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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ACVR2A-AKT3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ACVR2A-AKT3
	FusionPDB ID: 1904
	FusionGDB2.0 ID: 1904
		Hgene	Tgene
	Gene symbol	ACVR2A	AKT3
	Gene ID	92	10000
	Gene name	activin A receptor type 2A	AKT serine/threonine kinase 3
	Synonyms	ACTRII\|ACVR2	MPPH\|MPPH2\|PKB-GAMMA\|PKBG\|PRKBG\|RAC-PK-gamma\|RAC-gamma\|STK-2
	Cytomap	2q22.3-q23.1	1q43-q44
	Type of gene	protein-coding	protein-coding
	Description	activin receptor type-2Aactivin A receptor, type IIA	RAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
	Modification date	20200313	20200313
	UniProtAcc	P27037	Q9Y243
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000241416, ENST00000404590, ENST00000495775, ENST00000535787,	ENST00000492957, ENST00000263826, ENST00000336199, ENST00000366539, ENST00000366540,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 7 X 7=392	19 X 18 X 8=2736
	# samples	10	19
	** MAII score	log2(10/392*10)=-1.97085365434048 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/2736*10)=-3.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ACVR2A [Title/Abstract] AND AKT3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ACVR2A(148602776)-AKT3(243828185), # samples:3
Anticipated loss of major functional domain due to fusion event.	ACVR2A-AKT3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACVR2A-AKT3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACVR2A-AKT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACVR2A-AKT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ACVR2A	GO:0030509	BMP signaling pathway	18436533
Hgene	ACVR2A	GO:0032927	positive regulation of activin receptor signaling pathway	12665502
Hgene	ACVR2A	GO:0045648	positive regulation of erythrocyte differentiation	9032295
Tgene	AKT3	GO:0043536	positive regulation of blood vessel endothelial cell migration	28254819
Tgene	AKT3	GO:1905564	positive regulation of vascular endothelial cell proliferation	28254819

Fusion gene breakpoints across ACVR2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AKT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-G9-6348-01A	ACVR2A	chr2	148602776	-	AKT3	chr1	243828185	-
ChimerDB4	PRAD	TCGA-G9-6348-01A	ACVR2A	chr2	148602776	+	AKT3	chr1	243828185	-
ChimerDB4	PRAD	TCGA-G9-6348	ACVR2A	chr2	148602776	+	AKT3	chr1	243828185	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000241416	ACVR2A	chr2	148602776	+	ENST00000336199	AKT3	chr1	243828185	-	2141	691	636	1916	426
ENST00000241416	ACVR2A	chr2	148602776	+	ENST00000366540	AKT3	chr1	243828185	-	1941	691	636	1916	426
ENST00000241416	ACVR2A	chr2	148602776	+	ENST00000366539	AKT3	chr1	243828185	-	5445	691	636	1958	440
ENST00000241416	ACVR2A	chr2	148602776	+	ENST00000263826	AKT3	chr1	243828185	-	4026	691	636	1958	440
ENST00000404590	ACVR2A	chr2	148602776	+	ENST00000336199	AKT3	chr1	243828185	-	1675	225	170	1450	426
ENST00000404590	ACVR2A	chr2	148602776	+	ENST00000366540	AKT3	chr1	243828185	-	1475	225	170	1450	426
ENST00000404590	ACVR2A	chr2	148602776	+	ENST00000366539	AKT3	chr1	243828185	-	4979	225	170	1492	440
ENST00000404590	ACVR2A	chr2	148602776	+	ENST00000263826	AKT3	chr1	243828185	-	3560	225	170	1492	440

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000241416	ENST00000336199	ACVR2A	chr2	148602776	+	AKT3	chr1	243828185	-	0.000185123	0.9998149
ENST00000241416	ENST00000366540	ACVR2A	chr2	148602776	+	AKT3	chr1	243828185	-	0.000158602	0.99984133
ENST00000241416	ENST00000366539	ACVR2A	chr2	148602776	+	AKT3	chr1	243828185	-	0.000146314	0.9998536
ENST00000241416	ENST00000263826	ACVR2A	chr2	148602776	+	AKT3	chr1	243828185	-	0.000177255	0.9998228
ENST00000404590	ENST00000336199	ACVR2A	chr2	148602776	+	AKT3	chr1	243828185	-	0.000337805	0.99966216
ENST00000404590	ENST00000366540	ACVR2A	chr2	148602776	+	AKT3	chr1	243828185	-	0.000322046	0.999678
ENST00000404590	ENST00000366539	ACVR2A	chr2	148602776	+	AKT3	chr1	243828185	-	0.000198379	0.9998017
ENST00000404590	ENST00000263826	ACVR2A	chr2	148602776	+	AKT3	chr1	243828185	-	0.000272105	0.9997279

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>1904_1904_1_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000241416_AKT3_chr1_243828185_ENST00000263826_length(amino acids)=440AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------

>1904_1904_2_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000241416_AKT3_chr1_243828185_ENST00000336199_length(amino acids)=426AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------

>1904_1904_3_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000241416_AKT3_chr1_243828185_ENST00000366539_length(amino acids)=440AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------

>1904_1904_4_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000241416_AKT3_chr1_243828185_ENST00000366540_length(amino acids)=426AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------

>1904_1904_5_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000404590_AKT3_chr1_243828185_ENST00000263826_length(amino acids)=440AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------

>1904_1904_6_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000404590_AKT3_chr1_243828185_ENST00000336199_length(amino acids)=426AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------

>1904_1904_7_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000404590_AKT3_chr1_243828185_ENST00000366539_length(amino acids)=440AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------

>1904_1904_8_ACVR2A-AKT3_ACVR2A_chr2_148602776_ENST00000404590_AKT3_chr1_243828185_ENST00000366540_length(amino acids)=426AA_BP=18
MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG
EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD
RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT
PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:148602776/chr1:243828185)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ACVR2A P27037	AKT3 Q9Y243
FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity). {ECO:0000250\|UniProtKB:P27038, ECO:0000269\|PubMed:1314589}.	FUNCTION: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269\|PubMed:18524868, ECO:0000269\|PubMed:21191416}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000263826

148_405

57.333333333333336

480.0

Domain

Protein kinase

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000263826

406_479

57.333333333333336

480.0

Domain

AGC-kinase C-terminal

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000336199

148_405

57.333333333333336

476.0

Domain

Protein kinase

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000336199

406_479

57.333333333333336

476.0

Domain

AGC-kinase C-terminal

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000366539

148_405

57.333333333333336

480.0

Domain

Protein kinase

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000366539

406_479

57.333333333333336

480.0

Domain

AGC-kinase C-terminal

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000366540

148_405

57.333333333333336

466.0

Domain

Protein kinase

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000366540

406_479

57.333333333333336

466.0

Domain

AGC-kinase C-terminal

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000263826

154_162

57.333333333333336

480.0

Nucleotide binding

ATP

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000336199

154_162

57.333333333333336

476.0

Nucleotide binding

ATP

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000366539

154_162

57.333333333333336

480.0

Nucleotide binding

ATP

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000366540

154_162

57.333333333333336

466.0

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ACVR2A

chr2:148602776

chr1:243828185

ENST00000241416

192_485

18.333333333333332

514.0

Domain

Protein kinase

Hgene

ACVR2A

chr2:148602776

chr1:243828185

ENST00000404590

192_485

18.333333333333332

514.0

Domain

Protein kinase

Hgene

ACVR2A

chr2:148602776

chr1:243828185

ENST00000241416

198_206

18.333333333333332

514.0

Nucleotide binding

ATP

Hgene

ACVR2A

chr2:148602776

chr1:243828185

ENST00000404590

198_206

18.333333333333332

514.0

Nucleotide binding

ATP

Hgene

ACVR2A

chr2:148602776

chr1:243828185

ENST00000241416

162_513

18.333333333333332

514.0

Topological domain

Cytoplasmic

Hgene

ACVR2A

chr2:148602776

chr1:243828185

ENST00000241416

20_135

18.333333333333332

514.0

Topological domain

Extracellular

Hgene

ACVR2A

chr2:148602776

chr1:243828185

ENST00000404590

162_513

18.333333333333332

514.0

Topological domain

Cytoplasmic

Hgene

ACVR2A

chr2:148602776

chr1:243828185

ENST00000404590

20_135

18.333333333333332

514.0

Topological domain

Extracellular

Hgene

ACVR2A

chr2:148602776

chr1:243828185

ENST00000241416

136_161

18.333333333333332

514.0

Transmembrane

Helical

Hgene

ACVR2A

chr2:148602776

chr1:243828185

ENST00000404590

136_161

18.333333333333332

514.0

Transmembrane

Helical

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000263826

5_107

57.333333333333336

480.0

Domain

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000336199

5_107

57.333333333333336

476.0

Domain

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000366539

5_107

57.333333333333336

480.0

Domain

Tgene

AKT3

chr2:148602776

chr1:243828185

ENST00000366540

5_107

57.333333333333336

466.0

Domain

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>922_ACVR2A_148602776_AKT3_243828185_922_ACVR2A_148602776_AKT3_243828185_ranked_0.pdb	ACVR2A	148602776	148602776	ENST00000263826	AKT3	chr1	243828185	-	MGAAAKLAFAVFLISCSSECQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIG EEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKD RLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEI	440

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ACVR2A_pLDDT.png

AKT3_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ACVR2A
AKT3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ACVR2A-AKT3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ACVR2A-AKT3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source