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Fusion Protein:CREBBP-ZSCAN32 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: CREBBP-ZSCAN32 | FusionPDB ID: 19394 | FusionGDB2.0 ID: 19394 | Hgene | Tgene | Gene symbol | CREBBP | ZSCAN32 | Gene ID | 1387 | 54925 |
| Gene name | CREB binding protein | zinc finger and SCAN domain containing 32 | |
| Synonyms | CBP|KAT3A|MKHK1|RSTS|RSTS1 | HCCS-5|ZNF434 | |
| Cytomap | 16p13.3 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBP | zinc finger and SCAN domain-containing protein 32human cervical cancer suppressor gene 5 proteinzinc finger protein 434 | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | Q92793 | . | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000262367, ENST00000382070, | ENST00000304926, ENST00000396846, ENST00000396852, ENST00000422427, ENST00000439568, ENST00000573830, ENST00000574940, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 43 X 38 X 17=27778 | 1 X 2 X 1=2 |
| # samples | 61 | 1 | |
| ** MAII score | log2(61/27778*10)=-5.50898967694577 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/2*10)=2.32192809488736 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: CREBBP [Title/Abstract] AND ZSCAN32 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CREBBP(3832685)-ZSCAN32(3440517), # samples:1 CREBBP(3832685)-ZSCAN32(3434941), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | CREBBP-ZSCAN32 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-ZSCAN32 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-ZSCAN32 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-ZSCAN32 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CREBBP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21539536 |
| Hgene | CREBBP | GO:0006355 | regulation of transcription, DNA-templated | 12169688 |
| Hgene | CREBBP | GO:0006473 | protein acetylation | 15273251|24207024|24939902|28790157|30540930 |
| Hgene | CREBBP | GO:0016573 | histone acetylation | 11742995 |
| Hgene | CREBBP | GO:0018076 | N-terminal peptidyl-lysine acetylation | 12435739 |
| Hgene | CREBBP | GO:0034644 | cellular response to UV | 24939902 |
| Hgene | CREBBP | GO:0045893 | positive regulation of transcription, DNA-templated | 11742995 |
| Hgene | CREBBP | GO:1990258 | histone glutamine methylation | 30540930 |
| Fusion gene breakpoints across CREBBP (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ZSCAN32 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-60-2715 | CREBBP | chr16 | 3832685 | - | ZSCAN32 | chr16 | 3434941 | - |
| ChimerDB4 | LUSC | TCGA-60-2715 | CREBBP | chr16 | 3832685 | - | ZSCAN32 | chr16 | 3440517 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000262367 | CREBBP | chr16 | 3832685 | - | ENST00000304926 | ZSCAN32 | chr16 | 3434941 | - | 4493 | 2383 | 606 | 3725 | 1039 |
| ENST00000262367 | CREBBP | chr16 | 3832685 | - | ENST00000396852 | ZSCAN32 | chr16 | 3434941 | - | 4493 | 2383 | 606 | 3725 | 1039 |
| ENST00000262367 | CREBBP | chr16 | 3832685 | - | ENST00000396846 | ZSCAN32 | chr16 | 3434941 | - | 4492 | 2383 | 606 | 3725 | 1039 |
| ENST00000382070 | CREBBP | chr16 | 3832685 | - | ENST00000304926 | ZSCAN32 | chr16 | 3434941 | - | 3773 | 1663 | 0 | 3005 | 1001 |
| ENST00000382070 | CREBBP | chr16 | 3832685 | - | ENST00000396852 | ZSCAN32 | chr16 | 3434941 | - | 3773 | 1663 | 0 | 3005 | 1001 |
| ENST00000382070 | CREBBP | chr16 | 3832685 | - | ENST00000396846 | ZSCAN32 | chr16 | 3434941 | - | 3772 | 1663 | 0 | 3005 | 1001 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000262367 | ENST00000304926 | CREBBP | chr16 | 3832685 | - | ZSCAN32 | chr16 | 3434941 | - | 0.00272345 | 0.9972766 |
| ENST00000262367 | ENST00000396852 | CREBBP | chr16 | 3832685 | - | ZSCAN32 | chr16 | 3434941 | - | 0.00272345 | 0.9972766 |
| ENST00000262367 | ENST00000396846 | CREBBP | chr16 | 3832685 | - | ZSCAN32 | chr16 | 3434941 | - | 0.002720889 | 0.9972791 |
| ENST00000382070 | ENST00000304926 | CREBBP | chr16 | 3832685 | - | ZSCAN32 | chr16 | 3434941 | - | 0.001320676 | 0.99867934 |
| ENST00000382070 | ENST00000396852 | CREBBP | chr16 | 3832685 | - | ZSCAN32 | chr16 | 3434941 | - | 0.001320676 | 0.99867934 |
| ENST00000382070 | ENST00000396846 | CREBBP | chr16 | 3832685 | - | ZSCAN32 | chr16 | 3434941 | - | 0.001318249 | 0.9986817 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >19394_19394_1_CREBBP-ZSCAN32_CREBBP_chr16_3832685_ENST00000262367_ZSCAN32_chr16_3434941_ENST00000304926_length(amino acids)=1039AA_BP=1 MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATG VNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSL PHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSN PNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLATGVPWGYEETKTLLAILSSSQFYGKLQTCQQNSQIYR AMAEGLWEQGFLRTPEQCRTKFKSLQLSYRKVRRGRVPEPCIFYEEMNALSGSWASAPPMASDAVPGQEGSDIEAGELNHQNGEPTEVED GTVDGADRDEKDFRNPGQEVRKLDLPVLFPNRLGFEFKNEIKKENLKWDDSEEVEINKALQRKSRGVYWHSELQKGLESEPTSRRQCRNS PGESEEKTPSQEKMSHQSFCARDKACTHILCGKNCSQSVHSPHKPALKLEKVSQCPECGKTFSRSSYLVRHQRIHTGEKPHKCSECGKGF SERSNLTAHLRTHTGERPYQCGQCGKSFNQSSSLIVHQRTHTGEKPYQCIVCGKRFNNSSQFSAHRRIHTGESPYKCAVCGKIFNNSSHF -------------------------------------------------------------- >19394_19394_2_CREBBP-ZSCAN32_CREBBP_chr16_3832685_ENST00000262367_ZSCAN32_chr16_3434941_ENST00000396846_length(amino acids)=1039AA_BP=1 MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATG VNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSL PHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSN PNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLATGVPWGYEETKTLLAILSSSQFYGKLQTCQQNSQIYR AMAEGLWEQGFLRTPEQCRTKFKSLQLSYRKVRRGRVPEPCIFYEEMNALSGSWASAPPMASDAVPGQEGSDIEAGELNHQNGEPTEVED GTVDGADRDEKDFRNPGQEVRKLDLPVLFPNRLGFEFKNEIKKENLKWDDSEEVEINKALQRKSRGVYWHSELQKGLESEPTSRRQCRNS PGESEEKTPSQEKMSHQSFCARDKACTHILCGKNCSQSVHSPHKPALKLEKVSQCPECGKTFSRSSYLVRHQRIHTGEKPHKCSECGKGF SERSNLTAHLRTHTGERPYQCGQCGKSFNQSSSLIVHQRTHTGEKPYQCIVCGKRFNNSSQFSAHRRIHTGESPYKCAVCGKIFNNSSHF -------------------------------------------------------------- >19394_19394_3_CREBBP-ZSCAN32_CREBBP_chr16_3832685_ENST00000262367_ZSCAN32_chr16_3434941_ENST00000396852_length(amino acids)=1039AA_BP=1 MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATG VNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSL PHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSN PNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLATGVPWGYEETKTLLAILSSSQFYGKLQTCQQNSQIYR AMAEGLWEQGFLRTPEQCRTKFKSLQLSYRKVRRGRVPEPCIFYEEMNALSGSWASAPPMASDAVPGQEGSDIEAGELNHQNGEPTEVED GTVDGADRDEKDFRNPGQEVRKLDLPVLFPNRLGFEFKNEIKKENLKWDDSEEVEINKALQRKSRGVYWHSELQKGLESEPTSRRQCRNS PGESEEKTPSQEKMSHQSFCARDKACTHILCGKNCSQSVHSPHKPALKLEKVSQCPECGKTFSRSSYLVRHQRIHTGEKPHKCSECGKGF SERSNLTAHLRTHTGERPYQCGQCGKSFNQSSSLIVHQRTHTGEKPYQCIVCGKRFNNSSQFSAHRRIHTGESPYKCAVCGKIFNNSSHF -------------------------------------------------------------- >19394_19394_4_CREBBP-ZSCAN32_CREBBP_chr16_3832685_ENST00000382070_ZSCAN32_chr16_3434941_ENST00000304926_length(amino acids)=1001AA_BP=0 LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATG VNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSL PHCRTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPA QPQTHQQMRTLNPLATGVPWGYEETKTLLAILSSSQFYGKLQTCQQNSQIYRAMAEGLWEQGFLRTPEQCRTKFKSLQLSYRKVRRGRVP EPCIFYEEMNALSGSWASAPPMASDAVPGQEGSDIEAGELNHQNGEPTEVEDGTVDGADRDEKDFRNPGQEVRKLDLPVLFPNRLGFEFK NEIKKENLKWDDSEEVEINKALQRKSRGVYWHSELQKGLESEPTSRRQCRNSPGESEEKTPSQEKMSHQSFCARDKACTHILCGKNCSQS VHSPHKPALKLEKVSQCPECGKTFSRSSYLVRHQRIHTGEKPHKCSECGKGFSERSNLTAHLRTHTGERPYQCGQCGKSFNQSSSLIVHQ RTHTGEKPYQCIVCGKRFNNSSQFSAHRRIHTGESPYKCAVCGKIFNNSSHFSAHRKTHTGEKPYRCSHCERGFTKNSALTRHQTVHMKA -------------------------------------------------------------- >19394_19394_5_CREBBP-ZSCAN32_CREBBP_chr16_3832685_ENST00000382070_ZSCAN32_chr16_3434941_ENST00000396846_length(amino acids)=1001AA_BP=0 LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATG VNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSL PHCRTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPA QPQTHQQMRTLNPLATGVPWGYEETKTLLAILSSSQFYGKLQTCQQNSQIYRAMAEGLWEQGFLRTPEQCRTKFKSLQLSYRKVRRGRVP EPCIFYEEMNALSGSWASAPPMASDAVPGQEGSDIEAGELNHQNGEPTEVEDGTVDGADRDEKDFRNPGQEVRKLDLPVLFPNRLGFEFK NEIKKENLKWDDSEEVEINKALQRKSRGVYWHSELQKGLESEPTSRRQCRNSPGESEEKTPSQEKMSHQSFCARDKACTHILCGKNCSQS VHSPHKPALKLEKVSQCPECGKTFSRSSYLVRHQRIHTGEKPHKCSECGKGFSERSNLTAHLRTHTGERPYQCGQCGKSFNQSSSLIVHQ RTHTGEKPYQCIVCGKRFNNSSQFSAHRRIHTGESPYKCAVCGKIFNNSSHFSAHRKTHTGEKPYRCSHCERGFTKNSALTRHQTVHMKA -------------------------------------------------------------- >19394_19394_6_CREBBP-ZSCAN32_CREBBP_chr16_3832685_ENST00000382070_ZSCAN32_chr16_3434941_ENST00000396852_length(amino acids)=1001AA_BP=0 LRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATG VNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSL PHCRTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPA QPQTHQQMRTLNPLATGVPWGYEETKTLLAILSSSQFYGKLQTCQQNSQIYRAMAEGLWEQGFLRTPEQCRTKFKSLQLSYRKVRRGRVP EPCIFYEEMNALSGSWASAPPMASDAVPGQEGSDIEAGELNHQNGEPTEVEDGTVDGADRDEKDFRNPGQEVRKLDLPVLFPNRLGFEFK NEIKKENLKWDDSEEVEINKALQRKSRGVYWHSELQKGLESEPTSRRQCRNSPGESEEKTPSQEKMSHQSFCARDKACTHILCGKNCSQS VHSPHKPALKLEKVSQCPECGKTFSRSSYLVRHQRIHTGEKPHKCSECGKGFSERSNLTAHLRTHTGERPYQCGQCGKSFNQSSSLIVHQ RTHTGEKPYQCIVCGKRFNNSSQFSAHRRIHTGESPYKCAVCGKIFNNSSHFSAHRKTHTGEKPYRCSHCERGFTKNSALTRHQTVHMKA -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:3832685/chr16:3440517) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CREBBP | . |
| FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:9707565}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 347_433 | 524.3333333333334 | 2443.0 | Zinc finger | TAZ-type 1 |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 347_433 | 486.3333333333333 | 2405.0 | Zinc finger | TAZ-type 1 |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000304926 | 3 | 6 | 212_296 | 38.333333333333336 | 486.0 | Domain | Note=KRAB | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000304926 | 3 | 6 | 37_119 | 38.333333333333336 | 486.0 | Domain | SCAN box | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000304926 | 3 | 6 | 521_543 | 38.333333333333336 | 486.0 | Zinc finger | C2H2-type 1 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000304926 | 3 | 6 | 549_571 | 38.333333333333336 | 486.0 | Zinc finger | C2H2-type 2 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000304926 | 3 | 6 | 577_599 | 38.333333333333336 | 486.0 | Zinc finger | C2H2-type 3 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000304926 | 3 | 6 | 605_627 | 38.333333333333336 | 486.0 | Zinc finger | C2H2-type 4 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000304926 | 3 | 6 | 633_655 | 38.333333333333336 | 486.0 | Zinc finger | C2H2-type 5 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000304926 | 3 | 6 | 661_683 | 38.333333333333336 | 486.0 | Zinc finger | C2H2-type 6 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396846 | 3 | 6 | 521_543 | 250.33333333333334 | 698.0 | Zinc finger | C2H2-type 1 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396846 | 3 | 6 | 549_571 | 250.33333333333334 | 698.0 | Zinc finger | C2H2-type 2 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396846 | 3 | 6 | 577_599 | 250.33333333333334 | 698.0 | Zinc finger | C2H2-type 3 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396846 | 3 | 6 | 605_627 | 250.33333333333334 | 698.0 | Zinc finger | C2H2-type 4 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396846 | 3 | 6 | 633_655 | 250.33333333333334 | 698.0 | Zinc finger | C2H2-type 5 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396846 | 3 | 6 | 661_683 | 250.33333333333334 | 698.0 | Zinc finger | C2H2-type 6 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396852 | 4 | 7 | 521_543 | 250.33333333333334 | 698.0 | Zinc finger | C2H2-type 1 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396852 | 4 | 7 | 549_571 | 250.33333333333334 | 698.0 | Zinc finger | C2H2-type 2 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396852 | 4 | 7 | 577_599 | 250.33333333333334 | 698.0 | Zinc finger | C2H2-type 3 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396852 | 4 | 7 | 605_627 | 250.33333333333334 | 698.0 | Zinc finger | C2H2-type 4 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396852 | 4 | 7 | 633_655 | 250.33333333333334 | 698.0 | Zinc finger | C2H2-type 5 | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396852 | 4 | 7 | 661_683 | 250.33333333333334 | 698.0 | Zinc finger | C2H2-type 6 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 1061_1064 | 524.3333333333334 | 2443.0 | Compositional bias | Note=Poly-Glu |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 1199_1487 | 524.3333333333334 | 2443.0 | Compositional bias | Note=Cys/His-rich |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 1555_1562 | 524.3333333333334 | 2443.0 | Compositional bias | Note=Poly-Glu |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 1943_1948 | 524.3333333333334 | 2443.0 | Compositional bias | Note=Poly-Pro |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 1967_1970 | 524.3333333333334 | 2443.0 | Compositional bias | Note=Poly-Gln |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 2081_2085 | 524.3333333333334 | 2443.0 | Compositional bias | Note=Poly-Gln |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 2199_2216 | 524.3333333333334 | 2443.0 | Compositional bias | Note=Poly-Gln |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 2245_2248 | 524.3333333333334 | 2443.0 | Compositional bias | Note=Poly-Gln |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 2297_2300 | 524.3333333333334 | 2443.0 | Compositional bias | Note=Poly-Gln |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 1061_1064 | 486.3333333333333 | 2405.0 | Compositional bias | Note=Poly-Glu |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 1199_1487 | 486.3333333333333 | 2405.0 | Compositional bias | Note=Cys/His-rich |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 1555_1562 | 486.3333333333333 | 2405.0 | Compositional bias | Note=Poly-Glu |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 1943_1948 | 486.3333333333333 | 2405.0 | Compositional bias | Note=Poly-Pro |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 1967_1970 | 486.3333333333333 | 2405.0 | Compositional bias | Note=Poly-Gln |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 2081_2085 | 486.3333333333333 | 2405.0 | Compositional bias | Note=Poly-Gln |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 2199_2216 | 486.3333333333333 | 2405.0 | Compositional bias | Note=Poly-Gln |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 2245_2248 | 486.3333333333333 | 2405.0 | Compositional bias | Note=Poly-Gln |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 2297_2300 | 486.3333333333333 | 2405.0 | Compositional bias | Note=Poly-Gln |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 1103_1175 | 524.3333333333334 | 2443.0 | Domain | Bromo |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 1323_1700 | 524.3333333333334 | 2443.0 | Domain | CBP/p300-type HAT |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 587_666 | 524.3333333333334 | 2443.0 | Domain | KIX |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 1103_1175 | 486.3333333333333 | 2405.0 | Domain | Bromo |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 1323_1700 | 486.3333333333333 | 2405.0 | Domain | CBP/p300-type HAT |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 587_666 | 486.3333333333333 | 2405.0 | Domain | KIX |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 1434_1436 | 524.3333333333334 | 2443.0 | Region | Acetyl-CoA binding |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 1446_1447 | 524.3333333333334 | 2443.0 | Region | Acetyl-CoA binding |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 1434_1436 | 486.3333333333333 | 2405.0 | Region | Acetyl-CoA binding |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 1446_1447 | 486.3333333333333 | 2405.0 | Region | Acetyl-CoA binding |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 1701_1744 | 524.3333333333334 | 2443.0 | Zinc finger | ZZ-type |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 1765_1846 | 524.3333333333334 | 2443.0 | Zinc finger | TAZ-type 2 |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 1701_1744 | 486.3333333333333 | 2405.0 | Zinc finger | ZZ-type |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 1765_1846 | 486.3333333333333 | 2405.0 | Zinc finger | TAZ-type 2 |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396846 | 3 | 6 | 212_296 | 250.33333333333334 | 698.0 | Domain | Note=KRAB | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396846 | 3 | 6 | 37_119 | 250.33333333333334 | 698.0 | Domain | SCAN box | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396852 | 4 | 7 | 212_296 | 250.33333333333334 | 698.0 | Domain | Note=KRAB | |
| Tgene | ZSCAN32 | chr16:3832685 | chr16:3434941 | ENST00000396852 | 4 | 7 | 37_119 | 250.33333333333334 | 698.0 | Domain | SCAN box |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| CREBBP | EGR1, HNF4A, NFE2L2, TDG, AIRE, NCOA6, BRCA1, CREB1, AR, N4BP2, CTNNB1, RELA, SS18L1, PIAS3, NPAS2, EBF1, E2F1, E2F3, KLF5, PML, SRF, TP53, KLF1, ING1, SMAD1, CSNK2A1, CUX1, ATF1, EWSR1, NR3C1, HNF1A, HOXB7, MSX1, HTT, TCF3, MGMT, KMT2A, MYOD1, ATF2, JUN, MECOM, GLI3, DDX5, PTMA, MYB, FOXO1, FOXO4, RPS6KA3, CITED1, STAT1, STAT6, MAF, PELP1, RPS6KA2, RBBP4, RBBP7, ONECUT1, SERTAD1, SREBF1, SREBF2, NFATC2, TRIP4, HIF1A, NFE2, STAT2, SMARCA4, NCOA1, ESR1, MAML1, MYBL2, KAT2B, GTF2B, CITED2, IRF3, NUP98, TRERF1, TGS1, KLF4, STAT3, NEUROG1, HIPK2, KHDRBS1, GATA1, PHOX2A, SNIP1, NFATC4, KLF13, XRCC6, FOS, POLR2A, SMARCB1, CCNC, CDK8, MED21, NKX2-1, NCOA3, PPARG, ATF4, RPA2, PPARGC1A, HIST3H3, HIST4H4, EP300, ANAPC7, ANAPC5, CDC16, ANAPC2, CDH1, CDC20, REL, DDX17, GCM1, MAP3K5, MAPK10, MKNK1, APC, PAPOLA, CPSF6, TBX21, NCOR1, NCOR2, CARM1, ESR2, YY1, MYC, PLAGL1, MIER1, HDAC1, SP1, SP3, HDAC3, VDR, DAXX, CEBPB, CEBPD, PARP1, tat, PTMS, ATXN3, CTBP1, HIST1H3A, MTF1, SETD1A, MYBL1, NLK, SMAD3, DEK, FGFR1, RPS6KA1, CDKN1A, SND1, NCOA2, KAT6A, SRCAP, TAF6L, ETS1, ETS2, RUNX2, MAFK, TCF12, HDAC2, HOXB6, KPNA2, KPNA6, NR5A1, HMGA1, FOXO3, HIST1H4A, HES6, RUVBL1, FOSL1, FOSB, JUNB, FOXM1, HMGB1, HMGB2, POU1F1, IRF1, SMAD2, RARA, SH3GL1, BCL6, GRIP1, KLF8, NFYB, TRIM28, POT1, WDR5, IRF5, AKT1, CDC27, ATF3, ATG3, MDM2, HOXB2, HOXB3, HOXB9, HOXD12, HOXD13, HOXD10, HOXD4, HOXB4, HOXA10, HOXA9, PBX1, SMARCA2, MYH9, MSH6, MSH2, ZBTB2, ZNF639, ACTA2, CSNK2A2, TP73, PRLR, MED25, PTOV1, IFNAR2, IRF9, TBP, RPS6KA5, IRF7, KAT5, PYGO2, HBP1, TACC2, NPAT, CCNE1, ELAVL1, KDM3B, PSMC5, MDC1, LYN, HCK, SRC, ZCCHC12, RAD23A, RUNX1, CHUK, IKBKB, IKBKG, HIST2H2BE, LIG4, TLR2, EPAS1, K8, MTDH, MEIS1, LDLR, vIRF-1, vIRF-3, DYRK1B, DYRK1A, CDK2, EID1, COPS2, PSME3, WRN, KLF2, UBE2D1, CREBBP, UBE2I, MAPK3, FHL1, HIST1H2BB, Ctnnb1, Cebpb, EID3, POU2F3, Spi1, Nfic, ELK1, MAPK1, TFDP1, CREM, ZEB1, CRTC1, MAML2, HCVgp1, CENPJ, HSF1, FHL2, CDH2, PHOX2B, DDIT3, XAF1, BMI1, HHV8GK18_gp81, Ar, CCND3, TXNDC11, CCNA2, C3orf62, PPP1R13L, BRMS1, PCNA, UBE2S, TLE3, MUS81, PTTG1, MED23, E7, SNAI1, TFAP2B, SMAD4, NR3C2, ARNTL, CLOCK, E6, SUMO1, NFATC1, CPSF4, USP7, RFPL3, CTGF, NFYA, KIAA0430, HELZ, NISCH, SOWAHA, PCGF3, EIF4ENIF1, PAN2, JUP, HSPA8, LAMP2, TRIM25, HNRNPL, DUX4, HLF, EGLN3, FGF2, TH, FBXL19, USP14, BBC3, RBBP5, GATA3, BYRF1, TP53BP1, KIAA1429, ATF7IP, ATRX, CASP8AP2, CBX4, CHAF1A, CHD3, EIF3D, GATAD2A, HIPK3, HMGXB4, FBXO38, PIAS2, PPP1R8, PPP2R2A, PTPRF, RNF111, RPL3, RPL35, SETDB1, SP100, TOPORS, UIMC1, ZCCHC7, ZMYM2, ZNF451, ZNF106, HIPK1, PIAS1, FAF1, KISS1, ZHX1, ZMYM5, ZNFX1, WDR77, PPP1CC, BRIP1, CCAR2, HSPB1, MAPT, PNKP, PPP1CA, POLR1E, DDX3X, TSPYL2, PYCR1, TRIM24, SMG7, AFP, BRD4, KDM2B, ACSS1, ACTB, ANKS1A, ANKS1B, ANXA7, APP, BAG5, TUBB, CNTRL, CEP290, CHRDL1, CLASP2, EEF1A1, EEF2, EIF4G2, FUS, GAA, GPR161, GRIA3, GSTO2, HEXA, HIVEP1, HIVEP2, HMG20A, HUWE1, IQGAP1, KDM6B, KDM2A, CAMSAP2, EPG5, KIF5A, MAP1B, MYO1E, OGT, PAPPA, PAX6, PHLDA1, RAD50, RBM24, RBM5, RFK, RNF7, RPS20, EXOC5, SEMA3B, SEPT3, SLC1A4, SNAPC5, SNRNP200, SOS2, SPTAN1, SYT1, TIAL1, TIAM1, TP53BP2, KDM6A, VAT1L, WAS, YTHDF2, BCAT2, CDC25A, TERF2IP, TGM1, BAG2, GMEB2, HIST1H2AB, LATS1, RXRA, NEUROD1, CIITA, FOXH1, T, ERG, ETV4, FEV, FOXI1, FOXQ1, GATA2, HNF1B, KLF15, LHX3, NFIA, NFIB, PAX7, PAX8, SOX9, SP7, TAL1, TEAD1, TLX1, SNAI2, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| CREBBP |  |
| ZSCAN32 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 1162_1180 | 524.3333333333334 | 2443.0 | ASF1A |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 1162_1180 | 486.3333333333333 | 2405.0 | ASF1A |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 1433_1435 | 524.3333333333334 | 2443.0 | histone |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 1433_1435 | 486.3333333333333 | 2405.0 | histone |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 1124_1170 | 524.3333333333334 | 2443.0 | histone |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 1124_1170 | 486.3333333333333 | 2405.0 | histone |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000262367 | - | 6 | 31 | 1460_1891 | 524.3333333333334 | 2443.0 | TRERF1 |
| Hgene | CREBBP | chr16:3832685 | chr16:3434941 | ENST00000382070 | - | 5 | 30 | 1460_1891 | 486.3333333333333 | 2405.0 | TRERF1 |
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Related Drugs to CREBBP-ZSCAN32 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to CREBBP-ZSCAN32 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CREBBP | C4551859 | RUBINSTEIN-TAYBI SYNDROME 1 | 12 | CLINGEN;GENOMICS_ENGLAND;UNIPROT |
| Hgene | CREBBP | C0035934 | Rubinstein-Taybi Syndrome | 6 | CLINGEN;CTD_human |
| Hgene | CREBBP | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Hgene | CREBBP | C0376358 | Malignant neoplasm of prostate | 2 | CTD_human |
| Hgene | CREBBP | C4511003 | Acute myeloid leukemia with t(8;16)(p11;p13) translocation | 2 | ORPHANET |
| Hgene | CREBBP | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
| Hgene | CREBBP | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Hgene | CREBBP | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | CREBBP | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
| Hgene | CREBBP | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | CREBBP | C0011573 | Endogenous depression | 1 | PSYGENET |
| Hgene | CREBBP | C0024301 | Lymphoma, Follicular | 1 | CTD_human |
| Hgene | CREBBP | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Hgene | CREBBP | C0079745 | Lymphoma, Large-Cell, Follicular | 1 | CTD_human |
| Hgene | CREBBP | C0079758 | Lymphoma, Mixed-Cell, Follicular | 1 | CTD_human |
| Hgene | CREBBP | C0079765 | Lymphoma, Small Cleaved-Cell, Follicular | 1 | CTD_human |
| Hgene | CREBBP | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
| Hgene | CREBBP | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Hgene | CREBBP | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Hgene | CREBBP | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
| Hgene | CREBBP | C1862941 | Amyotrophic Lateral Sclerosis, Sporadic | 1 | CTD_human |
| Hgene | CREBBP | C1956130 | Lymphoma, Follicular, Grade 1 | 1 | CTD_human |
| Hgene | CREBBP | C1956131 | Lymphoma, Follicular, Grade 3 | 1 | CTD_human |
| Hgene | CREBBP | C1956132 | Lymphoma, Follicular, Grade 2 | 1 | CTD_human |
| Hgene | CREBBP | C4551993 | Amyotrophic Lateral Sclerosis, Familial | 1 | CTD_human |
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