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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ADAMTS17-CERS3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ADAMTS17-CERS3
FusionPDB ID: 2055
FusionGDB2.0 ID: 2055
HgeneTgene
Gene symbol

ADAMTS17

CERS3

Gene ID

170691

204219

Gene nameADAM metallopeptidase with thrombospondin type 1 motif 17ceramide synthase 3
SynonymsWMS4ARCI9|LASS3
Cytomap

15q26.3

15q26.3

Type of geneprotein-codingprotein-coding
DescriptionA disintegrin and metalloproteinase with thrombospondin motifs 17a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17ceramide synthase 3LAG1 homolog, ceramide synthase 3LAG1 longevity assurance homolog 3dihydroceramide synthase 3sphingosine N-acyltransferase CERS3
Modification date2020031320200313
UniProtAcc

Q8TE56

Q8IU89

Ensembl transtripts involved in fusion geneENST idsENST00000268070, ENST00000559976, 
ENST00000560944, ENST00000284382, 
ENST00000394113, ENST00000538112, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score24 X 8 X 8=15368 X 7 X 7=392
# samples 1411
** MAII scorelog2(14/1536*10)=-3.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/392*10)=-1.83335013059055
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ADAMTS17 [Title/Abstract] AND CERS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ADAMTS17(100692817)-CERS3(100943070), # samples:2
ADAMTS17(100692817)-CERS3(100996251), # samples:2
Anticipated loss of major functional domain due to fusion event.ADAMTS17-CERS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS17-CERS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS17-CERS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS17-CERS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAMTS17-CERS3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ADAMTS17-CERS3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ADAMTS17-CERS3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCERS3

GO:0046513

ceramide biosynthetic process

17977534|22038835


check buttonFusion gene breakpoints across ADAMTS17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CERS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-33-4532-01AADAMTS17chr15

100692817

-CERS3chr15

100943070

-
ChimerDB4LUSCTCGA-33-4532-01AADAMTS17chr15

100692817

-CERS3chr15

100996251

-
ChimerDB4LUSCTCGA-33-4532ADAMTS17chr15

100692817

-CERS3chr15

100943070

-
ChimerDB4LUSCTCGA-33-4532ADAMTS17chr15

100692817

-CERS3chr15

100996175

-
ChimerDB4LUSCTCGA-33-4532ADAMTS17chr15

100692817

-CERS3chr15

100996251

-
ChimerDB4LUSCTCGA-56-6545-01AADAMTS17chr15

100794341

-CERS3chr15

100943070

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000268070ADAMTS17chr15100692817-ENST00000284382CERS3chr15100943070-40501579371731564
ENST00000268070ADAMTS17chr15100794341-ENST00000394113CERS3chr15100943070-15361181371203388

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000268070ENST00000284382ADAMTS17chr15100692817-CERS3chr15100943070-0.0071074940.9928925
ENST00000268070ENST00000394113ADAMTS17chr15100794341-CERS3chr15100943070-0.0612790470.938721

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>2055_2055_1_ADAMTS17-CERS3_ADAMTS17_chr15_100692817_ENST00000268070_CERS3_chr15_100943070_ENST00000284382_length(amino acids)=564AA_BP=514
MAPPPSALLLRRHGPGGLPVPGTMCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRT
PPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGRPAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLG
QEQVLIQPLNNSQGPFSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVADADMVQY
HGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVD
AAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLS
WSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMESIQDVRSDDEDYEEEEEEEEEEATKG

--------------------------------------------------------------

>2055_2055_2_ADAMTS17-CERS3_ADAMTS17_chr15_100794341_ENST00000268070_CERS3_chr15_100943070_ENST00000394113_length(amino acids)=388AA_BP=
MAPPPSALLLRRHGPGGLPVPGTMCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRT
PPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGRPAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLG
QEQVLIQPLNNSQGPFSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVADADMVQY
HGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVD

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:100692817/chr15:100943070)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAMTS17

Q8TE56

CERS3

Q8IU89

FUNCTION: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) and ultra long chain (more than C26:0) as acyl donor (PubMed:17977534, PubMed:22038835, PubMed:26887952). It is crucial for the synthesis of ultra long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:23754960). {ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:22038835, ECO:0000269|PubMed:23754960, ECO:0000269|PubMed:26887952}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-102260_120491.01096.0Compositional biasNote=Arg-rich
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-72260_120358.33333333333331096.0Compositional biasNote=Arg-rich
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022232_452491.01096.0DomainPeptidase M12B
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022199_206491.01096.0MotifCysteine switch
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722199_206358.33333333333331096.0MotifCysteine switch
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113346_355333.0384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214346_355333.0384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113346_355333.0384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113346_355333.0384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214346_355333.0384.0Compositional biasNote=Poly-Glu
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113346_355333.0384.0Compositional biasNote=Poly-Glu

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022599_701491.01096.0Compositional biasNote=Cys-rich
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722599_701358.33333333333331096.0Compositional biasNote=Cys-rich
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-10221045_1084491.01096.0DomainPLAC
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022453_542491.01096.0DomainNote=Disintegrin
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022543_598491.01096.0DomainTSP type-1 1
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022800_860491.01096.0DomainTSP type-1 2
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022861_922491.01096.0DomainTSP type-1 3
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022925_968491.01096.0DomainTSP type-1 4
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022972_1029491.01096.0DomainTSP type-1 5
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-7221045_1084358.33333333333331096.0DomainPLAC
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722232_452358.33333333333331096.0DomainPeptidase M12B
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722453_542358.33333333333331096.0DomainNote=Disintegrin
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722543_598358.33333333333331096.0DomainTSP type-1 1
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722800_860358.33333333333331096.0DomainTSP type-1 2
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722861_922358.33333333333331096.0DomainTSP type-1 3
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722925_968358.33333333333331096.0DomainTSP type-1 4
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722972_1029358.33333333333331096.0DomainTSP type-1 5
HgeneADAMTS17chr15:100692817chr15:100943070ENST00000268070-1022702_779491.01096.0RegionNote=Spacer
HgeneADAMTS17chr15:100794341chr15:100943070ENST00000268070-722702_779358.33333333333331096.0RegionNote=Spacer
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113130_331333.0384.0DomainTLC
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214130_331333.0384.0DomainTLC
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113130_331333.0384.0DomainTLC
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113130_331333.0384.0DomainTLC
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214130_331333.0384.0DomainTLC
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113130_331333.0384.0DomainTLC
TgeneCERS3chr15:100692817chr15:100943070ENST00000284382111366_127333.0384.0RegionHomeobox-like
TgeneCERS3chr15:100692817chr15:100943070ENST00000394113121466_127333.0384.0RegionHomeobox-like
TgeneCERS3chr15:100692817chr15:100943070ENST00000538112111366_127333.0384.0RegionHomeobox-like
TgeneCERS3chr15:100794341chr15:100943070ENST00000284382111366_127333.0384.0RegionHomeobox-like
TgeneCERS3chr15:100794341chr15:100943070ENST00000394113121466_127333.0384.0RegionHomeobox-like
TgeneCERS3chr15:100794341chr15:100943070ENST00000538112111366_127333.0384.0RegionHomeobox-like
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113319_383333.0384.0Topological domainCytoplasmic
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214319_383333.0384.0Topological domainCytoplasmic
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113319_383333.0384.0Topological domainCytoplasmic
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113319_383333.0384.0Topological domainCytoplasmic
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214319_383333.0384.0Topological domainCytoplasmic
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113319_383333.0384.0Topological domainCytoplasmic
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113139_159333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113174_194333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113205_225333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113264_284333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000002843821113298_318333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST00000284382111332_52333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214139_159333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214174_194333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214205_225333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214264_284333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000003941131214298_318333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST00000394113121432_52333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113139_159333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113174_194333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113205_225333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113264_284333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST000005381121113298_318333.0384.0TransmembraneHelical
TgeneCERS3chr15:100692817chr15:100943070ENST00000538112111332_52333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113139_159333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113174_194333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113205_225333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113264_284333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000002843821113298_318333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST00000284382111332_52333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214139_159333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214174_194333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214205_225333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214264_284333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000003941131214298_318333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST00000394113121432_52333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113139_159333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113174_194333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113205_225333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113264_284333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST000005381121113298_318333.0384.0TransmembraneHelical
TgeneCERS3chr15:100794341chr15:100943070ENST00000538112111332_52333.0384.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ADAMTS17
CERS3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ADAMTS17-CERS3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ADAMTS17-CERS3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource