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Fusion Protein:CPM-NUP107 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: CPM-NUP107 | FusionPDB ID: 18997 | FusionGDB2.0 ID: 18997 | Hgene | Tgene | Gene symbol | CPM | NUP107 | Gene ID | 1368 | 57122 |
Gene name | carboxypeptidase M | nucleoporin 107 | |
Synonyms | - | NPHS11|NUP84|ODG6|ODG6; GAMOS7 | |
Cytomap | 12q15 | 12q15 | |
Type of gene | protein-coding | protein-coding | |
Description | carboxypeptidase Mrenal carboxypeptidaseurinary carboxypeptidase B | nuclear pore complex protein Nup107nucleoporin 107kDa | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P14384 | P57740 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000338356, ENST00000546373, ENST00000551568, ENST00000549691, | ENST00000378905, ENST00000539906, ENST00000401003, ENST00000229179, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 15 X 8 X 7=840 | 27 X 22 X 9=5346 |
# samples | 17 | 37 | |
** MAII score | log2(17/840*10)=-2.30485458152842 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(37/5346*10)=-3.85286266172677 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: CPM [Title/Abstract] AND NUP107 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CPM(69326458)-NUP107(69135593), # samples:1 CPM(69326458)-NUP107(69084411), # samples:1 NUP107(69115932)-CPM(69279669), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | CPM-NUP107 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CPM-NUP107 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. NUP107-CPM seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. NUP107-CPM seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | NUP107 | GO:0006406 | mRNA export from nucleus | 11684705 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | GBM | TCGA-06-0174-01A | CPM | chr12 | 69326458 | - | NUP107 | chr12 | 69135593 | + |
ChimerDB4 | GBM | TCGA-06-0686-01A | CPM | chr12 | 69326458 | - | NUP107 | chr12 | 69084411 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000546373 | CPM | chr12 | 69326458 | - | ENST00000229179 | NUP107 | chr12 | 69135593 | + | 1083 | 264 | 297 | 539 | 80 |
ENST00000546373 | CPM | chr12 | 69326458 | - | ENST00000378905 | NUP107 | chr12 | 69135593 | + | 761 | 264 | 297 | 539 | 80 |
ENST00000546373 | CPM | chr12 | 69326458 | - | ENST00000539906 | NUP107 | chr12 | 69135593 | + | 609 | 264 | 297 | 539 | 80 |
ENST00000551568 | CPM | chr12 | 69326458 | - | ENST00000229179 | NUP107 | chr12 | 69135593 | + | 1040 | 221 | 254 | 496 | 80 |
ENST00000551568 | CPM | chr12 | 69326458 | - | ENST00000378905 | NUP107 | chr12 | 69135593 | + | 718 | 221 | 254 | 496 | 80 |
ENST00000551568 | CPM | chr12 | 69326458 | - | ENST00000539906 | NUP107 | chr12 | 69135593 | + | 566 | 221 | 254 | 496 | 80 |
ENST00000338356 | CPM | chr12 | 69326458 | - | ENST00000229179 | NUP107 | chr12 | 69135593 | + | 1026 | 207 | 240 | 482 | 80 |
ENST00000338356 | CPM | chr12 | 69326458 | - | ENST00000378905 | NUP107 | chr12 | 69135593 | + | 704 | 207 | 240 | 482 | 80 |
ENST00000338356 | CPM | chr12 | 69326458 | - | ENST00000539906 | NUP107 | chr12 | 69135593 | + | 552 | 207 | 240 | 482 | 80 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000546373 | ENST00000229179 | CPM | chr12 | 69326458 | - | NUP107 | chr12 | 69135593 | + | 0.27606067 | 0.72393936 |
ENST00000546373 | ENST00000378905 | CPM | chr12 | 69326458 | - | NUP107 | chr12 | 69135593 | + | 0.24924032 | 0.75075966 |
ENST00000546373 | ENST00000539906 | CPM | chr12 | 69326458 | - | NUP107 | chr12 | 69135593 | + | 0.13923629 | 0.8607637 |
ENST00000551568 | ENST00000229179 | CPM | chr12 | 69326458 | - | NUP107 | chr12 | 69135593 | + | 0.3365718 | 0.66342825 |
ENST00000551568 | ENST00000378905 | CPM | chr12 | 69326458 | - | NUP107 | chr12 | 69135593 | + | 0.3308266 | 0.6691734 |
ENST00000551568 | ENST00000539906 | CPM | chr12 | 69326458 | - | NUP107 | chr12 | 69135593 | + | 0.19505501 | 0.804945 |
ENST00000338356 | ENST00000229179 | CPM | chr12 | 69326458 | - | NUP107 | chr12 | 69135593 | + | 0.37325263 | 0.6267473 |
ENST00000338356 | ENST00000378905 | CPM | chr12 | 69326458 | - | NUP107 | chr12 | 69135593 | + | 0.29051054 | 0.7094895 |
ENST00000338356 | ENST00000539906 | CPM | chr12 | 69326458 | - | NUP107 | chr12 | 69135593 | + | 0.17020287 | 0.8297971 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >18997_18997_1_CPM-NUP107_CPM_chr12_69326458_ENST00000338356_NUP107_chr12_69135593_ENST00000229179_length(amino acids)=80AA_BP= -------------------------------------------------------------- >18997_18997_2_CPM-NUP107_CPM_chr12_69326458_ENST00000338356_NUP107_chr12_69135593_ENST00000378905_length(amino acids)=80AA_BP= -------------------------------------------------------------- >18997_18997_3_CPM-NUP107_CPM_chr12_69326458_ENST00000338356_NUP107_chr12_69135593_ENST00000539906_length(amino acids)=80AA_BP= -------------------------------------------------------------- >18997_18997_4_CPM-NUP107_CPM_chr12_69326458_ENST00000546373_NUP107_chr12_69135593_ENST00000229179_length(amino acids)=80AA_BP= -------------------------------------------------------------- >18997_18997_5_CPM-NUP107_CPM_chr12_69326458_ENST00000546373_NUP107_chr12_69135593_ENST00000378905_length(amino acids)=80AA_BP= -------------------------------------------------------------- >18997_18997_6_CPM-NUP107_CPM_chr12_69326458_ENST00000546373_NUP107_chr12_69135593_ENST00000539906_length(amino acids)=80AA_BP= -------------------------------------------------------------- >18997_18997_7_CPM-NUP107_CPM_chr12_69326458_ENST00000551568_NUP107_chr12_69135593_ENST00000229179_length(amino acids)=80AA_BP= -------------------------------------------------------------- >18997_18997_8_CPM-NUP107_CPM_chr12_69326458_ENST00000551568_NUP107_chr12_69135593_ENST00000378905_length(amino acids)=80AA_BP= -------------------------------------------------------------- >18997_18997_9_CPM-NUP107_CPM_chr12_69326458_ENST00000551568_NUP107_chr12_69135593_ENST00000539906_length(amino acids)=80AA_BP= -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69326458/chr12:69135593) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CPM | NUP107 |
FUNCTION: Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins. {ECO:0000269|PubMed:12457462}. | FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:12552102, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:30179222}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
NUP107 | SEH1L, NUP133, NUP85, NUP160, NUP43, NUP37, SEC13, TPR, NUP214, KPNB1, Nup107, Nup98, SIRT7, NUP98, WRNIP1, CUL3, CENPF, NUP153, TP53BP1, PNPT1, EIF4B, CORO1B, MYL1, C1QBP, CPSF6, VCP, PYCARD, CUL7, OBSL1, SUZ12, EED, PNKD, NTRK1, IFI16, SYNE1, APC, PRKDC, RRP1B, NALCN, CD1E, ACTBL2, HSP90AB1, XPO1, SENP1, SENP2, AHCTF1, RANGAP1, H2AFV, NUP50, RANBP2, B9D2, ACLY, RCC1, GLE1, ITPR2, KPNA4, NUP88, RAN, UBE2I, SUMO1, AAAS, RAE1, NUP155, NUP93, NUPL1, WDR1, NXF1, IPO7, NUPL2, NUP205, NUP210, NUP188, NUP62, NXT1, SEC61A1, NUP54, TMEM214, SMPD4, NDC1, KRAS, IP6K3, TMEM209, NUP35, RPUSD3, RGPD8, POM121C, Ranbp2, Ube2i, Rcc1, Kifc1, Nup155, Nup214, FOXA3, FOXI2, FOXK2, FOXL1, FOXP3, FOXQ1, CDC5L, ZNF746, DUSP13, SPAST, UXS1, SIGLECL1, CD70, RAF1, PDHA1, TRIM25, BRCA1, EGLN3, TGFB1, NKX2-1, RNF4, CDC34, BPLF1, EZH2, DCPS, MYC, CDK9, CANX, EZR, LMNA, TOMM20, MGST3, PTRH2, KIAA1429, HIST1H4A, Dppa3, BIRC3, LMBR1L, PLEKHA4, GAPDH, M, nsp16, nsp4, nsp6, ORF6, MAU2, LRRC31, CIT, KIF14, PRC1, TRIM66, FKBP8, PTPN1, RHOT2, SLC25A46, SUMO2, NUPR1, CIC, LGALS9, DYRK1A, BKRF1, DNAJC1, ANAPC2, COX8A, DERL1, EMD, KRT8, LMNB1, LRRC59, RPN1, SEC61B, STIM1, SYNE3, TMPO, NAA40, VPS33A, RGPD1, EFNA4, COMTD1, SLFN11, FBXW7, FBXO32, RCHY1, SIRT6, GLI3, |
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Gene | STRING network |
CPM | |
NUP107 | ![]() |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to CPM-NUP107 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to CPM-NUP107 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | NUP107 | C4225228 | NEPHROTIC SYNDROME, TYPE 11 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | NUP107 | C0018051 | Gonadal Dysgenesis | 1 | GENOMICS_ENGLAND |
Tgene | NUP107 | C0685837 | Pure Gonadal Dysgenesis, 46, XX | 1 | ORPHANET |
Tgene | NUP107 | C0795949 | Galloway Mowat syndrome | 1 | ORPHANET |
Tgene | NUP107 | C0949595 | Gonadal Dysgenesis, 46,XX | 1 | ORPHANET |
Tgene | NUP107 | C1868672 | NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE | 1 | ORPHANET |
Tgene | NUP107 | C4748084 | OVARIAN DYSGENESIS 6 | 1 | UNIPROT |