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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CYP51A1-KRIT1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CYP51A1-KRIT1
	FusionPDB ID: 21113
	FusionGDB2.0 ID: 21113
		Hgene	Tgene
	Gene symbol	CYP51A1	KRIT1
	Gene ID	1595	889
	Gene name	cytochrome P450 family 51 subfamily A member 1	KRIT1 ankyrin repeat containing
	Synonyms	CP51\|CYP51\|CYPL1\|LDM\|P450-14DM\|P450L1	CAM\|CCM1
	Cytomap	7q21.2	7q21.2
	Type of gene	protein-coding	protein-coding
	Description	lanosterol 14-alpha demethylaseCYPLIcytochrome P450 51A1cytochrome P450, 51 (lanosterol 14-alpha-demethylase)cytochrome P450, family 51, subfamily A, polypeptide 1cytochrome P450-14DMcytochrome P45014DMcytochrome P450LIsterol 14-alpha demethylase	krev interaction trapped protein 1ankyrin repeat-containing protein Krit1cerebral cavernous malformations 1 proteinkrev interaction trapped 1
	Modification date	20200313	20200313
	UniProtAcc	Q16850	O00522
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000003100, ENST00000450723,	ENST00000466166, ENST00000340022, ENST00000394503, ENST00000394505, ENST00000394507, ENST00000412043,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 5 X 4=80	3 X 3 X 3=27
	# samples	4	3
	** MAII score	log2(4/80*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CYP51A1 [Title/Abstract] AND KRIT1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CYP51A1(91755566)-KRIT1(91864960), # samples:1
Anticipated loss of major functional domain due to fusion event.	CYP51A1-KRIT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CYP51A1-KRIT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CYP51A1-KRIT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CYP51A1-KRIT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CYP51A1-KRIT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CYP51A1-KRIT1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CYP51A1-KRIT1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CYP51A1	GO:0006694	steroid biosynthetic process	20149798

Fusion gene breakpoints across CYP51A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KRIT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	5357N	CYP51A1	chr7	91755566	-	KRIT1	chr7	91864960	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000003100	CYP51A1	chr7	91755566	-	ENST00000394507	KRIT1	chr7	91864960	-	4429	936	166	2661	831
ENST00000003100	CYP51A1	chr7	91755566	-	ENST00000340022	KRIT1	chr7	91864960	-	3985	936	166	2661	831
ENST00000003100	CYP51A1	chr7	91755566	-	ENST00000412043	KRIT1	chr7	91864960	-	3040	936	166	2661	831
ENST00000003100	CYP51A1	chr7	91755566	-	ENST00000394505	KRIT1	chr7	91864960	-	3040	936	166	2661	831
ENST00000003100	CYP51A1	chr7	91755566	-	ENST00000394503	KRIT1	chr7	91864960	-	2881	936	166	2517	783

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000003100	ENST00000394507	CYP51A1	chr7	91755566	-	KRIT1	chr7	91864960	-	0.000120029	0.99987996
ENST00000003100	ENST00000340022	CYP51A1	chr7	91755566	-	KRIT1	chr7	91864960	-	0.000136473	0.9998635
ENST00000003100	ENST00000412043	CYP51A1	chr7	91755566	-	KRIT1	chr7	91864960	-	0.000311928	0.99968815
ENST00000003100	ENST00000394505	CYP51A1	chr7	91755566	-	KRIT1	chr7	91864960	-	0.000311928	0.99968815
ENST00000003100	ENST00000394503	CYP51A1	chr7	91755566	-	KRIT1	chr7	91864960	-	0.000352204	0.99964774

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21113_21113_1_CYP51A1-KRIT1_CYP51A1_chr7_91755566_ENST00000003100_KRIT1_chr7_91864960_ENST00000340022_length(amino acids)=831AA_BP=256
MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEF
LENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI
IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRWLDERHAQSHFIP
ALFRPSPLERIKTNVINPAYATESGQTENSLHMGYSALEIKSKMLALEKADTCIYNPLFGSDLQYTNRVDKVVINPYFGLGAPDYSKIQI
PKQEKWQRSMSSVTEDKERQWVDDFPLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNLLNGQL
SSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENKQNNWEEAAKLLKEAINKPYEKVRIYRMDGSYRSVELKHGNNTTVQ
QIMEGMRLSQETQQYFTIWICSENLSLQLKPYHKPLQHVRDWPEILAELTNLDPQRETPQLFLRRDVRLPLEVEKQIEDPLAILILFDEA
RYNLLKGFYTAPDAKLITLASLLLQIVYGNYESKKHKQGFLNEENLKSIVPVTKLKSKAPHWTNRILHEYKNLSTSEGVSKEMHHLQRMF
LQNCWEIPTYGAAFFTGQIFTKASPSNHKVIPVYVGVNIKGLHLLNMETKALLISLKYGCFMWQLGDTDTCFQIHSMENKMSFIVHTKQA

--------------------------------------------------------------

>21113_21113_2_CYP51A1-KRIT1_CYP51A1_chr7_91755566_ENST00000003100_KRIT1_chr7_91864960_ENST00000394503_length(amino acids)=783AA_BP=256
MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEF
LENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI
IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRWLDERHAQSHFIP
ALFRPSPLERIKTNVINPAYATESGQTENSLHMGYSALEIKSKMLALEKADTCIYNPLFGSDLQYTNRVDKVVINPYFGLGAPDYSKIQI
PKQEKWQRSMSSVTEDKYGKVEATRILLEKGKCNPNLLNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENKQNN
WEEAAKLLKEAINKPYEKVRIYRMDGSYRSVELKHGNNTTVQQIMEGMRLSQETQQYFTIWICSENLSLQLKPYHKPLQHVRDWPEILAE
LTNLDPQRETPQLFLRRDVRLPLEVEKQIEDPLAILILFDEARYNLLKGFYTAPDAKLITLASLLLQIVYGNYESKKHKQGFLNEENLKS
IVPVTKLKSKAPHWTNRILHEYKNLSTSEGVSKEMHHLQRMFLQNCWEIPTYGAAFFTGQIFTKASPSNHKVIPVYVGVNIKGLHLLNME

--------------------------------------------------------------

>21113_21113_3_CYP51A1-KRIT1_CYP51A1_chr7_91755566_ENST00000003100_KRIT1_chr7_91864960_ENST00000394505_length(amino acids)=831AA_BP=256
MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEF
LENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI
IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRWLDERHAQSHFIP
ALFRPSPLERIKTNVINPAYATESGQTENSLHMGYSALEIKSKMLALEKADTCIYNPLFGSDLQYTNRVDKVVINPYFGLGAPDYSKIQI
PKQEKWQRSMSSVTEDKERQWVDDFPLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNLLNGQL
SSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENKQNNWEEAAKLLKEAINKPYEKVRIYRMDGSYRSVELKHGNNTTVQ
QIMEGMRLSQETQQYFTIWICSENLSLQLKPYHKPLQHVRDWPEILAELTNLDPQRETPQLFLRRDVRLPLEVEKQIEDPLAILILFDEA
RYNLLKGFYTAPDAKLITLASLLLQIVYGNYESKKHKQGFLNEENLKSIVPVTKLKSKAPHWTNRILHEYKNLSTSEGVSKEMHHLQRMF
LQNCWEIPTYGAAFFTGQIFTKASPSNHKVIPVYVGVNIKGLHLLNMETKALLISLKYGCFMWQLGDTDTCFQIHSMENKMSFIVHTKQA

--------------------------------------------------------------

>21113_21113_4_CYP51A1-KRIT1_CYP51A1_chr7_91755566_ENST00000003100_KRIT1_chr7_91864960_ENST00000394507_length(amino acids)=831AA_BP=256
MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEF
LENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI
IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRWLDERHAQSHFIP
ALFRPSPLERIKTNVINPAYATESGQTENSLHMGYSALEIKSKMLALEKADTCIYNPLFGSDLQYTNRVDKVVINPYFGLGAPDYSKIQI
PKQEKWQRSMSSVTEDKERQWVDDFPLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNLLNGQL
SSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENKQNNWEEAAKLLKEAINKPYEKVRIYRMDGSYRSVELKHGNNTTVQ
QIMEGMRLSQETQQYFTIWICSENLSLQLKPYHKPLQHVRDWPEILAELTNLDPQRETPQLFLRRDVRLPLEVEKQIEDPLAILILFDEA
RYNLLKGFYTAPDAKLITLASLLLQIVYGNYESKKHKQGFLNEENLKSIVPVTKLKSKAPHWTNRILHEYKNLSTSEGVSKEMHHLQRMF
LQNCWEIPTYGAAFFTGQIFTKASPSNHKVIPVYVGVNIKGLHLLNMETKALLISLKYGCFMWQLGDTDTCFQIHSMENKMSFIVHTKQA

--------------------------------------------------------------

>21113_21113_5_CYP51A1-KRIT1_CYP51A1_chr7_91755566_ENST00000003100_KRIT1_chr7_91864960_ENST00000412043_length(amino acids)=831AA_BP=256
MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEF
LENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI
IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRWLDERHAQSHFIP
ALFRPSPLERIKTNVINPAYATESGQTENSLHMGYSALEIKSKMLALEKADTCIYNPLFGSDLQYTNRVDKVVINPYFGLGAPDYSKIQI
PKQEKWQRSMSSVTEDKERQWVDDFPLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNLLNGQL
SSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENKQNNWEEAAKLLKEAINKPYEKVRIYRMDGSYRSVELKHGNNTTVQ
QIMEGMRLSQETQQYFTIWICSENLSLQLKPYHKPLQHVRDWPEILAELTNLDPQRETPQLFLRRDVRLPLEVEKQIEDPLAILILFDEA
RYNLLKGFYTAPDAKLITLASLLLQIVYGNYESKKHKQGFLNEENLKSIVPVTKLKSKAPHWTNRILHEYKNLSTSEGVSKEMHHLQRMF
LQNCWEIPTYGAAFFTGQIFTKASPSNHKVIPVYVGVNIKGLHLLNMETKALLISLKYGCFMWQLGDTDTCFQIHSMENKMSFIVHTKQA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:91755566/chr7:91864960)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CYP51A1 Q16850	KRIT1 O00522
FUNCTION: A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25-dihydrolanosterol likely through sequential oxidative conversion of 14-alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid (PubMed:20149798, PubMed:8619637). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:20149798, PubMed:8619637). {ECO:0000269\|PubMed:20149798, ECO:0000269\|PubMed:8619637}.	FUNCTION: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels. {ECO:0000250\|UniProtKB:Q6S5J6, ECO:0000269\|PubMed:11741838, ECO:0000269\|PubMed:17916086, ECO:0000269\|PubMed:20332120, ECO:0000269\|PubMed:20616044, ECO:0000269\|PubMed:20668652, ECO:0000269\|PubMed:21633110, ECO:0000269\|PubMed:23317506}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CYP51A1

chr7:91755566

chr7:91864960

ENST00000003100

24_44

256.6666666666667

510.0

Transmembrane

Helical

Hgene

CYP51A1

chr7:91755566

chr7:91864960

ENST00000450723

24_44

151.66666666666666

405.0

Transmembrane

Helical

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000340022

420_734

161.66666666666666

737.0

Domain

FERM

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394503

420_734

161.66666666666666

689.0

Domain

FERM

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394505

420_734

161.66666666666666

737.0

Domain

FERM

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394507

420_734

161.66666666666666

737.0

Domain

FERM

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000412043

420_734

161.66666666666666

737.0

Domain

FERM

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000340022

287_316

161.66666666666666

737.0

Repeat

ANK 1

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000340022

320_350

161.66666666666666

737.0

Repeat

ANK 2

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000340022

354_383

161.66666666666666

737.0

Repeat

ANK 3

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000340022

388_419

161.66666666666666

737.0

Repeat

ANK 4

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394503

287_316

161.66666666666666

689.0

Repeat

ANK 1

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394503

320_350

161.66666666666666

689.0

Repeat

ANK 2

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394503

354_383

161.66666666666666

689.0

Repeat

ANK 3

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394503

388_419

161.66666666666666

689.0

Repeat

ANK 4

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394505

287_316

161.66666666666666

737.0

Repeat

ANK 1

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394505

320_350

161.66666666666666

737.0

Repeat

ANK 2

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394505

354_383

161.66666666666666

737.0

Repeat

ANK 3

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394505

388_419

161.66666666666666

737.0

Repeat

ANK 4

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394507

287_316

161.66666666666666

737.0

Repeat

ANK 1

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394507

320_350

161.66666666666666

737.0

Repeat

ANK 2

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394507

354_383

161.66666666666666

737.0

Repeat

ANK 3

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394507

388_419

161.66666666666666

737.0

Repeat

ANK 4

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000412043

287_316

161.66666666666666

737.0

Repeat

ANK 1

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000412043

320_350

161.66666666666666

737.0

Repeat

ANK 2

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000412043

354_383

161.66666666666666

737.0

Repeat

ANK 3

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000412043

388_419

161.66666666666666

737.0

Repeat

ANK 4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000340022

1_170

161.66666666666666

737.0

Region

Note=N-terminal domain similar to Nudix hydrolase domain

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394503

1_170

161.66666666666666

689.0

Region

Note=N-terminal domain similar to Nudix hydrolase domain

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394505

1_170

161.66666666666666

737.0

Region

Note=N-terminal domain similar to Nudix hydrolase domain

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000394507

1_170

161.66666666666666

737.0

Region

Note=N-terminal domain similar to Nudix hydrolase domain

Tgene

KRIT1

chr7:91755566

chr7:91864960

ENST00000412043

1_170

161.66666666666666

737.0

Region

Note=N-terminal domain similar to Nudix hydrolase domain

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CYP51A1
KRIT1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to CYP51A1-KRIT1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CYP51A1-KRIT1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source