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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CNST-RGS7

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CNST-RGS7
	FusionPDB ID: 17853
	FusionGDB2.0 ID: 17853
		Hgene	Tgene
	Gene symbol	CNST	RGS7
	Gene ID	163882	6000
	Gene name	consortin, connexin sorting protein	regulator of G protein signaling 7
	Synonyms	C1orf71\|PPP1R64	-
	Cytomap	1q44	1q43\|1q23.1
	Type of gene	protein-coding	protein-coding
	Description	consortinprotein phosphatase 1, regulatory subunit 64	regulator of G-protein signaling 7regulator of G-protein signaling RGS7regulator of G-protein signalling 7
	Modification date	20200327	20200313
	UniProtAcc	Q6PJW8	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000483271, ENST00000366512, ENST00000366513,	ENST00000331110, ENST00000348120, ENST00000366562, ENST00000366563, ENST00000366564, ENST00000366565, ENST00000401882, ENST00000407727, ENST00000446183,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 6 X 8=384	13 X 11 X 8=1144
	# samples	11	14
	** MAII score	log2(11/384*10)=-1.8036027871965 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/1144*10)=-3.03058831983342 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CNST [Title/Abstract] AND RGS7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CNST(246811339)-RGS7(240990472), # samples:3
Anticipated loss of major functional domain due to fusion event.	CNST-RGS7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CNST-RGS7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CNST-RGS7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CNST-RGS7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CNST-RGS7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CNST-RGS7 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. CNST-RGS7 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CNST	GO:0010923	negative regulation of phosphatase activity	19389623
Tgene	RGS7	GO:0043547	positive regulation of GTPase activity	10521509

Fusion gene breakpoints across CNST (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RGS7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-HT-8108-01A	CNST	chr1	246811339	-	RGS7	chr1	240990472	-
ChimerDB4	LGG	TCGA-HT-8108-01A	CNST	chr1	246811339	+	RGS7	chr1	240990472	-
ChimerDB4	LGG	TCGA-HT-8108	CNST	chr1	246811339	+	RGS7	chr1	240990472	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000366513	CNST	chr1	246811339	+	ENST00000331110	RGS7	chr1	240990472	-	2961	2105	164	2929	921
ENST00000366513	CNST	chr1	246811339	+	ENST00000348120	RGS7	chr1	240990472	-	3635	2105	164	2929	921
ENST00000366513	CNST	chr1	246811339	+	ENST00000366563	RGS7	chr1	240990472	-	3635	2105	164	2929	921
ENST00000366513	CNST	chr1	246811339	+	ENST00000366564	RGS7	chr1	240990472	-	3554	2105	164	2905	913
ENST00000366513	CNST	chr1	246811339	+	ENST00000366565	RGS7	chr1	240990472	-	3608	2105	164	2959	931
ENST00000366513	CNST	chr1	246811339	+	ENST00000446183	RGS7	chr1	240990472	-	3490	2105	164	2929	921
ENST00000366513	CNST	chr1	246811339	+	ENST00000366562	RGS7	chr1	240990472	-	2906	2105	164	2905	914
ENST00000366513	CNST	chr1	246811339	+	ENST00000401882	RGS7	chr1	240990472	-	2930	2105	164	2929	922
ENST00000366513	CNST	chr1	246811339	+	ENST00000407727	RGS7	chr1	240990472	-	2984	2105	164	2983	940

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000366513	ENST00000331110	CNST	chr1	246811339	+	RGS7	chr1	240990472	-	0.0024722	0.9975278
ENST00000366513	ENST00000348120	CNST	chr1	246811339	+	RGS7	chr1	240990472	-	0.001173861	0.9988261
ENST00000366513	ENST00000366563	CNST	chr1	246811339	+	RGS7	chr1	240990472	-	0.001173861	0.9988261
ENST00000366513	ENST00000366564	CNST	chr1	246811339	+	RGS7	chr1	240990472	-	0.001304543	0.99869543
ENST00000366513	ENST00000366565	CNST	chr1	246811339	+	RGS7	chr1	240990472	-	0.001109431	0.9988906
ENST00000366513	ENST00000446183	CNST	chr1	246811339	+	RGS7	chr1	240990472	-	0.001510664	0.99848926
ENST00000366513	ENST00000366562	CNST	chr1	246811339	+	RGS7	chr1	240990472	-	0.002603383	0.9973966
ENST00000366513	ENST00000401882	CNST	chr1	246811339	+	RGS7	chr1	240990472	-	0.002521821	0.9974782
ENST00000366513	ENST00000407727	CNST	chr1	246811339	+	RGS7	chr1	240990472	-	0.002157568	0.99784243

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>17853_17853_1_CNST-RGS7_CNST_chr1_246811339_ENST00000366513_RGS7_chr1_240990472_ENST00000331110_length(amino acids)=921AA_BP=647
METDPAPSGSPPCASDSQTWKVFNVTLNGSPKDALMDDSDTPTYYLQIEPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSD
SAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLGKDKKIPGKRSPRSKKGTAKKIPPGLFSGDIAPLMQEKVLSAV
TYAVDDEEAAEVNANEQPEAPKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWE
TKWKTVQPHTVTALRNSEKGFNGEDFERLTKICATHQDPLLSKHKIAAVEKSQERKCSTQLLVSEDPKEGGATTKESESKTCLGTESSKE
SQHTVEPLGSSPCCHQMDVQTDSPSLSVTAGKDHMEELLCSAEATLALHTQSSETAGSPSGPDSSEDACEDDSRLQLAQTEACQDVARIE
GIAEDPKVFLSSKSKTEPLISPGCDRIPPALISEGKYSQAQRKELRLPLRDASEALPTDQLENNELNELQQPDLTDSDGKSPQAQADSDG
SENVLCGNNQISDLGILLPEVCMAPEEKGDKDDQLNKETEDYLNSLLEGCLKDTEDSLSYEDNQDDDSDLLQDLSPEEASYSLQENLPSD
ESCLSLDDLAKRIEIAEPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKM
SKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAV
EDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGRN

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>17853_17853_2_CNST-RGS7_CNST_chr1_246811339_ENST00000366513_RGS7_chr1_240990472_ENST00000348120_length(amino acids)=921AA_BP=647
METDPAPSGSPPCASDSQTWKVFNVTLNGSPKDALMDDSDTPTYYLQIEPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSD
SAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLGKDKKIPGKRSPRSKKGTAKKIPPGLFSGDIAPLMQEKVLSAV
TYAVDDEEAAEVNANEQPEAPKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWE
TKWKTVQPHTVTALRNSEKGFNGEDFERLTKICATHQDPLLSKHKIAAVEKSQERKCSTQLLVSEDPKEGGATTKESESKTCLGTESSKE
SQHTVEPLGSSPCCHQMDVQTDSPSLSVTAGKDHMEELLCSAEATLALHTQSSETAGSPSGPDSSEDACEDDSRLQLAQTEACQDVARIE
GIAEDPKVFLSSKSKTEPLISPGCDRIPPALISEGKYSQAQRKELRLPLRDASEALPTDQLENNELNELQQPDLTDSDGKSPQAQADSDG
SENVLCGNNQISDLGILLPEVCMAPEEKGDKDDQLNKETEDYLNSLLEGCLKDTEDSLSYEDNQDDDSDLLQDLSPEEASYSLQENLPSD
ESCLSLDDLAKRIEIAEPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKM
SKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAV
EDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGRN

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>17853_17853_3_CNST-RGS7_CNST_chr1_246811339_ENST00000366513_RGS7_chr1_240990472_ENST00000366562_length(amino acids)=914AA_BP=647
METDPAPSGSPPCASDSQTWKVFNVTLNGSPKDALMDDSDTPTYYLQIEPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSD
SAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLGKDKKIPGKRSPRSKKGTAKKIPPGLFSGDIAPLMQEKVLSAV
TYAVDDEEAAEVNANEQPEAPKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWE
TKWKTVQPHTVTALRNSEKGFNGEDFERLTKICATHQDPLLSKHKIAAVEKSQERKCSTQLLVSEDPKEGGATTKESESKTCLGTESSKE
SQHTVEPLGSSPCCHQMDVQTDSPSLSVTAGKDHMEELLCSAEATLALHTQSSETAGSPSGPDSSEDACEDDSRLQLAQTEACQDVARIE
GIAEDPKVFLSSKSKTEPLISPGCDRIPPALISEGKYSQAQRKELRLPLRDASEALPTDQLENNELNELQQPDLTDSDGKSPQAQADSDG
SENVLCGNNQISDLGILLPEVCMAPEEKGDKDDQLNKETEDYLNSLLEGCLKDTEDSLSYEDNQDDDSDLLQDLSPEEASYSLQENLPSD
ESCLSLDDLAKRIEIAEPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKM
SKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAV
EDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGKS

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>17853_17853_4_CNST-RGS7_CNST_chr1_246811339_ENST00000366513_RGS7_chr1_240990472_ENST00000366563_length(amino acids)=921AA_BP=647
METDPAPSGSPPCASDSQTWKVFNVTLNGSPKDALMDDSDTPTYYLQIEPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSD
SAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLGKDKKIPGKRSPRSKKGTAKKIPPGLFSGDIAPLMQEKVLSAV
TYAVDDEEAAEVNANEQPEAPKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWE
TKWKTVQPHTVTALRNSEKGFNGEDFERLTKICATHQDPLLSKHKIAAVEKSQERKCSTQLLVSEDPKEGGATTKESESKTCLGTESSKE
SQHTVEPLGSSPCCHQMDVQTDSPSLSVTAGKDHMEELLCSAEATLALHTQSSETAGSPSGPDSSEDACEDDSRLQLAQTEACQDVARIE
GIAEDPKVFLSSKSKTEPLISPGCDRIPPALISEGKYSQAQRKELRLPLRDASEALPTDQLENNELNELQQPDLTDSDGKSPQAQADSDG
SENVLCGNNQISDLGILLPEVCMAPEEKGDKDDQLNKETEDYLNSLLEGCLKDTEDSLSYEDNQDDDSDLLQDLSPEEASYSLQENLPSD
ESCLSLDDLAKRIEIAEPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKM
SKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAV
EDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGRN

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>17853_17853_5_CNST-RGS7_CNST_chr1_246811339_ENST00000366513_RGS7_chr1_240990472_ENST00000366564_length(amino acids)=913AA_BP=647
METDPAPSGSPPCASDSQTWKVFNVTLNGSPKDALMDDSDTPTYYLQIEPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSD
SAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLGKDKKIPGKRSPRSKKGTAKKIPPGLFSGDIAPLMQEKVLSAV
TYAVDDEEAAEVNANEQPEAPKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWE
TKWKTVQPHTVTALRNSEKGFNGEDFERLTKICATHQDPLLSKHKIAAVEKSQERKCSTQLLVSEDPKEGGATTKESESKTCLGTESSKE
SQHTVEPLGSSPCCHQMDVQTDSPSLSVTAGKDHMEELLCSAEATLALHTQSSETAGSPSGPDSSEDACEDDSRLQLAQTEACQDVARIE
GIAEDPKVFLSSKSKTEPLISPGCDRIPPALISEGKYSQAQRKELRLPLRDASEALPTDQLENNELNELQQPDLTDSDGKSPQAQADSDG
SENVLCGNNQISDLGILLPEVCMAPEEKGDKDDQLNKETEDYLNSLLEGCLKDTEDSLSYEDNQDDDSDLLQDLSPEEASYSLQENLPSD
ESCLSLDDLAKRIEIAEPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKM
SKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAV
EDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGKS

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>17853_17853_6_CNST-RGS7_CNST_chr1_246811339_ENST00000366513_RGS7_chr1_240990472_ENST00000366565_length(amino acids)=931AA_BP=647
METDPAPSGSPPCASDSQTWKVFNVTLNGSPKDALMDDSDTPTYYLQIEPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSD
SAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLGKDKKIPGKRSPRSKKGTAKKIPPGLFSGDIAPLMQEKVLSAV
TYAVDDEEAAEVNANEQPEAPKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWE
TKWKTVQPHTVTALRNSEKGFNGEDFERLTKICATHQDPLLSKHKIAAVEKSQERKCSTQLLVSEDPKEGGATTKESESKTCLGTESSKE
SQHTVEPLGSSPCCHQMDVQTDSPSLSVTAGKDHMEELLCSAEATLALHTQSSETAGSPSGPDSSEDACEDDSRLQLAQTEACQDVARIE
GIAEDPKVFLSSKSKTEPLISPGCDRIPPALISEGKYSQAQRKELRLPLRDASEALPTDQLENNELNELQQPDLTDSDGKSPQAQADSDG
SENVLCGNNQISDLGILLPEVCMAPEEKGDKDDQLNKETEDYLNSLLEGCLKDTEDSLSYEDNQDDDSDLLQDLSPEEASYSLQENLPSD
ESCLSLDDLAKRIEIAEPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKM
SKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAV
EDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGN

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>17853_17853_7_CNST-RGS7_CNST_chr1_246811339_ENST00000366513_RGS7_chr1_240990472_ENST00000401882_length(amino acids)=922AA_BP=647
METDPAPSGSPPCASDSQTWKVFNVTLNGSPKDALMDDSDTPTYYLQIEPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSD
SAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLGKDKKIPGKRSPRSKKGTAKKIPPGLFSGDIAPLMQEKVLSAV
TYAVDDEEAAEVNANEQPEAPKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWE
TKWKTVQPHTVTALRNSEKGFNGEDFERLTKICATHQDPLLSKHKIAAVEKSQERKCSTQLLVSEDPKEGGATTKESESKTCLGTESSKE
SQHTVEPLGSSPCCHQMDVQTDSPSLSVTAGKDHMEELLCSAEATLALHTQSSETAGSPSGPDSSEDACEDDSRLQLAQTEACQDVARIE
GIAEDPKVFLSSKSKTEPLISPGCDRIPPALISEGKYSQAQRKELRLPLRDASEALPTDQLENNELNELQQPDLTDSDGKSPQAQADSDG
SENVLCGNNQISDLGILLPEVCMAPEEKGDKDDQLNKETEDYLNSLLEGCLKDTEDSLSYEDNQDDDSDLLQDLSPEEASYSLQENLPSD
ESCLSLDDLAKRIEIAEPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKM
SKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAV
EDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGRN

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>17853_17853_8_CNST-RGS7_CNST_chr1_246811339_ENST00000366513_RGS7_chr1_240990472_ENST00000407727_length(amino acids)=940AA_BP=647
METDPAPSGSPPCASDSQTWKVFNVTLNGSPKDALMDDSDTPTYYLQIEPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSD
SAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLGKDKKIPGKRSPRSKKGTAKKIPPGLFSGDIAPLMQEKVLSAV
TYAVDDEEAAEVNANEQPEAPKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWE
TKWKTVQPHTVTALRNSEKGFNGEDFERLTKICATHQDPLLSKHKIAAVEKSQERKCSTQLLVSEDPKEGGATTKESESKTCLGTESSKE
SQHTVEPLGSSPCCHQMDVQTDSPSLSVTAGKDHMEELLCSAEATLALHTQSSETAGSPSGPDSSEDACEDDSRLQLAQTEACQDVARIE
GIAEDPKVFLSSKSKTEPLISPGCDRIPPALISEGKYSQAQRKELRLPLRDASEALPTDQLENNELNELQQPDLTDSDGKSPQAQADSDG
SENVLCGNNQISDLGILLPEVCMAPEEKGDKDDQLNKETEDYLNSLLEGCLKDTEDSLSYEDNQDDDSDLLQDLSPEEASYSLQENLPSD
ESCLSLDDLAKRIEIAEPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKM
SKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAV
EDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGN

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>17853_17853_9_CNST-RGS7_CNST_chr1_246811339_ENST00000366513_RGS7_chr1_240990472_ENST00000446183_length(amino acids)=921AA_BP=647
METDPAPSGSPPCASDSQTWKVFNVTLNGSPKDALMDDSDTPTYYLQIEPQDGCHPGDSVERSVTCLPSASDENENQLDGDGHEHLTSSD
SAMGKPQVSEQDSLNNNESCTLSCEVAAGENLQNTLCEASRDEQAFLGKDKKIPGKRSPRSKKGTAKKIPPGLFSGDIAPLMQEKVLSAV
TYAVDDEEAAEVNANEQPEAPKLVLQSLFSLIRGEVEQLDSRALPLCLHQIAESYFQEEDYEKAMKFIQLERLYHEQLLANLSAIQEQWE
TKWKTVQPHTVTALRNSEKGFNGEDFERLTKICATHQDPLLSKHKIAAVEKSQERKCSTQLLVSEDPKEGGATTKESESKTCLGTESSKE
SQHTVEPLGSSPCCHQMDVQTDSPSLSVTAGKDHMEELLCSAEATLALHTQSSETAGSPSGPDSSEDACEDDSRLQLAQTEACQDVARIE
GIAEDPKVFLSSKSKTEPLISPGCDRIPPALISEGKYSQAQRKELRLPLRDASEALPTDQLENNELNELQQPDLTDSDGKSPQAQADSDG
SENVLCGNNQISDLGILLPEVCMAPEEKGDKDDQLNKETEDYLNSLLEGCLKDTEDSLSYEDNQDDDSDLLQDLSPEEASYSLQENLPSD
ESCLSLDDLAKRIEIAEPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKM
SKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAV
EDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGRN

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:246811339/chr1:240990472)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CNST Q6PJW8	.
FUNCTION: Required for targeting of connexins to the plasma membrane. {ECO:0000269\|PubMed:19864490}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000348120

255_316

150.0

626.6666666666666

Domain

Note=G protein gamma

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000348120

333_448

150.0

626.6666666666666

Domain

RGS

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000366562

255_316

203.0

470.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000366562

333_448

203.0

470.0

Domain

RGS

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000366563

255_316

203.0

689.6666666666666

Domain

Note=G protein gamma

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000366563

333_448

203.0

689.6666666666666

Domain

RGS

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000366564

255_316

203.0

470.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000366564

333_448

203.0

470.0

Domain

RGS

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000366565

255_316

203.0

488.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000366565

333_448

203.0

488.0

Domain

RGS

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000401882

255_316

150.0

425.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000401882

333_448

150.0

425.0

Domain

RGS

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000407727

255_316

203.0

496.0

Domain

Note=G protein gamma

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000407727

333_448

203.0

496.0

Domain

RGS

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CNST

chr1:246811339

chr1:240990472

ENST00000366512

1_664

617.0

Topological domain

Cytoplasmic

Hgene

CNST

chr1:246811339

chr1:240990472

ENST00000366512

686_725

617.0

Topological domain

Extracellular

Hgene

CNST

chr1:246811339

chr1:240990472

ENST00000366513

1_664

612.0

726.0

Topological domain

Cytoplasmic

Hgene

CNST

chr1:246811339

chr1:240990472

ENST00000366513

686_725

612.0

726.0

Topological domain

Extracellular

Hgene

CNST

chr1:246811339

chr1:240990472

ENST00000366512

665_685

617.0

Transmembrane

Helical

Hgene

CNST

chr1:246811339

chr1:240990472

ENST00000366513

665_685

612.0

726.0

Transmembrane

Helical

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000348120

37_112

150.0

626.6666666666666

Domain

DEP

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000366562

37_112

203.0

470.0

Domain

DEP

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000366563

37_112

203.0

689.6666666666666

Domain

DEP

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000366564

37_112

203.0

470.0

Domain

DEP

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000366565

37_112

203.0

488.0

Domain

DEP

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000401882

37_112

150.0

425.0

Domain

DEP

Tgene

RGS7

chr1:246811339

chr1:240990472

ENST00000407727

37_112

203.0

496.0

Domain

DEP

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

AA seq

Len(AA seq)

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CNST_pLDDT.png

RGS7_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CNST
RGS7

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to CNST-RGS7

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CNST-RGS7

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source