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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ABCA2-TRIM14

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABCA2-TRIM14
FusionPDB ID: 185
FusionGDB2.0 ID: 185
HgeneTgene
Gene symbol

ABCA2

TRIM14

Gene ID

20

9830

Gene nameATP binding cassette subfamily A member 2tripartite motif containing 14
SynonymsABC2-
Cytomap

9q34.3

9q22.33

Type of geneprotein-codingprotein-coding
DescriptionATP-binding cassette sub-family A member 2ATP-binding cassette 2ATP-binding cassette transporter 2ATP-binding cassette, sub-family A (ABC1), member 2ATP-binding cassette, sub-family A, member 2tripartite motif-containing protein 14tripartite motif protein TRIM14
Modification date2020031320200315
UniProtAcc

Q9BZC7

.
Ensembl transtripts involved in fusion geneENST idsENST00000265662, ENST00000341511, 
ENST00000371605, ENST00000492260, 
ENST00000341469, ENST00000342043, 
ENST00000478530, ENST00000538344, 
ENST00000375098, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 10 X 3=2707 X 7 X 3=147
# samples 108
** MAII scorelog2(10/270*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABCA2 [Title/Abstract] AND TRIM14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABCA2(139922527)-TRIM14(100862446), # samples:3
Anticipated loss of major functional domain due to fusion event.ABCA2-TRIM14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA2-TRIM14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA2-TRIM14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA2-TRIM14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCA2

GO:0006357

regulation of transcription by RNA polymerase II

15238223

HgeneABCA2

GO:0010872

regulation of cholesterol esterification

24201375

HgeneABCA2

GO:0032384

negative regulation of intracellular cholesterol transport

21810484

HgeneABCA2

GO:0032805

positive regulation of low-density lipoprotein particle receptor catabolic process

21810484

HgeneABCA2

GO:0042986

positive regulation of amyloid precursor protein biosynthetic process

20704561

HgeneABCA2

GO:0045540

regulation of cholesterol biosynthetic process

21810484

HgeneABCA2

GO:0046512

sphingosine biosynthetic process

26510981

HgeneABCA2

GO:0071072

negative regulation of phospholipid biosynthetic process

24201375

HgeneABCA2

GO:0090155

negative regulation of sphingolipid biosynthetic process

24201375

HgeneABCA2

GO:0090156

cellular sphingolipid homeostasis

26510981

HgeneABCA2

GO:0090370

negative regulation of cholesterol efflux

21810484

HgeneABCA2

GO:0099040

ceramide translocation

24201375

HgeneABCA2

GO:1905598

negative regulation of low-density lipoprotein receptor activity

21810484

HgeneABCA2

GO:1905601

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

21810484

TgeneTRIM14

GO:0032897

negative regulation of viral transcription

18248090

TgeneTRIM14

GO:0045087

innate immune response

18248090

TgeneTRIM14

GO:0051091

positive regulation of DNA-binding transcription factor activity

23077300

TgeneTRIM14

GO:0051092

positive regulation of NF-kappaB transcription factor activity

23077300


check buttonFusion gene breakpoints across ABCA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRIM14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-E1-5304-01AABCA2chr9

139922527

-TRIM14chr9

100862446

-
ChimerDB4LGGTCGA-E1-5304ABCA2chr9

139922526

-TRIM14chr9

100862446

-
ChimerDB4LGGTCGA-E1-5304ABCA2chr9

139922527

-TRIM14chr9

100862446

-
ChimerDB4LGGTCGA-E1-5304ABCA2chr9

139923169

-TRIM14chr9

100862446

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341511ABCA2chr9139922527-ENST00000375098TRIM14chr9100862446-1583116501141363
ENST00000265662ABCA2chr9139922527-ENST00000375098TRIM14chr9100862446-16812141481239363
ENST00000371605ABCA2chr9139922527-ENST00000375098TRIM14chr9100862446-16812141481239363
ENST00000341511ABCA2chr9139922526-ENST00000375098TRIM14chr9100862446-1583116501141363
ENST00000265662ABCA2chr9139922526-ENST00000375098TRIM14chr9100862446-16812141481239363
ENST00000371605ABCA2chr9139922526-ENST00000375098TRIM14chr9100862446-16812141481239363

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341511ENST00000375098ABCA2chr9139922527-TRIM14chr9100862446-0.0251190810.974881
ENST00000265662ENST00000375098ABCA2chr9139922527-TRIM14chr9100862446-0.0246457010.9753543
ENST00000371605ENST00000375098ABCA2chr9139922527-TRIM14chr9100862446-0.0246457010.9753543
ENST00000341511ENST00000375098ABCA2chr9139922526-TRIM14chr9100862446-0.0251190810.974881
ENST00000265662ENST00000375098ABCA2chr9139922526-TRIM14chr9100862446-0.0246457010.9753543
ENST00000371605ENST00000375098ABCA2chr9139922526-TRIM14chr9100862446-0.0246457010.9753543

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>185_185_1_ABCA2-TRIM14_ABCA2_chr9_139922526_ENST00000265662_TRIM14_chr9_100862446_ENST00000375098_length(amino acids)=363AA_BP=22
MGFLHQLQLLLWKNVTLKRRSPANAESSKTWLKGKFTELRLLLDEEEALAKKFIDKNTQLTLQVYREQADSCREQLDIMNDLSNRVWSIS
QEPDPVQRLQAYTATEQEMQQQMSLGELCHPVPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLSDPSSTKPGTLLKTSPSPER
SLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPVPVLRFDALWQVLARDCFATGRHYWEVDVQEAGAGWWVGAAYASLRRRGA
SAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIP

--------------------------------------------------------------

>185_185_2_ABCA2-TRIM14_ABCA2_chr9_139922526_ENST00000341511_TRIM14_chr9_100862446_ENST00000375098_length(amino acids)=363AA_BP=22
MGFLHQLQLLLWKNVTLKRRSPANAESSKTWLKGKFTELRLLLDEEEALAKKFIDKNTQLTLQVYREQADSCREQLDIMNDLSNRVWSIS
QEPDPVQRLQAYTATEQEMQQQMSLGELCHPVPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLSDPSSTKPGTLLKTSPSPER
SLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPVPVLRFDALWQVLARDCFATGRHYWEVDVQEAGAGWWVGAAYASLRRRGA
SAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIP

--------------------------------------------------------------

>185_185_3_ABCA2-TRIM14_ABCA2_chr9_139922526_ENST00000371605_TRIM14_chr9_100862446_ENST00000375098_length(amino acids)=363AA_BP=22
MGFLHQLQLLLWKNVTLKRRSPANAESSKTWLKGKFTELRLLLDEEEALAKKFIDKNTQLTLQVYREQADSCREQLDIMNDLSNRVWSIS
QEPDPVQRLQAYTATEQEMQQQMSLGELCHPVPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLSDPSSTKPGTLLKTSPSPER
SLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPVPVLRFDALWQVLARDCFATGRHYWEVDVQEAGAGWWVGAAYASLRRRGA
SAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIP

--------------------------------------------------------------

>185_185_4_ABCA2-TRIM14_ABCA2_chr9_139922527_ENST00000265662_TRIM14_chr9_100862446_ENST00000375098_length(amino acids)=363AA_BP=22
MGFLHQLQLLLWKNVTLKRRSPANAESSKTWLKGKFTELRLLLDEEEALAKKFIDKNTQLTLQVYREQADSCREQLDIMNDLSNRVWSIS
QEPDPVQRLQAYTATEQEMQQQMSLGELCHPVPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLSDPSSTKPGTLLKTSPSPER
SLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPVPVLRFDALWQVLARDCFATGRHYWEVDVQEAGAGWWVGAAYASLRRRGA
SAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIP

--------------------------------------------------------------

>185_185_5_ABCA2-TRIM14_ABCA2_chr9_139922527_ENST00000341511_TRIM14_chr9_100862446_ENST00000375098_length(amino acids)=363AA_BP=22
MGFLHQLQLLLWKNVTLKRRSPANAESSKTWLKGKFTELRLLLDEEEALAKKFIDKNTQLTLQVYREQADSCREQLDIMNDLSNRVWSIS
QEPDPVQRLQAYTATEQEMQQQMSLGELCHPVPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLSDPSSTKPGTLLKTSPSPER
SLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPVPVLRFDALWQVLARDCFATGRHYWEVDVQEAGAGWWVGAAYASLRRRGA
SAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIP

--------------------------------------------------------------

>185_185_6_ABCA2-TRIM14_ABCA2_chr9_139922527_ENST00000371605_TRIM14_chr9_100862446_ENST00000375098_length(amino acids)=363AA_BP=22
MGFLHQLQLLLWKNVTLKRRSPANAESSKTWLKGKFTELRLLLDEEEALAKKFIDKNTQLTLQVYREQADSCREQLDIMNDLSNRVWSIS
QEPDPVQRLQAYTATEQEMQQQMSLGELCHPVPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLSDPSSTKPGTLLKTSPSPER
SLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPVPVLRFDALWQVLARDCFATGRHYWEVDVQEAGAGWWVGAAYASLRRRGA
SAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:139922527/chr9:100862446)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCA2

Q9BZC7

.
FUNCTION: Probable lipid tranporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (PubMed:15238223, PubMed:21810484, PubMed:24201375) (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity). {ECO:0000250|UniProtKB:P41234, ECO:0000269|PubMed:15238223, ECO:0000269|PubMed:21810484, ECO:0000269|PubMed:22086926, ECO:0000269|PubMed:24201375, ECO:0000269|PubMed:26510981, ECO:0000305|PubMed:15999530}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRIM14chr9:139922526chr9:100862446ENST0000034146916135_156101.0443.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM14chr9:139922526chr9:100862446ENST0000034204317135_156101.0564.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM14chr9:139922526chr9:100862446ENST0000037509817135_156101.0660.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneTRIM14chr9:139922527chr9:100862446ENST0000034146916135_156101.0443.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM14chr9:139922527chr9:100862446ENST0000034204317135_156101.0564.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM14chr9:139922527chr9:100862446ENST0000037509817135_156101.0660.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneTRIM14chr9:139922526chr9:100862446ENST0000034146916249_442101.0443.0DomainB30.2/SPRY
TgeneTRIM14chr9:139922526chr9:100862446ENST0000034204317249_442101.0564.0DomainB30.2/SPRY
TgeneTRIM14chr9:139922526chr9:100862446ENST0000037509817249_442101.0660.3333333333334DomainB30.2/SPRY
TgeneTRIM14chr9:139922527chr9:100862446ENST0000034146916249_442101.0443.0DomainB30.2/SPRY
TgeneTRIM14chr9:139922527chr9:100862446ENST0000034204317249_442101.0564.0DomainB30.2/SPRY
TgeneTRIM14chr9:139922527chr9:100862446ENST0000037509817249_442101.0660.3333333333334DomainB30.2/SPRY

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-1492050_228522.02437.0DomainABC transporter 2
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-149990_122122.02437.0DomainABC transporter 1
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-1482050_228522.02436.0DomainABC transporter 2
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-148990_122122.02436.0DomainABC transporter 1
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-1492050_228522.02437.0DomainABC transporter 2
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-149990_122122.02437.0DomainABC transporter 1
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-1482050_228522.02436.0DomainABC transporter 2
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-148990_122122.02436.0DomainABC transporter 1
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-1491024_103122.02437.0Nucleotide bindingATP 1
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-1492087_209422.02437.0Nucleotide bindingATP 2
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-1481024_103122.02436.0Nucleotide bindingATP 1
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-1482087_209422.02436.0Nucleotide bindingATP 2
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-1491024_103122.02437.0Nucleotide bindingATP 1
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-1492087_209422.02437.0Nucleotide bindingATP 2
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-1481024_103122.02436.0Nucleotide bindingATP 1
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-1482087_209422.02436.0Nucleotide bindingATP 2
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-1491456_147622.02437.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-1491792_181222.02437.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-1491841_186122.02437.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-1491872_189222.02437.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-1491905_192522.02437.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-1491991_201122.02437.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-14922_4222.02437.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-14954_7422.02437.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-149699_71922.02437.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-149750_77022.02437.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-149782_80222.02437.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-149813_83322.02437.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-149857_87722.02437.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000341511-149893_91322.02437.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-1481456_147622.02436.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-1481792_181222.02436.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-1481841_186122.02436.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-1481872_189222.02436.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-1481905_192522.02436.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-1481991_201122.02436.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-14822_4222.02436.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-14854_7422.02436.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-148699_71922.02436.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-148750_77022.02436.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-148782_80222.02436.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-148813_83322.02436.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-148857_87722.02436.0TransmembraneHelical
HgeneABCA2chr9:139922526chr9:100862446ENST00000371605-148893_91322.02436.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-1491456_147622.02437.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-1491792_181222.02437.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-1491841_186122.02437.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-1491872_189222.02437.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-1491905_192522.02437.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-1491991_201122.02437.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-14922_4222.02437.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-14954_7422.02437.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-149699_71922.02437.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-149750_77022.02437.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-149782_80222.02437.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-149813_83322.02437.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-149857_87722.02437.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000341511-149893_91322.02437.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-1481456_147622.02436.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-1481792_181222.02436.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-1481841_186122.02436.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-1481872_189222.02436.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-1481905_192522.02436.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-1481991_201122.02436.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-14822_4222.02436.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-14854_7422.02436.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-148699_71922.02436.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-148750_77022.02436.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-148782_80222.02436.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-148813_83322.02436.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-148857_87722.02436.0TransmembraneHelical
HgeneABCA2chr9:139922527chr9:100862446ENST00000371605-148893_91322.02436.0TransmembraneHelical
TgeneTRIM14chr9:139922526chr9:100862446ENST000003414691676_109101.0443.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM14chr9:139922526chr9:100862446ENST000003420431776_109101.0564.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM14chr9:139922526chr9:100862446ENST000003750981776_109101.0660.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneTRIM14chr9:139922527chr9:100862446ENST000003414691676_109101.0443.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM14chr9:139922527chr9:100862446ENST000003420431776_109101.0564.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM14chr9:139922527chr9:100862446ENST000003750981776_109101.0660.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneTRIM14chr9:139922526chr9:100862446ENST000003414691619_61101.0443.0Zinc fingerB box-type
TgeneTRIM14chr9:139922526chr9:100862446ENST000003420431719_61101.0564.0Zinc fingerB box-type
TgeneTRIM14chr9:139922526chr9:100862446ENST000003750981719_61101.0660.3333333333334Zinc fingerB box-type
TgeneTRIM14chr9:139922527chr9:100862446ENST000003414691619_61101.0443.0Zinc fingerB box-type
TgeneTRIM14chr9:139922527chr9:100862446ENST000003420431719_61101.0564.0Zinc fingerB box-type
TgeneTRIM14chr9:139922527chr9:100862446ENST000003750981719_61101.0660.3333333333334Zinc fingerB box-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>713_ABCA2_139922527_TRIM14_100862446_ranked_0.pdbABCA2139922526139922527ENST00000375098TRIM14chr9100862446-
MGFLHQLQLLLWKNVTLKRRSPANAESSKTWLKGKFTELRLLLDEEEALAKKFIDKNTQLTLQVYREQADSCREQLDIMNDLSNRVWSIS
QEPDPVQRLQAYTATEQEMQQQMSLGELCHPVPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLSDPSSTKPGTLLKTSPSPER
SLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPVPVLRFDALWQVLARDCFATGRHYWEVDVQEAGAGWWVGAAYASLRRRGA
SAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIP
363


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ABCA2_pLDDT.png
all structure
all structure
TRIM14_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABCA2
TRIM14


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ABCA2-TRIM14


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ABCA2-TRIM14


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource