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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CYTH1-CUX1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CYTH1-CUX1
FusionPDB ID: 21133
FusionGDB2.0 ID: 21133
HgeneTgene
Gene symbol

CYTH1

CUX1

Gene ID

9267

1523

Gene namecytohesin 1cut like homeobox 1
SynonymsB2-1|CYTOHESIN-1|D17S811E|PSCD1|SEC7CASP|CDP|CDP/Cut|CDP1|COY1|CUTL1|CUX|Clox|Cux/CDP|GDDI|GOLIM6|Nbla10317|p100|p110|p200|p75
Cytomap

17q25.3

7q22.1

Type of geneprotein-codingprotein-coding
Descriptioncytohesin-1PH, SEC7 and coiled-coil domain-containing protein 1SEC7 homolog B2-1cytoadhesin 1homolog of secretory protein SEC7pleckstrin homology, Sec7 and coiled-coil domains 1protein CASPHomeobox protein cut-like 1CCAAT displacement proteinCUX1 gene Alternatively Spliced Productcut homologgolgi integral membrane protein 6homeobox protein cux-1putative protein product of Nbla10317
Modification date2020031320200320
UniProtAcc

Q15438

P39880

Ensembl transtripts involved in fusion geneENST idsENST00000361101, ENST00000446868, 
ENST00000585509, ENST00000589297, 
ENST00000591455, ENST00000586175, 
ENST00000589296, 		ENST00000560541, 
ENST00000292535, ENST00000360264, 
ENST00000425244, ENST00000546411, 
ENST00000549414, ENST00000550008, 
ENST00000556210, ENST00000292538, 
ENST00000393824, ENST00000437600, 
ENST00000547394, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 13 X 7=163826 X 23 X 9=5382
# samples 1929
** MAII scorelog2(19/1638*10)=-3.10786403331006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/5382*10)=-4.21401758562548
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CYTH1 [Title/Abstract] AND CUX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CYTH1(76696412)-CUX1(101916636), # samples:2
Anticipated loss of major functional domain due to fusion event.CYTH1-CUX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CYTH1-CUX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CYTH1-CUX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CYTH1-CUX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CYTH1-CUX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CYTH1-CUX1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CYTH1-CUX1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CYTH1-CUX1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
CYTH1-CUX1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCYTH1

GO:0030155

regulation of cell adhesion

12606567


check buttonFusion gene breakpoints across CYTH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CUX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-IG-A3YCCYTH1chr17

76696412

-CUX1chr7

101916636

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000589297CYTH1chr1776696412-ENST00000437600CUX1chr7101916636+271510664951847450
ENST00000589297CYTH1chr1776696412-ENST00000292538CUX1chr7101916636+271510664951847450
ENST00000589297CYTH1chr1776696412-ENST00000393824CUX1chr7101916636+223610664951847450
ENST00000589297CYTH1chr1776696412-ENST00000547394CUX1chr7101916636+271510664951847450
ENST00000591455CYTH1chr1776696412-ENST00000437600CUX1chr7101916636+2248599491380443
ENST00000591455CYTH1chr1776696412-ENST00000292538CUX1chr7101916636+2248599491380443
ENST00000591455CYTH1chr1776696412-ENST00000393824CUX1chr7101916636+1769599491380443
ENST00000591455CYTH1chr1776696412-ENST00000547394CUX1chr7101916636+2248599491380443
ENST00000446868CYTH1chr1776696412-ENST00000437600CUX1chr7101916636+2270621711402443
ENST00000446868CYTH1chr1776696412-ENST00000292538CUX1chr7101916636+2270621711402443
ENST00000446868CYTH1chr1776696412-ENST00000393824CUX1chr7101916636+1791621711402443
ENST00000446868CYTH1chr1776696412-ENST00000547394CUX1chr7101916636+2270621711402443
ENST00000361101CYTH1chr1776696412-ENST00000437600CUX1chr7101916636+2270621711402443
ENST00000361101CYTH1chr1776696412-ENST00000292538CUX1chr7101916636+2270621711402443
ENST00000361101CYTH1chr1776696412-ENST00000393824CUX1chr7101916636+1791621711402443
ENST00000361101CYTH1chr1776696412-ENST00000547394CUX1chr7101916636+2270621711402443

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000589297ENST00000437600CYTH1chr1776696412-CUX1chr7101916636+0.0097506190.99024934
ENST00000589297ENST00000292538CYTH1chr1776696412-CUX1chr7101916636+0.0097506190.99024934
ENST00000589297ENST00000393824CYTH1chr1776696412-CUX1chr7101916636+0.0094980870.9905019
ENST00000589297ENST00000547394CYTH1chr1776696412-CUX1chr7101916636+0.0097506190.99024934
ENST00000591455ENST00000437600CYTH1chr1776696412-CUX1chr7101916636+0.0140178160.9859822
ENST00000591455ENST00000292538CYTH1chr1776696412-CUX1chr7101916636+0.0140178160.9859822
ENST00000591455ENST00000393824CYTH1chr1776696412-CUX1chr7101916636+0.0142805530.9857195
ENST00000591455ENST00000547394CYTH1chr1776696412-CUX1chr7101916636+0.0140178160.9859822
ENST00000446868ENST00000437600CYTH1chr1776696412-CUX1chr7101916636+0.0137719720.98622805
ENST00000446868ENST00000292538CYTH1chr1776696412-CUX1chr7101916636+0.0137719720.98622805
ENST00000446868ENST00000393824CYTH1chr1776696412-CUX1chr7101916636+0.014185510.9858145
ENST00000446868ENST00000547394CYTH1chr1776696412-CUX1chr7101916636+0.0137719720.98622805
ENST00000361101ENST00000437600CYTH1chr1776696412-CUX1chr7101916636+0.0137719720.98622805
ENST00000361101ENST00000292538CYTH1chr1776696412-CUX1chr7101916636+0.0137719720.98622805
ENST00000361101ENST00000393824CYTH1chr1776696412-CUX1chr7101916636+0.014185510.9858145
ENST00000361101ENST00000547394CYTH1chr1776696412-CUX1chr7101916636+0.0137719720.98622805

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21133_21133_1_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000361101_CUX1_chr7_101916636_ENST00000292538_length(amino acids)=443AA_BP=182
MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLL
KNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
QSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSII
SSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYL

--------------------------------------------------------------

>21133_21133_2_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000361101_CUX1_chr7_101916636_ENST00000393824_length(amino acids)=443AA_BP=182
MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLL
KNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
QSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSII
SSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYL

--------------------------------------------------------------

>21133_21133_3_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000361101_CUX1_chr7_101916636_ENST00000437600_length(amino acids)=443AA_BP=182
MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLL
KNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
QSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSII
SSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYL

--------------------------------------------------------------

>21133_21133_4_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000361101_CUX1_chr7_101916636_ENST00000547394_length(amino acids)=443AA_BP=182
MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLL
KNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
QSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSII
SSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYL

--------------------------------------------------------------

>21133_21133_5_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000446868_CUX1_chr7_101916636_ENST00000292538_length(amino acids)=443AA_BP=182
MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLL
KNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
QSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSII
SSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYL

--------------------------------------------------------------

>21133_21133_6_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000446868_CUX1_chr7_101916636_ENST00000393824_length(amino acids)=443AA_BP=182
MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLL
KNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
QSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSII
SSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYL

--------------------------------------------------------------

>21133_21133_7_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000446868_CUX1_chr7_101916636_ENST00000437600_length(amino acids)=443AA_BP=182
MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLL
KNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
QSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSII
SSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYL

--------------------------------------------------------------

>21133_21133_8_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000446868_CUX1_chr7_101916636_ENST00000547394_length(amino acids)=443AA_BP=182
MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLL
KNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
QSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSII
SSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYL

--------------------------------------------------------------

>21133_21133_9_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000589297_CUX1_chr7_101916636_ENST00000292538_length(amino acids)=450AA_BP=189
MARTLGPQERGLTVVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQF
LIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYC
QCNNGVFQSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQV
DSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKR
ERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDNGAAAGDLWQ

--------------------------------------------------------------

>21133_21133_10_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000589297_CUX1_chr7_101916636_ENST00000393824_length(amino acids)=450AA_BP=189
MARTLGPQERGLTVVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQF
LIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYC
QCNNGVFQSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQV
DSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKR
ERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDNGAAAGDLWQ

--------------------------------------------------------------

>21133_21133_11_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000589297_CUX1_chr7_101916636_ENST00000437600_length(amino acids)=450AA_BP=189
MARTLGPQERGLTVVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQF
LIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYC
QCNNGVFQSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQV
DSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKR
ERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDNGAAAGDLWQ

--------------------------------------------------------------

>21133_21133_12_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000589297_CUX1_chr7_101916636_ENST00000547394_length(amino acids)=450AA_BP=189
MARTLGPQERGLTVVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQF
LIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYC
QCNNGVFQSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQV
DSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKR
ERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDNGAAAGDLWQ

--------------------------------------------------------------

>21133_21133_13_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000591455_CUX1_chr7_101916636_ENST00000292538_length(amino acids)=443AA_BP=182
MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLL
KNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
QSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSII
SSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYL

--------------------------------------------------------------

>21133_21133_14_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000591455_CUX1_chr7_101916636_ENST00000393824_length(amino acids)=443AA_BP=182
MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLL
KNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
QSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSII
SSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYL

--------------------------------------------------------------

>21133_21133_15_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000591455_CUX1_chr7_101916636_ENST00000437600_length(amino acids)=443AA_BP=182
MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLL
KNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
QSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSII
SSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYL

--------------------------------------------------------------

>21133_21133_16_CYTH1-CUX1_CYTH1_chr17_76696412_ENST00000591455_CUX1_chr7_101916636_ENST00000547394_length(amino acids)=443AA_BP=182
MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENDLL
KNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
QSTGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSII
SSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:76696412/chr7:101916636)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYTH1

Q15438

CUX1

P39880

FUNCTION: Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. {ECO:0000250|UniProtKB:Q9QX11, ECO:0000269|PubMed:10652308, ECO:0000269|PubMed:29420262, ECO:0000269|PubMed:9653114}.FUNCTION: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCYTH1chr17:76696412chr7:101916636ENST00000361101-71310_67183.33333333333334399.0Coiled coilOntology_term=ECO:0000255
HgeneCYTH1chr17:76696412chr7:101916636ENST00000446868-71410_67183.33333333333334399.0Coiled coilOntology_term=ECO:0000255
HgeneCYTH1chr17:76696412chr7:101916636ENST00000591455-71310_67183.33333333333334398.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST0000029253502456_40701506.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST000002925381323502_556418.3333333333333679.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST0000036026402456_40701517.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST000003938241222502_556379.3333333333333640.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST000004376001323502_556416.3333333333333677.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST0000054641102456_4070.01404.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST000005473941222502_556402.3333333333333663.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST0000054941402356_4070.01484.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST0000055000802256_4070.01450.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST0000055621002256_4070.01348.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST000002925350241406_143801506.0Compositional biasNote=Ala-rich
TgeneCUX1chr17:76696412chr7:101916636ENST000003602640241406_143801517.0Compositional biasNote=Ala-rich
TgeneCUX1chr17:76696412chr7:101916636ENST0000042524412221406_1438372.3333333333333633.0Compositional biasNote=Ala-rich
TgeneCUX1chr17:76696412chr7:101916636ENST000005464110241406_14380.01404.0Compositional biasNote=Ala-rich
TgeneCUX1chr17:76696412chr7:101916636ENST000005494140231406_14380.01484.0Compositional biasNote=Ala-rich
TgeneCUX1chr17:76696412chr7:101916636ENST000005500080221406_14380.01450.0Compositional biasNote=Ala-rich
TgeneCUX1chr17:76696412chr7:101916636ENST000005562100221406_14380.01348.0Compositional biasNote=Ala-rich
TgeneCUX1chr17:76696412chr7:101916636ENST000002925350241117_120401506.0DNA bindingCUT 3
TgeneCUX1chr17:76696412chr7:101916636ENST000002925350241244_130301506.0DNA bindingHomeobox
TgeneCUX1chr17:76696412chr7:101916636ENST00000292535024542_62901506.0DNA bindingCUT 1
TgeneCUX1chr17:76696412chr7:101916636ENST00000292535024934_102101506.0DNA bindingCUT 2
TgeneCUX1chr17:76696412chr7:101916636ENST000003602640241117_120401517.0DNA bindingCUT 3
TgeneCUX1chr17:76696412chr7:101916636ENST000003602640241244_130301517.0DNA bindingHomeobox
TgeneCUX1chr17:76696412chr7:101916636ENST00000360264024542_62901517.0DNA bindingCUT 1
TgeneCUX1chr17:76696412chr7:101916636ENST00000360264024934_102101517.0DNA bindingCUT 2
TgeneCUX1chr17:76696412chr7:101916636ENST0000042524412221117_1204372.3333333333333633.0DNA bindingCUT 3
TgeneCUX1chr17:76696412chr7:101916636ENST0000042524412221244_1303372.3333333333333633.0DNA bindingHomeobox
TgeneCUX1chr17:76696412chr7:101916636ENST000004252441222542_629372.3333333333333633.0DNA bindingCUT 1
TgeneCUX1chr17:76696412chr7:101916636ENST000004252441222934_1021372.3333333333333633.0DNA bindingCUT 2
TgeneCUX1chr17:76696412chr7:101916636ENST000005464110241117_12040.01404.0DNA bindingCUT 3
TgeneCUX1chr17:76696412chr7:101916636ENST000005464110241244_13030.01404.0DNA bindingHomeobox
TgeneCUX1chr17:76696412chr7:101916636ENST00000546411024542_6290.01404.0DNA bindingCUT 1
TgeneCUX1chr17:76696412chr7:101916636ENST00000546411024934_10210.01404.0DNA bindingCUT 2
TgeneCUX1chr17:76696412chr7:101916636ENST000005494140231117_12040.01484.0DNA bindingCUT 3
TgeneCUX1chr17:76696412chr7:101916636ENST000005494140231244_13030.01484.0DNA bindingHomeobox
TgeneCUX1chr17:76696412chr7:101916636ENST00000549414023542_6290.01484.0DNA bindingCUT 1
TgeneCUX1chr17:76696412chr7:101916636ENST00000549414023934_10210.01484.0DNA bindingCUT 2
TgeneCUX1chr17:76696412chr7:101916636ENST000005500080221117_12040.01450.0DNA bindingCUT 3
TgeneCUX1chr17:76696412chr7:101916636ENST000005500080221244_13030.01450.0DNA bindingHomeobox
TgeneCUX1chr17:76696412chr7:101916636ENST00000550008022542_6290.01450.0DNA bindingCUT 1
TgeneCUX1chr17:76696412chr7:101916636ENST00000550008022934_10210.01450.0DNA bindingCUT 2
TgeneCUX1chr17:76696412chr7:101916636ENST000005562100221117_12040.01348.0DNA bindingCUT 3
TgeneCUX1chr17:76696412chr7:101916636ENST000005562100221244_13030.01348.0DNA bindingHomeobox
TgeneCUX1chr17:76696412chr7:101916636ENST00000556210022542_6290.01348.0DNA bindingCUT 1
TgeneCUX1chr17:76696412chr7:101916636ENST00000556210022934_10210.01348.0DNA bindingCUT 2
TgeneCUX1chr17:76696412chr7:101916636ENST000002925381323641_678418.3333333333333679.0Topological domainLumenal
TgeneCUX1chr17:76696412chr7:101916636ENST000003938241222641_678379.3333333333333640.0Topological domainLumenal
TgeneCUX1chr17:76696412chr7:101916636ENST000004376001323641_678416.3333333333333677.0Topological domainLumenal
TgeneCUX1chr17:76696412chr7:101916636ENST000005473941222641_678402.3333333333333663.0Topological domainLumenal
TgeneCUX1chr17:76696412chr7:101916636ENST000002925381323620_640418.3333333333333679.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneCUX1chr17:76696412chr7:101916636ENST000003938241222620_640379.3333333333333640.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneCUX1chr17:76696412chr7:101916636ENST000004376001323620_640416.3333333333333677.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneCUX1chr17:76696412chr7:101916636ENST000005473941222620_640402.3333333333333663.0TransmembraneHelical%3B Anchor for type IV membrane protein

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCYTH1chr17:76696412chr7:101916636ENST00000361101-713260_377183.33333333333334399.0DomainPH
HgeneCYTH1chr17:76696412chr7:101916636ENST00000361101-71373_202183.33333333333334399.0DomainSEC7
HgeneCYTH1chr17:76696412chr7:101916636ENST00000446868-714260_377183.33333333333334399.0DomainPH
HgeneCYTH1chr17:76696412chr7:101916636ENST00000446868-71473_202183.33333333333334399.0DomainSEC7
HgeneCYTH1chr17:76696412chr7:101916636ENST00000591455-713260_377183.33333333333334398.0DomainPH
HgeneCYTH1chr17:76696412chr7:101916636ENST00000591455-71373_202183.33333333333334398.0DomainSEC7
HgeneCYTH1chr17:76696412chr7:101916636ENST00000361101-713269_277183.33333333333334399.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneCYTH1chr17:76696412chr7:101916636ENST00000361101-713388_396183.33333333333334399.0RegionC-terminal autoinhibitory region
HgeneCYTH1chr17:76696412chr7:101916636ENST00000446868-714269_277183.33333333333334399.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneCYTH1chr17:76696412chr7:101916636ENST00000446868-714388_396183.33333333333334399.0RegionC-terminal autoinhibitory region
HgeneCYTH1chr17:76696412chr7:101916636ENST00000591455-713269_277183.33333333333334398.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneCYTH1chr17:76696412chr7:101916636ENST00000591455-713388_396183.33333333333334398.0RegionC-terminal autoinhibitory region
TgeneCUX1chr17:76696412chr7:101916636ENST00000292538132367_450418.3333333333333679.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST00000393824122267_450379.3333333333333640.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST00000425244122256_407372.3333333333333633.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST00000437600132367_450416.3333333333333677.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST00000547394122267_450402.3333333333333663.0Coiled coilOntology_term=ECO:0000255
TgeneCUX1chr17:76696412chr7:101916636ENST0000029253813231_619418.3333333333333679.0Topological domainCytoplasmic
TgeneCUX1chr17:76696412chr7:101916636ENST0000039382412221_619379.3333333333333640.0Topological domainCytoplasmic
TgeneCUX1chr17:76696412chr7:101916636ENST0000043760013231_619416.3333333333333677.0Topological domainCytoplasmic
TgeneCUX1chr17:76696412chr7:101916636ENST0000054739412221_619402.3333333333333663.0Topological domainCytoplasmic


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CYTH1
CUX1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CYTH1-CUX1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CYTH1-CUX1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource