EVPLL, ARHGAP22, BANP, GART, ZSCAN29, CHAMP1, ZBTB43, APOBEC3C, TP73, MAP7D1, CORO1C, DHX9, EHMT2, SNRPD1, RREB1, HGS, ATF7, PCGF6, SIM2, SRSF3, DNAJC7, EIF3A, SDHA, RPLP0, CSK, HCFC1, EIF3F, DDX1, RUNX1, ZIC2, EIF3D, PAX3, YY1, BAZ1A, CCT3, DNAJA3, MAPK14, PNMA2, PDS5A, SSRP1, SERPINB3, PDCD2L, ZNF446, FLII, PKM, NUP155, ATP5A1, HSP90AA1, ACAP2, RANGAP1, POLD1, MORC2, NUP107, RFX1, PARP1, EPB41, DDB1, POGZ, ZNF148, HRNR, SFSWAP, NOP58, NR2C2, NVL, IVNS1ABP, AKAP8L, PDIA6, LRRC47, CAT, SRBD1, PSMB2, LARP1, TBX2, LMX1B, CCT2, DPF2, CAPZA1, VWA9, PPP2CB, GPR75-ASB3, ASB3, POLR3E, PAF1, ZNF592, GTPBP1, FOXD2, SEC61B, ZBTB17, CTCF, RB1CC1, KIFC1, ACTR1A, ZBED4, EPB41L2, PHF12, TFAM, WDR34, TAF5, CDIPT, YTHDC2, TSR1, SNX9, KRT80, TONSL, ZKSCAN8, BHLHE41, SYNCRIP, CHEK2, BAZ2A, SLC1A5, ZBTB7A, GMPS, SEC13, NOL6, RPS12, CLTC, SLC16A1, FLNA, EP400, TTF2, NUP160, EIF3C, CCAR2, SIX4, WRNIP1, CCT8, CNP, GATA3, RPS17, NR3C1, CD3EAP, TERF2IP, TRIM25, NAA40, S100P, MAD2L1, SRC, T, ELF4, ELK3, ERG, FEV, FOS, FOXL1, FOXQ1, GATA2, GCM1, EN1, HNF1A, HNF1B, HNF4A, IRF4, IRF8, KLF12, KLF15, KLF3, KLF5, KLF8, LHX2, LHX3, LHX4, LHX6, MYB, PAX2, PAX7, PAX8, PAX9, PRDM1, SOX10, SOX15, SOX17, SOX5, SOX6, SOX9, SP7, TBR1, TLX1, TLX2, TLX3, VSX1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CICall structure
ZFP57


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CIC-ZFP57


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CIC-ZFP57


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCICC4539848MENTAL RETARDATION, AUTOSOMAL DOMINANT 453GENOMICS_ENGLAND;UNIPROT
HgeneCICC0020796Profound Mental Retardation2CTD_human
HgeneCICC0025363Mental Retardation, Psychosocial2CTD_human
HgeneCICC0917816Mental deficiency2CTD_human
HgeneCICC3714756Intellectual Disability2CTD_human
HgeneCICC0027627Neoplasm Metastasis1CTD_human
HgeneCICC0041671Attention Deficit Disorder1CTD_human
HgeneCICC0087012Ataxia, Spinocerebellar1CTD_human
HgeneCICC0752120Spinocerebellar Ataxia Type 11CTD_human
HgeneCICC0752121Spinocerebellar Ataxia Type 21CTD_human
HgeneCICC0752122Spinocerebellar Ataxia Type 41CTD_human
HgeneCICC0752123Spinocerebellar Ataxia Type 51CTD_human
HgeneCICC0752124Spinocerebellar Ataxia Type 6 (disorder)1CTD_human
HgeneCICC0752125Spinocerebellar Ataxia Type 71CTD_human
HgeneCICC1263846Attention deficit hyperactivity disorder1CTD_human
HgeneCICC1321905Minimal Brain Dysfunction1CTD_human
HgeneCICC1510586Autism Spectrum Disorders1CTD_human