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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CUX1-THSD7A

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CUX1-THSD7A
	FusionPDB ID: 20745
	FusionGDB2.0 ID: 20745
		Hgene	Tgene
	Gene symbol	CUX1	THSD7A
	Gene ID	1523	221981
	Gene name	cut like homeobox 1	thrombospondin type 1 domain containing 7A
	Synonyms	CASP\|CDP\|CDP/Cut\|CDP1\|COY1\|CUTL1\|CUX\|Clox\|Cux/CDP\|GDDI\|GOLIM6\|Nbla10317\|p100\|p110\|p200\|p75	-
	Cytomap	7q22.1	7p21.3
	Type of gene	protein-coding	protein-coding
	Description	protein CASPHomeobox protein cut-like 1CCAAT displacement proteinCUX1 gene Alternatively Spliced Productcut homologgolgi integral membrane protein 6homeobox protein cux-1putative protein product of Nbla10317	thrombospondin type-1 domain-containing protein 7Athrombospondin, type I, domain containing 7A
	Modification date	20200320	20200322
	UniProtAcc	P39880	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000560541, ENST00000292535, ENST00000292538, ENST00000360264, ENST00000393824, ENST00000425244, ENST00000437600, ENST00000546411, ENST00000547394, ENST00000549414, ENST00000550008, ENST00000556210,	ENST00000423059, ENST00000480061,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	32 X 26 X 13=10816	7 X 7 X 5=245
	# samples	37	7
	** MAII score	log2(37/10816*10)=-4.86949797576587 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CUX1 [Title/Abstract] AND THSD7A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CUX1(101713697)-THSD7A(11676588), # samples:2
Anticipated loss of major functional domain due to fusion event.	CUX1-THSD7A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CUX1-THSD7A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CUX1-THSD7A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CUX1-THSD7A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CUX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across THSD7A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-6961-01A	CUX1	chr7	101713697	-	THSD7A	chr7	11676588	-
ChimerDB4	HNSC	TCGA-CV-6961-01A	CUX1	chr7	101713697	+	THSD7A	chr7	11676588	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000437600	CUX1	chr7	101713697	+	ENST00000423059	THSD7A	chr7	11676588	-	10874	653	352	5436	1694
ENST00000292538	CUX1	chr7	101713697	+	ENST00000423059	THSD7A	chr7	11676588	-	10548	327	26	5110	1694
ENST00000393824	CUX1	chr7	101713697	+	ENST00000423059	THSD7A	chr7	11676588	-	10434	213	23	4996	1657
ENST00000547394	CUX1	chr7	101713697	+	ENST00000423059	THSD7A	chr7	11676588	-	10496	275	22	5058	1678
ENST00000360264	CUX1	chr7	101713697	+	ENST00000423059	THSD7A	chr7	11676588	-	10542	321	20	5104	1694
ENST00000425244	CUX1	chr7	101713697	+	ENST00000423059	THSD7A	chr7	11676588	-	10532	311	10	5094	1694
ENST00000292535	CUX1	chr7	101713697	+	ENST00000423059	THSD7A	chr7	11676588	-	10527	306	38	5089	1683
ENST00000549414	CUX1	chr7	101713697	+	ENST00000423059	THSD7A	chr7	11676588	-	10489	268	0	5051	1683
ENST00000556210	CUX1	chr7	101713697	+	ENST00000423059	THSD7A	chr7	11676588	-	10489	268	0	5051	1683
ENST00000550008	CUX1	chr7	101713697	+	ENST00000423059	THSD7A	chr7	11676588	-	10489	268	0	5051	1683
ENST00000546411	CUX1	chr7	101713697	+	ENST00000423059	THSD7A	chr7	11676588	-	10489	268	0	5051	1683

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000437600	ENST00000423059	CUX1	chr7	101713697	+	THSD7A	chr7	11676588	-	0.00040224	0.9995977
ENST00000292538	ENST00000423059	CUX1	chr7	101713697	+	THSD7A	chr7	11676588	-	0.000266156	0.99973387
ENST00000393824	ENST00000423059	CUX1	chr7	101713697	+	THSD7A	chr7	11676588	-	0.000264938	0.99973506
ENST00000547394	ENST00000423059	CUX1	chr7	101713697	+	THSD7A	chr7	11676588	-	0.000262052	0.9997379
ENST00000360264	ENST00000423059	CUX1	chr7	101713697	+	THSD7A	chr7	11676588	-	0.000264637	0.9997353
ENST00000425244	ENST00000423059	CUX1	chr7	101713697	+	THSD7A	chr7	11676588	-	0.000262179	0.9997378
ENST00000292535	ENST00000423059	CUX1	chr7	101713697	+	THSD7A	chr7	11676588	-	0.000270461	0.9997296
ENST00000549414	ENST00000423059	CUX1	chr7	101713697	+	THSD7A	chr7	11676588	-	0.000258994	0.999741
ENST00000556210	ENST00000423059	CUX1	chr7	101713697	+	THSD7A	chr7	11676588	-	0.000258994	0.999741
ENST00000550008	ENST00000423059	CUX1	chr7	101713697	+	THSD7A	chr7	11676588	-	0.000258994	0.999741
ENST00000546411	ENST00000423059	CUX1	chr7	101713697	+	THSD7A	chr7	11676588	-	0.000258994	0.999741

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>20745_20745_1_CUX1-THSD7A_CUX1_chr7_101713697_ENST00000292535_THSD7A_chr7_11676588_ENST00000423059_length(amino acids)=1683AA_BP=89
MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPG
PWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQ
VREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSS
PCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCINKT
GKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCAT
YGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECE
VSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCI
NSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPC
TVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCP
SSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRK
QDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQ
PVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSG
VKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDY
LCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQL
SEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRP
CPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGD
CYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWCQRSDGINVTGG
CLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSSNSTLEQCTLIPVVVLPTMEDKRGDVKTSRAVHPTQPSSNPAGRGRTWF

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>20745_20745_2_CUX1-THSD7A_CUX1_chr7_101713697_ENST00000292538_THSD7A_chr7_11676588_ENST00000423059_length(amino acids)=1694AA_BP=100
MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFL
NVYKRLIDVPGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKP
LECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCP
NLTEFQVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGY
QTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCL
SQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQ
LCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECG
PGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSAL
QEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCI
VTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGP
GRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIET
QYCPCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSN
WSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNT
ADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYD
YNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRT
VTQPFQGDGRPCPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVL
EESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWC
QRSDGINVTGGCLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSSNSTLEQCTLIPVVVLPTMEDKRGDVKTSRAVHPTQPS

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>20745_20745_3_CUX1-THSD7A_CUX1_chr7_101713697_ENST00000360264_THSD7A_chr7_11676588_ENST00000423059_length(amino acids)=1694AA_BP=100
MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFL
NVYKRLIDVPGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKP
LECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCP
NLTEFQVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGY
QTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCL
SQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQ
LCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECG
PGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSAL
QEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCI
VTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGP
GRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIET
QYCPCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSN
WSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNT
ADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYD
YNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRT
VTQPFQGDGRPCPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVL
EESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWC
QRSDGINVTGGCLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSSNSTLEQCTLIPVVVLPTMEDKRGDVKTSRAVHPTQPS

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>20745_20745_4_CUX1-THSD7A_CUX1_chr7_101713697_ENST00000393824_THSD7A_chr7_11676588_ENST00000423059_length(amino acids)=1657AA_BP=63
MAANVGSMFQYWKRFDLQQLQDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPGPWGRCMGDECGPGGIQTRAVWCAHVE
GWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPK
PLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQ
VRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKE
CQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGN
QTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKL
RKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAP
CPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTT
TWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANG
GRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQ
IPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGD
IKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVN
QAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISE
WGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVD
LKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPCYRWQYGQWSP
CQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGG
IQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWCQRSDGINVTGGCLVMSQPDADRSCNPPCSQPHSYCSE
TKTCHCEEGYTEVMSSNSTLEQCTLIPVVVLPTMEDKRGDVKTSRAVHPTQPSSNPAGRGRTWFLQPFGPDGRLKTWVYGVAAGAFVLLI

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>20745_20745_5_CUX1-THSD7A_CUX1_chr7_101713697_ENST00000425244_THSD7A_chr7_11676588_ENST00000423059_length(amino acids)=1694AA_BP=100
MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFL
NVYKRLIDVPGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKP
LECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCP
NLTEFQVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGY
QTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCL
SQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQ
LCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECG
PGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSAL
QEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCI
VTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGP
GRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIET
QYCPCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSN
WSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNT
ADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYD
YNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRT
VTQPFQGDGRPCPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVL
EESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWC
QRSDGINVTGGCLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSSNSTLEQCTLIPVVVLPTMEDKRGDVKTSRAVHPTQPS

--------------------------------------------------------------

>20745_20745_6_CUX1-THSD7A_CUX1_chr7_101713697_ENST00000437600_THSD7A_chr7_11676588_ENST00000423059_length(amino acids)=1694AA_BP=100
MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFL
NVYKRLIDVPGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKP
LECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCP
NLTEFQVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGY
QTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCL
SQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQ
LCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECG
PGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSAL
QEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCI
VTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGP
GRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIET
QYCPCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSN
WSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNT
ADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYD
YNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRT
VTQPFQGDGRPCPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVL
EESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWC
QRSDGINVTGGCLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSSNSTLEQCTLIPVVVLPTMEDKRGDVKTSRAVHPTQPS

--------------------------------------------------------------

>20745_20745_7_CUX1-THSD7A_CUX1_chr7_101713697_ENST00000546411_THSD7A_chr7_11676588_ENST00000423059_length(amino acids)=1683AA_BP=89
MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPG
PWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQ
VREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSS
PCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCINKT
GKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCAT
YGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECE
VSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCI
NSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPC
TVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCP
SSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRK
QDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQ
PVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSG
VKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDY
LCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQL
SEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRP
CPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGD
CYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWCQRSDGINVTGG
CLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSSNSTLEQCTLIPVVVLPTMEDKRGDVKTSRAVHPTQPSSNPAGRGRTWF

--------------------------------------------------------------

>20745_20745_8_CUX1-THSD7A_CUX1_chr7_101713697_ENST00000547394_THSD7A_chr7_11676588_ENST00000423059_length(amino acids)=1678AA_BP=84
MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEIDALSKRSKEAEAAFLNVYKRLIDVPGPWGRC
MGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIA
CIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPCEAE
ELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCINKTGKAAD
LSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCATYGWRT
TEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWS
AWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGE
EVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHW
QTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKE
GDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQ
AGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNW
SDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRS
KWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPE
EMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAV
CGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLM
DQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKD
WSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWCQRSDGINVTGGCLVMS
QPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSSNSTLEQCTLIPVVVLPTMEDKRGDVKTSRAVHPTQPSSNPAGRGRTWFLQPFG

--------------------------------------------------------------

>20745_20745_9_CUX1-THSD7A_CUX1_chr7_101713697_ENST00000549414_THSD7A_chr7_11676588_ENST00000423059_length(amino acids)=1683AA_BP=89
MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPG
PWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQ
VREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSS
PCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCINKT
GKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCAT
YGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECE
VSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCI
NSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPC
TVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCP
SSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRK
QDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQ
PVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSG
VKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDY
LCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQL
SEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRP
CPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGD
CYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWCQRSDGINVTGG
CLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSSNSTLEQCTLIPVVVLPTMEDKRGDVKTSRAVHPTQPSSNPAGRGRTWF

--------------------------------------------------------------

>20745_20745_10_CUX1-THSD7A_CUX1_chr7_101713697_ENST00000550008_THSD7A_chr7_11676588_ENST00000423059_length(amino acids)=1683AA_BP=89
MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPG
PWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQ
VREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSS
PCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCINKT
GKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCAT
YGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECE
VSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCI
NSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPC
TVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCP
SSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRK
QDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQ
PVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSG
VKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDY
LCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQL
SEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRP
CPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGD
CYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWCQRSDGINVTGG
CLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSSNSTLEQCTLIPVVVLPTMEDKRGDVKTSRAVHPTQPSSNPAGRGRTWF

--------------------------------------------------------------

>20745_20745_11_CUX1-THSD7A_CUX1_chr7_101713697_ENST00000556210_THSD7A_chr7_11676588_ENST00000423059_length(amino acids)=1683AA_BP=89
MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPG
PWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQ
VREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSS
PCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCINKT
GKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCAT
YGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECE
VSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCI
NSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPC
TVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCP
SSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRK
QDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQ
PVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSG
VKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDY
LCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQL
SEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRP
CPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGD
CYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWCQRSDGINVTGG
CLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSSNSTLEQCTLIPVVVLPTMEDKRGDVKTSRAVHPTQPSSNPAGRGRTWF

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:101713697/chr7:11676588)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CUX1 P39880	.
FUNCTION: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250\|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269\|PubMed:15099520}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

267_315

63.333333333333336

1658.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

1035_1095

63.333333333333336

1658.0

Domain

TSP type-1 13

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

1096_1163

63.333333333333336

1658.0

Domain

TSP type-1 14

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

1166_1220

63.333333333333336

1658.0

Domain

TSP type-1 15

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

120_192

63.333333333333336

1658.0

Domain

TSP type-1 2

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

1221_1284

63.333333333333336

1658.0

Domain

TSP type-1 16

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

1286_1341

63.333333333333336

1658.0

Domain

TSP type-1 17

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

1342_1412

63.333333333333336

1658.0

Domain

TSP type-1 18

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

1414_1475

63.333333333333336

1658.0

Domain

TSP type-1 19

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

194_247

63.333333333333336

1658.0

Domain

TSP type-1 3

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

360_416

63.333333333333336

1658.0

Domain

TSP type-1 4

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

423_510

63.333333333333336

1658.0

Domain

TSP type-1 5

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

512_574

63.333333333333336

1658.0

Domain

TSP type-1 6

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

634_695

63.333333333333336

1658.0

Domain

TSP type-1 7

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

696_769

63.333333333333336

1658.0

Domain

TSP type-1 8

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

771_831

63.333333333333336

1658.0

Domain

TSP type-1 9

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

832_904

63.333333333333336

1658.0

Domain

TSP type-1 10

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

906_959

63.333333333333336

1658.0

Domain

TSP type-1 11

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

960_1033

63.333333333333336

1658.0

Domain

TSP type-1 12

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

1629_1657

63.333333333333336

1658.0

Topological domain

Cytoplasmic

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

1608_1628

63.333333333333336

1658.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000292535

56_407

89.33333333333333

1506.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000292538

502_556

100.33333333333333

679.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000292538

67_450

100.33333333333333

679.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000360264

56_407

100.33333333333333

1517.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000393824

502_556

63.333333333333336

640.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000393824

67_450

63.333333333333336

640.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000425244

56_407

100.33333333333333

633.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000437600

502_556

100.33333333333333

677.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000437600

67_450

100.33333333333333

677.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000546411

56_407

89.33333333333333

1404.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000547394

502_556

84.33333333333333

663.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000547394

67_450

84.33333333333333

663.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000549414

56_407

89.33333333333333

1484.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000550008

56_407

89.33333333333333

1450.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000556210

56_407

89.33333333333333

1348.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000292535

1406_1438

89.33333333333333

1506.0

Compositional bias

Note=Ala-rich

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000360264

1406_1438

100.33333333333333

1517.0

Compositional bias

Note=Ala-rich

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000425244

1406_1438

100.33333333333333

633.0

Compositional bias

Note=Ala-rich

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000546411

1406_1438

89.33333333333333

1404.0

Compositional bias

Note=Ala-rich

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000549414

1406_1438

89.33333333333333

1484.0

Compositional bias

Note=Ala-rich

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000550008

1406_1438

89.33333333333333

1450.0

Compositional bias

Note=Ala-rich

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000556210

1406_1438

89.33333333333333

1348.0

Compositional bias

Note=Ala-rich

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000292535

1117_1204

89.33333333333333

1506.0

DNA binding

CUT 3

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000292535

1244_1303

89.33333333333333

1506.0

DNA binding

Homeobox

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000292535

542_629

89.33333333333333

1506.0

DNA binding

CUT 1

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000292535

934_1021

89.33333333333333

1506.0

DNA binding

CUT 2

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000360264

1117_1204

100.33333333333333

1517.0

DNA binding

CUT 3

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000360264

1244_1303

100.33333333333333

1517.0

DNA binding

Homeobox

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000360264

542_629

100.33333333333333

1517.0

DNA binding

CUT 1

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000360264

934_1021

100.33333333333333

1517.0

DNA binding

CUT 2

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000425244

1117_1204

100.33333333333333

633.0

DNA binding

CUT 3

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000425244

1244_1303

100.33333333333333

633.0

DNA binding

Homeobox

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000425244

542_629

100.33333333333333

633.0

DNA binding

CUT 1

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000425244

934_1021

100.33333333333333

633.0

DNA binding

CUT 2

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000546411

1117_1204

89.33333333333333

1404.0

DNA binding

CUT 3

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000546411

1244_1303

89.33333333333333

1404.0

DNA binding

Homeobox

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000546411

542_629

89.33333333333333

1404.0

DNA binding

CUT 1

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000546411

934_1021

89.33333333333333

1404.0

DNA binding

CUT 2

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000549414

1117_1204

89.33333333333333

1484.0

DNA binding

CUT 3

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000549414

1244_1303

89.33333333333333

1484.0

DNA binding

Homeobox

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000549414

542_629

89.33333333333333

1484.0

DNA binding

CUT 1

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000549414

934_1021

89.33333333333333

1484.0

DNA binding

CUT 2

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000550008

1117_1204

89.33333333333333

1450.0

DNA binding

CUT 3

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000550008

1244_1303

89.33333333333333

1450.0

DNA binding

Homeobox

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000550008

542_629

89.33333333333333

1450.0

DNA binding

CUT 1

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000550008

934_1021

89.33333333333333

1450.0

DNA binding

CUT 2

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000556210

1117_1204

89.33333333333333

1348.0

DNA binding

CUT 3

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000556210

1244_1303

89.33333333333333

1348.0

DNA binding

Homeobox

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000556210

542_629

89.33333333333333

1348.0

DNA binding

CUT 1

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000556210

934_1021

89.33333333333333

1348.0

DNA binding

CUT 2

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000292538

1_619

100.33333333333333

679.0

Topological domain

Cytoplasmic

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000292538

641_678

100.33333333333333

679.0

Topological domain

Lumenal

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000393824

1_619

63.333333333333336

640.0

Topological domain

Cytoplasmic

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000393824

641_678

63.333333333333336

640.0

Topological domain

Lumenal

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000437600

1_619

100.33333333333333

677.0

Topological domain

Cytoplasmic

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000437600

641_678

100.33333333333333

677.0

Topological domain

Lumenal

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000547394

1_619

84.33333333333333

663.0

Topological domain

Cytoplasmic

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000547394

641_678

84.33333333333333

663.0

Topological domain

Lumenal

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000292538

620_640

100.33333333333333

679.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000393824

620_640

63.333333333333336

640.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000437600

620_640

100.33333333333333

677.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Hgene

CUX1

chr7:101713697

chr7:11676588

ENST00000547394

620_640

84.33333333333333

663.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

57_116

63.333333333333336

1658.0

Domain

TSP type-1 1

Tgene

THSD7A

chr7:101713697

chr7:11676588

ENST00000423059

48_1607

63.333333333333336

1658.0

Topological domain

Extracellular

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CUX1
THSD7A

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to CUX1-THSD7A

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CUX1-THSD7A

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source