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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CSMD1-C15orf41

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CSMD1-C15orf41
	FusionPDB ID: 19730
	FusionGDB2.0 ID: 19730
		Hgene	Tgene
	Gene symbol	CSMD1	C15orf41
	Gene ID	64478	84529
	Gene name	CUB and Sushi multiple domains 1	chromosome 15 open reading frame 41
	Synonyms	PPP1R24	HH114
	Cytomap	8p23.2	15q14
	Type of gene	protein-coding	protein-coding
	Description	CUB and sushi domain-containing protein 1protein phosphatase 1, regulatory subunit 24	protein C15orf41uncharacterized protein C15orf41
	Modification date	20200313	20200313
	UniProtAcc	Q96PZ7	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000400186, ENST00000520002, ENST00000537824, ENST00000539096, ENST00000542608, ENST00000602557, ENST00000602723, ENST00000523387,	ENST00000562489, ENST00000563167, ENST00000565792, ENST00000338183, ENST00000567389, ENST00000569302, ENST00000437989, ENST00000562877, ENST00000566621,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	31 X 30 X 4=3720	8 X 5 X 7=280
	# samples	32	10
	** MAII score	log2(32/3720*10)=-3.53915881110803 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CSMD1 [Title/Abstract] AND C15orf41 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CSMD1(4851854)-C15orf41(37100525), # samples:3
Anticipated loss of major functional domain due to fusion event.	CSMD1-C15orf41 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. CSMD1-C15orf41 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CSMD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C15orf41 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-63-5131-01A	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+
ChimerDB4	LUSC	TCGA-63-5131	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+
ChimerDB4	LUSC	TCGA-63-5131	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000602723	CSMD1	chr8	4851854	-	ENST00000566621	C15orf41	chr15	37100525	+	2270	370	289	606	105
ENST00000602723	CSMD1	chr8	4851854	-	ENST00000437989	C15orf41	chr15	37100525	+	1877	370	81	386	101
ENST00000602723	CSMD1	chr8	4851854	-	ENST00000562877	C15orf41	chr15	37100525	+	500	370	81	386	101
ENST00000400186	CSMD1	chr8	4851854	-	ENST00000566621	C15orf41	chr15	37100525	+	2270	370	289	606	105
ENST00000400186	CSMD1	chr8	4851854	-	ENST00000437989	C15orf41	chr15	37100525	+	1877	370	81	386	101
ENST00000400186	CSMD1	chr8	4851854	-	ENST00000562877	C15orf41	chr15	37100525	+	500	370	81	386	101
ENST00000520002	CSMD1	chr8	4851854	-	ENST00000566621	C15orf41	chr15	37100525	+	2541	641	190	657	155
ENST00000520002	CSMD1	chr8	4851854	-	ENST00000437989	C15orf41	chr15	37100525	+	2148	641	190	657	155
ENST00000520002	CSMD1	chr8	4851854	-	ENST00000562877	C15orf41	chr15	37100525	+	771	641	190	657	155
ENST00000602557	CSMD1	chr8	4851854	-	ENST00000566621	C15orf41	chr15	37100525	+	2541	641	190	657	155
ENST00000602557	CSMD1	chr8	4851854	-	ENST00000437989	C15orf41	chr15	37100525	+	2148	641	190	657	155
ENST00000602557	CSMD1	chr8	4851854	-	ENST00000562877	C15orf41	chr15	37100525	+	771	641	190	657	155
ENST00000537824	CSMD1	chr8	4851854	-	ENST00000566621	C15orf41	chr15	37100525	+	1985	85	4	321	105
ENST00000537824	CSMD1	chr8	4851854	-	ENST00000437989	C15orf41	chr15	37100525	+	1592	85	1040	1345	101
ENST00000537824	CSMD1	chr8	4851854	-	ENST00000562877	C15orf41	chr15	37100525	+	215	85	4	213	70
ENST00000542608	CSMD1	chr8	4851854	-	ENST00000566621	C15orf41	chr15	37100525	+	1985	85	4	321	105
ENST00000542608	CSMD1	chr8	4851854	-	ENST00000437989	C15orf41	chr15	37100525	+	1592	85	1040	1345	101
ENST00000542608	CSMD1	chr8	4851854	-	ENST00000562877	C15orf41	chr15	37100525	+	215	85	4	213	70
ENST00000539096	CSMD1	chr8	4851854	-	ENST00000566621	C15orf41	chr15	37100525	+	1985	85	4	321	105
ENST00000539096	CSMD1	chr8	4851854	-	ENST00000437989	C15orf41	chr15	37100525	+	1592	85	1040	1345	101
ENST00000539096	CSMD1	chr8	4851854	-	ENST00000562877	C15orf41	chr15	37100525	+	215	85	4	213	70
ENST00000602723	CSMD1	chr8	4851853	-	ENST00000566621	C15orf41	chr15	37100524	+	2270	370	289	606	105
ENST00000602723	CSMD1	chr8	4851853	-	ENST00000437989	C15orf41	chr15	37100524	+	1877	370	81	386	101
ENST00000602723	CSMD1	chr8	4851853	-	ENST00000562877	C15orf41	chr15	37100524	+	500	370	81	386	101
ENST00000400186	CSMD1	chr8	4851853	-	ENST00000566621	C15orf41	chr15	37100524	+	2270	370	289	606	105
ENST00000400186	CSMD1	chr8	4851853	-	ENST00000437989	C15orf41	chr15	37100524	+	1877	370	81	386	101
ENST00000400186	CSMD1	chr8	4851853	-	ENST00000562877	C15orf41	chr15	37100524	+	500	370	81	386	101
ENST00000520002	CSMD1	chr8	4851853	-	ENST00000566621	C15orf41	chr15	37100524	+	2541	641	190	657	155
ENST00000520002	CSMD1	chr8	4851853	-	ENST00000437989	C15orf41	chr15	37100524	+	2148	641	190	657	155
ENST00000520002	CSMD1	chr8	4851853	-	ENST00000562877	C15orf41	chr15	37100524	+	771	641	190	657	155
ENST00000602557	CSMD1	chr8	4851853	-	ENST00000566621	C15orf41	chr15	37100524	+	2541	641	190	657	155
ENST00000602557	CSMD1	chr8	4851853	-	ENST00000437989	C15orf41	chr15	37100524	+	2148	641	190	657	155
ENST00000602557	CSMD1	chr8	4851853	-	ENST00000562877	C15orf41	chr15	37100524	+	771	641	190	657	155
ENST00000537824	CSMD1	chr8	4851853	-	ENST00000566621	C15orf41	chr15	37100524	+	1985	85	4	321	105
ENST00000537824	CSMD1	chr8	4851853	-	ENST00000437989	C15orf41	chr15	37100524	+	1592	85	1040	1345	101
ENST00000537824	CSMD1	chr8	4851853	-	ENST00000562877	C15orf41	chr15	37100524	+	215	85	4	213	70
ENST00000542608	CSMD1	chr8	4851853	-	ENST00000566621	C15orf41	chr15	37100524	+	1985	85	4	321	105
ENST00000542608	CSMD1	chr8	4851853	-	ENST00000437989	C15orf41	chr15	37100524	+	1592	85	1040	1345	101
ENST00000542608	CSMD1	chr8	4851853	-	ENST00000562877	C15orf41	chr15	37100524	+	215	85	4	213	70
ENST00000539096	CSMD1	chr8	4851853	-	ENST00000566621	C15orf41	chr15	37100524	+	1985	85	4	321	105
ENST00000539096	CSMD1	chr8	4851853	-	ENST00000437989	C15orf41	chr15	37100524	+	1592	85	1040	1345	101
ENST00000539096	CSMD1	chr8	4851853	-	ENST00000562877	C15orf41	chr15	37100524	+	215	85	4	213	70

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000602723	ENST00000566621	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.06397683	0.9360232
ENST00000602723	ENST00000437989	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.04267222	0.95732784
ENST00000602723	ENST00000562877	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.31530428	0.68469566
ENST00000400186	ENST00000566621	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.06397683	0.9360232
ENST00000400186	ENST00000437989	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.04267222	0.95732784
ENST00000400186	ENST00000562877	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.31530428	0.68469566
ENST00000520002	ENST00000566621	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.17829996	0.8217
ENST00000520002	ENST00000437989	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.44590136	0.55409867
ENST00000520002	ENST00000562877	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.53764594	0.46235403
ENST00000602557	ENST00000566621	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.17829996	0.8217
ENST00000602557	ENST00000437989	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.44590136	0.55409867
ENST00000602557	ENST00000562877	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.53764594	0.46235403
ENST00000537824	ENST00000566621	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.113826334	0.8861736
ENST00000537824	ENST00000437989	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.12322064	0.8767794
ENST00000537824	ENST00000562877	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.39209157	0.60790837
ENST00000542608	ENST00000566621	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.113826334	0.8861736
ENST00000542608	ENST00000437989	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.12322064	0.8767794
ENST00000542608	ENST00000562877	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.39209157	0.60790837
ENST00000539096	ENST00000566621	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.113826334	0.8861736
ENST00000539096	ENST00000437989	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.12322064	0.8767794
ENST00000539096	ENST00000562877	CSMD1	chr8	4851854	-	C15orf41	chr15	37100525	+	0.39209157	0.60790837
ENST00000602723	ENST00000566621	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.06397683	0.9360232
ENST00000602723	ENST00000437989	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.04267222	0.95732784
ENST00000602723	ENST00000562877	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.31530428	0.68469566
ENST00000400186	ENST00000566621	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.06397683	0.9360232
ENST00000400186	ENST00000437989	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.04267222	0.95732784
ENST00000400186	ENST00000562877	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.31530428	0.68469566
ENST00000520002	ENST00000566621	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.17829996	0.8217
ENST00000520002	ENST00000437989	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.44590136	0.55409867
ENST00000520002	ENST00000562877	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.53764594	0.46235403
ENST00000602557	ENST00000566621	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.17829996	0.8217
ENST00000602557	ENST00000437989	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.44590136	0.55409867
ENST00000602557	ENST00000562877	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.53764594	0.46235403
ENST00000537824	ENST00000566621	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.113826334	0.8861736
ENST00000537824	ENST00000437989	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.12322064	0.8767794
ENST00000537824	ENST00000562877	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.39209157	0.60790837
ENST00000542608	ENST00000566621	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.113826334	0.8861736
ENST00000542608	ENST00000437989	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.12322064	0.8767794
ENST00000542608	ENST00000562877	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.39209157	0.60790837
ENST00000539096	ENST00000566621	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.113826334	0.8861736
ENST00000539096	ENST00000437989	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.12322064	0.8767794
ENST00000539096	ENST00000562877	CSMD1	chr8	4851853	-	C15orf41	chr15	37100524	+	0.39209157	0.60790837

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>19730_19730_1_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000400186_C15orf41_chr15_37100524_ENST00000437989_length(amino acids)=101AA_BP=
MQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLRLALPSGDYLAPLIALPSSEEPSVSRACGVSADMTAWRRFQSLLLLLGLLVLCAR

--------------------------------------------------------------

>19730_19730_2_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000400186_C15orf41_chr15_37100524_ENST00000562877_length(amino acids)=101AA_BP=
MQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLRLALPSGDYLAPLIALPSSEEPSVSRACGVSADMTAWRRFQSLLLLLGLLVLCAR

--------------------------------------------------------------

>19730_19730_3_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000400186_C15orf41_chr15_37100524_ENST00000566621_length(amino acids)=105AA_BP=27
MRGGDSSRCSCFSGCWCCARGSSLQRRIWARLSHLLVWIYPGAGLQPGKGHPAQSLFPHEHCHLMPQHSLTLKILEEKLGGKGESGSNFT

--------------------------------------------------------------

>19730_19730_4_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000520002_C15orf41_chr15_37100524_ENST00000437989_length(amino acids)=155AA_BP=
MPPLQVSPGCARSSPRFSPSRSLAALVPSCPARPALVPGPGPASPGLRARSSSALQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLR

--------------------------------------------------------------

>19730_19730_5_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000520002_C15orf41_chr15_37100524_ENST00000562877_length(amino acids)=155AA_BP=
MPPLQVSPGCARSSPRFSPSRSLAALVPSCPARPALVPGPGPASPGLRARSSSALQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLR

--------------------------------------------------------------

>19730_19730_6_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000520002_C15orf41_chr15_37100524_ENST00000566621_length(amino acids)=155AA_BP=
MPPLQVSPGCARSSPRFSPSRSLAALVPSCPARPALVPGPGPASPGLRARSSSALQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLR

--------------------------------------------------------------

>19730_19730_7_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000537824_C15orf41_chr15_37100524_ENST00000437989_length(amino acids)=101AA_BP=
MGNTNNNNVIFADSFNLYTLLDFFQKTKYVIYTLFIFYQRRFVKICLLLFLLKDTNLVPTCVDFNSEWGALNQKREAEDEMLKKGQANFC

--------------------------------------------------------------

>19730_19730_8_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000537824_C15orf41_chr15_37100524_ENST00000562877_length(amino acids)=70AA_BP=27

--------------------------------------------------------------

>19730_19730_9_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000537824_C15orf41_chr15_37100524_ENST00000566621_length(amino acids)=105AA_BP=27
MRGGDSSRCSCFSGCWCCARGSSLQRRIWARLSHLLVWIYPGAGLQPGKGHPAQSLFPHEHCHLMPQHSLTLKILEEKLGGKGESGSNFT

--------------------------------------------------------------

>19730_19730_10_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000539096_C15orf41_chr15_37100524_ENST00000437989_length(amino acids)=101AA_BP=
MGNTNNNNVIFADSFNLYTLLDFFQKTKYVIYTLFIFYQRRFVKICLLLFLLKDTNLVPTCVDFNSEWGALNQKREAEDEMLKKGQANFC

--------------------------------------------------------------

>19730_19730_11_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000539096_C15orf41_chr15_37100524_ENST00000562877_length(amino acids)=70AA_BP=27

--------------------------------------------------------------

>19730_19730_12_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000539096_C15orf41_chr15_37100524_ENST00000566621_length(amino acids)=105AA_BP=27
MRGGDSSRCSCFSGCWCCARGSSLQRRIWARLSHLLVWIYPGAGLQPGKGHPAQSLFPHEHCHLMPQHSLTLKILEEKLGGKGESGSNFT

--------------------------------------------------------------

>19730_19730_13_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000542608_C15orf41_chr15_37100524_ENST00000437989_length(amino acids)=101AA_BP=
MGNTNNNNVIFADSFNLYTLLDFFQKTKYVIYTLFIFYQRRFVKICLLLFLLKDTNLVPTCVDFNSEWGALNQKREAEDEMLKKGQANFC

--------------------------------------------------------------

>19730_19730_14_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000542608_C15orf41_chr15_37100524_ENST00000562877_length(amino acids)=70AA_BP=27

--------------------------------------------------------------

>19730_19730_15_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000542608_C15orf41_chr15_37100524_ENST00000566621_length(amino acids)=105AA_BP=27
MRGGDSSRCSCFSGCWCCARGSSLQRRIWARLSHLLVWIYPGAGLQPGKGHPAQSLFPHEHCHLMPQHSLTLKILEEKLGGKGESGSNFT

--------------------------------------------------------------

>19730_19730_16_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000602557_C15orf41_chr15_37100524_ENST00000437989_length(amino acids)=155AA_BP=
MPPLQVSPGCARSSPRFSPSRSLAALVPSCPARPALVPGPGPASPGLRARSSSALQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLR

--------------------------------------------------------------

>19730_19730_17_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000602557_C15orf41_chr15_37100524_ENST00000562877_length(amino acids)=155AA_BP=
MPPLQVSPGCARSSPRFSPSRSLAALVPSCPARPALVPGPGPASPGLRARSSSALQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLR

--------------------------------------------------------------

>19730_19730_18_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000602557_C15orf41_chr15_37100524_ENST00000566621_length(amino acids)=155AA_BP=
MPPLQVSPGCARSSPRFSPSRSLAALVPSCPARPALVPGPGPASPGLRARSSSALQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLR

--------------------------------------------------------------

>19730_19730_19_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000602723_C15orf41_chr15_37100524_ENST00000437989_length(amino acids)=101AA_BP=
MQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLRLALPSGDYLAPLIALPSSEEPSVSRACGVSADMTAWRRFQSLLLLLGLLVLCAR

--------------------------------------------------------------

>19730_19730_20_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000602723_C15orf41_chr15_37100524_ENST00000562877_length(amino acids)=101AA_BP=
MQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLRLALPSGDYLAPLIALPSSEEPSVSRACGVSADMTAWRRFQSLLLLLGLLVLCAR

--------------------------------------------------------------

>19730_19730_21_CSMD1-C15orf41_CSMD1_chr8_4851853_ENST00000602723_C15orf41_chr15_37100524_ENST00000566621_length(amino acids)=105AA_BP=27
MRGGDSSRCSCFSGCWCCARGSSLQRRIWARLSHLLVWIYPGAGLQPGKGHPAQSLFPHEHCHLMPQHSLTLKILEEKLGGKGESGSNFT

--------------------------------------------------------------

>19730_19730_22_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000400186_C15orf41_chr15_37100525_ENST00000437989_length(amino acids)=101AA_BP=
MQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLRLALPSGDYLAPLIALPSSEEPSVSRACGVSADMTAWRRFQSLLLLLGLLVLCAR

--------------------------------------------------------------

>19730_19730_23_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000400186_C15orf41_chr15_37100525_ENST00000562877_length(amino acids)=101AA_BP=
MQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLRLALPSGDYLAPLIALPSSEEPSVSRACGVSADMTAWRRFQSLLLLLGLLVLCAR

--------------------------------------------------------------

>19730_19730_24_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000400186_C15orf41_chr15_37100525_ENST00000566621_length(amino acids)=105AA_BP=27
MRGGDSSRCSCFSGCWCCARGSSLQRRIWARLSHLLVWIYPGAGLQPGKGHPAQSLFPHEHCHLMPQHSLTLKILEEKLGGKGESGSNFT

--------------------------------------------------------------

>19730_19730_25_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000520002_C15orf41_chr15_37100525_ENST00000437989_length(amino acids)=155AA_BP=
MPPLQVSPGCARSSPRFSPSRSLAALVPSCPARPALVPGPGPASPGLRARSSSALQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLR

--------------------------------------------------------------

>19730_19730_26_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000520002_C15orf41_chr15_37100525_ENST00000562877_length(amino acids)=155AA_BP=
MPPLQVSPGCARSSPRFSPSRSLAALVPSCPARPALVPGPGPASPGLRARSSSALQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLR

--------------------------------------------------------------

>19730_19730_27_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000520002_C15orf41_chr15_37100525_ENST00000566621_length(amino acids)=155AA_BP=
MPPLQVSPGCARSSPRFSPSRSLAALVPSCPARPALVPGPGPASPGLRARSSSALQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLR

--------------------------------------------------------------

>19730_19730_28_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000537824_C15orf41_chr15_37100525_ENST00000437989_length(amino acids)=101AA_BP=
MGNTNNNNVIFADSFNLYTLLDFFQKTKYVIYTLFIFYQRRFVKICLLLFLLKDTNLVPTCVDFNSEWGALNQKREAEDEMLKKGQANFC

--------------------------------------------------------------

>19730_19730_29_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000537824_C15orf41_chr15_37100525_ENST00000562877_length(amino acids)=70AA_BP=27

--------------------------------------------------------------

>19730_19730_30_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000537824_C15orf41_chr15_37100525_ENST00000566621_length(amino acids)=105AA_BP=27
MRGGDSSRCSCFSGCWCCARGSSLQRRIWARLSHLLVWIYPGAGLQPGKGHPAQSLFPHEHCHLMPQHSLTLKILEEKLGGKGESGSNFT

--------------------------------------------------------------

>19730_19730_31_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000539096_C15orf41_chr15_37100525_ENST00000437989_length(amino acids)=101AA_BP=
MGNTNNNNVIFADSFNLYTLLDFFQKTKYVIYTLFIFYQRRFVKICLLLFLLKDTNLVPTCVDFNSEWGALNQKREAEDEMLKKGQANFC

--------------------------------------------------------------

>19730_19730_32_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000539096_C15orf41_chr15_37100525_ENST00000562877_length(amino acids)=70AA_BP=27

--------------------------------------------------------------

>19730_19730_33_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000539096_C15orf41_chr15_37100525_ENST00000566621_length(amino acids)=105AA_BP=27
MRGGDSSRCSCFSGCWCCARGSSLQRRIWARLSHLLVWIYPGAGLQPGKGHPAQSLFPHEHCHLMPQHSLTLKILEEKLGGKGESGSNFT

--------------------------------------------------------------

>19730_19730_34_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000542608_C15orf41_chr15_37100525_ENST00000437989_length(amino acids)=101AA_BP=
MGNTNNNNVIFADSFNLYTLLDFFQKTKYVIYTLFIFYQRRFVKICLLLFLLKDTNLVPTCVDFNSEWGALNQKREAEDEMLKKGQANFC

--------------------------------------------------------------

>19730_19730_35_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000542608_C15orf41_chr15_37100525_ENST00000562877_length(amino acids)=70AA_BP=27

--------------------------------------------------------------

>19730_19730_36_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000542608_C15orf41_chr15_37100525_ENST00000566621_length(amino acids)=105AA_BP=27
MRGGDSSRCSCFSGCWCCARGSSLQRRIWARLSHLLVWIYPGAGLQPGKGHPAQSLFPHEHCHLMPQHSLTLKILEEKLGGKGESGSNFT

--------------------------------------------------------------

>19730_19730_37_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000602557_C15orf41_chr15_37100525_ENST00000437989_length(amino acids)=155AA_BP=
MPPLQVSPGCARSSPRFSPSRSLAALVPSCPARPALVPGPGPASPGLRARSSSALQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLR

--------------------------------------------------------------

>19730_19730_38_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000602557_C15orf41_chr15_37100525_ENST00000562877_length(amino acids)=155AA_BP=
MPPLQVSPGCARSSPRFSPSRSLAALVPSCPARPALVPGPGPASPGLRARSSSALQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLR

--------------------------------------------------------------

>19730_19730_39_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000602557_C15orf41_chr15_37100525_ENST00000566621_length(amino acids)=155AA_BP=
MPPLQVSPGCARSSPRFSPSRSLAALVPSCPARPALVPGPGPASPGLRARSSSALQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLR

--------------------------------------------------------------

>19730_19730_40_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000602723_C15orf41_chr15_37100525_ENST00000437989_length(amino acids)=101AA_BP=
MQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLRLALPSGDYLAPLIALPSSEEPSVSRACGVSADMTAWRRFQSLLLLLGLLVLCAR

--------------------------------------------------------------

>19730_19730_41_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000602723_C15orf41_chr15_37100525_ENST00000562877_length(amino acids)=101AA_BP=
MQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLRLALPSGDYLAPLIALPSSEEPSVSRACGVSADMTAWRRFQSLLLLLGLLVLCAR

--------------------------------------------------------------

>19730_19730_42_CSMD1-C15orf41_CSMD1_chr8_4851854_ENST00000602723_C15orf41_chr15_37100525_ENST00000566621_length(amino acids)=105AA_BP=27
MRGGDSSRCSCFSGCWCCARGSSLQRRIWARLSHLLVWIYPGAGLQPGKGHPAQSLFPHEHCHLMPQHSLTLKILEEKLGGKGESGSNFT

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:4851854/chr15:37100525)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CSMD1 Q96PZ7	.
FUNCTION: Potential suppressor of squamous cell carcinomas.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>130_CSMD1_4851854_C15orf41_37100525_ranked_0.pdb	CSMD1	4851853	4851854	ENST00000562877	C15orf41	chr15	37100525	+	MPPLQVSPGCARSSPRFSPSRSLAALVPSCPARPALVPGPGPASPGLRARSSSALQWLGTRCYEREASRAPRPSGGVGCAAGLGTGLSLR	155

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CSMD1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CSMD1
C15orf41

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CSMD1-C15orf41

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CSMD1-C15orf41

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source