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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CPT1A-TRIM24

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CPT1A-TRIM24
	FusionPDB ID: 19234
	FusionGDB2.0 ID: 19234
		Hgene	Tgene
	Gene symbol	CPT1A	TRIM24
	Gene ID	1374	8805
	Gene name	carnitine palmitoyltransferase 1A	tripartite motif containing 24
	Synonyms	CPT1\|CPT1-L\|L-CPT1	PTC6\|RNF82\|TF1A\|TIF1\|TIF1A\|TIF1ALPHA\|hTIF1
	Cytomap	11q13.3	7q33-q34
	Type of gene	protein-coding	protein-coding
	Description	carnitine O-palmitoyltransferase 1, liver isoformCPT ICPTI-Lcarnitine O-palmitoyltransferase I, liver isoformcarnitine palmitoyltransferase 1A (liver)carnitine palmitoyltransferase I, liver	transcription intermediary factor 1-alphaE3 ubiquitin-protein ligase TRIM24RING finger protein 82RING-type E3 ubiquitin transferase TIF1-alphaTIF1-alphatranscriptional intermediary factor 1
	Modification date	20200315	20200313
	UniProtAcc	P50416	O15164
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000265641, ENST00000376618, ENST00000539743, ENST00000540367, ENST00000537756, ENST00000538994,	ENST00000497516, ENST00000343526, ENST00000415680,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	25 X 23 X 12=6900	10 X 9 X 7=630
	# samples	32	11
	** MAII score	log2(32/6900*10)=-4.43045255166553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/630*10)=-2.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CPT1A [Title/Abstract] AND TRIM24 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CPT1A(68574935)-TRIM24(138235808), # samples:2
Anticipated loss of major functional domain due to fusion event.	CPT1A-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CPT1A-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CPT1A-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CPT1A-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CPT1A-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CPT1A-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CPT1A-TRIM24 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. CPT1A-TRIM24 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. CPT1A-TRIM24 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. CPT1A-TRIM24 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CPT1A-TRIM24 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. CPT1A-TRIM24 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CPT1A	GO:0001676	long-chain fatty acid metabolic process	11350182
Hgene	CPT1A	GO:0009437	carnitine metabolic process	11350182
Tgene	TRIM24	GO:0016567	protein ubiquitination	19556538
Tgene	TRIM24	GO:0071391	cellular response to estrogen stimulus	21164480

Fusion gene breakpoints across CPT1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRIM24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRP	TCGA-HE-7130-01A	CPT1A	chr11	68574935	-	TRIM24	chr7	138235808	+
ChimerDB4	KIRP	TCGA-HE-7130	CPT1A	chr11	68574935	-	TRIM24	chr7	138235808	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000540367	CPT1A	chr11	68574935	-	ENST00000343526	TRIM24	chr7	138235808	+	7534	482	23	2491	822
ENST00000540367	CPT1A	chr11	68574935	-	ENST00000415680	TRIM24	chr7	138235808	+	3024	482	23	2389	788
ENST00000539743	CPT1A	chr11	68574935	-	ENST00000343526	TRIM24	chr7	138235808	+	7534	482	23	2491	822
ENST00000539743	CPT1A	chr11	68574935	-	ENST00000415680	TRIM24	chr7	138235808	+	3024	482	23	2389	788

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000540367	ENST00000343526	CPT1A	chr11	68574935	-	TRIM24	chr7	138235808	+	0.000173646	0.9998264
ENST00000540367	ENST00000415680	CPT1A	chr11	68574935	-	TRIM24	chr7	138235808	+	0.000584986	0.99941504
ENST00000539743	ENST00000343526	CPT1A	chr11	68574935	-	TRIM24	chr7	138235808	+	0.000173646	0.9998264
ENST00000539743	ENST00000415680	CPT1A	chr11	68574935	-	TRIM24	chr7	138235808	+	0.000584986	0.99941504

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>19234_19234_1_CPT1A-TRIM24_CPT1A_chr11_68574935_ENST00000539743_TRIM24_chr7_138235808_ENST00000343526_length(amino acids)=822AA_BP=153
MKMAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPSSWLIVVVGVMTTMYAKIDPSLGIIAKIN
RTLETANCMSSQTKNVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEHGKMSRATKIWMITYRLRHLLRARCDASPVTNNTIQFHC
DPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRM
QGPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTP
SSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSVPSPGLAGPVTMTS
VHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSILTSLLLNSS
QSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLT
NFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTI
KKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEFRNESEDNKFSDDSDDDFVQPRKK

--------------------------------------------------------------

>19234_19234_2_CPT1A-TRIM24_CPT1A_chr11_68574935_ENST00000539743_TRIM24_chr7_138235808_ENST00000415680_length(amino acids)=788AA_BP=153
MKMAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPSSWLIVVVGVMTTMYAKIDPSLGIIAKIN
RTLETANCMSSQTKNVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEHGKMSRATKIWMITYRLRHLLRARCDASPVTNNTIQFHC
DPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQQPPPRLINFQNHSPKPNGPVLP
PHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLP
SLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKV
PVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKS
EWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKK
KTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEP

--------------------------------------------------------------

>19234_19234_3_CPT1A-TRIM24_CPT1A_chr11_68574935_ENST00000540367_TRIM24_chr7_138235808_ENST00000343526_length(amino acids)=822AA_BP=153
MKMAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPSSWLIVVVGVMTTMYAKIDPSLGIIAKIN
RTLETANCMSSQTKNVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEHGKMSRATKIWMITYRLRHLLRARCDASPVTNNTIQFHC
DPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRM
QGPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTP
SSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSVPSPGLAGPVTMTS
VHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSILTSLLLNSS
QSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLT
NFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTI
KKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEFRNESEDNKFSDDSDDDFVQPRKK

--------------------------------------------------------------

>19234_19234_4_CPT1A-TRIM24_CPT1A_chr11_68574935_ENST00000540367_TRIM24_chr7_138235808_ENST00000415680_length(amino acids)=788AA_BP=153
MKMAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPSSWLIVVVGVMTTMYAKIDPSLGIIAKIN
RTLETANCMSSQTKNVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEHGKMSRATKIWMITYRLRHLLRARCDASPVTNNTIQFHC
DPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQQPPPRLINFQNHSPKPNGPVLP
PHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLP
SLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKV
PVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKS
EWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKK
KTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:68574935/chr7:138235808)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CPT1A P50416	TRIM24 O15164
FUNCTION: Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:9691089, PubMed:11350182, PubMed:14517221). Plays an important role in hepatic triglyceride metabolism (By similarity). {ECO:0000250\|UniProtKB:P32198, ECO:0000269\|PubMed:11350182, ECO:0000269\|PubMed:14517221, ECO:0000269\|PubMed:9691089}.	FUNCTION: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). {ECO:0000250, ECO:0000269\|PubMed:16322096, ECO:0000269\|PubMed:19556538, ECO:0000269\|PubMed:21164480}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000265641

2_47

151.0

774.0

Topological domain

Cytoplasmic

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000265641

74_102

151.0

774.0

Topological domain

Mitochondrial intermembrane

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000376618

2_47

151.0

757.0

Topological domain

Cytoplasmic

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000376618

74_102

151.0

757.0

Topological domain

Mitochondrial intermembrane

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000539743

2_47

151.0

774.0

Topological domain

Cytoplasmic

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000539743

74_102

151.0

774.0

Topological domain

Mitochondrial intermembrane

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000540367

2_47

151.0

757.0

Topological domain

Cytoplasmic

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000540367

74_102

151.0

757.0

Topological domain

Mitochondrial intermembrane

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000265641

103_122

151.0

774.0

Transmembrane

Helical

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000265641

48_73

151.0

774.0

Transmembrane

Helical

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000376618

103_122

151.0

757.0

Transmembrane

Helical

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000376618

48_73

151.0

757.0

Transmembrane

Helical

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000539743

103_122

151.0

774.0

Transmembrane

Helical

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000539743

48_73

151.0

774.0

Transmembrane

Helical

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000540367

103_122

151.0

757.0

Transmembrane

Helical

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000540367

48_73

151.0

757.0

Transmembrane

Helical

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000343526

932_987

381.0

1051.0

Domain

Bromo

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000415680

932_987

381.0

1017.0

Domain

Bromo

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000343526

891_907

381.0

1051.0

Motif

Nuclear localization signal

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000415680

891_907

381.0

1017.0

Motif

Nuclear localization signal

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000343526

754_779

381.0

1051.0

Region

Note=Nuclear receptor binding site (NRBS)

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000415680

754_779

381.0

1017.0

Region

Note=Nuclear receptor binding site (NRBS)

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000343526

826_873

381.0

1051.0

Zinc finger

PHD-type

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000415680

826_873

381.0

1017.0

Zinc finger

PHD-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000265641

555_567

151.0

774.0

Region

Coenzyme A binding

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000376618

555_567

151.0

757.0

Region

Coenzyme A binding

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000539743

555_567

151.0

774.0

Region

Coenzyme A binding

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000540367

555_567

151.0

757.0

Region

Coenzyme A binding

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000265641

123_773

151.0

774.0

Topological domain

Cytoplasmic

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000376618

123_773

151.0

757.0

Topological domain

Cytoplasmic

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000539743

123_773

151.0

774.0

Topological domain

Cytoplasmic

Hgene

CPT1A

chr11:68574935

chr7:138235808

ENST00000540367

123_773

151.0

757.0

Topological domain

Cytoplasmic

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000343526

289_359

381.0

1051.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000415680

289_359

381.0

1017.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000343526

344_347

381.0

1051.0

Compositional bias

Note=Poly-Gln

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000343526

9_15

381.0

1051.0

Compositional bias

Note=Poly-Ala

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000415680

344_347

381.0

1017.0

Compositional bias

Note=Poly-Gln

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000415680

9_15

381.0

1017.0

Compositional bias

Note=Poly-Ala

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000343526

158_211

381.0

1051.0

Zinc finger

B box-type 1

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000343526

218_259

381.0

1051.0

Zinc finger

B box-type 2

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000343526

56_82

381.0

1051.0

Zinc finger

RING-type

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000415680

158_211

381.0

1017.0

Zinc finger

B box-type 1

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000415680

218_259

381.0

1017.0

Zinc finger

B box-type 2

Tgene

TRIM24

chr11:68574935

chr7:138235808

ENST00000415680

56_82

381.0

1017.0

Zinc finger

RING-type

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1602_CPT1A_68574935_TRIM24_138235808_ranked_0.pdb	CPT1A	68574935	68574935	ENST00000415680	TRIM24	chr7	138235808	+	MKMAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPSSWLIVVVGVMTTMYAKIDPSLGIIAKIN RTLETANCMSSQTKNVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEHGKMSRATKIWMITYRLRHLLRARCDASPVTNNTIQFHC DPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGLPNPRM QGPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTP SSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSVPSPGLAGPVTMTS VHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSILTSLLLNSS QSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLT NFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTI KKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEFRNESEDNKFSDDSDDDFVQPRKK	822

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CPT1A_pLDDT.png

TRIM24_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

TRIM24

ZNF10, TRIM28, TRIM24, PML, NR3C2, ESR1, THRA, RARA, RXRA, NR3C1, AR, TRIM33, GTF2E1, TAF7, TAF11, UBE2U, ATF4, NFE2L2, STAT6, FOSL1, ESR2, PPARG, TP53, BRD7, HIST1H3A, HIST1H3D, HIST1H3C, HIST1H3E, HIST1H3I, HIST1H3G, HIST1H3J, HIST1H3H, HIST1H3B, HIST1H3F, HIST2H4B, HIST1H4I, HIST1H4A, HIST1H4D, HIST1H4F, HIST1H4K, HIST1H4C, HIST1H4H, HIST1H4B, HIST1H4E, HIST1H4L, HIST2H4A, HIST1H4J, HIST4H4, NCOA1, NONO, CDK12, SNRPA, SF3B2, SF3B1, RNF141, RNF181, TRIM8, BRCA1, RNF2, MAGEA10, RFPL4B, QPRT, HSPB1, NTRK1, MUS81, PTEN, TCF4, FOXI1, USP37, NANOG, ZNF264, ZNF483, ZNF324B, WDYHV1, ZNF695, ZIM2, SYCE3, ZNF764, ZNF785, ZNF331, ZNF133, ZNF254, ZNF550, CDC16, CNKSR1, MTNR1B, DTNBP1, STAT3, NR1I3, SOX2, TNRC6A, UBE2I, MYC, MCM2, SUPT6H, MCM4, PEX5, MCM6, MCM7, SUPT16H, SSRP1, SPOP, FBXO38, PLEKHA4, CREBBP, SMG7, H2AFY, NPM1, H2AFY2, BRD2, SET, ZC3H18, RSF1, MBD1, E2F2, TOP2A, BRPF1, AFF4, PADI2, TFDP2, ZCCHC8, MLKL, PPIH, TFDP1, VPS72, ENPP6, GADD45GIP1, SEZ6L, RAD18, PSD, CDH16, YEATS4, DSC2, MLLT1, RNF43, C10orf71, RCOR2, TANC1, ACTR6, RIBC2, FMN2, RBM7, NOLC1, SRCAP, RNPS1, XPC, MFAP1, DNASE2B, XPO1, TRAF3, UBE2D1, DNAJC19, CEP78, CALM1, SUMO2, SOD1, MARCKS, CALR, PDIA4, DPP7, PTMA, RPS28, PDIA3, HSPE1, CSTB, ALDOA, MOB2, MIF, DDTL, RPRD1B, TPM3, CYCS, STMN1, BASP1, SSB, LCE3D, PGK1, PFN1, TKT, NPC2, PA2G4, TAB1, MARCKSL1, CNPY2, MYL12B, ARHGDIA, MTPN, TPI1, MDH1, PGAM1, TBCA, HMGN1, GGH, PTMS, HSP90B1, MAT2A, ANXA5, PPIB, FABP5, PDIA6, DDX39B, CMBL, TALDO1, TPM4, NUDC, CKB, NUCKS1, GSTO1, HDGF, TAGLN2, PRDX5, PARK7, PEBP1, MYL6, AHSG, SOD2, TRIM37, APEX1, ASF1A, CBX3, HIST1H2BG, TERF2IP, ZNF330, HORMAD2, MAD2L1, ZNF418, ZNF776, CRYAA, ZNF287, ABTB2, CCT8L2, ZNF17, ZNF718, ZNF484, KRT37, NUP62, PIAS4, KXD1, KNSTRN, MAGEA9, NUP62CL, ZNF726, LURAP1, ZNF383, KRT39, TGM7, ZNF460, ZNF543, KRT38, TRIM52, NLRP3, T, ELF1, ELF3, ELF4, ELF5, ERG, ETS1, ETV4, FEV, FOS, GATA2, HNF1B, HNF4A, KLF15, KLF5, KLF6, KLF8, LHX1, LHX2, LHX3, LHX4, MYOD1, NFIC, NFIX, PAX6, SOX17, SOX5, SP7, TLX3, YY1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CPT1A
TRIM24

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CPT1A-TRIM24

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CPT1A-TRIM24

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	TRIM24	C0238463	Papillary thyroid carcinoma	2	ORPHANET
Tgene	TRIM24	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	TRIM24	C2239176	Liver carcinoma	1	CTD_human
Tgene	TRIM24	C3658266	Prostatic Cancer, Castration-Resistant	1	CTD_human
Tgene	TRIM24	C3658267	Prostatic Neoplasms, Castration-Resistant	1	CTD_human