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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CLPB-PTPN1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CLPB-PTPN1
FusionPDB ID: 17294
FusionGDB2.0 ID: 17294
HgeneTgene
Gene symbol

CLPB

PTPN1

Gene ID

81570

5770

Gene namecaseinolytic mitochondrial matrix peptidase chaperone subunit Bprotein tyrosine phosphatase non-receptor type 1
SynonymsANKCLB|HSP78|MEGCANN|MGCA7|SKD3PTP1B
Cytomap

11q13.4

20q13.13

Type of geneprotein-codingprotein-coding
Descriptioncaseinolytic peptidase B protein homologClpB caseinolytic peptidase B homologClpB homolog, mitochondrial AAA ATPase chaperoninankyrin-repeat containing bacterial clp fusionsuppressor of potassium transport defect 3testicular secretory protein Li 11tyrosine-protein phosphatase non-receptor type 1protein tyrosine phosphatase, placentalprotein-tyrosine phosphatase 1B
Modification date2020031320200329
UniProtAcc

Q9H078

Q99952

Ensembl transtripts involved in fusion geneENST idsENST00000294053, ENST00000340729, 
ENST00000437826, ENST00000538039, 
ENST00000543042, ENST00000445069, 
ENST00000538021, ENST00000542555, 
ENST00000371621, ENST00000541713, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 12 X 7=142814 X 14 X 5=980
# samples 1819
** MAII scorelog2(18/1428*10)=-2.98792716769943
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/980*10)=-2.36678233067162
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CLPB [Title/Abstract] AND PTPN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CLPB(72040751)-PTPN1(49191054), # samples:3
Anticipated loss of major functional domain due to fusion event.CLPB-PTPN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLPB-PTPN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLPB-PTPN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CLPB-PTPN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLPB

GO:0034605

cellular response to heat

2745427

TgenePTPN1

GO:0030100

regulation of endocytosis

21135139

TgenePTPN1

GO:0030968

endoplasmic reticulum unfolded protein response

22169477

TgenePTPN1

GO:0035335

peptidyl-tyrosine dephosphorylation

21135139

TgenePTPN1

GO:0061098

positive regulation of protein tyrosine kinase activity

21216966

TgenePTPN1

GO:1903898

negative regulation of PERK-mediated unfolded protein response

21216966


check buttonFusion gene breakpoints across CLPB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTPN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0HL-01ACLPBchr11

72040751

-PTPN1chr20

49191054

+
ChimerDB4BRCATCGA-BH-A0HLCLPBchr11

72040750

-PTPN1chr20

49191053

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000294053CLPBchr1172040751-ENST00000371621PTPN1chr2049191054+413811371742090638
ENST00000294053CLPBchr1172040751-ENST00000541713PTPN1chr2049191054+236111371742090638
ENST00000538039CLPBchr1172040751-ENST00000371621PTPN1chr2049191054+39979961231949608
ENST00000538039CLPBchr1172040751-ENST00000541713PTPN1chr2049191054+22209961231949608
ENST00000437826CLPBchr1172040751-ENST00000371621PTPN1chr2049191054+39799781501931593
ENST00000437826CLPBchr1172040751-ENST00000541713PTPN1chr2049191054+22029781501931593
ENST00000340729CLPBchr1172040751-ENST00000371621PTPN1chr2049191054+3847846601799579
ENST00000340729CLPBchr1172040751-ENST00000541713PTPN1chr2049191054+2070846601799579
ENST00000543042CLPBchr1172040751-ENST00000371621PTPN1chr2049191054+39159143321867511
ENST00000543042CLPBchr1172040751-ENST00000541713PTPN1chr2049191054+21389143321867511
ENST00000294053CLPBchr1172040750-ENST00000371621PTPN1chr2049191053+413811371742090638
ENST00000294053CLPBchr1172040750-ENST00000541713PTPN1chr2049191053+236111371742090638
ENST00000538039CLPBchr1172040750-ENST00000371621PTPN1chr2049191053+39979961231949608
ENST00000538039CLPBchr1172040750-ENST00000541713PTPN1chr2049191053+22209961231949608
ENST00000437826CLPBchr1172040750-ENST00000371621PTPN1chr2049191053+39799781501931593
ENST00000437826CLPBchr1172040750-ENST00000541713PTPN1chr2049191053+22029781501931593
ENST00000340729CLPBchr1172040750-ENST00000371621PTPN1chr2049191053+3847846601799579
ENST00000340729CLPBchr1172040750-ENST00000541713PTPN1chr2049191053+2070846601799579
ENST00000543042CLPBchr1172040750-ENST00000371621PTPN1chr2049191053+39159143321867511
ENST00000543042CLPBchr1172040750-ENST00000541713PTPN1chr2049191053+21389143321867511

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000294053ENST00000371621CLPBchr1172040751-PTPN1chr2049191054+0.0023579080.9976421
ENST00000294053ENST00000541713CLPBchr1172040751-PTPN1chr2049191054+0.0063291860.9936708
ENST00000538039ENST00000371621CLPBchr1172040751-PTPN1chr2049191054+0.0014657250.9985343
ENST00000538039ENST00000541713CLPBchr1172040751-PTPN1chr2049191054+0.0041985080.9958015
ENST00000437826ENST00000371621CLPBchr1172040751-PTPN1chr2049191054+0.0039552650.99604475
ENST00000437826ENST00000541713CLPBchr1172040751-PTPN1chr2049191054+0.0118282930.98817164
ENST00000340729ENST00000371621CLPBchr1172040751-PTPN1chr2049191054+0.0025540860.99744594
ENST00000340729ENST00000541713CLPBchr1172040751-PTPN1chr2049191054+0.0064856630.9935143
ENST00000543042ENST00000371621CLPBchr1172040751-PTPN1chr2049191054+0.000710320.99928963
ENST00000543042ENST00000541713CLPBchr1172040751-PTPN1chr2049191054+0.0015487410.99845123
ENST00000294053ENST00000371621CLPBchr1172040750-PTPN1chr2049191053+0.0023579080.9976421
ENST00000294053ENST00000541713CLPBchr1172040750-PTPN1chr2049191053+0.0063291860.9936708
ENST00000538039ENST00000371621CLPBchr1172040750-PTPN1chr2049191053+0.0014657250.9985343
ENST00000538039ENST00000541713CLPBchr1172040750-PTPN1chr2049191053+0.0041985080.9958015
ENST00000437826ENST00000371621CLPBchr1172040750-PTPN1chr2049191053+0.0039552650.99604475
ENST00000437826ENST00000541713CLPBchr1172040750-PTPN1chr2049191053+0.0118282930.98817164
ENST00000340729ENST00000371621CLPBchr1172040750-PTPN1chr2049191053+0.0025540860.99744594
ENST00000340729ENST00000541713CLPBchr1172040750-PTPN1chr2049191053+0.0064856630.9935143
ENST00000543042ENST00000371621CLPBchr1172040750-PTPN1chr2049191053+0.000710320.99928963
ENST00000543042ENST00000541713CLPBchr1172040750-PTPN1chr2049191053+0.0015487410.99845123

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>17294_17294_1_CLPB-PTPN1_CLPB_chr11_72040750_ENST00000294053_PTPN1_chr20_49191053_ENST00000371621_length(amino acids)=638AA_BP=321
MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSPALFSGRGAATGGRQGGRFDTKCLAAATWGR
LPGPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNN
SVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTAL
HYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQ
LELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIK
KVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEE
TQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCY

--------------------------------------------------------------

>17294_17294_2_CLPB-PTPN1_CLPB_chr11_72040750_ENST00000294053_PTPN1_chr20_49191053_ENST00000541713_length(amino acids)=638AA_BP=321
MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSPALFSGRGAATGGRQGGRFDTKCLAAATWGR
LPGPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNN
SVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTAL
HYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQ
LELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIK
KVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEE
TQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCY

--------------------------------------------------------------

>17294_17294_3_CLPB-PTPN1_CLPB_chr11_72040750_ENST00000340729_PTPN1_chr20_49191053_ENST00000371621_length(amino acids)=579AA_BP=262
MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSPALFSGRGAATGGRQGGRFDTKCLAAATWGR
LPGPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSSVVQVLLAAGADPNLGDDFSSVYKTAKEQ
GIHSLEVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRTSEAKLKCAQYWP
QKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCS
AGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHI
PPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPE

--------------------------------------------------------------

>17294_17294_4_CLPB-PTPN1_CLPB_chr11_72040750_ENST00000340729_PTPN1_chr20_49191053_ENST00000541713_length(amino acids)=579AA_BP=262
MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSPALFSGRGAATGGRQGGRFDTKCLAAATWGR
LPGPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSSVVQVLLAAGADPNLGDDFSSVYKTAKEQ
GIHSLEVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRTSEAKLKCAQYWP
QKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCS
AGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHI
PPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPE

--------------------------------------------------------------

>17294_17294_5_CLPB-PTPN1_CLPB_chr11_72040750_ENST00000437826_PTPN1_chr20_49191053_ENST00000371621_length(amino acids)=593AA_BP=276
MPRGCHLGTPSWSRRNTPRTGQLERGPQQGRTGHVRPGRSAGGSLLQQESVQQGCSPVGSCPCQQYARSQQPQETAKNDAQSRSWAGLNA
GVSLKNTKISSSEWPLRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRH
ITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLL
RTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESG
SLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWK
ELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGA

--------------------------------------------------------------

>17294_17294_6_CLPB-PTPN1_CLPB_chr11_72040750_ENST00000437826_PTPN1_chr20_49191053_ENST00000541713_length(amino acids)=593AA_BP=276
MPRGCHLGTPSWSRRNTPRTGQLERGPQQGRTGHVRPGRSAGGSLLQQESVQQGCSPVGSCPCQQYARSQQPQETAKNDAQSRSWAGLNA
GVSLKNTKISSSEWPLRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRH
ITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLL
RTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESG
SLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWK
ELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGA

--------------------------------------------------------------

>17294_17294_7_CLPB-PTPN1_CLPB_chr11_72040750_ENST00000538039_PTPN1_chr20_49191053_ENST00000371621_length(amino acids)=608AA_BP=291
MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSPALFSGRGAATGGRQGGRFDTKCLAAATWGR
LPGPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNN
SVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGH
TPLDYAREGEVMKLLRTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPES
PASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEG
AKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQD

--------------------------------------------------------------

>17294_17294_8_CLPB-PTPN1_CLPB_chr11_72040750_ENST00000538039_PTPN1_chr20_49191053_ENST00000541713_length(amino acids)=608AA_BP=291
MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSPALFSGRGAATGGRQGGRFDTKCLAAATWGR
LPGPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNN
SVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGH
TPLDYAREGEVMKLLRTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPES
PASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEG
AKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQD

--------------------------------------------------------------

>17294_17294_9_CLPB-PTPN1_CLPB_chr11_72040750_ENST00000543042_PTPN1_chr20_49191053_ENST00000371621_length(amino acids)=511AA_BP=194
MEHRRPCSPDVGQPPGGAREDASIPNASRLPLGDAFLVPKKHSQDRTAGTGSPAGPDWACADVNAKHRLGWTALMVAAINRNNSVVQVLL
AAGADPNLGDDFSSVYKTAKEQGIHSLEVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAR
EGEVMKLLRTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNF
LFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGD
SSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRV

--------------------------------------------------------------

>17294_17294_10_CLPB-PTPN1_CLPB_chr11_72040750_ENST00000543042_PTPN1_chr20_49191053_ENST00000541713_length(amino acids)=511AA_BP=194
MEHRRPCSPDVGQPPGGAREDASIPNASRLPLGDAFLVPKKHSQDRTAGTGSPAGPDWACADVNAKHRLGWTALMVAAINRNNSVVQVLL
AAGADPNLGDDFSSVYKTAKEQGIHSLEVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAR
EGEVMKLLRTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNF
LFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGD
SSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRV

--------------------------------------------------------------

>17294_17294_11_CLPB-PTPN1_CLPB_chr11_72040751_ENST00000294053_PTPN1_chr20_49191054_ENST00000371621_length(amino acids)=638AA_BP=321
MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSPALFSGRGAATGGRQGGRFDTKCLAAATWGR
LPGPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNN
SVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTAL
HYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQ
LELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIK
KVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEE
TQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCY

--------------------------------------------------------------

>17294_17294_12_CLPB-PTPN1_CLPB_chr11_72040751_ENST00000294053_PTPN1_chr20_49191054_ENST00000541713_length(amino acids)=638AA_BP=321
MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSPALFSGRGAATGGRQGGRFDTKCLAAATWGR
LPGPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNN
SVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTAL
HYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQ
LELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIK
KVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEE
TQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCY

--------------------------------------------------------------

>17294_17294_13_CLPB-PTPN1_CLPB_chr11_72040751_ENST00000340729_PTPN1_chr20_49191054_ENST00000371621_length(amino acids)=579AA_BP=262
MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSPALFSGRGAATGGRQGGRFDTKCLAAATWGR
LPGPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSSVVQVLLAAGADPNLGDDFSSVYKTAKEQ
GIHSLEVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRTSEAKLKCAQYWP
QKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCS
AGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHI
PPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPE

--------------------------------------------------------------

>17294_17294_14_CLPB-PTPN1_CLPB_chr11_72040751_ENST00000340729_PTPN1_chr20_49191054_ENST00000541713_length(amino acids)=579AA_BP=262
MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSPALFSGRGAATGGRQGGRFDTKCLAAATWGR
LPGPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSSVVQVLLAAGADPNLGDDFSSVYKTAKEQ
GIHSLEVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRTSEAKLKCAQYWP
QKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCS
AGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHI
PPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPE

--------------------------------------------------------------

>17294_17294_15_CLPB-PTPN1_CLPB_chr11_72040751_ENST00000437826_PTPN1_chr20_49191054_ENST00000371621_length(amino acids)=593AA_BP=276
MPRGCHLGTPSWSRRNTPRTGQLERGPQQGRTGHVRPGRSAGGSLLQQESVQQGCSPVGSCPCQQYARSQQPQETAKNDAQSRSWAGLNA
GVSLKNTKISSSEWPLRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRH
ITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLL
RTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESG
SLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWK
ELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGA

--------------------------------------------------------------

>17294_17294_16_CLPB-PTPN1_CLPB_chr11_72040751_ENST00000437826_PTPN1_chr20_49191054_ENST00000541713_length(amino acids)=593AA_BP=276
MPRGCHLGTPSWSRRNTPRTGQLERGPQQGRTGHVRPGRSAGGSLLQQESVQQGCSPVGSCPCQQYARSQQPQETAKNDAQSRSWAGLNA
GVSLKNTKISSSEWPLRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEDGGQDGASRH
ITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLL
RTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESG
SLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWK
ELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGA

--------------------------------------------------------------

>17294_17294_17_CLPB-PTPN1_CLPB_chr11_72040751_ENST00000538039_PTPN1_chr20_49191054_ENST00000371621_length(amino acids)=608AA_BP=291
MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSPALFSGRGAATGGRQGGRFDTKCLAAATWGR
LPGPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNN
SVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGH
TPLDYAREGEVMKLLRTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPES
PASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEG
AKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQD

--------------------------------------------------------------

>17294_17294_18_CLPB-PTPN1_CLPB_chr11_72040751_ENST00000538039_PTPN1_chr20_49191054_ENST00000541713_length(amino acids)=608AA_BP=291
MLGSLVLRRKALAPRLLLRLLRSPTLRGHGGASGRNVTTGSLGEPQWLRVATGGRPGTSPALFSGRGAATGGRQGGRFDTKCLAAATWGR
LPGPEETLPGQDSWNGVPSRAGLGMCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNN
SVVQVLLAAGADPNLGDDFSSVYKTAKEQGIHSLEVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGH
TPLDYAREGEVMKLLRTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPES
PASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEG
AKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQD

--------------------------------------------------------------

>17294_17294_19_CLPB-PTPN1_CLPB_chr11_72040751_ENST00000543042_PTPN1_chr20_49191054_ENST00000371621_length(amino acids)=511AA_BP=194
MEHRRPCSPDVGQPPGGAREDASIPNASRLPLGDAFLVPKKHSQDRTAGTGSPAGPDWACADVNAKHRLGWTALMVAAINRNNSVVQVLL
AAGADPNLGDDFSSVYKTAKEQGIHSLEVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAR
EGEVMKLLRTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNF
LFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGD
SSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRV

--------------------------------------------------------------

>17294_17294_20_CLPB-PTPN1_CLPB_chr11_72040751_ENST00000543042_PTPN1_chr20_49191054_ENST00000541713_length(amino acids)=511AA_BP=194
MEHRRPCSPDVGQPPGGAREDASIPNASRLPLGDAFLVPKKHSQDRTAGTGSPAGPDWACADVNAKHRLGWTALMVAAINRNNSVVQVLL
AAGADPNLGDDFSSVYKTAKEQGIHSLEVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDYAR
EGEVMKLLRTSEAKLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNF
LFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGD
SSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:72040751/chr20:49191054)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLPB

Q9H078

PTPN1

Q99952

FUNCTION: May function as a regulatory ATPase and be related to secretion/protein trafficking process. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6 (PubMed:31522117). {ECO:0000269|PubMed:31522117}.FUNCTION: Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLPBchr11:72040750chr20:49191053ENST00000294053-717133_162321.0708.0RepeatNote=ANK 1
HgeneCLPBchr11:72040750chr20:49191053ENST00000294053-717166_195321.0708.0RepeatNote=ANK 2
HgeneCLPBchr11:72040750chr20:49191053ENST00000294053-717265_295321.0708.0RepeatNote=ANK 3
HgeneCLPBchr11:72040750chr20:49191053ENST00000340729-515133_162262.0649.0RepeatNote=ANK 1
HgeneCLPBchr11:72040750chr20:49191053ENST00000340729-515166_195262.0649.0RepeatNote=ANK 2
HgeneCLPBchr11:72040750chr20:49191053ENST00000437826-818133_162276.0663.0RepeatNote=ANK 1
HgeneCLPBchr11:72040750chr20:49191053ENST00000437826-818166_195276.0663.0RepeatNote=ANK 2
HgeneCLPBchr11:72040750chr20:49191053ENST00000538039-616133_162291.0678.0RepeatNote=ANK 1
HgeneCLPBchr11:72040750chr20:49191053ENST00000538039-616166_195291.0678.0RepeatNote=ANK 2
HgeneCLPBchr11:72040751chr20:49191054ENST00000294053-717133_162321.0708.0RepeatNote=ANK 1
HgeneCLPBchr11:72040751chr20:49191054ENST00000294053-717166_195321.0708.0RepeatNote=ANK 2
HgeneCLPBchr11:72040751chr20:49191054ENST00000294053-717265_295321.0708.0RepeatNote=ANK 3
HgeneCLPBchr11:72040751chr20:49191054ENST00000340729-515133_162262.0649.0RepeatNote=ANK 1
HgeneCLPBchr11:72040751chr20:49191054ENST00000340729-515166_195262.0649.0RepeatNote=ANK 2
HgeneCLPBchr11:72040751chr20:49191054ENST00000437826-818133_162276.0663.0RepeatNote=ANK 1
HgeneCLPBchr11:72040751chr20:49191054ENST00000437826-818166_195276.0663.0RepeatNote=ANK 2
HgeneCLPBchr11:72040751chr20:49191054ENST00000538039-616133_162291.0678.0RepeatNote=ANK 1
HgeneCLPBchr11:72040751chr20:49191054ENST00000538039-616166_195291.0678.0RepeatNote=ANK 2
TgenePTPN1chr11:72040750chr20:49191053ENST00000371621310215_221118.0436.0RegionSubstrate binding
TgenePTPN1chr11:72040751chr20:49191054ENST00000371621310215_221118.0436.0RegionSubstrate binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLPBchr11:72040750chr20:49191053ENST00000294053-717381_388321.0708.0Nucleotide bindingATP
HgeneCLPBchr11:72040750chr20:49191053ENST00000340729-515381_388262.0649.0Nucleotide bindingATP
HgeneCLPBchr11:72040750chr20:49191053ENST00000437826-818381_388276.0663.0Nucleotide bindingATP
HgeneCLPBchr11:72040750chr20:49191053ENST00000538039-616381_388291.0678.0Nucleotide bindingATP
HgeneCLPBchr11:72040751chr20:49191054ENST00000294053-717381_388321.0708.0Nucleotide bindingATP
HgeneCLPBchr11:72040751chr20:49191054ENST00000340729-515381_388262.0649.0Nucleotide bindingATP
HgeneCLPBchr11:72040751chr20:49191054ENST00000437826-818381_388276.0663.0Nucleotide bindingATP
HgeneCLPBchr11:72040751chr20:49191054ENST00000538039-616381_388291.0678.0Nucleotide bindingATP
HgeneCLPBchr11:72040750chr20:49191053ENST00000294053-717298_327321.0708.0RepeatNote=ANK 4
HgeneCLPBchr11:72040750chr20:49191053ENST00000340729-515265_295262.0649.0RepeatNote=ANK 3
HgeneCLPBchr11:72040750chr20:49191053ENST00000340729-515298_327262.0649.0RepeatNote=ANK 4
HgeneCLPBchr11:72040750chr20:49191053ENST00000437826-818265_295276.0663.0RepeatNote=ANK 3
HgeneCLPBchr11:72040750chr20:49191053ENST00000437826-818298_327276.0663.0RepeatNote=ANK 4
HgeneCLPBchr11:72040750chr20:49191053ENST00000538039-616265_295291.0678.0RepeatNote=ANK 3
HgeneCLPBchr11:72040750chr20:49191053ENST00000538039-616298_327291.0678.0RepeatNote=ANK 4
HgeneCLPBchr11:72040751chr20:49191054ENST00000294053-717298_327321.0708.0RepeatNote=ANK 4
HgeneCLPBchr11:72040751chr20:49191054ENST00000340729-515265_295262.0649.0RepeatNote=ANK 3
HgeneCLPBchr11:72040751chr20:49191054ENST00000340729-515298_327262.0649.0RepeatNote=ANK 4
HgeneCLPBchr11:72040751chr20:49191054ENST00000437826-818265_295276.0663.0RepeatNote=ANK 3
HgeneCLPBchr11:72040751chr20:49191054ENST00000437826-818298_327276.0663.0RepeatNote=ANK 4
HgeneCLPBchr11:72040751chr20:49191054ENST00000538039-616265_295291.0678.0RepeatNote=ANK 3
HgeneCLPBchr11:72040751chr20:49191054ENST00000538039-616298_327291.0678.0RepeatNote=ANK 4
TgenePTPN1chr11:72040750chr20:49191053ENST000003716213103_277118.0436.0DomainTyrosine-protein phosphatase
TgenePTPN1chr11:72040751chr20:49191054ENST000003716213103_277118.0436.0DomainTyrosine-protein phosphatase


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CLPB
PTPN1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CLPB-PTPN1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CLPB-PTPN1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource