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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CUX1-MARCH10

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CUX1-MARCH10
FusionPDB ID: 20733
FusionGDB2.0 ID: 20733
HgeneTgene
Gene symbol

CUX1

MARCH10

Gene ID

1523

162333

Gene namecut like homeobox 1membrane associated ring-CH-type finger 10
SynonymsCASP|CDP|CDP/Cut|CDP1|COY1|CUTL1|CUX|Clox|Cux/CDP|GDDI|GOLIM6|Nbla10317|p100|p110|p200|p75MARCH-X|MARCH10|RNF190
Cytomap

7q22.1

17q23.2

Type of geneprotein-codingprotein-coding
Descriptionprotein CASPHomeobox protein cut-like 1CCAAT displacement proteinCUX1 gene Alternatively Spliced Productcut homologgolgi integral membrane protein 6homeobox protein cux-1putative protein product of Nbla10317probable E3 ubiquitin-protein ligase MARCH10RING-type E3 ubiquitin transferase MARCH10membrane associated ring finger 10membrane-associated RING finger protein 10membrane-associated RING-CH protein Xmembrane-associated ring finger (C3HC4) 10, E3 ubiq
Modification date2020032020200313
UniProtAcc

P39880

.
Ensembl transtripts involved in fusion geneENST idsENST00000292538, ENST00000360264, 
ENST00000393824, ENST00000425244, 
ENST00000437600, ENST00000547394, 
ENST00000292535, ENST00000546411, 
ENST00000549414, ENST00000550008, 
ENST00000556210, ENST00000560541, 
ENST00000582358, ENST00000311269, 
ENST00000456609, ENST00000544856, 
ENST00000583600, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score32 X 26 X 13=1081610 X 6 X 6=360
# samples 379
** MAII scorelog2(37/10816*10)=-4.86949797576587
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CUX1 [Title/Abstract] AND MARCH10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CUX1(101459373)-MARCH10(60837367), # samples:2
Anticipated loss of major functional domain due to fusion event.CUX1-MARCH10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CUX1-MARCH10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CUX1-MARCH10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CUX1-MARCH10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CUX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MARCH10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0T7-01ACUX1chr7

101459373

-MARCH10chr17

60837367

-
ChimerDB4BRCATCGA-A2-A0T7-01ACUX1chr7

101459373

+MARCH10chr17

60837367

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000437600CUX1chr7101459373+ENST00000456609MARCH10chr1760837367-30214153522631759
ENST00000437600CUX1chr7101459373+ENST00000311269MARCH10chr1760837367-30204153522631759
ENST00000437600CUX1chr7101459373+ENST00000583600MARCH10chr1760837367-31344153522745797
ENST00000437600CUX1chr7101459373+ENST00000544856MARCH10chr1760837367-31644153522604750
ENST00000292538CUX1chr7101459373+ENST00000456609MARCH10chr1760837367-269589262305759
ENST00000292538CUX1chr7101459373+ENST00000311269MARCH10chr1760837367-269489262305759
ENST00000292538CUX1chr7101459373+ENST00000583600MARCH10chr1760837367-280889262419797
ENST00000292538CUX1chr7101459373+ENST00000544856MARCH10chr1760837367-283889262278750
ENST00000393824CUX1chr7101459373+ENST00000456609MARCH10chr1760837367-269286232302759
ENST00000393824CUX1chr7101459373+ENST00000311269MARCH10chr1760837367-269186232302759
ENST00000393824CUX1chr7101459373+ENST00000583600MARCH10chr1760837367-280586232416797
ENST00000393824CUX1chr7101459373+ENST00000544856MARCH10chr1760837367-283586232275750
ENST00000547394CUX1chr7101459373+ENST00000456609MARCH10chr1760837367-269185222301759
ENST00000547394CUX1chr7101459373+ENST00000311269MARCH10chr1760837367-269085222301759
ENST00000547394CUX1chr7101459373+ENST00000583600MARCH10chr1760837367-280485222415797
ENST00000547394CUX1chr7101459373+ENST00000544856MARCH10chr1760837367-283485222274750
ENST00000360264CUX1chr7101459373+ENST00000456609MARCH10chr1760837367-268983202299759
ENST00000360264CUX1chr7101459373+ENST00000311269MARCH10chr1760837367-268883202299759
ENST00000360264CUX1chr7101459373+ENST00000583600MARCH10chr1760837367-280283202413797
ENST00000360264CUX1chr7101459373+ENST00000544856MARCH10chr1760837367-283283202272750
ENST00000425244CUX1chr7101459373+ENST00000456609MARCH10chr1760837367-267973102289759
ENST00000425244CUX1chr7101459373+ENST00000311269MARCH10chr1760837367-267873102289759
ENST00000425244CUX1chr7101459373+ENST00000583600MARCH10chr1760837367-279273102403797
ENST00000425244CUX1chr7101459373+ENST00000544856MARCH10chr1760837367-282273102262750

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000437600ENST00000456609CUX1chr7101459373+MARCH10chr1760837367-0.0030020140.99699795
ENST00000437600ENST00000311269CUX1chr7101459373+MARCH10chr1760837367-0.003056350.99694365
ENST00000437600ENST00000583600CUX1chr7101459373+MARCH10chr1760837367-0.0040822920.99591774
ENST00000437600ENST00000544856CUX1chr7101459373+MARCH10chr1760837367-0.0030991090.9969009
ENST00000292538ENST00000456609CUX1chr7101459373+MARCH10chr1760837367-0.0019665180.99803346
ENST00000292538ENST00000311269CUX1chr7101459373+MARCH10chr1760837367-0.0020031540.99799687
ENST00000292538ENST00000583600CUX1chr7101459373+MARCH10chr1760837367-0.002783790.9972162
ENST00000292538ENST00000544856CUX1chr7101459373+MARCH10chr1760837367-0.002039750.9979602
ENST00000393824ENST00000456609CUX1chr7101459373+MARCH10chr1760837367-0.0019720070.998028
ENST00000393824ENST00000311269CUX1chr7101459373+MARCH10chr1760837367-0.0020089850.99799097
ENST00000393824ENST00000583600CUX1chr7101459373+MARCH10chr1760837367-0.0027874190.9972126
ENST00000393824ENST00000544856CUX1chr7101459373+MARCH10chr1760837367-0.0020471010.9979528
ENST00000547394ENST00000456609CUX1chr7101459373+MARCH10chr1760837367-0.0019601970.9980398
ENST00000547394ENST00000311269CUX1chr7101459373+MARCH10chr1760837367-0.0019967680.9980032
ENST00000547394ENST00000583600CUX1chr7101459373+MARCH10chr1760837367-0.0027767020.99722326
ENST00000547394ENST00000544856CUX1chr7101459373+MARCH10chr1760837367-0.002033110.9979668
ENST00000360264ENST00000456609CUX1chr7101459373+MARCH10chr1760837367-0.0019500570.99805
ENST00000360264ENST00000311269CUX1chr7101459373+MARCH10chr1760837367-0.0019864660.9980135
ENST00000360264ENST00000583600CUX1chr7101459373+MARCH10chr1760837367-0.0027609550.997239
ENST00000360264ENST00000544856CUX1chr7101459373+MARCH10chr1760837367-0.0020219750.99797803
ENST00000425244ENST00000456609CUX1chr7101459373+MARCH10chr1760837367-0.0019855630.99801445
ENST00000425244ENST00000311269CUX1chr7101459373+MARCH10chr1760837367-0.0020227880.9979772
ENST00000425244ENST00000583600CUX1chr7101459373+MARCH10chr1760837367-0.0028113640.9971886
ENST00000425244ENST00000544856CUX1chr7101459373+MARCH10chr1760837367-0.0020667890.99793327

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>20733_20733_1_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000292538_MARCH10_chr17_60837367_ENST00000311269_length(amino acids)=759AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPADQAPMVLLRKR
KPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQS
ELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRF
GGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEP
RQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSS
DSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHL
HVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGC
VGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNH

--------------------------------------------------------------

>20733_20733_2_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000292538_MARCH10_chr17_60837367_ENST00000456609_length(amino acids)=759AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPADQAPMVLLRKR
KPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQS
ELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRF
GGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEP
RQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSS
DSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHL
HVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGC
VGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNH

--------------------------------------------------------------

>20733_20733_3_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000292538_MARCH10_chr17_60837367_ENST00000544856_length(amino acids)=750AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPDQAPMVLLRKRK
PNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSE
LHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRFG
GTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPR
QEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSSD
SEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLH
VSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGCV
GSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNHN

--------------------------------------------------------------

>20733_20733_4_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000292538_MARCH10_chr17_60837367_ENST00000583600_length(amino acids)=797AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPAESEPTWWNKPE
TDLGGPSGWCSLGKKGPMSRSIPPCEADQAPMVLLRKRKPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNT
KLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILS
LNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRFGGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQ
RLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPRQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPIS
PRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSSDSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTS
QPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLHVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLK
KLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFY

--------------------------------------------------------------

>20733_20733_5_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000360264_MARCH10_chr17_60837367_ENST00000311269_length(amino acids)=759AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPADQAPMVLLRKR
KPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQS
ELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRF
GGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEP
RQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSS
DSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHL
HVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGC
VGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNH

--------------------------------------------------------------

>20733_20733_6_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000360264_MARCH10_chr17_60837367_ENST00000456609_length(amino acids)=759AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPADQAPMVLLRKR
KPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQS
ELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRF
GGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEP
RQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSS
DSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHL
HVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGC
VGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNH

--------------------------------------------------------------

>20733_20733_7_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000360264_MARCH10_chr17_60837367_ENST00000544856_length(amino acids)=750AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPDQAPMVLLRKRK
PNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSE
LHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRFG
GTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPR
QEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSSD
SEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLH
VSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGCV
GSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNHN

--------------------------------------------------------------

>20733_20733_8_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000360264_MARCH10_chr17_60837367_ENST00000583600_length(amino acids)=797AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPAESEPTWWNKPE
TDLGGPSGWCSLGKKGPMSRSIPPCEADQAPMVLLRKRKPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNT
KLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILS
LNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRFGGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQ
RLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPRQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPIS
PRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSSDSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTS
QPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLHVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLK
KLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFY

--------------------------------------------------------------

>20733_20733_9_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000393824_MARCH10_chr17_60837367_ENST00000311269_length(amino acids)=759AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPADQAPMVLLRKR
KPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQS
ELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRF
GGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEP
RQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSS
DSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHL
HVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGC
VGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNH

--------------------------------------------------------------

>20733_20733_10_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000393824_MARCH10_chr17_60837367_ENST00000456609_length(amino acids)=759AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPADQAPMVLLRKR
KPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQS
ELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRF
GGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEP
RQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSS
DSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHL
HVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGC
VGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNH

--------------------------------------------------------------

>20733_20733_11_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000393824_MARCH10_chr17_60837367_ENST00000544856_length(amino acids)=750AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPDQAPMVLLRKRK
PNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSE
LHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRFG
GTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPR
QEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSSD
SEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLH
VSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGCV
GSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNHN

--------------------------------------------------------------

>20733_20733_12_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000393824_MARCH10_chr17_60837367_ENST00000583600_length(amino acids)=797AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPAESEPTWWNKPE
TDLGGPSGWCSLGKKGPMSRSIPPCEADQAPMVLLRKRKPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNT
KLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILS
LNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRFGGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQ
RLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPRQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPIS
PRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSSDSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTS
QPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLHVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLK
KLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFY

--------------------------------------------------------------

>20733_20733_13_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000425244_MARCH10_chr17_60837367_ENST00000311269_length(amino acids)=759AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPADQAPMVLLRKR
KPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQS
ELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRF
GGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEP
RQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSS
DSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHL
HVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGC
VGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNH

--------------------------------------------------------------

>20733_20733_14_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000425244_MARCH10_chr17_60837367_ENST00000456609_length(amino acids)=759AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPADQAPMVLLRKR
KPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQS
ELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRF
GGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEP
RQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSS
DSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHL
HVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGC
VGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNH

--------------------------------------------------------------

>20733_20733_15_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000425244_MARCH10_chr17_60837367_ENST00000544856_length(amino acids)=750AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPDQAPMVLLRKRK
PNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSE
LHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRFG
GTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPR
QEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSSD
SEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLH
VSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGCV
GSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNHN

--------------------------------------------------------------

>20733_20733_16_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000425244_MARCH10_chr17_60837367_ENST00000583600_length(amino acids)=797AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPAESEPTWWNKPE
TDLGGPSGWCSLGKKGPMSRSIPPCEADQAPMVLLRKRKPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNT
KLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILS
LNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRFGGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQ
RLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPRQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPIS
PRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSSDSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTS
QPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLHVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLK
KLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFY

--------------------------------------------------------------

>20733_20733_17_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000437600_MARCH10_chr17_60837367_ENST00000311269_length(amino acids)=759AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPADQAPMVLLRKR
KPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQS
ELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRF
GGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEP
RQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSS
DSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHL
HVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGC
VGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNH

--------------------------------------------------------------

>20733_20733_18_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000437600_MARCH10_chr17_60837367_ENST00000456609_length(amino acids)=759AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPADQAPMVLLRKR
KPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQS
ELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRF
GGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEP
RQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSS
DSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHL
HVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGC
VGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNH

--------------------------------------------------------------

>20733_20733_19_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000437600_MARCH10_chr17_60837367_ENST00000544856_length(amino acids)=750AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPDQAPMVLLRKRK
PNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSE
LHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRFG
GTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPR
QEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSSD
SEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLH
VSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGCV
GSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNHN

--------------------------------------------------------------

>20733_20733_20_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000437600_MARCH10_chr17_60837367_ENST00000583600_length(amino acids)=797AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPAESEPTWWNKPE
TDLGGPSGWCSLGKKGPMSRSIPPCEADQAPMVLLRKRKPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNT
KLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILS
LNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRFGGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQ
RLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPRQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPIS
PRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSSDSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTS
QPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLHVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLK
KLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFY

--------------------------------------------------------------

>20733_20733_21_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000547394_MARCH10_chr17_60837367_ENST00000311269_length(amino acids)=759AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPADQAPMVLLRKR
KPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQS
ELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRF
GGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEP
RQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSS
DSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHL
HVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGC
VGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNH

--------------------------------------------------------------

>20733_20733_22_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000547394_MARCH10_chr17_60837367_ENST00000456609_length(amino acids)=759AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPADQAPMVLLRKR
KPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQS
ELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRF
GGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEP
RQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSS
DSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHL
HVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGC
VGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNH

--------------------------------------------------------------

>20733_20733_23_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000547394_MARCH10_chr17_60837367_ENST00000544856_length(amino acids)=750AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPDQAPMVLLRKRK
PNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSE
LHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRFG
GTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPR
QEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSSD
SEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLH
VSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGCV
GSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNHN

--------------------------------------------------------------

>20733_20733_24_CUX1-MARCH10_CUX1_chr7_101459373_ENST00000547394_MARCH10_chr17_60837367_ENST00000583600_length(amino acids)=797AA_BP=21
MAANVGSMFQYWKRFDLQQLQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPAESEPTWWNKPE
TDLGGPSGWCSLGKKGPMSRSIPPCEADQAPMVLLRKRKPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNT
KLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILS
LNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRFGGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQ
RLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPRQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPIS
PRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSSDSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTS
QPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLHVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLK
KLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFY

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:101459373/chr17:60837367)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CUX1

P39880

.
FUNCTION: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMARCH10chr7:101459373chr17:60837367ENST00000311269211575_58170.0809.0Compositional biasNote=Poly-Ser
TgeneMARCH10chr7:101459373chr17:60837367ENST00000456609211575_58170.0809.0Compositional biasNote=Poly-Ser
TgeneMARCH10chr7:101459373chr17:60837367ENST00000311269211651_72170.0809.0Zinc fingerRING-CH-type
TgeneMARCH10chr7:101459373chr17:60837367ENST00000456609211651_72170.0809.0Zinc fingerRING-CH-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCUX1chr7:101459373chr17:60837367ENST00000292535+12456_40701506.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr17:60837367ENST00000292538+123502_55621.0679.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr17:60837367ENST00000292538+12367_45021.0679.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr17:60837367ENST00000360264+12456_40721.01517.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr17:60837367ENST00000393824+122502_55621.0640.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr17:60837367ENST00000393824+12267_45021.0640.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr17:60837367ENST00000425244+12256_40721.0633.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr17:60837367ENST00000437600+123502_55621.0677.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr17:60837367ENST00000437600+12367_45021.0677.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr17:60837367ENST00000546411+12456_4070.01404.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr17:60837367ENST00000547394+122502_55621.0663.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr17:60837367ENST00000547394+12267_45021.0663.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr17:60837367ENST00000549414+12356_4070.01484.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr17:60837367ENST00000550008+12256_4070.01450.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr17:60837367ENST00000556210+12256_4070.01348.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr17:60837367ENST00000292535+1241406_143801506.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr17:60837367ENST00000360264+1241406_143821.01517.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr17:60837367ENST00000425244+1221406_143821.0633.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr17:60837367ENST00000546411+1241406_14380.01404.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr17:60837367ENST00000549414+1231406_14380.01484.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr17:60837367ENST00000550008+1221406_14380.01450.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr17:60837367ENST00000556210+1221406_14380.01348.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr17:60837367ENST00000292535+1241117_120401506.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr17:60837367ENST00000292535+1241244_130301506.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr17:60837367ENST00000292535+124542_62901506.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr17:60837367ENST00000292535+124934_102101506.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr17:60837367ENST00000360264+1241117_120421.01517.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr17:60837367ENST00000360264+1241244_130321.01517.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr17:60837367ENST00000360264+124542_62921.01517.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr17:60837367ENST00000360264+124934_102121.01517.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr17:60837367ENST00000425244+1221117_120421.0633.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr17:60837367ENST00000425244+1221244_130321.0633.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr17:60837367ENST00000425244+122542_62921.0633.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr17:60837367ENST00000425244+122934_102121.0633.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr17:60837367ENST00000546411+1241117_12040.01404.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr17:60837367ENST00000546411+1241244_13030.01404.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr17:60837367ENST00000546411+124542_6290.01404.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr17:60837367ENST00000546411+124934_10210.01404.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr17:60837367ENST00000549414+1231117_12040.01484.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr17:60837367ENST00000549414+1231244_13030.01484.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr17:60837367ENST00000549414+123542_6290.01484.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr17:60837367ENST00000549414+123934_10210.01484.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr17:60837367ENST00000550008+1221117_12040.01450.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr17:60837367ENST00000550008+1221244_13030.01450.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr17:60837367ENST00000550008+122542_6290.01450.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr17:60837367ENST00000550008+122934_10210.01450.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr17:60837367ENST00000556210+1221117_12040.01348.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr17:60837367ENST00000556210+1221244_13030.01348.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr17:60837367ENST00000556210+122542_6290.01348.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr17:60837367ENST00000556210+122934_10210.01348.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr17:60837367ENST00000292538+1231_61921.0679.0Topological domainCytoplasmic
HgeneCUX1chr7:101459373chr17:60837367ENST00000292538+123641_67821.0679.0Topological domainLumenal
HgeneCUX1chr7:101459373chr17:60837367ENST00000393824+1221_61921.0640.0Topological domainCytoplasmic
HgeneCUX1chr7:101459373chr17:60837367ENST00000393824+122641_67821.0640.0Topological domainLumenal
HgeneCUX1chr7:101459373chr17:60837367ENST00000437600+1231_61921.0677.0Topological domainCytoplasmic
HgeneCUX1chr7:101459373chr17:60837367ENST00000437600+123641_67821.0677.0Topological domainLumenal
HgeneCUX1chr7:101459373chr17:60837367ENST00000547394+1221_61921.0663.0Topological domainCytoplasmic
HgeneCUX1chr7:101459373chr17:60837367ENST00000547394+122641_67821.0663.0Topological domainLumenal
HgeneCUX1chr7:101459373chr17:60837367ENST00000292538+123620_64021.0679.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneCUX1chr7:101459373chr17:60837367ENST00000393824+122620_64021.0640.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneCUX1chr7:101459373chr17:60837367ENST00000437600+123620_64021.0677.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneCUX1chr7:101459373chr17:60837367ENST00000547394+122620_64021.0663.0TransmembraneHelical%3B Anchor for type IV membrane protein


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CUX1
MARCH10


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CUX1-MARCH10


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CUX1-MARCH10


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource