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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ADAMTS12-RAI14

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ADAMTS12-RAI14
FusionPDB ID: 2045
FusionGDB2.0 ID: 2045
HgeneTgene
Gene symbol

ADAMTS12

RAI14

Gene ID

81792

26064

Gene nameADAM metallopeptidase with thrombospondin type 1 motif 12retinoic acid induced 14
SynonymsPRO4389NORPEG|RAI13
Cytomap

5p13.3-p13.2

5p13.2

Type of geneprotein-codingprotein-coding
DescriptionA disintegrin and metalloproteinase with thrombospondin motifs 12ADAM-TS 12ADAM-TS12ADAMTS-12a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12ankycorbinankyrin repeat and coiled-coil structure-containing proteinnovel retinal pigment epithelial cell proteinretinoic acid-induced protein 14
Modification date2020031320200313
UniProtAcc

P58397

.
Ensembl transtripts involved in fusion geneENST idsENST00000352040, ENST00000504830, 
ENST00000515401, ENST00000504582, 
ENST00000397449, ENST00000507276, 
ENST00000265109, ENST00000428746, 
ENST00000503673, ENST00000506376, 
ENST00000512629, ENST00000515799, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 4=14410 X 8 X 7=560
# samples 612
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/560*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ADAMTS12 [Title/Abstract] AND RAI14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ADAMTS12(33881224)-RAI14(34757573), # samples:3
Anticipated loss of major functional domain due to fusion event.ADAMTS12-RAI14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS12-RAI14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS12-RAI14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS12-RAI14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAMTS12

GO:0030167

proteoglycan catabolic process

17895370

HgeneADAMTS12

GO:0032331

negative regulation of chondrocyte differentiation

22247065

HgeneADAMTS12

GO:0050727

regulation of inflammatory response

23019333

HgeneADAMTS12

GO:0051603

proteolysis involved in cellular protein catabolic process

16611630

HgeneADAMTS12

GO:0071773

cellular response to BMP stimulus

22247065

HgeneADAMTS12

GO:1901509

regulation of endothelial tube morphogenesis

17895370

HgeneADAMTS12

GO:1902203

negative regulation of hepatocyte growth factor receptor signaling pathway

17895370

HgeneADAMTS12

GO:1902548

negative regulation of cellular response to vascular endothelial growth factor stimulus

17895370

HgeneADAMTS12

GO:2001113

negative regulation of cellular response to hepatocyte growth factor stimulus

17895370


check buttonFusion gene breakpoints across ADAMTS12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAI14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A44Q-06AADAMTS12chr5

33881224

-RAI14chr5

34757573

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000504830ADAMTS12chr533881224-ENST00000265109RAI14chr534757573+559482533637311131
ENST00000504830ADAMTS12chr533881224-ENST00000512629RAI14chr534757573+364582533636441102
ENST00000504830ADAMTS12chr533881224-ENST00000428746RAI14chr534757573+557882533637311131
ENST00000504830ADAMTS12chr533881224-ENST00000503673RAI14chr534757573+377282533637311131
ENST00000504830ADAMTS12chr533881224-ENST00000515799RAI14chr534757573+377482533637311131
ENST00000504830ADAMTS12chr533881224-ENST00000506376RAI14chr534757573+375282533637311131
ENST00000352040ADAMTS12chr533881224-ENST00000265109RAI14chr534757573+53435748534801131
ENST00000352040ADAMTS12chr533881224-ENST00000512629RAI14chr534757573+33945748533931103
ENST00000352040ADAMTS12chr533881224-ENST00000428746RAI14chr534757573+53275748534801131
ENST00000352040ADAMTS12chr533881224-ENST00000503673RAI14chr534757573+35215748534801131
ENST00000352040ADAMTS12chr533881224-ENST00000515799RAI14chr534757573+35235748534801131
ENST00000352040ADAMTS12chr533881224-ENST00000506376RAI14chr534757573+35015748534801131
ENST00000515401ADAMTS12chr533881224-ENST00000265109RAI14chr534757573+542165216335581131
ENST00000515401ADAMTS12chr533881224-ENST00000512629RAI14chr534757573+347265216334711103
ENST00000515401ADAMTS12chr533881224-ENST00000428746RAI14chr534757573+540565216335581131
ENST00000515401ADAMTS12chr533881224-ENST00000503673RAI14chr534757573+359965216335581131
ENST00000515401ADAMTS12chr533881224-ENST00000515799RAI14chr534757573+360165216335581131
ENST00000515401ADAMTS12chr533881224-ENST00000506376RAI14chr534757573+357965216335581131

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000504830ENST00000265109ADAMTS12chr533881224-RAI14chr534757573+0.0007109030.99928904
ENST00000504830ENST00000512629ADAMTS12chr533881224-RAI14chr534757573+0.0010228670.9989772
ENST00000504830ENST00000428746ADAMTS12chr533881224-RAI14chr534757573+0.0007154460.99928457
ENST00000504830ENST00000503673ADAMTS12chr533881224-RAI14chr534757573+0.0017862050.99821377
ENST00000504830ENST00000515799ADAMTS12chr533881224-RAI14chr534757573+0.0017735210.99822646
ENST00000504830ENST00000506376ADAMTS12chr533881224-RAI14chr534757573+0.0018402960.9981597
ENST00000352040ENST00000265109ADAMTS12chr533881224-RAI14chr534757573+0.0005451710.9994548
ENST00000352040ENST00000512629ADAMTS12chr533881224-RAI14chr534757573+0.0008137070.99918634
ENST00000352040ENST00000428746ADAMTS12chr533881224-RAI14chr534757573+0.0005498180.99945015
ENST00000352040ENST00000503673ADAMTS12chr533881224-RAI14chr534757573+0.0014035570.9985965
ENST00000352040ENST00000515799ADAMTS12chr533881224-RAI14chr534757573+0.0013919450.99860805
ENST00000352040ENST00000506376ADAMTS12chr533881224-RAI14chr534757573+0.0014520410.998548
ENST00000515401ENST00000265109ADAMTS12chr533881224-RAI14chr534757573+0.0006078990.99939203
ENST00000515401ENST00000512629ADAMTS12chr533881224-RAI14chr534757573+0.00088230.9991177
ENST00000515401ENST00000428746ADAMTS12chr533881224-RAI14chr534757573+0.0006130580.9993869
ENST00000515401ENST00000503673ADAMTS12chr533881224-RAI14chr534757573+0.0015371560.9984629
ENST00000515401ENST00000515799ADAMTS12chr533881224-RAI14chr534757573+0.0015246090.9984754
ENST00000515401ENST00000506376ADAMTS12chr533881224-RAI14chr534757573+0.0015916240.9984084

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>2045_2045_1_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000352040_RAI14_chr5_34757573_ENST00000265109_length(amino acids)=1131AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS
DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL
EDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ
TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ

--------------------------------------------------------------

>2045_2045_2_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000352040_RAI14_chr5_34757573_ENST00000428746_length(amino acids)=1131AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS
DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL
EDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ
TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ

--------------------------------------------------------------

>2045_2045_3_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000352040_RAI14_chr5_34757573_ENST00000503673_length(amino acids)=1131AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS
DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL
EDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ
TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ

--------------------------------------------------------------

>2045_2045_4_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000352040_RAI14_chr5_34757573_ENST00000506376_length(amino acids)=1131AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS
DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL
EDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ
TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ

--------------------------------------------------------------

>2045_2045_5_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000352040_RAI14_chr5_34757573_ENST00000512629_length(amino acids)=1103AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSD
STTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIH
SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKL
GLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLF
EKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLT
NVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAA
MTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKR
YAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQM

--------------------------------------------------------------

>2045_2045_6_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000352040_RAI14_chr5_34757573_ENST00000515799_length(amino acids)=1131AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS
DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL
EDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ
TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ

--------------------------------------------------------------

>2045_2045_7_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000504830_RAI14_chr5_34757573_ENST00000265109_length(amino acids)=1131AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS
DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL
EDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ
TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ

--------------------------------------------------------------

>2045_2045_8_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000504830_RAI14_chr5_34757573_ENST00000428746_length(amino acids)=1131AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS
DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL
EDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ
TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ

--------------------------------------------------------------

>2045_2045_9_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000504830_RAI14_chr5_34757573_ENST00000503673_length(amino acids)=1131AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS
DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL
EDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ
TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ

--------------------------------------------------------------

>2045_2045_10_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000504830_RAI14_chr5_34757573_ENST00000506376_length(amino acids)=1131AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS
DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL
EDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ
TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ

--------------------------------------------------------------

>2045_2045_11_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000504830_RAI14_chr5_34757573_ENST00000512629_length(amino acids)=1102AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSD
STTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIH
SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKL
GLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLF
EKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLT
NVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAA
MTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKR
YAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQM

--------------------------------------------------------------

>2045_2045_12_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000504830_RAI14_chr5_34757573_ENST00000515799_length(amino acids)=1131AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS
DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL
EDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ
TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ

--------------------------------------------------------------

>2045_2045_13_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000515401_RAI14_chr5_34757573_ENST00000265109_length(amino acids)=1131AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS
DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL
EDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ
TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ

--------------------------------------------------------------

>2045_2045_14_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000515401_RAI14_chr5_34757573_ENST00000428746_length(amino acids)=1131AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS
DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL
EDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ
TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ

--------------------------------------------------------------

>2045_2045_15_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000515401_RAI14_chr5_34757573_ENST00000503673_length(amino acids)=1131AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS
DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL
EDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ
TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ

--------------------------------------------------------------

>2045_2045_16_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000515401_RAI14_chr5_34757573_ENST00000506376_length(amino acids)=1131AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS
DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL
EDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ
TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ

--------------------------------------------------------------

>2045_2045_17_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000515401_RAI14_chr5_34757573_ENST00000512629_length(amino acids)=1103AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSD
STTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIH
SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKL
GLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLF
EKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLT
NVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAA
MTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKR
YAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQM

--------------------------------------------------------------

>2045_2045_18_ADAMTS12-RAI14_ADAMTS12_chr5_33881224_ENST00000515401_RAI14_chr5_34757573_ENST00000515799_length(amino acids)=1131AA_BP=163
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW
VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTNEWNKNDDRLLQAVEN
GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG
KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA
DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS
DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAEL
EDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ
TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:33881224/chr5:34757573)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAMTS12

P58397

.
FUNCTION: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. {ECO:0000269|PubMed:16611630, ECO:0000269|PubMed:17895370, ECO:0000269|PubMed:18485748}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRAI14chr5:33881224chr5:34757573ENST00000265109118349_37412.0981.0Coiled coilOntology_term=ECO:0000255
TgeneRAI14chr5:33881224chr5:34757573ENST00000265109118425_94712.0981.0Coiled coilOntology_term=ECO:0000255
TgeneRAI14chr5:33881224chr5:34757573ENST00000428746118349_37412.0981.0Coiled coilOntology_term=ECO:0000255
TgeneRAI14chr5:33881224chr5:34757573ENST00000428746118425_94712.0981.0Coiled coilOntology_term=ECO:0000255
TgeneRAI14chr5:33881224chr5:34757573ENST00000503673219349_37412.0981.0Coiled coilOntology_term=ECO:0000255
TgeneRAI14chr5:33881224chr5:34757573ENST00000503673219425_94712.0981.0Coiled coilOntology_term=ECO:0000255
TgeneRAI14chr5:33881224chr5:34757573ENST00000506376017349_3744.0973.0Coiled coilOntology_term=ECO:0000255
TgeneRAI14chr5:33881224chr5:34757573ENST00000506376017425_9474.0973.0Coiled coilOntology_term=ECO:0000255
TgeneRAI14chr5:33881224chr5:34757573ENST00000512629117349_37412.0952.0Coiled coilOntology_term=ECO:0000255
TgeneRAI14chr5:33881224chr5:34757573ENST00000512629117425_94712.0952.0Coiled coilOntology_term=ECO:0000255
TgeneRAI14chr5:33881224chr5:34757573ENST00000515799320349_37415.0984.0Coiled coilOntology_term=ECO:0000255
TgeneRAI14chr5:33881224chr5:34757573ENST00000515799320425_94715.0984.0Coiled coilOntology_term=ECO:0000255
TgeneRAI14chr5:33881224chr5:34757573ENST00000265109118270_27612.0981.0MotifNuclear localization signal
TgeneRAI14chr5:33881224chr5:34757573ENST00000428746118270_27612.0981.0MotifNuclear localization signal
TgeneRAI14chr5:33881224chr5:34757573ENST00000503673219270_27612.0981.0MotifNuclear localization signal
TgeneRAI14chr5:33881224chr5:34757573ENST00000506376017270_2764.0973.0MotifNuclear localization signal
TgeneRAI14chr5:33881224chr5:34757573ENST00000512629117270_27612.0952.0MotifNuclear localization signal
TgeneRAI14chr5:33881224chr5:34757573ENST00000515799320270_27615.0984.0MotifNuclear localization signal
TgeneRAI14chr5:33881224chr5:34757573ENST00000265109118118_14712.0981.0RepeatNote=ANK 4
TgeneRAI14chr5:33881224chr5:34757573ENST00000265109118151_18012.0981.0RepeatNote=ANK 5
TgeneRAI14chr5:33881224chr5:34757573ENST00000265109118184_21312.0981.0RepeatNote=ANK 6
TgeneRAI14chr5:33881224chr5:34757573ENST0000026510911818_5112.0981.0RepeatNote=ANK 1
TgeneRAI14chr5:33881224chr5:34757573ENST00000265109118217_24712.0981.0RepeatNote=ANK 7
TgeneRAI14chr5:33881224chr5:34757573ENST0000026510911852_8112.0981.0RepeatNote=ANK 2
TgeneRAI14chr5:33881224chr5:34757573ENST0000026510911885_11412.0981.0RepeatNote=ANK 3
TgeneRAI14chr5:33881224chr5:34757573ENST00000428746118118_14712.0981.0RepeatNote=ANK 4
TgeneRAI14chr5:33881224chr5:34757573ENST00000428746118151_18012.0981.0RepeatNote=ANK 5
TgeneRAI14chr5:33881224chr5:34757573ENST00000428746118184_21312.0981.0RepeatNote=ANK 6
TgeneRAI14chr5:33881224chr5:34757573ENST0000042874611818_5112.0981.0RepeatNote=ANK 1
TgeneRAI14chr5:33881224chr5:34757573ENST00000428746118217_24712.0981.0RepeatNote=ANK 7
TgeneRAI14chr5:33881224chr5:34757573ENST0000042874611852_8112.0981.0RepeatNote=ANK 2
TgeneRAI14chr5:33881224chr5:34757573ENST0000042874611885_11412.0981.0RepeatNote=ANK 3
TgeneRAI14chr5:33881224chr5:34757573ENST00000503673219118_14712.0981.0RepeatNote=ANK 4
TgeneRAI14chr5:33881224chr5:34757573ENST00000503673219151_18012.0981.0RepeatNote=ANK 5
TgeneRAI14chr5:33881224chr5:34757573ENST00000503673219184_21312.0981.0RepeatNote=ANK 6
TgeneRAI14chr5:33881224chr5:34757573ENST0000050367321918_5112.0981.0RepeatNote=ANK 1
TgeneRAI14chr5:33881224chr5:34757573ENST00000503673219217_24712.0981.0RepeatNote=ANK 7
TgeneRAI14chr5:33881224chr5:34757573ENST0000050367321952_8112.0981.0RepeatNote=ANK 2
TgeneRAI14chr5:33881224chr5:34757573ENST0000050367321985_11412.0981.0RepeatNote=ANK 3
TgeneRAI14chr5:33881224chr5:34757573ENST00000506376017118_1474.0973.0RepeatNote=ANK 4
TgeneRAI14chr5:33881224chr5:34757573ENST00000506376017151_1804.0973.0RepeatNote=ANK 5
TgeneRAI14chr5:33881224chr5:34757573ENST00000506376017184_2134.0973.0RepeatNote=ANK 6
TgeneRAI14chr5:33881224chr5:34757573ENST0000050637601718_514.0973.0RepeatNote=ANK 1
TgeneRAI14chr5:33881224chr5:34757573ENST00000506376017217_2474.0973.0RepeatNote=ANK 7
TgeneRAI14chr5:33881224chr5:34757573ENST0000050637601752_814.0973.0RepeatNote=ANK 2
TgeneRAI14chr5:33881224chr5:34757573ENST0000050637601785_1144.0973.0RepeatNote=ANK 3
TgeneRAI14chr5:33881224chr5:34757573ENST00000512629117118_14712.0952.0RepeatNote=ANK 4
TgeneRAI14chr5:33881224chr5:34757573ENST00000512629117151_18012.0952.0RepeatNote=ANK 5
TgeneRAI14chr5:33881224chr5:34757573ENST00000512629117184_21312.0952.0RepeatNote=ANK 6
TgeneRAI14chr5:33881224chr5:34757573ENST0000051262911718_5112.0952.0RepeatNote=ANK 1
TgeneRAI14chr5:33881224chr5:34757573ENST00000512629117217_24712.0952.0RepeatNote=ANK 7
TgeneRAI14chr5:33881224chr5:34757573ENST0000051262911752_8112.0952.0RepeatNote=ANK 2
TgeneRAI14chr5:33881224chr5:34757573ENST0000051262911785_11412.0952.0RepeatNote=ANK 3
TgeneRAI14chr5:33881224chr5:34757573ENST00000515799320118_14715.0984.0RepeatNote=ANK 4
TgeneRAI14chr5:33881224chr5:34757573ENST00000515799320151_18015.0984.0RepeatNote=ANK 5
TgeneRAI14chr5:33881224chr5:34757573ENST00000515799320184_21315.0984.0RepeatNote=ANK 6
TgeneRAI14chr5:33881224chr5:34757573ENST0000051579932018_5115.0984.0RepeatNote=ANK 1
TgeneRAI14chr5:33881224chr5:34757573ENST00000515799320217_24715.0984.0RepeatNote=ANK 7
TgeneRAI14chr5:33881224chr5:34757573ENST0000051579932052_8115.0984.0RepeatNote=ANK 2
TgeneRAI14chr5:33881224chr5:34757573ENST0000051579932085_11415.0984.0RepeatNote=ANK 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-222302_305163.01510.0Compositional biasNote=Poly-Glu
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-222597_700163.01510.0Compositional biasNote=Cys-rich
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-224302_305163.01595.0Compositional biasNote=Poly-Glu
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-224597_700163.01595.0Compositional biasNote=Cys-rich
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-2221313_1366163.01510.0DomainTSP type-1 5
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-2221368_1422163.01510.0DomainTSP type-1 6
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-2221423_1471163.01510.0DomainTSP type-1 7
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-2221472_1532163.01510.0DomainTSP type-1 8
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-2221535_1575163.01510.0DomainPLAC
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-222246_456163.01510.0DomainPeptidase M12B
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-222465_544163.01510.0DomainNote=Disintegrin
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-222542_597163.01510.0DomainTSP type-1 1
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-222823_883163.01510.0DomainTSP type-1 2
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-222887_943163.01510.0DomainTSP type-1 3
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-222944_997163.01510.0DomainTSP type-1 4
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-2241313_1366163.01595.0DomainTSP type-1 5
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-2241368_1422163.01595.0DomainTSP type-1 6
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-2241423_1471163.01595.0DomainTSP type-1 7
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-2241472_1532163.01595.0DomainTSP type-1 8
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-2241535_1575163.01595.0DomainPLAC
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-224246_456163.01595.0DomainPeptidase M12B
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-224465_544163.01595.0DomainNote=Disintegrin
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-224542_597163.01595.0DomainTSP type-1 1
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-224823_883163.01595.0DomainTSP type-1 2
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-224887_943163.01595.0DomainTSP type-1 3
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-224944_997163.01595.0DomainTSP type-1 4
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-222208_213163.01510.0MotifCysteine switch
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-224208_213163.01595.0MotifCysteine switch
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-222701_827163.01510.0RegionNote=Spacer 1
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000352040-222997_1316163.01510.0RegionNote=Spacer 2
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-224701_827163.01595.0RegionNote=Spacer 1
HgeneADAMTS12chr5:33881224chr5:34757573ENST00000504830-224997_1316163.01595.0RegionNote=Spacer 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ADAMTS12
RAI14


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ADAMTS12-RAI14


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ADAMTS12-RAI14


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource