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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ADAM15-MRPL36

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ADAM15-MRPL36
FusionPDB ID: 1975
FusionGDB2.0 ID: 1975
HgeneTgene
Gene symbol

ADAM15

MRPL36

Gene ID

8751

64979

Gene nameADAM metallopeptidase domain 15mitochondrial ribosomal protein L36
SynonymsMDC15BRIP1|L36mt|MRP-L36|PRPL36|RPMJ
Cytomap

1q21.3

5p15.33

Type of geneprotein-codingprotein-coding
Descriptiondisintegrin and metalloproteinase domain-containing protein 15MDC-15a disintegrin and metalloproteinase domain 15 (metargidin)metalloprotease RGD disintegrin proteinmetalloproteinase-like, disintegrin-like, and cysteine-rich protein 1539S ribosomal protein L36, mitochondrialBRCA1-interacting protein 1mitochondrial large ribosomal subunit protein bL36mputative BRCA1-interacting protein
Modification date2020032020200313
UniProtAcc

Q13444

Q9P0J6

Ensembl transtripts involved in fusion geneENST idsENST00000472434, ENST00000271836, 
ENST00000355956, ENST00000356955, 
ENST00000359280, ENST00000360674, 
ENST00000368412, ENST00000447332, 
ENST00000449910, ENST00000531455, 
ENST00000368410, ENST00000368413, 
ENST00000382647, ENST00000505059, 
ENST00000505818, ENST00000508987, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 5=1802 X 2 X 2=8
# samples 73
** MAII scorelog2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context (manual curation of fusion genes in FusionPDB)

PubMed: ADAM15 [Title/Abstract] AND MRPL36 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ADAM15(155029557)-MRPL36(1798872), # samples:1
Anticipated loss of major functional domain due to fusion event.ADAM15-MRPL36 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAM15-MRPL36 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAM15-MRPL36 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAM15

GO:0002418

immune response to tumor cell

22505472

HgeneADAM15

GO:0006915

apoptotic process

22505472

HgeneADAM15

GO:0045087

innate immune response

22505472

HgeneADAM15

GO:1904628

cellular response to phorbol 13-acetate 12-myristate

22505472


check buttonFusion gene breakpoints across ADAM15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MRPL36 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AH26225ADAM15chr1

155029557

+MRPL36chr5

1798872

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000449910ADAM15chr1155029557+ENST00000505059MRPL36chr51798872-1493112081189393
ENST00000449910ADAM15chr1155029557+ENST00000505818MRPL36chr51798872-1493112081189393
ENST00000368412ADAM15chr1155029557+ENST00000505059MRPL36chr51798872-1493112081189393
ENST00000368412ADAM15chr1155029557+ENST00000505818MRPL36chr51798872-1493112081189393
ENST00000359280ADAM15chr1155029557+ENST00000505059MRPL36chr51798872-1493112081189393
ENST00000359280ADAM15chr1155029557+ENST00000505818MRPL36chr51798872-1493112081189393
ENST00000356955ADAM15chr1155029557+ENST00000505059MRPL36chr51798872-1493112081189393
ENST00000356955ADAM15chr1155029557+ENST00000505818MRPL36chr51798872-1493112081189393
ENST00000355956ADAM15chr1155029557+ENST00000505059MRPL36chr51798872-1493112081189393
ENST00000355956ADAM15chr1155029557+ENST00000505818MRPL36chr51798872-1493112081189393
ENST00000360674ADAM15chr1155029557+ENST00000505059MRPL36chr51798872-1493112081189393
ENST00000360674ADAM15chr1155029557+ENST00000505818MRPL36chr51798872-1493112081189393
ENST00000271836ADAM15chr1155029557+ENST00000505059MRPL36chr51798872-14731100361169377
ENST00000271836ADAM15chr1155029557+ENST00000505818MRPL36chr51798872-14731100361169377
ENST00000531455ADAM15chr1155029557+ENST00000505059MRPL36chr51798872-14581085361154372
ENST00000531455ADAM15chr1155029557+ENST00000505818MRPL36chr51798872-14581085361154372
ENST00000447332ADAM15chr1155029557+ENST00000505059MRPL36chr51798872-13791006351075346
ENST00000447332ADAM15chr1155029557+ENST00000505818MRPL36chr51798872-13791006351075346

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000449910ENST00000505059ADAM15chr1155029557+MRPL36chr51798872-0.1000785160.8999215
ENST00000449910ENST00000505818ADAM15chr1155029557+MRPL36chr51798872-0.1000785160.8999215
ENST00000368412ENST00000505059ADAM15chr1155029557+MRPL36chr51798872-0.1000785160.8999215
ENST00000368412ENST00000505818ADAM15chr1155029557+MRPL36chr51798872-0.1000785160.8999215
ENST00000359280ENST00000505059ADAM15chr1155029557+MRPL36chr51798872-0.1000785160.8999215
ENST00000359280ENST00000505818ADAM15chr1155029557+MRPL36chr51798872-0.1000785160.8999215
ENST00000356955ENST00000505059ADAM15chr1155029557+MRPL36chr51798872-0.1000785160.8999215
ENST00000356955ENST00000505818ADAM15chr1155029557+MRPL36chr51798872-0.1000785160.8999215
ENST00000355956ENST00000505059ADAM15chr1155029557+MRPL36chr51798872-0.1000785160.8999215
ENST00000355956ENST00000505818ADAM15chr1155029557+MRPL36chr51798872-0.1000785160.8999215
ENST00000360674ENST00000505059ADAM15chr1155029557+MRPL36chr51798872-0.1000785160.8999215
ENST00000360674ENST00000505818ADAM15chr1155029557+MRPL36chr51798872-0.1000785160.8999215
ENST00000271836ENST00000505059ADAM15chr1155029557+MRPL36chr51798872-0.104070630.89592934
ENST00000271836ENST00000505818ADAM15chr1155029557+MRPL36chr51798872-0.104070630.89592934
ENST00000531455ENST00000505059ADAM15chr1155029557+MRPL36chr51798872-0.196741820.8032581
ENST00000531455ENST00000505818ADAM15chr1155029557+MRPL36chr51798872-0.196741820.8032581
ENST00000447332ENST00000505059ADAM15chr1155029557+MRPL36chr51798872-0.214809050.78519094
ENST00000447332ENST00000505818ADAM15chr1155029557+MRPL36chr51798872-0.214809050.78519094

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>1975_1975_1_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000271836_MRPL36_chr5_1798872_ENST00000505059_length(amino acids)=377AA_BP=355
MFRTCCPRPARSAAAMRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLEL
DGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPI
ISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPLNV
RVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMIMEASTDCCLRW

--------------------------------------------------------------

>1975_1975_2_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000271836_MRPL36_chr5_1798872_ENST00000505818_length(amino acids)=377AA_BP=355
MFRTCCPRPARSAAAMRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLEL
DGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPI
ISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPLNV
RVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMIMEASTDCCLRW

--------------------------------------------------------------

>1975_1975_3_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000355956_MRPL36_chr5_1798872_ENST00000505059_length(amino acids)=393AA_BP=371
MLGSPRRPGRRPLLRALFRTCCPRPARSAAAMRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKK
VLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPER
SYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRT
LEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSG

--------------------------------------------------------------

>1975_1975_4_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000355956_MRPL36_chr5_1798872_ENST00000505818_length(amino acids)=393AA_BP=371
MLGSPRRPGRRPLLRALFRTCCPRPARSAAAMRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKK
VLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPER
SYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRT
LEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSG

--------------------------------------------------------------

>1975_1975_5_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000356955_MRPL36_chr5_1798872_ENST00000505059_length(amino acids)=393AA_BP=371
MLGSPRRPGRRPLLRALFRTCCPRPARSAAAMRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKK
VLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPER
SYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRT
LEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSG

--------------------------------------------------------------

>1975_1975_6_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000356955_MRPL36_chr5_1798872_ENST00000505818_length(amino acids)=393AA_BP=371
MLGSPRRPGRRPLLRALFRTCCPRPARSAAAMRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKK
VLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPER
SYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRT
LEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSG

--------------------------------------------------------------

>1975_1975_7_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000359280_MRPL36_chr5_1798872_ENST00000505059_length(amino acids)=393AA_BP=371
MLGSPRRPGRRPLLRALFRTCCPRPARSAAAMRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKK
VLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPER
SYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRT
LEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSG

--------------------------------------------------------------

>1975_1975_8_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000359280_MRPL36_chr5_1798872_ENST00000505818_length(amino acids)=393AA_BP=371
MLGSPRRPGRRPLLRALFRTCCPRPARSAAAMRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKK
VLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPER
SYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRT
LEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSG

--------------------------------------------------------------

>1975_1975_9_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000360674_MRPL36_chr5_1798872_ENST00000505059_length(amino acids)=393AA_BP=371
MLGSPRRPGRRPLLRALFRTCCPRPARSAAAMRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKK
VLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPER
SYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRT
LEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSG

--------------------------------------------------------------

>1975_1975_10_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000360674_MRPL36_chr5_1798872_ENST00000505818_length(amino acids)=393AA_BP=371
MLGSPRRPGRRPLLRALFRTCCPRPARSAAAMRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKK
VLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPER
SYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRT
LEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSG

--------------------------------------------------------------

>1975_1975_11_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000368412_MRPL36_chr5_1798872_ENST00000505059_length(amino acids)=393AA_BP=371
MLGSPRRPGRRPLLRALFRTCCPRPARSAAAMRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKK
VLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPER
SYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRT
LEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSG

--------------------------------------------------------------

>1975_1975_12_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000368412_MRPL36_chr5_1798872_ENST00000505818_length(amino acids)=393AA_BP=371
MLGSPRRPGRRPLLRALFRTCCPRPARSAAAMRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKK
VLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPER
SYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRT
LEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSG

--------------------------------------------------------------

>1975_1975_13_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000447332_MRPL36_chr5_1798872_ENST00000505059_length(amino acids)=346AA_BP=324
MRLALLWALGLLGAGSPLPSWPLPNIVSACNVEAPQVALRSSRQSQRRPRGSPWSPRSFRTISQLASKRCFRELVPGRPTLVWYQPDGTR
VVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHP
LGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLH

--------------------------------------------------------------

>1975_1975_14_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000447332_MRPL36_chr5_1798872_ENST00000505818_length(amino acids)=346AA_BP=324
MRLALLWALGLLGAGSPLPSWPLPNIVSACNVEAPQVALRSSRQSQRRPRGSPWSPRSFRTISQLASKRCFRELVPGRPTLVWYQPDGTR
VVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHP
LGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLH

--------------------------------------------------------------

>1975_1975_15_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000449910_MRPL36_chr5_1798872_ENST00000505059_length(amino acids)=393AA_BP=371
MLGSPRRPGRRPLLRALFRTCCPRPARSAAAMRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKK
VLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPER
SYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRT
LEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSG

--------------------------------------------------------------

>1975_1975_16_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000449910_MRPL36_chr5_1798872_ENST00000505818_length(amino acids)=393AA_BP=371
MLGSPRRPGRRPLLRALFRTCCPRPARSAAAMRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKK
VLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPER
SYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRT
LEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSG

--------------------------------------------------------------

>1975_1975_17_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000531455_MRPL36_chr5_1798872_ENST00000505059_length(amino acids)=372AA_BP=350
MRLALLWALGLLGAGSPLPSWPLPNIVLSWGVLGPAGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSH
ILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQ
DLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPLNVRVALV
GLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMIMEASTDCCLRWGSKTR

--------------------------------------------------------------

>1975_1975_18_ADAM15-MRPL36_ADAM15_chr1_155029557_ENST00000531455_MRPL36_chr5_1798872_ENST00000505818_length(amino acids)=372AA_BP=350
MRLALLWALGLLGAGSPLPSWPLPNIVLSWGVLGPAGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSH
ILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQ
DLHLPGHTCALSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLLDTFFRPLNVRVALV
GLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMIMEASTDCCLRWGSKTR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:155029557/chr5:1798872)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAM15

Q13444

MRPL36

Q9P0J6

FUNCTION: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:15818704, ECO:0000269|PubMed:17416588, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:18387333, ECO:0000269|PubMed:18434311}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAM15chr1:155029557chr5:1798872ENST00000271836+121509_6560815.0Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029557chr5:1798872ENST00000355956+122509_6560840.0Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029557chr5:1798872ENST00000356955+123509_6560864.0Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029557chr5:1798872ENST00000359280+122509_6560839.0Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029557chr5:1798872ENST00000360674+120509_6560812.6666666666666Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029557chr5:1798872ENST00000368412+121509_6560836.6666666666666Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029557chr5:1798872ENST00000368413+114509_6560521.0Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029557chr5:1798872ENST00000449910+123509_6560863.0Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029557chr5:1798872ENST00000531455+121509_6560825.0Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029557chr5:1798872ENST00000271836+121213_4140815.0DomainPeptidase M12B
HgeneADAM15chr1:155029557chr5:1798872ENST00000271836+121421_5080815.0DomainDisintegrin
HgeneADAM15chr1:155029557chr5:1798872ENST00000271836+121657_6850815.0DomainEGF-like
HgeneADAM15chr1:155029557chr5:1798872ENST00000355956+122213_4140840.0DomainPeptidase M12B
HgeneADAM15chr1:155029557chr5:1798872ENST00000355956+122421_5080840.0DomainDisintegrin
HgeneADAM15chr1:155029557chr5:1798872ENST00000355956+122657_6850840.0DomainEGF-like
HgeneADAM15chr1:155029557chr5:1798872ENST00000356955+123213_4140864.0DomainPeptidase M12B
HgeneADAM15chr1:155029557chr5:1798872ENST00000356955+123421_5080864.0DomainDisintegrin
HgeneADAM15chr1:155029557chr5:1798872ENST00000356955+123657_6850864.0DomainEGF-like
HgeneADAM15chr1:155029557chr5:1798872ENST00000359280+122213_4140839.0DomainPeptidase M12B
HgeneADAM15chr1:155029557chr5:1798872ENST00000359280+122421_5080839.0DomainDisintegrin
HgeneADAM15chr1:155029557chr5:1798872ENST00000359280+122657_6850839.0DomainEGF-like
HgeneADAM15chr1:155029557chr5:1798872ENST00000360674+120213_4140812.6666666666666DomainPeptidase M12B
HgeneADAM15chr1:155029557chr5:1798872ENST00000360674+120421_5080812.6666666666666DomainDisintegrin
HgeneADAM15chr1:155029557chr5:1798872ENST00000360674+120657_6850812.6666666666666DomainEGF-like
HgeneADAM15chr1:155029557chr5:1798872ENST00000368412+121213_4140836.6666666666666DomainPeptidase M12B
HgeneADAM15chr1:155029557chr5:1798872ENST00000368412+121421_5080836.6666666666666DomainDisintegrin
HgeneADAM15chr1:155029557chr5:1798872ENST00000368412+121657_6850836.6666666666666DomainEGF-like
HgeneADAM15chr1:155029557chr5:1798872ENST00000368413+114213_4140521.0DomainPeptidase M12B
HgeneADAM15chr1:155029557chr5:1798872ENST00000368413+114421_5080521.0DomainDisintegrin
HgeneADAM15chr1:155029557chr5:1798872ENST00000368413+114657_6850521.0DomainEGF-like
HgeneADAM15chr1:155029557chr5:1798872ENST00000449910+123213_4140863.0DomainPeptidase M12B
HgeneADAM15chr1:155029557chr5:1798872ENST00000449910+123421_5080863.0DomainDisintegrin
HgeneADAM15chr1:155029557chr5:1798872ENST00000449910+123657_6850863.0DomainEGF-like
HgeneADAM15chr1:155029557chr5:1798872ENST00000531455+121213_4140825.0DomainPeptidase M12B
HgeneADAM15chr1:155029557chr5:1798872ENST00000531455+121421_5080825.0DomainDisintegrin
HgeneADAM15chr1:155029557chr5:1798872ENST00000531455+121657_6850825.0DomainEGF-like
HgeneADAM15chr1:155029557chr5:1798872ENST00000271836+121177_1840815.0MotifCysteine switch
HgeneADAM15chr1:155029557chr5:1798872ENST00000271836+121484_4860815.0MotifCell attachment site
HgeneADAM15chr1:155029557chr5:1798872ENST00000271836+121815_8210815.0MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000271836+121850_8560815.0MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000355956+122177_1840840.0MotifCysteine switch
HgeneADAM15chr1:155029557chr5:1798872ENST00000355956+122484_4860840.0MotifCell attachment site
HgeneADAM15chr1:155029557chr5:1798872ENST00000355956+122815_8210840.0MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000355956+122850_8560840.0MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000356955+123177_1840864.0MotifCysteine switch
HgeneADAM15chr1:155029557chr5:1798872ENST00000356955+123484_4860864.0MotifCell attachment site
HgeneADAM15chr1:155029557chr5:1798872ENST00000356955+123815_8210864.0MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000356955+123850_8560864.0MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000359280+122177_1840839.0MotifCysteine switch
HgeneADAM15chr1:155029557chr5:1798872ENST00000359280+122484_4860839.0MotifCell attachment site
HgeneADAM15chr1:155029557chr5:1798872ENST00000359280+122815_8210839.0MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000359280+122850_8560839.0MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000360674+120177_1840812.6666666666666MotifCysteine switch
HgeneADAM15chr1:155029557chr5:1798872ENST00000360674+120484_4860812.6666666666666MotifCell attachment site
HgeneADAM15chr1:155029557chr5:1798872ENST00000360674+120815_8210812.6666666666666MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000360674+120850_8560812.6666666666666MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000368412+121177_1840836.6666666666666MotifCysteine switch
HgeneADAM15chr1:155029557chr5:1798872ENST00000368412+121484_4860836.6666666666666MotifCell attachment site
HgeneADAM15chr1:155029557chr5:1798872ENST00000368412+121815_8210836.6666666666666MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000368412+121850_8560836.6666666666666MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000368413+114177_1840521.0MotifCysteine switch
HgeneADAM15chr1:155029557chr5:1798872ENST00000368413+114484_4860521.0MotifCell attachment site
HgeneADAM15chr1:155029557chr5:1798872ENST00000368413+114815_8210521.0MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000368413+114850_8560521.0MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000449910+123177_1840863.0MotifCysteine switch
HgeneADAM15chr1:155029557chr5:1798872ENST00000449910+123484_4860863.0MotifCell attachment site
HgeneADAM15chr1:155029557chr5:1798872ENST00000449910+123815_8210863.0MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000449910+123850_8560863.0MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000531455+121177_1840825.0MotifCysteine switch
HgeneADAM15chr1:155029557chr5:1798872ENST00000531455+121484_4860825.0MotifCell attachment site
HgeneADAM15chr1:155029557chr5:1798872ENST00000531455+121815_8210825.0MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000531455+121850_8560825.0MotifSH3-binding
HgeneADAM15chr1:155029557chr5:1798872ENST00000271836+121207_6960815.0Topological domainExtracellular
HgeneADAM15chr1:155029557chr5:1798872ENST00000271836+121718_8630815.0Topological domainCytoplasmic
HgeneADAM15chr1:155029557chr5:1798872ENST00000355956+122207_6960840.0Topological domainExtracellular
HgeneADAM15chr1:155029557chr5:1798872ENST00000355956+122718_8630840.0Topological domainCytoplasmic
HgeneADAM15chr1:155029557chr5:1798872ENST00000356955+123207_6960864.0Topological domainExtracellular
HgeneADAM15chr1:155029557chr5:1798872ENST00000356955+123718_8630864.0Topological domainCytoplasmic
HgeneADAM15chr1:155029557chr5:1798872ENST00000359280+122207_6960839.0Topological domainExtracellular
HgeneADAM15chr1:155029557chr5:1798872ENST00000359280+122718_8630839.0Topological domainCytoplasmic
HgeneADAM15chr1:155029557chr5:1798872ENST00000360674+120207_6960812.6666666666666Topological domainExtracellular
HgeneADAM15chr1:155029557chr5:1798872ENST00000360674+120718_8630812.6666666666666Topological domainCytoplasmic
HgeneADAM15chr1:155029557chr5:1798872ENST00000368412+121207_6960836.6666666666666Topological domainExtracellular
HgeneADAM15chr1:155029557chr5:1798872ENST00000368412+121718_8630836.6666666666666Topological domainCytoplasmic
HgeneADAM15chr1:155029557chr5:1798872ENST00000368413+114207_6960521.0Topological domainExtracellular
HgeneADAM15chr1:155029557chr5:1798872ENST00000368413+114718_8630521.0Topological domainCytoplasmic
HgeneADAM15chr1:155029557chr5:1798872ENST00000449910+123207_6960863.0Topological domainExtracellular
HgeneADAM15chr1:155029557chr5:1798872ENST00000449910+123718_8630863.0Topological domainCytoplasmic
HgeneADAM15chr1:155029557chr5:1798872ENST00000531455+121207_6960825.0Topological domainExtracellular
HgeneADAM15chr1:155029557chr5:1798872ENST00000531455+121718_8630825.0Topological domainCytoplasmic
HgeneADAM15chr1:155029557chr5:1798872ENST00000271836+121697_7170815.0TransmembraneHelical
HgeneADAM15chr1:155029557chr5:1798872ENST00000355956+122697_7170840.0TransmembraneHelical
HgeneADAM15chr1:155029557chr5:1798872ENST00000356955+123697_7170864.0TransmembraneHelical
HgeneADAM15chr1:155029557chr5:1798872ENST00000359280+122697_7170839.0TransmembraneHelical
HgeneADAM15chr1:155029557chr5:1798872ENST00000360674+120697_7170812.6666666666666TransmembraneHelical
HgeneADAM15chr1:155029557chr5:1798872ENST00000368412+121697_7170836.6666666666666TransmembraneHelical
HgeneADAM15chr1:155029557chr5:1798872ENST00000368413+114697_7170521.0TransmembraneHelical
HgeneADAM15chr1:155029557chr5:1798872ENST00000449910+123697_7170863.0TransmembraneHelical
HgeneADAM15chr1:155029557chr5:1798872ENST00000531455+121697_7170825.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ADAM15
MRPL36


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ADAM15-MRPL36


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ADAM15-MRPL36


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource